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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for GAGAUGA

Z-value: 0.97

Motif logo

miRNA associated with seed GAGAUGA

NamemiRBASE accession
MIMAT0000435
MIMAT0019924
MIMAT0023713

Activity profile of GAGAUGA motif

Sorted Z-values of GAGAUGA motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_106959631 5.61 ENST00000486554.1
ENST00000372390.4
TSC22 domain family, member 3
chr11_+_113930291 5.27 ENST00000335953.4
zinc finger and BTB domain containing 16
chr13_+_48807288 3.91 ENST00000378565.5
integral membrane protein 2B
chr15_+_74833518 3.88 ENST00000346246.5
AT rich interactive domain 3B (BRIGHT-like)
chr19_+_18942720 3.35 ENST00000262803.5
UPF1 regulator of nonsense transcripts homolog (yeast)
chr17_+_19281034 2.97 ENST00000308406.5
ENST00000299612.7
mitogen-activated protein kinase 7
chr15_+_31619013 2.18 ENST00000307145.3
Kruppel-like factor 13
chr1_-_57045228 1.97 ENST00000371250.3
phosphatidic acid phosphatase type 2B
chr1_-_205290865 1.93 ENST00000367157.3
NUAK family, SNF1-like kinase, 2
chr2_-_217560248 1.93 ENST00000233813.4
insulin-like growth factor binding protein 5
chr19_-_13617247 1.88 ENST00000573710.2
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr5_+_142149955 1.88 ENST00000378004.3
Rho GTPase activating protein 26
chr17_+_47865917 1.83 ENST00000259021.4
ENST00000454930.2
ENST00000509773.1
ENST00000510819.1
ENST00000424009.2
K(lysine) acetyltransferase 7
chr4_+_87856129 1.80 ENST00000395146.4
ENST00000507468.1
AF4/FMR2 family, member 1
chr18_+_9136758 1.74 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ankyrin repeat domain 12
chr15_+_85923856 1.73 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
A kinase (PRKA) anchor protein 13
chr12_+_11802753 1.67 ENST00000396373.4
ets variant 6
chr22_+_40390930 1.62 ENST00000333407.6
family with sequence similarity 83, member F
chr16_-_79634595 1.45 ENST00000326043.4
ENST00000393350.1
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chr14_-_96830207 1.45 ENST00000359933.4
autophagy related 2B
chr7_+_20370746 1.43 ENST00000222573.4
integrin, beta 8
chr3_+_9975497 1.39 ENST00000397170.3
ENST00000383811.3
ENST00000452070.1
ENST00000326434.5
cysteine-rich with EGF-like domains 1
chr19_-_19739007 1.38 ENST00000586703.1
ENST00000591042.1
ENST00000407877.3
lysophosphatidic acid receptor 2
chr2_+_45878790 1.35 ENST00000306156.3
protein kinase C, epsilon
chr15_+_65134088 1.32 ENST00000323544.4
ENST00000437723.1
pleckstrin homology domain containing, family O member 2
Uncharacterized protein
chr2_+_28615669 1.31 ENST00000379619.1
ENST00000264716.4
FOS-like antigen 2
chr16_+_50187556 1.30 ENST00000561678.1
ENST00000357464.3
PAP associated domain containing 5
chr5_+_32711419 1.27 ENST00000265074.8
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr11_-_73309228 1.24 ENST00000356467.4
ENST00000064778.4
family with sequence similarity 168, member A
chr15_-_26108355 1.20 ENST00000356865.6
ATPase, class V, type 10A
chr5_-_100238956 1.18 ENST00000231461.5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr1_-_179198702 1.17 ENST00000502732.1
c-abl oncogene 2, non-receptor tyrosine kinase
chr14_+_101193164 1.15 ENST00000341267.4
delta-like 1 homolog (Drosophila)
chr6_-_132272504 1.12 ENST00000367976.3
connective tissue growth factor
chr8_+_102504651 1.12 ENST00000251808.3
ENST00000521085.1
grainyhead-like 2 (Drosophila)
chr1_+_62208091 1.09 ENST00000316485.6
ENST00000371158.2
InaD-like (Drosophila)
chr2_-_25475120 1.05 ENST00000380746.4
ENST00000402667.1
DNA (cytosine-5-)-methyltransferase 3 alpha
chr9_-_123476719 1.02 ENST00000373930.3
multiple EGF-like-domains 9
chr15_-_49338748 1.01 ENST00000559471.1
SECIS binding protein 2-like
chr12_+_69864129 1.00 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
fibroblast growth factor receptor substrate 2
chr17_-_48278983 0.99 ENST00000225964.5
collagen, type I, alpha 1
chrX_+_133507327 0.99 ENST00000332070.3
ENST00000394292.1
ENST00000370799.1
ENST00000416404.2
PHD finger protein 6
chr14_+_21538429 0.93 ENST00000298694.4
ENST00000555038.1
Rho guanine nucleotide exchange factor (GEF) 40
chr6_+_32709119 0.91 ENST00000374940.3
major histocompatibility complex, class II, DQ alpha 2
chr8_-_63998590 0.89 ENST00000260116.4
tocopherol (alpha) transfer protein
chr5_+_169064245 0.87 ENST00000256935.8
dedicator of cytokinesis 2
chr4_+_55095264 0.87 ENST00000257290.5
platelet-derived growth factor receptor, alpha polypeptide
chr2_-_96931679 0.86 ENST00000258439.3
ENST00000432959.1
transmembrane protein 127
chr15_+_39873268 0.86 ENST00000397591.2
ENST00000260356.5
thrombospondin 1
chr3_+_9834758 0.84 ENST00000485273.1
ENST00000433034.1
ENST00000397256.1
actin related protein 2/3 complex, subunit 4, 20kDa
ARPC4-TTLL3 readthrough
chr19_-_10121144 0.81 ENST00000264828.3
collagen, type V, alpha 3
chr9_-_35650900 0.80 ENST00000259608.3
signaling threshold regulating transmembrane adaptor 1
chr11_-_118661828 0.77 ENST00000264018.4
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr2_+_233562015 0.72 ENST00000427233.1
ENST00000373566.3
ENST00000373563.4
ENST00000428883.1
ENST00000456491.1
ENST00000409480.1
ENST00000421433.1
ENST00000425040.1
ENST00000430720.1
ENST00000409547.1
ENST00000423659.1
ENST00000409196.3
ENST00000409451.3
ENST00000429187.1
ENST00000440945.1
GRB10 interacting GYF protein 2
chr18_-_29522989 0.70 ENST00000582539.1
ENST00000283351.4
ENST00000582513.1
trafficking protein particle complex 8
chr16_+_70148230 0.69 ENST00000398122.3
ENST00000568530.1
pyruvate dehydrogenase phosphatase regulatory subunit
chr17_+_60704762 0.69 ENST00000303375.5
mannose receptor, C type 2
chrX_+_9983602 0.66 ENST00000380861.4
WWC family member 3
chr10_+_76871454 0.66 ENST00000372687.4
sterile alpha motif domain containing 8
chr7_-_42276612 0.66 ENST00000395925.3
ENST00000437480.1
GLI family zinc finger 3
chr3_-_24536253 0.65 ENST00000428492.1
ENST00000396671.2
ENST00000431815.1
ENST00000418247.1
ENST00000416420.1
ENST00000356447.4
thyroid hormone receptor, beta
chr16_+_66400533 0.64 ENST00000341529.3
cadherin 5, type 2 (vascular endothelium)
chr10_-_105615164 0.59 ENST00000355946.2
ENST00000369774.4
SH3 and PX domains 2A
chr13_-_33002151 0.59 ENST00000495479.1
ENST00000343281.4
ENST00000464470.1
ENST00000380139.4
ENST00000380133.2
NEDD4 binding protein 2-like 1
chr5_+_141303373 0.57 ENST00000432126.2
ENST00000194118.4
KIAA0141
chr19_-_14629224 0.57 ENST00000254322.2
DnaJ (Hsp40) homolog, subfamily B, member 1
chr1_-_155532484 0.55 ENST00000368346.3
ENST00000548830.1
ash1 (absent, small, or homeotic)-like (Drosophila)
chr1_+_178062855 0.54 ENST00000448150.3
RAS protein activator like 2
chr6_+_43265992 0.51 ENST00000449231.1
ENST00000372589.3
ENST00000372585.5
solute carrier family 22 (organic anion transporter), member 7
chr10_-_30024716 0.51 ENST00000375398.2
ENST00000375400.3
supervillin
chr10_+_104678032 0.50 ENST00000369878.4
ENST00000369875.3
cyclin M2
chr2_-_73053126 0.50 ENST00000272427.6
ENST00000410104.1
exocyst complex component 6B
chr3_+_49591881 0.50 ENST00000296452.4
bassoon presynaptic cytomatrix protein
chr17_-_47841485 0.49 ENST00000506156.1
ENST00000240364.2
family with sequence similarity 117, member A
chr12_+_103981044 0.48 ENST00000388887.2
stabilin 2
chr19_-_40324255 0.45 ENST00000593685.1
ENST00000600611.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr15_+_77287426 0.44 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
proline-serine-threonine phosphatase interacting protein 1
chr2_+_97481974 0.42 ENST00000377060.3
ENST00000305510.3
cyclin M3
chr2_-_25873079 0.41 ENST00000496972.2
dystrobrevin, beta
chr10_+_111767720 0.40 ENST00000356080.4
ENST00000277900.8
adducin 3 (gamma)
chr2_-_69870835 0.38 ENST00000409085.4
ENST00000406297.3
AP2 associated kinase 1
chr2_-_206950781 0.38 ENST00000403263.1
INO80 complex subunit D
chr11_-_118047376 0.37 ENST00000278947.5
sodium channel, voltage-gated, type II, beta subunit
chr17_+_14204389 0.37 ENST00000360954.2
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr6_+_114178512 0.37 ENST00000368635.4
myristoylated alanine-rich protein kinase C substrate
chr9_-_113342160 0.37 ENST00000401783.2
ENST00000374461.1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr16_-_23521710 0.36 ENST00000562117.1
ENST00000567468.1
ENST00000562944.1
ENST00000309859.4
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr19_+_3359561 0.36 ENST00000589123.1
ENST00000346156.5
ENST00000395111.3
ENST00000586919.1
nuclear factor I/C (CCAAT-binding transcription factor)
chr3_-_114790179 0.36 ENST00000462705.1
zinc finger and BTB domain containing 20
chr9_+_79074068 0.36 ENST00000444201.2
ENST00000376730.4
glucosaminyl (N-acetyl) transferase 1, core 2
chr12_-_42538657 0.35 ENST00000398675.3
glucoside xylosyltransferase 1
chr12_+_8234807 0.34 ENST00000339754.5
NECAP endocytosis associated 1
chr8_-_38853990 0.34 ENST00000456845.2
ENST00000397070.2
ENST00000517872.1
ENST00000412303.1
ENST00000456397.2
TM2 domain containing 2
chr7_+_31092076 0.33 ENST00000304166.4
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
chr19_-_38806560 0.33 ENST00000591755.1
ENST00000337679.8
ENST00000339413.6
Yip1 interacting factor homolog B (S. cerevisiae)
chr17_-_46623441 0.32 ENST00000330070.4
homeobox B2
chr12_-_53625958 0.31 ENST00000327550.3
ENST00000546717.1
ENST00000425354.2
ENST00000394426.1
retinoic acid receptor, gamma
chr11_-_62572901 0.30 ENST00000439713.2
ENST00000531131.1
ENST00000530875.1
ENST00000531709.2
ENST00000294172.2
nuclear RNA export factor 1
chr7_+_142985308 0.30 ENST00000310447.5
caspase 2, apoptosis-related cysteine peptidase
chr18_-_60987220 0.30 ENST00000398117.1
B-cell CLL/lymphoma 2
chr12_-_54673871 0.29 ENST00000209875.4
chromobox homolog 5
chr13_+_73632897 0.28 ENST00000377687.4
Kruppel-like factor 5 (intestinal)
chr20_-_48099182 0.28 ENST00000371741.4
potassium voltage-gated channel, Shab-related subfamily, member 1
chr12_+_2162447 0.28 ENST00000335762.5
ENST00000399655.1
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr9_+_90112741 0.27 ENST00000469640.2
death-associated protein kinase 1
chr6_-_91296602 0.27 ENST00000369325.3
ENST00000369327.3
mitogen-activated protein kinase kinase kinase 7
chr14_+_77228532 0.27 ENST00000167106.4
ENST00000554237.1
vasohibin 1
chr11_-_67236691 0.26 ENST00000544903.1
ENST00000308022.2
ENST00000393877.3
ENST00000452789.2
transmembrane protein 134
chr1_+_87794150 0.26 ENST00000370544.5
LIM domain only 4
chr10_+_105253661 0.25 ENST00000369780.4
neuralized E3 ubiquitin protein ligase 1
chr8_-_37756972 0.25 ENST00000330843.4
ENST00000522727.1
ENST00000287263.4
RAB11 family interacting protein 1 (class I)
chr8_-_18871159 0.25 ENST00000327040.8
ENST00000440756.2
pleckstrin and Sec7 domain containing 3
chr19_-_46234119 0.24 ENST00000317683.3
F-box protein 46
chrX_-_48824793 0.24 ENST00000376477.1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr2_-_9143786 0.24 ENST00000462696.1
ENST00000305997.3
membrane bound O-acyltransferase domain containing 2
chr2_+_120517174 0.24 ENST00000263708.2
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr5_-_147162078 0.23 ENST00000507386.1
janus kinase and microtubule interacting protein 2
chr20_+_56964169 0.22 ENST00000475243.1
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr1_-_186649543 0.21 ENST00000367468.5
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr9_-_20622478 0.21 ENST00000355930.6
ENST00000380338.4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr12_+_12764773 0.21 ENST00000228865.2
cAMP responsive element binding protein-like 2
chr12_+_60083118 0.21 ENST00000261187.4
ENST00000543448.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr3_-_37034702 0.21 ENST00000322716.5
EPM2A (laforin) interacting protein 1
chr12_-_117319236 0.21 ENST00000257572.5
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr2_-_85839146 0.20 ENST00000306336.5
ENST00000409734.3
chromosome 2 open reading frame 68
chr19_-_47128294 0.19 ENST00000596260.1
ENST00000597185.1
ENST00000598865.1
ENST00000594275.1
ENST00000291294.2
prostaglandin I2 (prostacyclin) receptor (IP)
chr8_-_82024290 0.18 ENST00000220597.4
phosphoprotein associated with glycosphingolipid microdomains 1
chr17_+_61086917 0.17 ENST00000424789.2
ENST00000389520.4
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr15_+_68871308 0.16 ENST00000261861.5
coronin, actin binding protein, 2B
chr12_-_65146636 0.16 ENST00000418919.2
glucosamine (N-acetyl)-6-sulfatase
chr10_+_11206925 0.16 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CUGBP, Elav-like family member 2
chr20_-_41818373 0.15 ENST00000373187.1
ENST00000356100.2
ENST00000373184.1
ENST00000373190.1
protein tyrosine phosphatase, receptor type, T
chr1_-_154155595 0.15 ENST00000328159.4
ENST00000368531.2
ENST00000323144.7
ENST00000368533.3
ENST00000341372.3
tropomyosin 3
chr6_+_132129151 0.15 ENST00000360971.2
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr11_+_76494253 0.13 ENST00000333090.4
tsukushi, small leucine rich proteoglycan
chrX_+_73641286 0.12 ENST00000587091.1
solute carrier family 16, member 2 (thyroid hormone transporter)
chr1_+_2323260 0.11 ENST00000378518.1
ENST00000605895.1
ENST00000378513.3
ENST00000306256.9
ENST00000378512.1
retention in endoplasmic reticulum sorting receptor 1
chrX_+_69664706 0.10 ENST00000194900.4
ENST00000374360.3
discs, large homolog 3 (Drosophila)
chr2_+_86947296 0.09 ENST00000283632.4
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr5_-_126366500 0.09 ENST00000308660.5
membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
chr19_-_47735918 0.09 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BCL2 binding component 3
chr17_+_38219063 0.08 ENST00000584985.1
ENST00000264637.4
ENST00000450525.2
thyroid hormone receptor, alpha
chr5_+_54455946 0.07 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
glutathione peroxidase 8 (putative)
chr13_+_25946201 0.06 ENST00000381655.2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr11_-_77532050 0.05 ENST00000308488.6
remodeling and spacing factor 1
chr2_+_220042933 0.04 ENST00000430297.2
family with sequence similarity 134, member A
chr3_-_179754706 0.04 ENST00000465751.1
ENST00000467460.1
peroxisomal biogenesis factor 5-like
chr20_-_62284766 0.04 ENST00000370053.1
stathmin-like 3
chr1_-_217262969 0.04 ENST00000361525.3
estrogen-related receptor gamma
chr11_+_66025167 0.03 ENST00000394067.2
ENST00000316924.5
ENST00000421552.1
ENST00000394078.1
kinesin light chain 2
chr15_+_67358163 0.03 ENST00000327367.4
SMAD family member 3
chr7_-_128695147 0.02 ENST00000482320.1
ENST00000393245.1
ENST00000471234.1
transportin 3
chr1_+_27153173 0.02 ENST00000374142.4
zinc finger, DHHC-type containing 18
chr1_+_51701924 0.02 ENST00000242719.3
ring finger protein 11
chr3_-_125094093 0.01 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
zinc finger protein 148
chr12_-_49449107 0.01 ENST00000301067.7
lysine (K)-specific methyltransferase 2D

Network of associatons between targets according to the STRING database.

First level regulatory network of GAGAUGA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294)
1.1 5.3 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.7 3.0 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.7 5.6 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.6 1.9 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.6 1.7 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.5 3.9 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.5 1.8 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.4 1.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.3 1.0 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.3 0.9 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.3 0.9 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605)
0.3 1.1 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.3 1.7 GO:0007296 vitellogenesis(GO:0007296)
0.3 0.8 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.2 0.7 GO:0008050 female courtship behavior(GO:0008050)
0.2 0.9 GO:0090210 vitamin E metabolic process(GO:0042360) regulation of establishment of blood-brain barrier(GO:0090210) negative regulation of establishment of blood-brain barrier(GO:0090212)
0.2 0.7 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.2 2.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.2 0.8 GO:0018094 protein polyglycylation(GO:0018094)
0.2 1.0 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072) cellular response to vitamin E(GO:0071306) response to fluoride(GO:1902617)
0.2 1.3 GO:0043634 polyadenylation-dependent ncRNA catabolic process(GO:0043634)
0.2 1.0 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.2 0.7 GO:0030242 pexophagy(GO:0030242)
0.1 0.6 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.1 1.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.5 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
0.1 1.4 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 1.4 GO:0001573 ganglioside metabolic process(GO:0001573)
0.1 0.9 GO:0044351 macropinocytosis(GO:0044351)
0.1 0.3 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 0.3 GO:0003431 growth plate cartilage chondrocyte growth(GO:0003430) growth plate cartilage chondrocyte development(GO:0003431)
0.1 0.7 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.6 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1 1.0 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.3 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 1.3 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 1.4 GO:0044804 nucleophagy(GO:0044804)
0.1 0.3 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.2 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.3 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 0.4 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.3 GO:0003334 keratinocyte development(GO:0003334)
0.1 2.9 GO:0010863 positive regulation of phospholipase C activity(GO:0010863)
0.0 1.3 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.3 GO:0035234 luteolysis(GO:0001554) ectopic germ cell programmed cell death(GO:0035234)
0.0 0.1 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.0 1.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.3 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.6 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.3 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.0 1.5 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.5 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 1.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 1.9 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.4 GO:0060352 cell adhesion molecule production(GO:0060352)
0.0 1.0 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.0 0.2 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.9 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.8 GO:0043029 T cell homeostasis(GO:0043029)
0.0 0.2 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.3 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.2 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 1.2 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.1 GO:0072501 cellular phosphate ion homeostasis(GO:0030643) negative regulation of glycogen biosynthetic process(GO:0045719) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.5 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.2 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.0 1.3 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.3 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0 0.2 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.4 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.2 GO:0042340 keratan sulfate catabolic process(GO:0042340)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.5 1.4 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.9 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.8 GO:0001520 outer dense fiber(GO:0001520)
0.1 1.0 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.7 GO:1990635 proximal dendrite(GO:1990635)
0.1 3.9 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 0.5 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.0 GO:0001741 XY body(GO:0001741)
0.1 0.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.7 GO:0030008 TRAPP complex(GO:0030008)
0.1 6.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 0.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.4 GO:0043073 germ cell nucleus(GO:0043073)
0.0 0.5 GO:0000145 exocyst(GO:0000145)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346) nuclear inclusion body(GO:0042405)
0.0 1.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 1.8 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 2.2 GO:0016605 PML body(GO:0016605)
0.0 0.0 GO:0031213 RSF complex(GO:0031213)
0.0 1.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.3 GO:0046930 pore complex(GO:0046930)
0.0 0.5 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 1.0 GO:0005604 basement membrane(GO:0005604)
0.0 1.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.9 GO:0035580 specific granule lumen(GO:0035580)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.6 GO:0043426 MRF binding(GO:0043426)
0.5 5.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 1.4 GO:0035276 ethanol binding(GO:0035276)
0.3 0.9 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.3 0.9 GO:0070052 collagen V binding(GO:0070052)
0.3 1.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.2 0.9 GO:0008431 vitamin E binding(GO:0008431)
0.2 0.7 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 1.3 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 0.8 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.2 1.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 1.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 1.0 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.2 1.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.2 1.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 1.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.7 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 2.9 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.4 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1 0.7 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 2.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.0 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 0.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 3.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 0.4 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.2 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.7 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.3 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1 0.5 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 3.3 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.9 GO:0042608 T cell receptor binding(GO:0042608)
0.1 0.3 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 0.9 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.5 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 1.1 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.1 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 1.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 3.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.2 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 1.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.8 GO:0043394 proteoglycan binding(GO:0043394)
0.0 1.0 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.3 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.5 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.0 0.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 1.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.3 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 5.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 ST GA12 PATHWAY G alpha 12 Pathway
0.1 1.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.6 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.7 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.9 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.8 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.7 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 1.1 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.2 PID ATF2 PATHWAY ATF-2 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.0 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 0.9 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 0.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 3.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 1.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 2.0 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 1.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.9 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 1.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.0 REACTOME NEGATIVE REGULATION OF FGFR SIGNALING Genes involved in Negative regulation of FGFR signaling
0.0 0.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 2.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.3 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 1.6 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.0 1.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins