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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FUBP1
Z-value: 0.63
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Transcription factors associated with FUBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FUBP1 | hg19_v2_chr1_-_78444776_78444800 | -0.23 | 7.1e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91576429 Show fit | 12.25 |
ENST00000552145.1
ENST00000546745.1 |
decorin |
|
| chr12_-_91576561 Show fit | 11.57 |
ENST00000547568.2
ENST00000552962.1 |
decorin |
|
| chr1_-_182360918 Show fit | 10.09 |
ENST00000339526.4
|
glutamate-ammonia ligase |
|
| chr1_-_182360498 Show fit | 9.32 |
ENST00000417584.2
|
glutamate-ammonia ligase |
|
| chr11_-_33891362 Show fit | 8.74 |
ENST00000395833.3
|
LIM domain only 2 (rhombotin-like 1) |
|
| chr9_-_110251836 Show fit | 6.56 |
ENST00000374672.4
|
Kruppel-like factor 4 (gut) |
|
| chr3_-_112127981 Show fit | 5.50 |
ENST00000486726.2
|
RP11-231E6.1 |
|
| chr2_+_113033164 Show fit | 4.74 |
ENST00000409871.1
ENST00000343936.4 |
zinc finger CCCH-type containing 6 |
|
| chr18_-_53255766 Show fit | 4.49 |
ENST00000566286.1
ENST00000564999.1 ENST00000566279.1 ENST00000354452.3 ENST00000356073.4 |
transcription factor 4 |
|
| chr12_+_57522258 Show fit | 4.21 |
ENST00000553277.1
ENST00000243077.3 |
low density lipoprotein receptor-related protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FUBP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 23.8 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 4.9 | 19.4 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.4 | 11.1 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.3 | 7.2 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 2.2 | 6.6 | GO:0071409 | negative regulation of muscle hyperplasia(GO:0014740) cellular response to cycloheximide(GO:0071409) |
| 0.2 | 6.2 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.3 | 5.3 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.1 | 4.8 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.2 | 4.5 | GO:0032703 | negative regulation of interleukin-2 production(GO:0032703) |
| 1.4 | 4.2 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 23.8 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 22.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 1.0 | 19.4 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.2 | 6.6 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 4.2 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.3 | 3.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.7 | 3.4 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.3 | 3.4 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 3.4 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 3.4 | GO:0045121 | membrane raft(GO:0045121) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 4.9 | 19.4 | GO:0016880 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.2 | 8.7 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.7 | 7.2 | GO:0030274 | LIM domain binding(GO:0030274) |
| 1.3 | 6.6 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.2 | 6.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 1.8 | 5.3 | GO:0036134 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
| 0.3 | 4.5 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.1 | 4.2 | GO:0042954 | apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954) |
| 1.0 | 4.1 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 17.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 7.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 4.8 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 3.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.9 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 2.4 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 2.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 2.2 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 23.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.7 | 19.4 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 8.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.4 | 6.6 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.4 | 6.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 5.2 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 4.3 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 3.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.3 | 3.6 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 3.5 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |