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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FOXC1
Z-value: 0.67
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Transcription factors associated with FOXC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXC1 | hg19_v2_chr6_+_1610681_1610681 | -0.12 | 8.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.4 | 22.1 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 2.4 | 14.3 | GO:1902730 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
| 3.0 | 11.9 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 2.9 | 11.5 | GO:1903224 | regulation of endodermal cell differentiation(GO:1903224) |
| 0.2 | 10.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.2 | 10.0 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.1 | 9.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 2.3 | 9.1 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 2.9 | 8.8 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) |
| 0.9 | 8.2 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 22.1 | GO:0005955 | calcineurin complex(GO:0005955) |
| 2.4 | 14.3 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.0 | 13.8 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 1.1 | 11.9 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.1 | 11.8 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 11.4 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 2.1 | 10.7 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.1 | 9.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 1.0 | 9.1 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.6 | 8.2 | GO:0042555 | MCM complex(GO:0042555) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.3 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 2.2 | 22.1 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.7 | 14.3 | GO:0070016 | gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016) |
| 0.9 | 11.9 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.5 | 10.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.4 | 9.1 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.2 | 8.2 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.7 | 7.6 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.7 | 7.6 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 1.9 | 7.4 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 19.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 13.7 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.3 | 12.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 10.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 9.9 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.2 | 9.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 8.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 6.3 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.3 | 6.2 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 5.4 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 20.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 16.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 12.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.3 | 11.9 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 10.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 9.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.5 | 9.1 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.5 | 8.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.4 | 7.4 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.5 | 7.3 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |