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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FOXN1
Z-value: 0.23
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Transcription factors associated with FOXN1
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXN1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 16.2 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.1 | 7.5 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 7.5 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.3 | 7.1 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.2 | 6.4 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 2.0 | 6.0 | GO:0006014 | D-ribose metabolic process(GO:0006014) |
| 0.4 | 5.0 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.1 | 5.0 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.6 | 4.8 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.9 | 4.6 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.7 | GO:0005635 | nuclear envelope(GO:0005635) |
| 1.5 | 7.7 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.6 | 7.2 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 5.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.5 | 5.6 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 5.1 | GO:0031514 | motile cilium(GO:0031514) |
| 0.7 | 4.3 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.4 | 4.2 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.0 | 4.1 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.2 | 3.9 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 8.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 7.1 | GO:0045309 | protein phosphorylated amino acid binding(GO:0045309) |
| 0.6 | 6.6 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 0.1 | 6.4 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 5.3 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
| 0.7 | 5.2 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.0 | 5.1 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.3 | 5.0 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 3.5 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.0 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 4.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 4.2 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 2.7 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 2.2 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 2.1 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 2.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.0 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 2.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.1 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 4.2 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 4.2 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.2 | 4.1 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 3.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 3.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 2.9 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 2.9 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 2.7 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 2.7 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |