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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FOXO3_FOXD2
Z-value: 0.14
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Transcription factors associated with FOXO3_FOXD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXD2 | hg19_v2_chr1_+_47901689_47901689 | -0.08 | 2.2e-01 | Click! |
| FOXO3 | hg19_v2_chr6_+_108882069_108882087, hg19_v2_chr6_+_108881012_108881038 | 0.01 | 8.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXO3_FOXD2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 39.1 | GO:0051639 | actin filament network formation(GO:0051639) |
| 2.7 | 35.4 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 10.7 | 32.1 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 2.8 | 28.5 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 2.7 | 26.7 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.6 | 26.4 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.3 | 24.8 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.9 | 22.8 | GO:1904886 | beta-catenin destruction complex disassembly(GO:1904886) |
| 0.5 | 21.3 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 2.9 | 20.5 | GO:0044800 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 63.6 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 53.0 | GO:0005769 | early endosome(GO:0005769) |
| 0.3 | 42.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 2.0 | 39.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 37.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 36.0 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 33.4 | GO:0005730 | nucleolus(GO:0005730) |
| 0.3 | 32.3 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.5 | 29.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 1.8 | 23.8 | GO:0042555 | MCM complex(GO:0042555) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 70.7 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.8 | 37.3 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.2 | 35.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 2.9 | 32.1 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.5 | 27.3 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 2.0 | 26.4 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.6 | 24.8 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 2.0 | 19.6 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 1.9 | 17.5 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 1.3 | 17.5 | GO:0042608 | T cell receptor binding(GO:0042608) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 61.4 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.7 | 32.0 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 29.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.3 | 26.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.5 | 26.2 | PID MYC PATHWAY | C-MYC pathway |
| 0.2 | 25.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.6 | 21.8 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 21.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.5 | 20.5 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.6 | 18.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 53.6 | REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER | Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| 0.4 | 39.4 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.7 | 34.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 1.3 | 32.1 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 25.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.5 | 23.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.2 | 23.6 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.3 | 23.2 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.8 | 21.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.4 | 21.3 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |