ISMARA results: FOXQ1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for FOXQ1

Z-value: 1.11

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Transcription factors associated with FOXQ1

Gene Symbol	Gene ID	Gene Info
FOXQ1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000164379.4	forkhead box Q1

Activity profile of FOXQ1 motif

Sorted Z-values of FOXQ1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_52456327 Show fit	27.47	ENST00000556760.1	C14orf166 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 14 open reading frame 166
chr3_-_49066811 Show fit	26.90	ENST00000442157.1 ENST00000326739.4	IMPDH2 Ensembl NCBI GeneCards UniProt NextProt Show fit	IMP (inosine 5'-monophosphate) dehydrogenase 2
chr2_-_225434538 Show fit	25.92	ENST00000409096.1	CUL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cullin 3
chr14_+_52456193 Show fit	24.34	ENST00000261700.3	C14orf166 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 14 open reading frame 166
chr3_-_107777208 Show fit	23.94	ENST00000398258.3	CD47 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD47 molecule
chr2_-_150444116 Show fit	23.90	ENST00000428879.1 ENST00000422782.2	MMADHC Ensembl NCBI GeneCards UniProt NextProt Show fit	methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr20_+_30327063 Show fit	22.04	ENST00000300403.6 ENST00000340513.4	TPX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	TPX2, microtubule-associated
chr10_-_36813162 Show fit	21.99	ENST00000440465.1	NAMPTL Ensembl NCBI GeneCards UniProt NextProt Show fit	nicotinamide phosphoribosyltransferase-like
chr2_-_151344172 Show fit	21.83	ENST00000375734.2 ENST00000263895.4 ENST00000454202.1	RND3 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho family GTPase 3
chr4_-_111119804 Show fit	21.76	ENST00000394607.3 ENST00000302274.3	ELOVL6 Ensembl NCBI GeneCards UniProt NextProt Show fit	ELOVL fatty acid elongase 6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXQ1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	55.3	GO:0006334	nucleosome assembly(GO:0006334)
4.3	51.8	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.8	49.3	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.9	48.4	GO:0009235	cobalamin metabolic process(GO:0009235)
5.3	37.0	GO:0006880	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
1.6	30.8	GO:0008228	opsonization(GO:0008228)
1.2	30.5	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.4	28.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
4.5	26.9	GO:0006177	GMP biosynthetic process(GO:0006177)
4.4	26.4	GO:0032468	Golgi calcium ion homeostasis(GO:0032468)

Showing 1 to 10 of 190 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	54.1	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
7.4	51.8	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.5	48.5	GO:0015935	small ribosomal subunit(GO:0015935)
0.5	44.6	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.3	44.5	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.2	40.5	GO:0005802	trans-Golgi network(GO:0005802)
5.3	37.0	GO:0044326	dendritic spine neck(GO:0044326)
2.5	30.5	GO:0031595	nuclear proteasome complex(GO:0031595)
0.4	28.4	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
2.9	25.9	GO:0005827	polar microtubule(GO:0005827)

Showing 1 to 10 of 101 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	51.8	GO:0000993	RNA polymerase II core binding(GO:0000993)
1.1	42.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2	39.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	36.3	GO:0005178	integrin binding(GO:0005178)
0.6	35.3	GO:0019894	kinesin binding(GO:0019894)
2.8	30.5	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.6	29.4	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.0	27.6	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
6.7	26.9	GO:0003938	IMP dehydrogenase activity(GO:0003938)
0.9	26.4	GO:0005388	calcium-transporting ATPase activity(GO:0005388)

Showing 1 to 10 of 147 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	40.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.4	35.9	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.8	25.9	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.4	23.5	PID PLK1 PATHWAY	PLK1 signaling events
0.4	22.9	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.3	17.8	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2	17.3	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	17.2	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.4	15.8	PID ALK1 PATHWAY	ALK1 signaling events
0.4	14.9	PID CD40 PATHWAY	CD40/CD40L signaling

Showing 1 to 10 of 45 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	32.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.4	30.5	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.9	27.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
1.6	26.9	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.5	25.8	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.7	23.9	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.4	23.5	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
1.4	22.9	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
1.0	21.8	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
1.3	19.6	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism

Showing 1 to 10 of 66 entries

Results for FOXQ1

Z-value: 1.11

Motif logo

Transcription factors associated with FOXQ1

Activity profile of FOXQ1 motif

Sorted Z-values of FOXQ1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXQ1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: