ISMARA results: FOXA3

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for FOXA3_FOXC2

Z-value: 0.25

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Transcription factors associated with FOXA3_FOXC2

Gene Symbol	Gene ID	Gene Info
FOXA3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000170608.2	forkhead box A3
FOXC2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000176692.4	forkhead box C2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXC2	hg19_v2_chr16_+_86600857_86600921	-0.14	3.4e-02	Click!

Activity profile of FOXA3_FOXC2 motif

Sorted Z-values of FOXA3_FOXC2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_26695013 Show fit	11.45	ENST00000555059.2	CTB-96E2.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	Homeobox protein SEBOX
chr17_-_26694979 Show fit	11.37	ENST00000438614.1	VTN Ensembl NCBI GeneCards UniProt NextProt Show fit	vitronectin
chr11_-_116708302 Show fit	10.42	ENST00000375320.1 ENST00000359492.2 ENST00000375329.2 ENST00000375323.1	APOA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	apolipoprotein A-I
chr11_+_62186498 Show fit	8.86	ENST00000278282.2	SCGB1A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	secretoglobin, family 1A, member 1 (uteroglobin)
chr12_-_92539614 Show fit	8.83	ENST00000256015.3	BTG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	B-cell translocation gene 1, anti-proliferative
chr17_-_39684550 Show fit	8.01	ENST00000455635.1 ENST00000361566.3	KRT19 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 19
chr10_+_71561649 Show fit	6.61	ENST00000398978.3 ENST00000354547.3 ENST00000357811.3	COL13A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	collagen, type XIII, alpha 1
chr4_-_174256276 Show fit	6.20	ENST00000296503.5	HMGB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	high mobility group box 2
chr14_-_36988882 Show fit	5.94	ENST00000498187.2	NKX2-1 Ensembl NCBI GeneCards UniProt NextProt Show fit	NK2 homeobox 1
chr17_+_72426891 Show fit	5.76	ENST00000392627.1	GPRC5C Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor, family C, group 5, member C

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA3_FOXC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	19.6	GO:0001958	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
1.6	14.3	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	11.7	GO:0006936	muscle contraction(GO:0006936)
2.6	10.4	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
1.5	8.9	GO:0010193	response to ozone(GO:0010193)
0.7	8.8	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.5	8.3	GO:0071985	multivesicular body sorting pathway(GO:0071985)
1.1	8.0	GO:0008218	bioluminescence(GO:0008218)
0.2	8.0	GO:0060706	cell differentiation involved in embryonic placenta development(GO:0060706)
1.6	7.8	GO:0021759	globus pallidus development(GO:0021759)

Showing 1 to 10 of 156 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	23.2	GO:0005615	extracellular space(GO:0005615)
4.9	19.6	GO:0005600	collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
3.6	14.3	GO:0071062	rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.9	12.9	GO:0030478	actin cap(GO:0030478)
0.1	12.8	GO:0072562	blood microparticle(GO:0072562)
1.8	10.6	GO:1990357	terminal web(GO:1990357)
3.5	10.4	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.1	9.4	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.1	8.3	GO:0005796	Golgi lumen(GO:0005796)
0.7	6.6	GO:0005579	membrane attack complex(GO:0005579)

Showing 1 to 10 of 76 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	23.8	GO:0008201	heparin binding(GO:0008201)
0.1	13.5	GO:0008307	structural constituent of muscle(GO:0008307)
0.5	12.9	GO:0005523	tropomyosin binding(GO:0005523)
0.0	11.6	GO:0003712	transcription cofactor activity(GO:0003712)
2.6	10.4	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.6	10.0	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
1.5	8.9	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	8.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.6	8.4	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.2	7.4	GO:0004181	metallocarboxypeptidase activity(GO:0004181)

Showing 1 to 10 of 118 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	25.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.4	19.6	NABA COLLAGENS	Genes encoding collagen proteins
0.3	18.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.5	15.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	11.7	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	10.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	9.3	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	6.3	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	6.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	5.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins

Showing 1 to 10 of 38 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	19.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	19.5	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.3	16.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.6	15.4	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.1	10.0	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2	8.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.3	6.8	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.2	6.5	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.2	5.7	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	5.5	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation

Showing 1 to 10 of 57 entries

Results for FOXA3_FOXC2

Z-value: 0.25

Motif logo

Transcription factors associated with FOXA3_FOXC2

Activity-expression correlation:

Activity profile of FOXA3_FOXC2 motif

Sorted Z-values of FOXA3_FOXC2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA3_FOXC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: