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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GATA5
Z-value: 0.45
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Transcription factors associated with GATA5
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.2 | GO:0031295 | T cell costimulation(GO:0031295) |
| 2.8 | 14.1 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 1.2 | 11.8 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.8 | 10.6 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.2 | 10.2 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.1 | 10.2 | GO:0002819 | regulation of adaptive immune response(GO:0002819) |
| 0.1 | 8.2 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.5 | 7.6 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 7.3 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 0.1 | 5.9 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 28.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 18.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 15.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.9 | 11.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 10.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.4 | 7.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 6.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 5.8 | GO:0005769 | early endosome(GO:0005769) |
| 0.1 | 4.0 | GO:0008305 | integrin complex(GO:0008305) |
| 0.5 | 3.7 | GO:0032437 | cuticular plate(GO:0032437) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 17.2 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.1 | 11.8 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.1 | 9.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 7.5 | GO:0051020 | GTPase binding(GO:0051020) |
| 0.1 | 6.9 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.5 | 6.5 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 5.9 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.0 | 5.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 5.9 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 1.0 | 5.2 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 10.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 9.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 8.5 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 6.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 4.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.2 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 3.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 2.7 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 23.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 14.4 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.7 | 11.8 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.4 | 10.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.4 | 7.5 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.0 | 6.9 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.3 | 3.8 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 3.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 3.4 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 3.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |