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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for GATA5

Z-value: 0.45

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Transcription factors associated with GATA5

Gene Symbol Gene ID Gene Info
GATA5
ENSG00000130700.6 GATA binding protein 5

Activity profile of GATA5 motif

Sorted Z-values of GATA5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_66874502 11.78 ENST00000558797.1
RP11-321F6.1
HCG2003567; Uncharacterized protein
chr1_-_160681593 10.42 ENST00000368045.3
ENST00000368046.3
CD48
CD48 molecule
chr6_-_32557610 9.53 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr6_+_33043703 7.64 ENST00000418931.2
ENST00000535465.1
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr13_-_46756351 7.55 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr4_+_155484155 7.05 ENST00000509493.1
FGB
fibrinogen beta chain
chr19_+_35820064 6.90 ENST00000341773.6
ENST00000600131.1
ENST00000270311.6
ENST00000595780.1
ENST00000597916.1
ENST00000593867.1
ENST00000600424.1
ENST00000599811.1
ENST00000536635.2
ENST00000085219.5
ENST00000544992.2
ENST00000419549.2
CD22
CD22 molecule
chr4_+_175204818 6.66 ENST00000503780.1
CEP44
centrosomal protein 44kDa
chr6_+_32709119 6.52 ENST00000374940.3
HLA-DQA2
major histocompatibility complex, class II, DQ alpha 2
chr15_+_99791567 6.27 ENST00000558879.1
ENST00000301981.3
ENST00000422500.2
ENST00000447360.2
ENST00000442993.2
LRRC28
leucine rich repeat containing 28
chr1_-_213031418 6.23 ENST00000356684.3
ENST00000426161.1
ENST00000424044.1
FLVCR1-AS1
FLVCR1 antisense RNA 1 (head to head)
chr1_+_174844645 5.92 ENST00000486220.1
RABGAP1L
RAB GTPase activating protein 1-like
chr8_+_9046503 5.41 ENST00000512942.2
RP11-10A14.5
RP11-10A14.5
chr10_+_7745232 5.11 ENST00000358415.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745303 4.90 ENST00000429820.1
ENST00000379587.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr4_+_155484103 4.79 ENST00000302068.4
FGB
fibrinogen beta chain
chr6_-_32908765 4.53 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr11_+_128563652 3.96 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr6_-_24936170 3.90 ENST00000538035.1
FAM65B
family with sequence similarity 65, member B
chr8_-_6837602 3.79 ENST00000382692.2
DEFA1
defensin, alpha 1
chr12_-_45270077 3.77 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NELL2
NEL-like 2 (chicken)
chr8_-_6875778 3.75 ENST00000535841.1
ENST00000327857.2
DEFA1B
DEFA3
defensin, alpha 1B
defensin, alpha 3, neutrophil-specific
chr12_-_45270151 3.74 ENST00000429094.2
NELL2
NEL-like 2 (chicken)
chr1_-_158656488 3.74 ENST00000368147.4
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr11_+_121461097 3.73 ENST00000527934.1
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr12_-_45269430 3.68 ENST00000395487.2
NELL2
NEL-like 2 (chicken)
chr9_-_35650900 3.55 ENST00000259608.3
SIT1
signaling threshold regulating transmembrane adaptor 1
chr11_-_33891362 3.36 ENST00000395833.3
LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_+_31916733 3.16 ENST00000483004.1
CFB
complement factor B
chr16_+_31539183 3.11 ENST00000302312.4
AHSP
alpha hemoglobin stabilizing protein
chr2_+_102615416 3.03 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr4_-_72649763 2.93 ENST00000513476.1
GC
group-specific component (vitamin D binding protein)
chr6_-_133079022 2.87 ENST00000525289.1
ENST00000326499.6
VNN2
vanin 2
chr12_+_54892550 2.83 ENST00000545638.2
NCKAP1L
NCK-associated protein 1-like
chr7_+_134331550 2.79 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
BPGM
2,3-bisphosphoglycerate mutase
chr1_+_115572415 2.75 ENST00000256592.1
TSHB
thyroid stimulating hormone, beta
chr9_+_91933407 2.73 ENST00000375807.3
ENST00000339901.4
SECISBP2
SECIS binding protein 2
chr1_-_17445930 2.67 ENST00000375486.4
ENST00000375481.1
ENST00000444885.2
PADI2
peptidyl arginine deiminase, type II
chr4_-_110723335 2.63 ENST00000394634.2
CFI
complement factor I
chr8_+_28196157 2.50 ENST00000522209.1
PNOC
prepronociceptin
chr4_-_110723194 2.44 ENST00000394635.3
CFI
complement factor I
chr8_+_117778736 2.44 ENST00000309822.2
ENST00000357148.3
ENST00000517814.1
ENST00000517820.1
UTP23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr1_+_156123318 2.43 ENST00000368285.3
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr19_+_9296279 2.41 ENST00000344248.2
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr12_-_9268707 2.40 ENST00000318602.7
A2M
alpha-2-macroglobulin
chr12_+_9102632 2.35 ENST00000539240.1
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr1_-_203274418 2.33 ENST00000457348.1
RP11-134P9.1
long intergenic non-protein coding RNA 1136
chr13_-_107214291 2.32 ENST00000375926.1
ARGLU1
arginine and glutamate rich 1
chr19_-_14889349 2.31 ENST00000315576.3
ENST00000392967.2
ENST00000346057.1
ENST00000353876.1
ENST00000353005.1
EMR2
egf-like module containing, mucin-like, hormone receptor-like 2
chr6_-_133055896 2.30 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
VNN3
vanin 3
chr5_-_150537279 2.28 ENST00000517486.1
ENST00000377751.5
ENST00000356496.5
ENST00000521512.1
ENST00000517757.1
ENST00000354546.5
ANXA6
annexin A6
chr9_-_6645628 2.27 ENST00000321612.6
GLDC
glycine dehydrogenase (decarboxylating)
chr17_-_61996192 2.26 ENST00000392824.4
CSHL1
chorionic somatomammotropin hormone-like 1
chr19_-_52133588 2.23 ENST00000570106.2
SIGLEC5
sialic acid binding Ig-like lectin 5
chr14_+_76618242 2.20 ENST00000557542.1
ENST00000557263.1
ENST00000557207.1
ENST00000312858.5
ENST00000261530.7
GPATCH2L
G patch domain containing 2-like
chr16_-_33647696 2.19 ENST00000558425.1
ENST00000569103.2
RP11-812E19.9
Uncharacterized protein
chr16_+_31366455 2.11 ENST00000268296.4
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr17_-_61996160 2.07 ENST00000458650.2
ENST00000351388.4
ENST00000323322.5
GH1
growth hormone 1
chr19_-_10450328 2.01 ENST00000160262.5
ICAM3
intercellular adhesion molecule 3
chr7_+_26332645 1.94 ENST00000396376.1
SNX10
sorting nexin 10
chr6_-_135271260 1.92 ENST00000265605.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr6_-_135271219 1.89 ENST00000367847.2
ENST00000367845.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr16_+_31366536 1.88 ENST00000562522.1
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr18_-_5419797 1.86 ENST00000542146.1
ENST00000427684.2
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr4_-_110723134 1.85 ENST00000510800.1
ENST00000512148.1
CFI
complement factor I
chr3_+_178276488 1.78 ENST00000432997.1
ENST00000455865.1
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr6_-_52710893 1.73 ENST00000284562.2
GSTA5
glutathione S-transferase alpha 5
chr13_-_99910673 1.71 ENST00000397473.2
ENST00000397470.2
GPR18
G protein-coupled receptor 18
chr4_-_47983519 1.68 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
CNGA1
cyclic nucleotide gated channel alpha 1
chr15_-_20193370 1.68 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr10_-_98031265 1.64 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr19_+_42580274 1.57 ENST00000359044.4
ZNF574
zinc finger protein 574
chr14_+_61995722 1.56 ENST00000556347.1
RP11-47I22.4
RP11-47I22.4
chr12_+_62860581 1.51 ENST00000393632.2
ENST00000393630.3
ENST00000280379.6
ENST00000546600.1
ENST00000552738.1
ENST00000393629.2
ENST00000552115.1
MON2
MON2 homolog (S. cerevisiae)
chr16_+_77224732 1.50 ENST00000569610.1
ENST00000248248.3
ENST00000567291.1
ENST00000320859.6
ENST00000563612.1
ENST00000563279.1
MON1B
MON1 secretory trafficking family member B
chr10_+_43916052 1.44 ENST00000442526.2
RP11-517P14.2
RP11-517P14.2
chr5_+_140261703 1.43 ENST00000409494.1
ENST00000289272.2
PCDHA13
protocadherin alpha 13
chrX_-_65253506 1.42 ENST00000427538.1
VSIG4
V-set and immunoglobulin domain containing 4
chr17_-_61996136 1.38 ENST00000342364.4
GH1
growth hormone 1
chr16_+_67927147 1.35 ENST00000291041.5
PSKH1
protein serine kinase H1
chr6_+_131571535 1.34 ENST00000474850.2
AKAP7
A kinase (PRKA) anchor protein 7
chr17_+_53344945 1.32 ENST00000575345.1
HLF
hepatic leukemia factor
chr18_+_39766626 1.32 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
LINC00907
long intergenic non-protein coding RNA 907
chr2_+_29336855 1.30 ENST00000404424.1
CLIP4
CAP-GLY domain containing linker protein family, member 4
chrX_-_55020511 1.28 ENST00000375006.3
ENST00000374992.2
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr6_+_31783291 1.27 ENST00000375651.5
ENST00000608703.1
ENST00000458062.2
HSPA1A
heat shock 70kDa protein 1A
chr6_-_33290580 1.26 ENST00000446511.1
ENST00000446403.1
ENST00000414083.2
ENST00000266000.6
ENST00000374542.5
DAXX
death-domain associated protein
chr1_+_196857144 1.25 ENST00000367416.2
ENST00000251424.4
ENST00000367418.2
CFHR4
complement factor H-related 4
chr10_+_15085936 1.23 ENST00000378217.3
OLAH
oleoyl-ACP hydrolase
chr5_-_39270725 1.21 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr6_-_154677900 1.20 ENST00000265198.4
ENST00000520261.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr2_+_69201705 1.19 ENST00000377938.2
GKN1
gastrokine 1
chr2_+_143635067 1.19 ENST00000264170.4
KYNU
kynureninase
chr1_-_182921119 1.19 ENST00000423786.1
SHCBP1L
SHC SH2-domain binding protein 1-like
chr19_-_14952689 1.17 ENST00000248058.1
OR7A10
olfactory receptor, family 7, subfamily A, member 10
chr14_+_21785693 1.17 ENST00000382933.4
ENST00000557351.1
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr14_-_82000140 1.14 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr2_-_109605663 1.12 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
EDAR
ectodysplasin A receptor
chr15_-_63674034 1.11 ENST00000344366.3
ENST00000422263.2
CA12
carbonic anhydrase XII
chr15_+_41245160 1.09 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr15_+_100106126 1.07 ENST00000558812.1
ENST00000338042.6
MEF2A
myocyte enhancer factor 2A
chr10_+_53806501 1.06 ENST00000373975.2
PRKG1
protein kinase, cGMP-dependent, type I
chr11_+_30252549 1.06 ENST00000254122.3
ENST00000417547.1
FSHB
follicle stimulating hormone, beta polypeptide
chr18_+_21032781 1.03 ENST00000339486.3
RIOK3
RIO kinase 3
chr15_+_100106155 0.95 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
MEF2A
myocyte enhancer factor 2A
chr11_+_118754475 0.92 ENST00000292174.4
CXCR5
chemokine (C-X-C motif) receptor 5
chr6_-_90529418 0.91 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1
MDN1, midasin homolog (yeast)
chr22_+_23412479 0.90 ENST00000248996.4
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr5_-_75919253 0.90 ENST00000296641.4
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr1_+_150229554 0.87 ENST00000369111.4
CA14
carbonic anhydrase XIV
chr10_+_15085895 0.85 ENST00000378228.3
OLAH
oleoyl-ACP hydrolase
chr15_-_34628951 0.83 ENST00000397707.2
ENST00000560611.1
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr6_-_29395509 0.81 ENST00000377147.2
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chrX_+_11777671 0.81 ENST00000380693.3
ENST00000380692.2
MSL3
male-specific lethal 3 homolog (Drosophila)
chr4_+_71570430 0.79 ENST00000417478.2
RUFY3
RUN and FYVE domain containing 3
chr14_+_39735411 0.78 ENST00000603904.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr3_+_46283916 0.78 ENST00000395940.2
CCR3
chemokine (C-C motif) receptor 3
chr3_-_137851220 0.77 ENST00000236709.3
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr12_-_54582655 0.69 ENST00000504338.1
ENST00000514685.1
ENST00000504797.1
ENST00000513838.1
ENST00000505128.1
ENST00000337581.3
ENST00000503306.1
ENST00000243112.5
ENST00000514196.1
ENST00000506169.1
ENST00000507904.1
ENST00000508394.2
SMUG1
single-strand-selective monofunctional uracil-DNA glycosylase 1
chr19_-_14992264 0.68 ENST00000327462.2
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr5_-_75919217 0.67 ENST00000504899.1
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr1_+_104159999 0.67 ENST00000414303.2
ENST00000423678.1
AMY2A
amylase, alpha 2A (pancreatic)
chr7_+_136553370 0.66 ENST00000445907.2
CHRM2
cholinergic receptor, muscarinic 2
chr4_-_48782259 0.63 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRYL
FRY-like
chr4_-_83769996 0.62 ENST00000511338.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr8_-_18666360 0.60 ENST00000286485.8
PSD3
pleckstrin and Sec7 domain containing 3
chr3_+_108541545 0.59 ENST00000295756.6
TRAT1
T cell receptor associated transmembrane adaptor 1
chr18_-_3874752 0.54 ENST00000534970.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr3_+_108541608 0.53 ENST00000426646.1
TRAT1
T cell receptor associated transmembrane adaptor 1
chr10_+_103911926 0.53 ENST00000605788.1
ENST00000405356.1
NOLC1
nucleolar and coiled-body phosphoprotein 1
chr14_-_61748550 0.52 ENST00000555868.1
TMEM30B
transmembrane protein 30B
chr9_-_95244781 0.52 ENST00000375544.3
ENST00000375543.1
ENST00000395538.3
ENST00000450139.2
ASPN
asporin
chr1_+_196743943 0.50 ENST00000471440.2
ENST00000391985.3
CFHR3
complement factor H-related 3
chr15_+_100106244 0.49 ENST00000557942.1
MEF2A
myocyte enhancer factor 2A
chr1_+_57320437 0.49 ENST00000361249.3
C8A
complement component 8, alpha polypeptide
chr2_+_191792376 0.48 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr7_-_81399411 0.48 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr3_-_183145873 0.47 ENST00000447025.2
ENST00000414362.2
ENST00000328913.3
MCF2L2
MCF.2 cell line derived transforming sequence-like 2
chr1_+_79115503 0.46 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr17_+_41323204 0.42 ENST00000542611.1
ENST00000590996.1
ENST00000389312.4
ENST00000589872.1
NBR1
neighbor of BRCA1 gene 1
chr16_-_87466740 0.40 ENST00000561928.1
ZCCHC14
zinc finger, CCHC domain containing 14
chr3_-_183145765 0.40 ENST00000473233.1
MCF2L2
MCF.2 cell line derived transforming sequence-like 2
chr6_+_153019023 0.39 ENST00000367245.5
ENST00000529453.1
MYCT1
myc target 1
chr17_-_72772462 0.37 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chrX_+_1733876 0.37 ENST00000381241.3
ASMT
acetylserotonin O-methyltransferase
chr3_+_46283863 0.35 ENST00000545097.1
ENST00000541018.1
CCR3
chemokine (C-C motif) receptor 3
chr3_-_178984759 0.34 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr2_+_201997676 0.31 ENST00000462763.1
ENST00000479953.2
CFLAR
CASP8 and FADD-like apoptosis regulator
chr12_-_68619586 0.31 ENST00000229134.4
IL26
interleukin 26
chr2_-_136594740 0.30 ENST00000264162.2
LCT
lactase
chrX_+_1734051 0.29 ENST00000381229.4
ENST00000381233.3
ASMT
acetylserotonin O-methyltransferase
chr3_-_182817297 0.29 ENST00000539926.1
ENST00000476176.1
MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr16_-_28503357 0.27 ENST00000333496.9
ENST00000561505.1
ENST00000567963.1
ENST00000354630.5
ENST00000355477.5
ENST00000357076.5
ENST00000565688.1
ENST00000359984.7
CLN3
ceroid-lipofuscinosis, neuronal 3
chr5_-_58652788 0.17 ENST00000405755.2
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_+_124824000 0.17 ENST00000529051.1
ENST00000344762.5
CCDC15
coiled-coil domain containing 15
chr3_+_118905564 0.14 ENST00000460625.1
UPK1B
uroplakin 1B
chr12_+_75874580 0.13 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr6_-_55739542 0.11 ENST00000446683.2
BMP5
bone morphogenetic protein 5
chr4_+_110834033 0.10 ENST00000509793.1
ENST00000265171.5
EGF
epidermal growth factor
chr15_-_63674218 0.08 ENST00000178638.3
CA12
carbonic anhydrase XII
chr3_+_155860751 0.08 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_+_171454639 0.05 ENST00000392078.3
ENST00000426496.2
PRRC2C
proline-rich coiled-coil 2C
chr2_+_166150541 0.02 ENST00000283256.6
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr6_+_126102292 0.01 ENST00000368357.3
NCOA7
nuclear receptor coactivator 7

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 14.1 GO:0002399 MHC class II protein complex assembly(GO:0002399)
1.3 3.8 GO:0035915 pore formation in membrane of other organism(GO:0035915)
1.2 3.7 GO:1902769 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
1.2 11.8 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.9 2.7 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
0.8 3.0 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.8 10.6 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.7 2.8 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
0.7 2.8 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.5 5.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.5 7.6 GO:0051639 actin filament network formation(GO:0051639)
0.5 2.3 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.4 3.4 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.4 2.5 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.4 2.4 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.4 1.2 GO:0097052 tryptophan catabolic process to acetyl-CoA(GO:0019442) L-kynurenine metabolic process(GO:0097052)
0.4 1.5 GO:0019086 late viral transcription(GO:0019086)
0.3 3.8 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3 1.3 GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.3 1.3 GO:1903935 response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936)
0.3 2.7 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.3 1.9 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.3 1.0 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.2 3.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 0.7 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.2 1.3 GO:0033133 fructose 2,6-bisphosphate metabolic process(GO:0006003) positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.2 5.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 1.2 GO:0055064 chloride ion homeostasis(GO:0055064)
0.2 1.7 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.2 2.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 4.0 GO:0035855 megakaryocyte development(GO:0035855)
0.2 0.5 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.2 0.8 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.2 10.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.2 3.1 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.2 3.4 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.2 1.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 1.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 1.0 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.7 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 14.2 GO:0031295 T cell costimulation(GO:0031295)
0.1 2.9 GO:0042359 vitamin D metabolic process(GO:0042359)
0.1 2.7 GO:0033189 response to vitamin A(GO:0033189)
0.1 7.3 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.1 0.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 2.3 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.1 1.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 0.9 GO:0048535 lymph node development(GO:0048535)
0.1 10.2 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.1 1.2 GO:0015671 oxygen transport(GO:0015671)
0.1 1.9 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 2.1 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.1 1.5 GO:0005513 detection of calcium ion(GO:0005513)
0.1 5.9 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 8.2 GO:0030449 regulation of complement activation(GO:0030449)
0.1 1.1 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 1.6 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 1.1 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.1 0.3 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 0.5 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1 1.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 3.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.7 GO:0045008 depyrimidination(GO:0045008)
0.1 4.0 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.1 0.1 GO:0021502 neural fold elevation formation(GO:0021502) allantois development(GO:1905069)
0.1 0.5 GO:0007000 nucleolus organization(GO:0007000)
0.0 3.5 GO:0006968 cellular defense response(GO:0006968)
0.0 1.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 1.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.8 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 1.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0006552 leucine catabolic process(GO:0006552)
0.0 1.1 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 2.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 1.3 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 1.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 1.6 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.9 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.5 GO:0099536 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916) synaptic signaling(GO:0099536) trans-synaptic signaling(GO:0099537)
0.0 1.3 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.8 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.9 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.5 GO:0006958 complement activation, classical pathway(GO:0006958)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 28.2 GO:0042613 MHC class II protein complex(GO:0042613)
1.1 3.4 GO:0070195 growth hormone receptor complex(GO:0070195)
0.9 11.8 GO:0005577 fibrinogen complex(GO:0005577)
0.8 2.3 GO:0005960 glycine cleavage complex(GO:0005960)
0.6 0.6 GO:0030427 site of polarized growth(GO:0030427)
0.5 3.7 GO:0032437 cuticular plate(GO:0032437)
0.5 1.9 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.4 7.6 GO:0001891 phagocytic cup(GO:0001891)
0.2 3.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 1.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.2 3.1 GO:0005833 hemoglobin complex(GO:0005833)
0.2 2.8 GO:0031209 SCAR complex(GO:0031209)
0.2 0.7 GO:0032279 asymmetric synapse(GO:0032279)
0.1 1.2 GO:0072687 meiotic spindle(GO:0072687)
0.1 1.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 1.9 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.8 GO:0072487 MSL complex(GO:0072487)
0.1 1.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 10.2 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 15.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 18.9 GO:0072562 blood microparticle(GO:0072562)
0.1 4.0 GO:0008305 integrin complex(GO:0008305)
0.1 2.4 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.3 GO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.0 0.7 GO:0071437 invadopodium(GO:0071437)
0.0 6.1 GO:0000922 spindle pole(GO:0000922)
0.0 1.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.2 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 2.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 5.8 GO:0005769 early endosome(GO:0005769)
0.0 1.9 GO:0043679 axon terminus(GO:0043679)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.3 GO:0070603 SWI/SNF superfamily-type complex(GO:0070603)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0005148 prolactin receptor binding(GO:0005148)
1.0 5.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.8 2.4 GO:0019959 interleukin-8 binding(GO:0019959)
0.7 2.8 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.7 2.1 GO:0016297 oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297)
0.6 3.0 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.6 17.2 GO:0042605 peptide antigen binding(GO:0042605)
0.5 2.7 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.5 3.1 GO:0030492 hemoglobin binding(GO:0030492)
0.5 6.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.5 2.7 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.4 2.3 GO:0005499 vitamin D binding(GO:0005499)
0.4 2.5 GO:0001515 opioid peptide activity(GO:0001515)
0.3 3.8 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.3 2.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.3 1.2 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.3 1.6 GO:0015057 thrombin receptor activity(GO:0015057)
0.3 1.3 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 3.7 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 1.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 1.3 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 0.7 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.2 4.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 0.7 GO:0016160 amylase activity(GO:0016160)
0.2 2.3 GO:0016594 glycine binding(GO:0016594)
0.1 2.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 2.4 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.9 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 1.7 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 2.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 6.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 11.8 GO:0051087 chaperone binding(GO:0051087)
0.1 3.7 GO:0001848 complement binding(GO:0001848)
0.1 1.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.3 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.5 GO:0004359 glutaminase activity(GO:0004359)
0.1 1.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.0 GO:0089720 caspase binding(GO:0089720)
0.1 9.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.9 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 5.9 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 3.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.3 GO:0032183 SUMO binding(GO:0032183)
0.1 0.3 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.1 1.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.5 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 5.2 GO:0005179 hormone activity(GO:0005179)
0.0 2.3 GO:0015485 cholesterol binding(GO:0015485)
0.0 4.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 5.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 7.5 GO:0051020 GTPase binding(GO:0051020)
0.0 2.9 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 5.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.5 GO:0042056 chemoattractant activity(GO:0042056)
0.0 1.2 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.8 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 17.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 9.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 1.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 3.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 8.5 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 2.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 2.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 0.9 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 3.0 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 10.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 2.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 6.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.5 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 3.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 23.7 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.7 11.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 7.5 REACTOME DEFENSINS Genes involved in Defensins
0.4 10.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.3 3.8 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 3.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 3.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 14.4 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 2.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 1.0 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 2.9 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 1.1 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 2.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 2.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 3.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 0.9 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 3.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.6 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 6.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 2.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)