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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GATA3
Z-value: 0.80
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Transcription factors associated with GATA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA3 | hg19_v2_chr10_+_8096631_8096660 | 0.06 | 3.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_139871948 Show fit | 34.12 |
ENST00000224167.2
ENST00000457950.1 ENST00000371625.3 ENST00000371623.3 |
prostaglandin D2 synthase 21kDa (brain) |
|
| chr7_+_142498725 Show fit | 31.40 |
ENST00000466254.1
|
T cell receptor beta constant 2 |
|
| chr2_-_89619904 Show fit | 30.20 |
ENST00000498574.1
|
immunoglobulin kappa variable 1-39 (gene/pseudogene) |
|
| chr2_-_89157161 Show fit | 27.24 |
ENST00000390237.2
|
immunoglobulin kappa constant |
|
| chr2_-_89340242 Show fit | 26.56 |
ENST00000480492.1
|
immunoglobulin kappa variable 1-12 |
|
| chrX_+_128913906 Show fit | 26.44 |
ENST00000356892.3
|
SAM and SH3 domain containing 3 |
|
| chrX_+_38420623 Show fit | 25.71 |
ENST00000378482.2
|
tetraspanin 7 |
|
| chr2_-_89399845 Show fit | 25.35 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
|
| chr2_+_89901292 Show fit | 24.43 |
ENST00000448155.2
|
immunoglobulin kappa variable 1D-39 |
|
| chr2_+_90108504 Show fit | 24.26 |
ENST00000390271.2
|
immunoglobulin kappa variable 6D-41 (non-functional) |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 531.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.6 | 73.2 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.7 | 62.4 | GO:0031294 | lymphocyte costimulation(GO:0031294) |
| 3.0 | 53.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 3.1 | 52.3 | GO:0030007 | cellular potassium ion homeostasis(GO:0030007) |
| 0.4 | 48.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 7.2 | 43.1 | GO:0061518 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 1.3 | 42.6 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 3.4 | 40.9 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 1.6 | 40.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 231.8 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 4.3 | 217.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 210.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 104.6 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.6 | 97.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 3.8 | 80.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 4.4 | 70.4 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 8.4 | 66.8 | GO:0060199 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
| 4.1 | 65.9 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.8 | 55.5 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 410.7 | GO:0003823 | antigen binding(GO:0003823) |
| 4.0 | 217.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 116.8 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.1 | 72.4 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 4.3 | 59.6 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.4 | 58.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 1.9 | 57.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 4.3 | 56.1 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 54.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.6 | 48.9 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 78.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.9 | 64.1 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 2.7 | 58.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 1.1 | 55.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 1.1 | 53.9 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 49.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.7 | 47.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 46.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.8 | 45.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 1.0 | 35.2 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 93.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 3.9 | 90.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.5 | 85.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 4.1 | 73.3 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 1.4 | 68.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.4 | 56.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.5 | 48.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.5 | 45.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.0 | 43.2 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.7 | 41.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |