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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Z-value: 0.94
Motif logo
Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000251493.2 | forkhead box D1 | |
| ENSG00000150907.6 | forkhead box O1 | |
| ENSG00000204060.4 | forkhead box O6 | |
| ENSG00000176165.7 | forkhead box G1 | |
| ENSG00000114861.14 | forkhead box P1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXO1 | hg19_v2_chr13_-_41240717_41240735 | 0.52 | 1.6e-16 | Click! |
| FOXD1 | hg19_v2_chr5_-_72744336_72744359 | -0.37 | 2.0e-08 | Click! |
| FOXG1 | hg19_v2_chr14_+_29236269_29236287, hg19_v2_chr14_+_29234870_29235050 | -0.08 | 2.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_145438469 Show fit | 55.45 |
ENST00000369317.4
|
thioredoxin interacting protein |
|
| chr11_+_117049854 Show fit | 54.35 |
ENST00000278951.7
|
SID1 transmembrane family, member 2 |
|
| chr12_-_92539614 Show fit | 53.24 |
ENST00000256015.3
|
B-cell translocation gene 1, anti-proliferative |
|
| chr11_+_117049445 Show fit | 41.16 |
ENST00000324225.4
ENST00000532960.1 |
SID1 transmembrane family, member 2 |
|
| chr13_-_46716969 Show fit | 39.76 |
ENST00000435666.2
|
lymphocyte cytosolic protein 1 (L-plastin) |
|
| chrX_-_106960285 Show fit | 39.37 |
ENST00000503515.1
ENST00000372397.2 |
TSC22 domain family, member 3 |
|
| chr11_+_117049910 Show fit | 35.73 |
ENST00000431081.2
ENST00000524842.1 |
SID1 transmembrane family, member 2 |
|
| chr6_+_89791507 Show fit | 34.56 |
ENST00000354922.3
|
proline-rich nuclear receptor coactivator 1 |
|
| chr19_+_12902289 Show fit | 33.77 |
ENST00000302754.4
|
jun B proto-oncogene |
|
| chr6_-_31550192 Show fit | 28.14 |
ENST00000429299.2
ENST00000446745.2 |
lymphotoxin beta (TNF superfamily, member 3) |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.9 | 131.2 | GO:0033227 | dsRNA transport(GO:0033227) |
| 4.3 | 56.3 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 3.2 | 51.2 | GO:0051639 | actin filament network formation(GO:0051639) |
| 2.4 | 48.7 | GO:0002347 | response to tumor cell(GO:0002347) |
| 0.2 | 44.1 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 5.4 | 42.9 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 12.0 | 35.9 | GO:0090219 | negative regulation of lipid kinase activity(GO:0090219) |
| 4.3 | 34.6 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 5.6 | 33.8 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.4 | 32.2 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 148.4 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 58.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 52.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 2.6 | 51.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 5.6 | 45.0 | GO:0035976 | AP1 complex(GO:0035976) |
| 1.2 | 38.6 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.2 | 34.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.4 | 30.6 | GO:0005776 | autophagosome(GO:0005776) |
| 6.1 | 30.5 | GO:0036398 | TCR signalosome(GO:0036398) |
| 1.4 | 30.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 21.9 | 131.2 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 4.5 | 57.9 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.2 | 54.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.2 | 49.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 48.2 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.2 | 40.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 4.4 | 39.4 | GO:0043426 | MRF binding(GO:0043426) |
| 0.8 | 36.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 1.2 | 32.3 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.2 | 31.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 67.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.8 | 53.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.9 | 47.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 39.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 36.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.8 | 27.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 25.9 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.2 | 25.6 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.3 | 22.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.5 | 22.0 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 55.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 1.0 | 53.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 1.4 | 38.1 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.7 | 34.9 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.7 | 29.5 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.9 | 28.5 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 1.0 | 24.7 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.5 | 21.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.4 | 19.9 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.7 | 19.4 | REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK | Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK |