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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for FOXJ2

Z-value: 0.97

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Transcription factors associated with FOXJ2

Gene Symbol Gene ID Gene Info
FOXJ2
ENSG00000065970.4 forkhead box J2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXJ2hg19_v2_chr12_+_8185288_8185339-0.161.9e-02Click!

Activity profile of FOXJ2 motif

Sorted Z-values of FOXJ2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_165797024 28.03 ENST00000372212.4
UCK2
uridine-cytidine kinase 2
chr1_-_197115818 25.00 ENST00000367409.4
ENST00000294732.7
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr18_+_3447572 20.44 ENST00000548489.2
TGIF1
TGFB-induced factor homeobox 1
chr11_+_35201826 20.07 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr3_+_171757346 18.36 ENST00000421757.1
ENST00000415807.2
ENST00000392699.1
FNDC3B
fibronectin type III domain containing 3B
chr15_+_64428529 17.45 ENST00000560861.1
SNX1
sorting nexin 1
chr15_+_66797627 17.38 ENST00000565627.1
ENST00000564179.1
ZWILCH
zwilch kinetochore protein
chr15_+_66797455 17.19 ENST00000446801.2
ZWILCH
zwilch kinetochore protein
chr1_+_45212074 16.89 ENST00000372217.1
KIF2C
kinesin family member 2C
chr13_-_37573432 13.52 ENST00000413537.2
ENST00000443765.1
ENST00000239891.3
ALG5
ALG5, dolichyl-phosphate beta-glucosyltransferase
chr1_-_43855444 12.88 ENST00000372455.4
MED8
mediator complex subunit 8
chr16_+_3068393 12.46 ENST00000573001.1
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr7_+_77469439 12.29 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr8_-_80993010 12.25 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
TPD52
tumor protein D52
chr10_+_28822236 12.19 ENST00000347934.4
ENST00000354911.4
WAC
WW domain containing adaptor with coiled-coil
chr14_+_52456327 11.95 ENST00000556760.1
C14orf166
chromosome 14 open reading frame 166
chr1_+_95616933 11.72 ENST00000604203.1
RP11-57H12.6
TMEM56-RWDD3 readthrough
chr12_-_96429423 11.43 ENST00000228740.2
LTA4H
leukotriene A4 hydrolase
chr10_-_36813162 11.07 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr2_+_216176540 10.97 ENST00000236959.9
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr9_+_5890802 10.60 ENST00000381477.3
ENST00000381476.1
ENST00000381471.1
MLANA
melan-A
chr1_+_145883868 10.51 ENST00000447947.2
GPR89C
G protein-coupled receptor 89C
chr14_+_52456193 10.44 ENST00000261700.3
C14orf166
chromosome 14 open reading frame 166
chr12_-_54071181 10.38 ENST00000338662.5
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr2_+_231921574 10.32 ENST00000308696.6
ENST00000373635.4
ENST00000440838.1
ENST00000409643.1
PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr3_-_64009658 10.12 ENST00000394431.2
PSMD6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr17_+_66511540 9.80 ENST00000588188.2
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr2_-_85641162 9.74 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
CAPG
capping protein (actin filament), gelsolin-like
chr3_+_157154578 9.44 ENST00000295927.3
PTX3
pentraxin 3, long
chr6_+_10748019 9.13 ENST00000543878.1
ENST00000461342.1
ENST00000475942.1
ENST00000379530.3
ENST00000473276.1
ENST00000481240.1
ENST00000467317.1
SYCP2L
TMEM14B
synaptonemal complex protein 2-like
transmembrane protein 14B
chr12_+_57623477 9.10 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr20_+_36373032 9.06 ENST00000373473.1
CTNNBL1
catenin, beta like 1
chr3_-_64009102 8.90 ENST00000478185.1
ENST00000482510.1
ENST00000497323.1
ENST00000492933.1
ENST00000295901.4
PSMD6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr4_-_99851766 8.85 ENST00000450253.2
EIF4E
eukaryotic translation initiation factor 4E
chr6_+_10747986 8.34 ENST00000379542.5
TMEM14B
transmembrane protein 14B
chr1_-_19811132 7.85 ENST00000433834.1
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr15_-_66797172 7.83 ENST00000569438.1
ENST00000569696.1
ENST00000307961.6
RPL4
ribosomal protein L4
chr3_+_128444994 7.65 ENST00000482525.1
RAB7A
RAB7A, member RAS oncogene family
chr1_+_93544791 7.53 ENST00000545708.1
ENST00000540243.1
ENST00000370298.4
MTF2
metal response element binding transcription factor 2
chr20_+_55926583 7.43 ENST00000395840.2
RAE1
ribonucleic acid export 1
chr6_-_170862322 7.29 ENST00000262193.6
PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr1_+_223889285 6.89 ENST00000433674.2
CAPN2
calpain 2, (m/II) large subunit
chr13_-_38172863 6.78 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr10_+_28822417 6.53 ENST00000428935.1
ENST00000420266.1
WAC
WW domain containing adaptor with coiled-coil
chr19_+_54619125 6.39 ENST00000445811.1
ENST00000419967.1
ENST00000445124.1
ENST00000447810.1
PRPF31
pre-mRNA processing factor 31
chr1_-_45452240 6.22 ENST00000372183.3
ENST00000372182.4
ENST00000360403.2
EIF2B3
eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
chr5_-_34919094 6.16 ENST00000341754.4
RAD1
RAD1 homolog (S. pombe)
chr1_+_150122034 5.60 ENST00000025469.6
ENST00000369124.4
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr12_-_8815215 5.60 ENST00000544889.1
ENST00000543369.1
MFAP5
microfibrillar associated protein 5
chr8_+_30244580 5.43 ENST00000523115.1
ENST00000519647.1
RBPMS
RNA binding protein with multiple splicing
chr16_-_30440530 5.35 ENST00000568434.1
DCTPP1
dCTP pyrophosphatase 1
chr6_+_31462658 5.26 ENST00000538442.1
MICB
MHC class I polypeptide-related sequence B
chr12_+_123949053 4.97 ENST00000350887.5
SNRNP35
small nuclear ribonucleoprotein 35kDa (U11/U12)
chr17_+_57287228 4.95 ENST00000578922.1
ENST00000300917.5
SMG8
SMG8 nonsense mediated mRNA decay factor
chr12_-_8815299 4.95 ENST00000535336.1
MFAP5
microfibrillar associated protein 5
chr12_+_27863706 4.93 ENST00000081029.3
ENST00000538315.1
ENST00000542791.1
MRPS35
mitochondrial ribosomal protein S35
chr6_+_30539153 4.80 ENST00000326195.8
ENST00000376545.3
ENST00000396515.4
ENST00000441867.1
ENST00000468958.1
ABCF1
ATP-binding cassette, sub-family F (GCN20), member 1
chr8_-_95274536 4.70 ENST00000297596.2
ENST00000396194.2
GEM
GTP binding protein overexpressed in skeletal muscle
chr1_-_94079648 4.65 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr4_+_57845024 4.61 ENST00000431623.2
ENST00000441246.2
POLR2B
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chr15_+_42697065 4.50 ENST00000565559.1
CAPN3
calpain 3, (p94)
chr13_-_46716969 4.42 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_-_164534657 4.34 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr7_-_80548667 4.23 ENST00000265361.3
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr15_+_67430339 4.21 ENST00000439724.3
SMAD3
SMAD family member 3
chr6_-_99842041 4.18 ENST00000254759.3
ENST00000369242.1
COQ3
coenzyme Q3 methyltransferase
chr10_+_105005644 4.18 ENST00000441178.2
RP11-332O19.5
ribulose-5-phosphate-3-epimerase-like 1
chr12_-_102874102 3.95 ENST00000392905.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_+_57774042 3.89 ENST00000309042.7
REST
RE1-silencing transcription factor
chr3_+_128444965 3.82 ENST00000265062.3
RAB7A
RAB7A, member RAS oncogene family
chr19_+_13134772 3.75 ENST00000587760.1
ENST00000585575.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr17_-_56494713 3.70 ENST00000407977.2
RNF43
ring finger protein 43
chrX_+_108779004 3.42 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr7_-_32529973 3.42 ENST00000410044.1
ENST00000409987.1
ENST00000409782.1
ENST00000450169.2
LSM5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_+_73771844 3.35 ENST00000440762.1
ENST00000444827.1
ENST00000415686.1
ENST00000411903.1
RP4-598G3.1
RP4-598G3.1
chr21_-_37451680 3.16 ENST00000399201.1
SETD4
SET domain containing 4
chr3_+_52017454 3.14 ENST00000476854.1
ENST00000476351.1
ENST00000494103.1
ENST00000404366.2
ENST00000469863.1
ACY1
aminoacylase 1
chr2_+_90060377 3.13 ENST00000436451.2
IGKV6D-21
immunoglobulin kappa variable 6D-21 (non-functional)
chr14_-_24553834 3.09 ENST00000397002.2
NRL
neural retina leucine zipper
chr7_-_144435985 3.07 ENST00000549981.1
TPK1
thiamin pyrophosphokinase 1
chr9_+_133569108 2.82 ENST00000372358.5
ENST00000546165.1
ENST00000372352.3
ENST00000372351.3
ENST00000372350.3
ENST00000495699.2
EXOSC2
exosome component 2
chr1_-_217250231 2.75 ENST00000493748.1
ENST00000463665.1
ESRRG
estrogen-related receptor gamma
chr17_-_56494908 2.71 ENST00000577716.1
RNF43
ring finger protein 43
chr1_+_91966384 2.69 ENST00000430031.2
ENST00000234626.6
CDC7
cell division cycle 7
chr21_-_35899113 2.65 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr17_-_56494882 2.64 ENST00000584437.1
RNF43
ring finger protein 43
chr2_-_55237484 2.52 ENST00000394609.2
RTN4
reticulon 4
chr12_-_102874330 2.33 ENST00000307046.8
IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_-_220263096 2.31 ENST00000463953.1
ENST00000354807.3
ENST00000414869.2
ENST00000498237.2
ENST00000498791.2
ENST00000544404.1
ENST00000480959.2
ENST00000322067.7
BPNT1
3'(2'), 5'-bisphosphate nucleotidase 1
chr10_+_28822636 2.25 ENST00000442148.1
ENST00000448193.1
WAC
WW domain containing adaptor with coiled-coil
chr3_-_57233966 2.19 ENST00000473921.1
ENST00000295934.3
HESX1
HESX homeobox 1
chrX_-_107682702 2.12 ENST00000372216.4
COL4A6
collagen, type IV, alpha 6
chr4_+_68424434 2.09 ENST00000265404.2
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr12_-_8815404 2.04 ENST00000359478.2
ENST00000396549.2
MFAP5
microfibrillar associated protein 5
chr6_-_43021612 1.97 ENST00000535468.1
CUL7
cullin 7
chr2_-_89459813 1.86 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr12_-_8815477 1.85 ENST00000433590.2
MFAP5
microfibrillar associated protein 5
chr3_+_178866199 1.84 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr6_-_31560729 1.82 ENST00000340027.5
ENST00000376073.4
ENST00000376072.3
NCR3
natural cytotoxicity triggering receptor 3
chr1_+_146373546 1.81 ENST00000446760.2
NBPF12
neuroblastoma breakpoint family, member 12
chr9_-_130679257 1.80 ENST00000361444.3
ENST00000335791.5
ENST00000343609.2
ST6GALNAC4
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr1_-_43855479 1.69 ENST00000290663.6
ENST00000372457.4
MED8
mediator complex subunit 8
chr4_-_38806404 1.67 ENST00000308979.2
ENST00000505940.1
ENST00000515861.1
TLR1
toll-like receptor 1
chr1_+_221054584 1.66 ENST00000549319.1
HLX
H2.0-like homeobox
chr12_+_6833237 1.56 ENST00000229251.3
ENST00000539735.1
ENST00000538410.1
COPS7A
COP9 signalosome subunit 7A
chr14_+_88471468 1.52 ENST00000267549.3
GPR65
G protein-coupled receptor 65
chr4_-_140005443 1.50 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
ELF2
E74-like factor 2 (ets domain transcription factor)
chr22_-_39268308 1.37 ENST00000407418.3
CBX6
chromobox homolog 6
chr6_-_43021437 1.30 ENST00000265348.3
CUL7
cullin 7
chr9_-_26892765 1.23 ENST00000520187.1
ENST00000333916.5
CAAP1
caspase activity and apoptosis inhibitor 1
chr12_-_68553512 1.22 ENST00000229135.3
IFNG
interferon, gamma
chr12_-_53074182 1.12 ENST00000252244.3
KRT1
keratin 1
chr6_-_26124138 1.02 ENST00000314332.5
ENST00000396984.1
HIST1H2BC
histone cluster 1, H2bc
chrX_+_99899180 1.02 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr18_+_32455201 0.96 ENST00000590831.2
DTNA
dystrobrevin, alpha
chr2_-_65593784 0.94 ENST00000443619.2
SPRED2
sprouty-related, EVH1 domain containing 2
chr1_+_28879588 0.88 ENST00000373830.3
TRNAU1AP
tRNA selenocysteine 1 associated protein 1
chr9_+_5510492 0.79 ENST00000397745.2
PDCD1LG2
programmed cell death 1 ligand 2
chr6_+_152130240 0.68 ENST00000427531.2
ESR1
estrogen receptor 1
chr1_-_27701307 0.65 ENST00000270879.4
ENST00000354982.2
FCN3
ficolin (collagen/fibrinogen domain containing) 3
chr20_+_32782375 0.65 ENST00000568305.1
ASIP
agouti signaling protein
chr2_+_162016804 0.65 ENST00000392749.2
ENST00000440506.1
TANK
TRAF family member-associated NFKB activator
chr4_+_110749143 0.61 ENST00000317735.4
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr21_-_27423339 0.57 ENST00000415997.1
APP
amyloid beta (A4) precursor protein
chr7_-_102283238 0.55 ENST00000340457.8
UPK3BL
uroplakin 3B-like
chr17_-_64225508 0.54 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr7_-_115608304 0.51 ENST00000457268.1
TFEC
transcription factor EC
chr15_-_56757329 0.46 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr12_-_102874378 0.44 ENST00000456098.1
IGF1
insulin-like growth factor 1 (somatomedin C)
chr7_+_73242069 0.39 ENST00000435050.1
CLDN4
claudin 4
chr8_-_54755789 0.37 ENST00000359530.2
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr1_-_217804377 0.16 ENST00000366935.3
ENST00000366934.3
GPATCH2
G patch domain containing 2
chr20_+_56964169 0.15 ENST00000475243.1
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr6_-_167571817 0.07 ENST00000366834.1
GPR31
G protein-coupled receptor 31
chr17_-_46115122 0.02 ENST00000006101.4
COPZ2
coatomer protein complex, subunit zeta 2

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXJ2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 28.0 GO:0009224 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
5.2 21.0 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
4.2 25.0 GO:0051661 maintenance of centrosome location(GO:0051661)
3.8 11.5 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
2.7 11.0 GO:0046452 dihydrofolate metabolic process(GO:0046452)
2.5 20.1 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
2.3 9.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
2.3 6.8 GO:1990523 bone regeneration(GO:1990523)
1.9 9.4 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
1.9 22.4 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
1.7 16.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.6 7.9 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
1.6 4.7 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
1.5 6.2 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
1.3 6.6 GO:1904075 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
1.3 9.1 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
1.3 3.9 GO:0061110 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
1.3 7.5 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
1.2 17.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
1.1 5.3 GO:0009149 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
1.1 6.4 GO:0048254 snoRNA localization(GO:0048254)
0.9 2.8 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.8 4.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.8 6.2 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.8 3.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.8 3.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.8 9.8 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.7 4.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.7 2.1 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.7 14.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.7 5.3 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.6 7.4 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.6 1.8 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.6 1.2 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.6 1.8 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.6 1.7 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.4 3.5 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.4 5.6 GO:0051451 myoblast migration(GO:0051451)
0.4 11.0 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.4 14.4 GO:0060216 definitive hemopoiesis(GO:0060216)
0.4 2.1 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.4 3.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.3 36.6 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.3 2.7 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.3 1.7 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.3 10.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.3 4.2 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.3 5.4 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.3 2.5 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.3 15.3 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.2 34.6 GO:0007062 sister chromatid cohesion(GO:0007062)
0.2 4.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 2.2 GO:0030916 otic vesicle formation(GO:0030916)
0.2 8.9 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.1 1.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 2.4 GO:0016540 protein autoprocessing(GO:0016540)
0.1 9.1 GO:0016445 somatic diversification of immunoglobulins(GO:0016445)
0.1 0.6 GO:0014004 microglia differentiation(GO:0014004) microglia development(GO:0014005) response to norepinephrine(GO:0071873) cellular response to norepinephrine stimulus(GO:0071874)
0.1 3.4 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 1.0 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 1.6 GO:0000338 protein deneddylation(GO:0000338)
0.1 0.7 GO:0060523 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.1 4.6 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 4.9 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.9 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.5 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1 2.7 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 0.7 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1 7.8 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.5 GO:0070986 left/right axis specification(GO:0070986)
0.1 2.3 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1 3.3 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.1 1.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 1.5 GO:0010447 response to acidic pH(GO:0010447)
0.1 0.9 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801) positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 13.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 1.5 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.1 6.5 GO:0030183 B cell differentiation(GO:0030183)
0.0 3.7 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 18.2 GO:0042493 response to drug(GO:0042493)
0.0 0.2 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 1.0 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.4 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 1.0 GO:0030574 collagen catabolic process(GO:0030574)
0.0 1.8 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 5.0 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.4 GO:0007035 vacuolar acidification(GO:0007035)
0.0 3.8 GO:0006260 DNA replication(GO:0006260)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
8.6 34.6 GO:1990423 RZZ complex(GO:1990423)
3.6 25.0 GO:0036449 microtubule minus-end(GO:0036449)
3.2 22.4 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
2.9 17.4 GO:0030905 retromer, tubulation complex(GO:0030905)
2.9 20.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
1.9 5.6 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
1.5 6.2 GO:0030896 checkpoint clamp complex(GO:0030896)
1.4 11.5 GO:0097208 alveolar lamellar body(GO:0097208)
1.2 17.6 GO:0008290 F-actin capping protein complex(GO:0008290)
1.1 9.1 GO:0070552 BRISC complex(GO:0070552)
0.9 6.6 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.9 29.3 GO:0005838 proteasome regulatory particle(GO:0005838)
0.8 8.9 GO:0033391 chromatoid body(GO:0033391)
0.8 6.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.7 14.4 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.7 3.3 GO:1990393 3M complex(GO:1990393)
0.6 7.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.6 10.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.6 1.7 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.6 15.1 GO:0035371 microtubule plus-end(GO:0035371)
0.5 4.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.5 9.8 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.5 3.4 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.5 9.1 GO:0000974 Prp19 complex(GO:0000974)
0.5 7.3 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.5 11.4 GO:0071011 precatalytic spliceosome(GO:0071011)
0.4 14.6 GO:0016592 mediator complex(GO:0016592)
0.4 1.8 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.3 7.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 2.8 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 20.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.2 5.4 GO:0005685 U1 snRNP(GO:0005685)
0.2 4.4 GO:0001891 phagocytic cup(GO:0001891)
0.2 4.9 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 5.3 GO:0051233 spindle midzone(GO:0051233)
0.2 2.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 4.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.0 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 2.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 21.0 GO:0005681 spliceosomal complex(GO:0005681)
0.1 21.7 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.4 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 6.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 2.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 3.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.4 GO:0031519 PcG protein complex(GO:0031519)
0.0 2.1 GO:0030315 T-tubule(GO:0030315)
0.0 1.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.5 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 1.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 28.0 GO:0004849 uridine kinase activity(GO:0004849)
3.5 17.4 GO:1990460 leptin receptor binding(GO:1990460)
1.8 11.0 GO:0019238 cyclohydrolase activity(GO:0019238)
1.7 16.9 GO:0019237 centromeric DNA binding(GO:0019237)
1.6 11.4 GO:0004301 epoxide hydrolase activity(GO:0004301)
1.4 43.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
1.3 9.1 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
1.2 13.5 GO:0004576 oligosaccharyl transferase activity(GO:0004576)
1.2 9.4 GO:0001849 complement component C1q binding(GO:0001849)
1.1 8.9 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
1.0 6.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.9 6.4 GO:0030621 U4 snRNA binding(GO:0030621)
0.9 24.7 GO:0070410 co-SMAD binding(GO:0070410)
0.8 5.4 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.7 20.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.6 1.8 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.6 5.3 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.6 5.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.6 1.7 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.5 9.8 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4 3.1 GO:0004046 aminoacylase activity(GO:0004046)
0.4 2.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.4 3.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.4 10.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 2.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.3 2.8 GO:0008312 7S RNA binding(GO:0008312)
0.3 4.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 1.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 9.1 GO:0005109 frizzled binding(GO:0005109)
0.2 7.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 4.6 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 16.2 GO:0019003 GDP binding(GO:0019003)
0.2 3.9 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.2 4.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 3.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 14.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 6.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 2.1 GO:0031432 titin binding(GO:0031432)
0.1 0.7 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 14.6 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 5.0 GO:0017069 snRNA binding(GO:0017069)
0.1 7.5 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.5 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 11.0 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.1 4.3 GO:0042287 MHC protein binding(GO:0042287)
0.1 22.0 GO:0051015 actin filament binding(GO:0051015)
0.1 0.7 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 1.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 2.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.6 GO:0051425 PTB domain binding(GO:0051425)
0.1 7.4 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.6 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 3.2 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 0.7 GO:0008252 nucleotidase activity(GO:0008252)
0.1 0.2 GO:0033149 FFAT motif binding(GO:0033149)
0.0 4.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 9.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 18.0 GO:0016887 ATPase activity(GO:0016887)
0.0 6.6 GO:0008201 heparin binding(GO:0008201)
0.0 0.9 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 3.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 4.4 GO:0003823 antigen binding(GO:0003823)
0.0 2.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 14.1 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 1.0 GO:0030165 PDZ domain binding(GO:0030165)
0.0 4.0 GO:0004175 endopeptidase activity(GO:0004175)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 20.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 28.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 4.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 9.4 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 4.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 8.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.2 20.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 14.4 PID NOTCH PATHWAY Notch signaling pathway
0.2 10.5 PID AURORA B PATHWAY Aurora B signaling
0.2 7.3 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.1 9.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 6.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 4.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 1.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 9.1 PID P73PATHWAY p73 transcription factor network
0.1 2.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 1.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 3.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.0 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 3.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 6.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.0 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 20.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.8 13.5 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.8 28.0 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.6 16.9 REACTOME KINESINS Genes involved in Kinesins
0.6 11.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.5 36.6 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.5 24.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 8.9 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.3 34.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 2.8 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.3 9.8 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.3 7.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 3.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 4.6 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.2 8.9 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.2 1.7 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.2 12.3 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 14.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.8 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 6.2 REACTOME TRANSLATION Genes involved in Translation
0.1 1.8 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 0.6 REACTOME OPSINS Genes involved in Opsins
0.1 9.6 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 1.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 3.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 2.5 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 2.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 3.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.7 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions