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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FOXO4
Z-value: 1.61
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Transcription factors associated with FOXO4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXO4 | hg19_v2_chrX_+_70316005_70316047 | 0.69 | 9.4e-32 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_42812143 Show fit | 27.62 |
ENST00000514985.1
|
selenoprotein P, plasma, 1 |
|
| chr5_-_42811986 Show fit | 27.49 |
ENST00000511224.1
ENST00000507920.1 ENST00000510965.1 |
selenoprotein P, plasma, 1 |
|
| chr1_-_182360918 Show fit | 23.86 |
ENST00000339526.4
|
glutamate-ammonia ligase |
|
| chr1_-_57045228 Show fit | 22.44 |
ENST00000371250.3
|
phosphatidic acid phosphatase type 2B |
|
| chr1_+_6845384 Show fit | 21.52 |
ENST00000303635.7
|
calmodulin binding transcription activator 1 |
|
| chr16_+_6069586 Show fit | 21.38 |
ENST00000547372.1
|
RNA binding protein, fox-1 homolog (C. elegans) 1 |
|
| chr14_-_60097297 Show fit | 20.58 |
ENST00000395090.1
|
reticulon 1 |
|
| chr1_-_182360498 Show fit | 19.92 |
ENST00000417584.2
|
glutamate-ammonia ligase |
|
| chr3_-_112127981 Show fit | 19.83 |
ENST00000486726.2
|
RP11-231E6.1 |
|
| chr19_-_36523709 Show fit | 19.76 |
ENST00000592017.1
ENST00000360535.4 |
CAP-GLY domain containing linker protein 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXO4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.9 | 43.8 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 1.7 | 40.7 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.6 | 37.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 3.3 | 36.8 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.1 | 26.6 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.4 | 26.4 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.4 | 21.5 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 4.0 | 19.8 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.1 | 18.0 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 2.1 | 16.6 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 58.1 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.3 | 49.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 2.3 | 43.8 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.1 | 30.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.3 | 28.0 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.3 | 27.4 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 21.1 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.1 | 19.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 17.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 2.7 | 16.3 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.9 | 43.8 | GO:0004356 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 1.1 | 33.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 32.4 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 3.8 | 30.2 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 21.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.8 | 21.1 | GO:0005521 | lamin binding(GO:0005521) |
| 4.9 | 19.8 | GO:0097001 | ceramide binding(GO:0097001) |
| 1.0 | 19.6 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.1 | 17.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.2 | 15.1 | GO:0030276 | clathrin binding(GO:0030276) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 33.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 28.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 16.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 14.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 14.6 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.2 | 11.6 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.2 | 9.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 8.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 8.1 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.3 | 7.5 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 43.8 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 25.0 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.7 | 22.4 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.3 | 18.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 15.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.5 | 13.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.3 | 11.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.5 | 11.5 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 10.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 10.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |