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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FOXF2_FOXJ1
Z-value: 0.44
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Transcription factors associated with FOXF2_FOXJ1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXJ1 | hg19_v2_chr17_-_74137374_74137385 | 0.27 | 4.8e-05 | Click! |
| FOXF2 | hg19_v2_chr6_+_1389989_1390069 | 0.07 | 2.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXF2_FOXJ1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 34.9 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 1.9 | 21.0 | GO:0090232 | peripheral nervous system myelin maintenance(GO:0032287) positive regulation of spindle checkpoint(GO:0090232) |
| 1.1 | 17.1 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.2 | 12.8 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 3.1 | 12.3 | GO:0006210 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 2.2 | 11.0 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.1 | 10.3 | GO:1903779 | regulation of cardiac conduction(GO:1903779) |
| 2.0 | 10.0 | GO:0018231 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.0 | 9.8 | GO:0007186 | G-protein coupled receptor signaling pathway(GO:0007186) |
| 0.3 | 8.9 | GO:0042994 | cytoplasmic sequestering of transcription factor(GO:0042994) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 38.5 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.5 | 33.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 18.8 | GO:0045202 | synapse(GO:0045202) |
| 0.1 | 17.1 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 12.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 1.6 | 11.0 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 10.7 | GO:0043235 | receptor complex(GO:0043235) |
| 0.8 | 9.1 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 8.9 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 8.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 21.0 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.5 | 13.6 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.5 | 13.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 11.7 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.9 | 11.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 2.5 | 10.0 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.1 | 8.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 1.6 | 8.2 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.3 | 7.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 1.5 | 7.7 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 36.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 7.7 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 6.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 6.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 5.3 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 5.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 5.2 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 5.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 4.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 4.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 13.4 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.5 | 12.3 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 12.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.6 | 11.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 8.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 7.1 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 6.2 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 5.8 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.2 | 5.4 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 4.8 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |