ISMARA results: FOXL1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for FOXL1

Z-value: 0.60

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Transcription factors associated with FOXL1

Gene Symbol	Gene ID	Gene Info
FOXL1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000176678.4	forkhead box L1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXL1	hg19_v2_chr16_+_86612112_86612123	0.33	5.4e-07	Click!

Activity profile of FOXL1 motif

Sorted Z-values of FOXL1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_89310012 Show fit	41.62	ENST00000493819.1	IGKV1-9 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-9
chr2_+_90108504 Show fit	35.21	ENST00000390271.2	IGKV6D-41 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 6D-41 (non-functional)
chr2_-_89399845 Show fit	34.74	ENST00000479981.1	IGKV1-16 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-16
chr12_+_69742121 Show fit	34.53	ENST00000261267.2 ENST00000549690.1 ENST00000548839.1	LYZ Ensembl NCBI GeneCards UniProt NextProt Show fit	lysozyme
chr4_-_71532339 Show fit	33.54	ENST00000254801.4	IGJ Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr2_+_90060377 Show fit	31.18	ENST00000436451.2	IGKV6D-21 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 6D-21 (non-functional)
chr2_-_89266286 Show fit	28.07	ENST00000464162.1	IGKV1-6 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-6
chr2_-_89417335 Show fit	27.86	ENST00000490686.1	IGKV1-17 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-17
chr12_-_91574142 Show fit	27.35	ENST00000547937.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr2_-_89459813 Show fit	26.35	ENST00000390256.2	IGKV6-21 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 6-21 (non-functional)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	443.5	GO:0006958	complement activation, classical pathway(GO:0006958)
1.5	262.7	GO:0002377	immunoglobulin production(GO:0002377)
9.9	119.2	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.5	40.2	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.8	38.1	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
6.9	34.5	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
7.5	29.9	GO:0071461	cellular response to redox state(GO:0071461)
4.0	27.7	GO:2000332	lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
2.7	26.6	GO:0006069	ethanol oxidation(GO:0006069)
0.2	25.1	GO:0070268	cornification(GO:0070268)

Showing 1 to 10 of 370 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	498.7	GO:0005615	extracellular space(GO:0005615)
1.2	194.9	GO:0072562	blood microparticle(GO:0072562)
3.8	176.4	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
8.4	117.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.5	47.7	GO:0035580	specific granule lumen(GO:0035580)
2.1	43.6	GO:0042613	MHC class II protein complex(GO:0042613)
3.3	29.6	GO:0005579	membrane attack complex(GO:0005579)
1.0	29.2	GO:0031092	platelet alpha granule membrane(GO:0031092)
6.4	25.4	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.3	23.6	GO:0005791	rough endoplasmic reticulum(GO:0005791)

Showing 1 to 10 of 144 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	548.4	GO:0003823	antigen binding(GO:0003823)
3.2	176.4	GO:0034987	immunoglobulin receptor binding(GO:0034987)
1.6	113.2	GO:0050840	extracellular matrix binding(GO:0050840)
0.8	38.1	GO:0004984	olfactory receptor activity(GO:0004984)
5.8	34.5	GO:0003796	lysozyme activity(GO:0003796)
3.0	29.9	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
4.6	27.7	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
4.4	26.6	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
4.2	25.4	GO:0030492	hemoglobin binding(GO:0030492)
1.0	20.9	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)

Showing 1 to 10 of 264 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	135.0	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	63.4	NABA CORE MATRISOME	Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.4	54.8	PID CMYB PATHWAY	C-MYB transcription factor network
0.2	52.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	36.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	26.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.3	18.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.7	18.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4	17.9	NABA COLLAGENS	Genes encoding collagen proteins
0.4	16.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Showing 1 to 10 of 70 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	117.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.5	42.6	REACTOME AMYLOIDS	Genes involved in Amyloids
0.4	41.7	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.8	38.9	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.7	37.9	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.2	29.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.2	28.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
3.3	26.6	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
1.1	19.5	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.3	17.0	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions

Showing 1 to 10 of 109 entries

Results for FOXL1

Z-value: 0.60

Motif logo

Transcription factors associated with FOXL1

Activity-expression correlation:

Activity profile of FOXL1 motif

Sorted Z-values of FOXL1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: