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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for GATA6

Z-value: 0.29

Motif logo

Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
ENSG00000141448.4 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19749386_197494040.152.6e-02Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_118958689 14.34 ENST00000535253.1
ENST00000392841.1
hydroxymethylbilane synthase
chr12_-_54689532 13.63 ENST00000540264.2
ENST00000312156.4
nuclear factor, erythroid 2
chr7_-_100239132 8.61 ENST00000223051.3
ENST00000431692.1
transferrin receptor 2
chr5_+_159848807 8.50 ENST00000352433.5
pituitary tumor-transforming 1
chr1_-_158656488 8.47 ENST00000368147.4
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr16_+_202686 7.60 ENST00000252951.2
hemoglobin, zeta
chr1_+_206317450 7.53 ENST00000358184.2
ENST00000361052.3
ENST00000360218.2
cathepsin E
chr19_-_13213662 6.88 ENST00000264824.4
lymphoblastic leukemia derived sequence 1
chr1_+_161136180 6.73 ENST00000352210.5
ENST00000367999.4
ENST00000544598.1
ENST00000535223.1
ENST00000432542.2
protoporphyrinogen oxidase
chr15_-_43513187 6.46 ENST00000540029.1
ENST00000441366.2
erythrocyte membrane protein band 4.2
chr7_+_130020180 6.08 ENST00000481342.1
ENST00000011292.3
ENST00000604896.1
carboxypeptidase A1 (pancreatic)
chr7_+_142457315 5.58 ENST00000486171.1
ENST00000311737.7
protease, serine, 1 (trypsin 1)
chr8_+_21823726 5.56 ENST00000433566.4
exportin 7
chr10_+_118305435 5.43 ENST00000369221.2
pancreatic lipase
chr12_-_120765565 5.12 ENST00000423423.3
ENST00000308366.4
phospholipase A2, group IB (pancreas)
chr10_+_118350468 4.41 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
pancreatic lipase-related protein 1
chr18_+_19749386 4.34 ENST00000269216.3
GATA binding protein 6
chr10_+_118350522 4.23 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
pancreatic lipase-related protein 1
chr9_+_33795533 3.95 ENST00000379405.3
protease, serine, 3
chr20_-_54967187 3.92 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
aurora kinase A
chr3_+_69812877 3.79 ENST00000457080.1
ENST00000328528.6
microphthalmia-associated transcription factor
chr19_+_10397621 3.74 ENST00000380770.3
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397648 3.68 ENST00000340992.4
ENST00000393717.2
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr1_+_25599018 3.54 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
Rh blood group, D antigen
chr1_+_25598989 3.51 ENST00000454452.2
Rh blood group, D antigen
chr6_-_30128657 3.40 ENST00000449742.2
ENST00000376704.3
tripartite motif containing 10
chr1_+_25598872 3.38 ENST00000328664.4
Rh blood group, D antigen
chr11_-_66206260 2.94 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
mitochondrial ribosomal protein L11
chr19_-_11494975 2.85 ENST00000222139.6
ENST00000592375.2
erythropoietin receptor
chr8_-_95449155 2.78 ENST00000481490.2
fibrinogen silencer binding protein
chr12_+_111843749 2.45 ENST00000341259.2
SH2B adaptor protein 3
chr4_-_103266219 2.08 ENST00000394833.2
solute carrier family 39 (zinc transporter), member 8
chr6_+_31674639 2.07 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr2_+_109237717 2.01 ENST00000409441.1
LIM and senescent cell antigen-like domains 1
chr11_-_116708302 1.83 ENST00000375320.1
ENST00000359492.2
ENST00000375329.2
ENST00000375323.1
apolipoprotein A-I
chr13_-_46716969 1.67 ENST00000435666.2
lymphocyte cytosolic protein 1 (L-plastin)
chr20_+_51588873 1.63 ENST00000371497.5
teashirt zinc finger homeobox 2
chr4_-_103266355 1.62 ENST00000424970.2
solute carrier family 39 (zinc transporter), member 8
chr3_+_69812701 1.57 ENST00000472437.1
microphthalmia-associated transcription factor
chr2_-_69098566 1.57 ENST00000295379.1
bone morphogenetic protein 10
chr6_+_12290586 1.57 ENST00000379375.5
endothelin 1
chr9_+_118950325 1.41 ENST00000534838.1
pregnancy-associated plasma protein A, pappalysin 1
chr14_+_53173910 1.37 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr16_+_333152 1.30 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
protein disulfide isomerase family A, member 2
chr2_+_87565634 1.29 ENST00000421835.2
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr14_+_53173890 1.21 ENST00000445930.2
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr1_-_24469602 1.12 ENST00000270800.1
interleukin 22 receptor, alpha 1
chr2_-_44065889 1.10 ENST00000543989.1
ENST00000405322.1
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_90538397 1.07 ENST00000443397.3
Uncharacterized protein
chr18_-_28742813 1.06 ENST00000257197.3
ENST00000257198.5
desmocollin 1
chr2_-_44065946 1.02 ENST00000260645.1
ATP-binding cassette, sub-family G (WHITE), member 5
chr17_-_4806369 0.98 ENST00000293780.4
cholinergic receptor, nicotinic, epsilon (muscle)
chr8_+_70378852 0.96 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
sulfatase 1
chr5_-_33984741 0.96 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
solute carrier family 45, member 2
chr3_+_88188254 0.95 ENST00000309495.5
zinc finger protein 654
chr1_-_27240455 0.94 ENST00000254227.3
nuclear receptor subfamily 0, group B, member 2
chr4_+_100495864 0.92 ENST00000265517.5
ENST00000422897.2
microsomal triglyceride transfer protein
chr14_-_23285011 0.90 ENST00000397532.3
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr5_-_135290705 0.89 ENST00000274507.1
leukocyte cell-derived chemotaxin 2
chr1_+_171217677 0.89 ENST00000402921.2
flavin containing monooxygenase 1
chr5_-_33984786 0.87 ENST00000296589.4
solute carrier family 45, member 2
chr8_-_20040638 0.86 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr7_+_155090271 0.85 ENST00000476756.1
insulin induced gene 1
chr8_-_20040601 0.83 ENST00000265808.7
ENST00000522513.1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr17_+_4835580 0.81 ENST00000329125.5
glycoprotein Ib (platelet), alpha polypeptide
chr2_-_214014959 0.81 ENST00000442445.1
ENST00000457361.1
ENST00000342002.2
IKAROS family zinc finger 2 (Helios)
chr19_-_51522955 0.80 ENST00000358789.3
kallikrein-related peptidase 10
chr14_-_23285069 0.79 ENST00000554758.1
ENST00000397528.4
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr12_+_53818855 0.76 ENST00000550839.1
anti-Mullerian hormone receptor, type II
chr3_+_137717571 0.74 ENST00000343735.4
claudin 18
chr17_-_62084241 0.73 ENST00000449662.2
intercellular adhesion molecule 2
chr8_-_93107696 0.73 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_+_75988768 0.63 ENST00000286639.6
basic leucine zipper transcription factor, ATF-like
chr10_-_127505167 0.59 ENST00000368786.1
uroporphyrinogen III synthase
chr8_-_38008783 0.57 ENST00000276449.4
steroidogenic acute regulatory protein
chr2_+_138722028 0.56 ENST00000280096.5
histamine N-methyltransferase
chr11_-_26743546 0.50 ENST00000280467.6
ENST00000396005.3
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr14_-_21945057 0.50 ENST00000397762.1
RAB2B, member RAS oncogene family
chr2_+_220436917 0.50 ENST00000243786.2
inhibin, alpha
chr18_+_43304092 0.47 ENST00000321925.4
ENST00000587601.1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr5_+_131409476 0.44 ENST00000296871.2
colony stimulating factor 2 (granulocyte-macrophage)
chr17_+_74381343 0.44 ENST00000392496.3
sphingosine kinase 1
chr9_+_125796806 0.43 ENST00000373642.1
G protein-coupled receptor 21
chr15_+_49715293 0.36 ENST00000267843.4
ENST00000560270.1
fibroblast growth factor 7
chr5_+_131892603 0.33 ENST00000378823.3
ENST00000265335.6
RAD50 homolog (S. cerevisiae)
chr6_-_46048116 0.33 ENST00000185206.6
chloride intracellular channel 5
chr17_+_43224684 0.32 ENST00000332499.2
hexamethylene bis-acetamide inducible 1
chr2_-_40739501 0.32 ENST00000403092.1
ENST00000402441.1
ENST00000448531.1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr5_+_135496675 0.32 ENST00000507637.1
SMAD family member 5
chr18_+_43304137 0.31 ENST00000502059.2
ENST00000586951.1
ENST00000589322.2
ENST00000415427.3
ENST00000535474.1
ENST00000402943.2
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr16_+_4475806 0.31 ENST00000262375.6
ENST00000355296.4
ENST00000431375.2
ENST00000574895.1
DnaJ (Hsp40) homolog, subfamily A, member 3
chr2_+_169757750 0.30 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
glucose-6-phosphatase, catalytic, 2
chr10_-_99531709 0.29 ENST00000266066.3
secreted frizzled-related protein 5
chr1_+_12524965 0.29 ENST00000471923.1
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr11_+_10326612 0.29 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
adrenomedullin
chr18_-_45663666 0.24 ENST00000535628.2
zinc finger and BTB domain containing 7C
chr21_-_39870339 0.20 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
v-ets avian erythroblastosis virus E26 oncogene homolog
chr2_+_102928009 0.19 ENST00000404917.2
ENST00000447231.1
interleukin 1 receptor-like 1
chr22_-_29784519 0.19 ENST00000357586.2
ENST00000356015.2
ENST00000432560.2
ENST00000317368.7
adaptor-related protein complex 1, beta 1 subunit
chr19_+_36132631 0.13 ENST00000379026.2
ENST00000379023.4
ENST00000402764.2
ENST00000479824.1
ets variant 2
chr12_-_10151773 0.12 ENST00000298527.6
ENST00000348658.4
C-type lectin domain family 1, member B
chr7_+_128379346 0.12 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
calumenin
chr1_+_171217622 0.11 ENST00000433267.1
ENST00000367750.3
flavin containing monooxygenase 1
chr14_+_21945335 0.09 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
TOX high mobility group box family member 4
chr19_-_55549624 0.04 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
glycoprotein VI (platelet)

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 21.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
1.4 4.3 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
1.4 8.6 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
1.4 2.8 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
1.3 3.9 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
1.3 5.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
1.2 14.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.8 3.9 GO:1904729 regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal lipid absorption(GO:1904729)
0.8 3.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.7 6.9 GO:0001955 blood vessel maturation(GO:0001955)
0.5 13.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.4 5.4 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.4 7.5 GO:0016540 protein autoprocessing(GO:0016540)
0.4 3.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.4 9.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 8.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.3 10.4 GO:0015695 organic cation transport(GO:0015695)
0.3 1.7 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.3 1.7 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
0.3 0.8 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 0.8 GO:1902612 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.2 0.6 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.2 8.5 GO:0045143 homologous chromosome segregation(GO:0045143)
0.2 0.3 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.2 0.8 GO:0071918 urea transmembrane transport(GO:0071918)
0.2 0.9 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 7.9 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 0.4 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.3 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 1.0 GO:0070995 NADPH oxidation(GO:0070995)
0.1 0.5 GO:0046882 negative regulation of B cell differentiation(GO:0045578) negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.1 3.4 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 0.4 GO:0060437 lung growth(GO:0060437)
0.1 1.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 1.7 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.6 GO:0001692 histamine metabolic process(GO:0001692)
0.1 0.4 GO:0045918 positive regulation of interleukin-23 production(GO:0032747) negative regulation of cytolysis(GO:0045918)
0.1 0.8 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.1 2.5 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.1 0.3 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 2.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.7 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.1 0.3 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.1 5.6 GO:0006611 protein export from nucleus(GO:0006611)
0.1 1.4 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.1 0.5 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.1 1.8 GO:0042438 melanin biosynthetic process(GO:0042438)
0.1 2.0 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 0.2 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.3 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.3 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.8 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.3 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 1.0 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.2 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 1.1 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.2 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.3 GO:1901798 positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 2.1 GO:0002576 platelet degranulation(GO:0002576)
0.0 6.1 GO:0030198 extracellular matrix organization(GO:0030198)
0.0 0.4 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.0 0.9 GO:0032024 positive regulation of insulin secretion(GO:0032024)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 8.5 GO:0032437 cuticular plate(GO:0032437)
0.7 8.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.6 1.8 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.5 7.6 GO:0005833 hemoglobin complex(GO:0005833)
0.5 3.9 GO:0032133 chromosome passenger complex(GO:0032133)
0.4 1.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 6.7 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.2 2.6 GO:0031595 nuclear proteasome complex(GO:0031595)
0.2 0.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 1.7 GO:0070083 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.2 2.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.2 0.5 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.8 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.7 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.6 GO:0030061 mitochondrial crista(GO:0030061)
0.1 10.9 GO:0016605 PML body(GO:0016605)
0.1 2.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 2.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.7 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 5.6 GO:0005643 nuclear pore(GO:0005643)
0.0 4.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 6.5 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 1.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.1 GO:0005921 gap junction(GO:0005921)
0.0 5.6 GO:0072562 blood microparticle(GO:0072562)
0.0 29.8 GO:0005615 extracellular space(GO:0005615)
0.0 3.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 26.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 4.3 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.3 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.3 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.6 GO:0004998 transferrin receptor activity(GO:0004998)
0.8 6.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.6 7.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.6 1.7 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.6 6.7 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.5 14.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.5 5.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.5 5.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.5 1.8 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.4 3.9 GO:0035174 histone serine kinase activity(GO:0035174)
0.4 1.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.4 10.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.3 7.5 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 1.6 GO:0031708 endothelin B receptor binding(GO:0031708)
0.3 13.6 GO:0050699 WW domain binding(GO:0050699)
0.2 2.6 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.2 0.8 GO:0015265 urea channel activity(GO:0015265)
0.2 3.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 0.8 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.2 14.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 1.6 GO:0031433 telethonin binding(GO:0031433)
0.2 1.7 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 4.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.8 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 2.7 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 1.8 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.1 1.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 1.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.4 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.1 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 4.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 8.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 5.4 GO:0070888 E-box binding(GO:0070888)
0.1 0.3 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.4 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.5 GO:0034711 inhibin binding(GO:0034711)
0.1 0.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 2.9 GO:0019843 rRNA binding(GO:0019843)
0.0 0.3 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 1.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 9.7 GO:0051015 actin filament binding(GO:0051015)
0.0 6.1 GO:0005178 integrin binding(GO:0005178)
0.0 9.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 2.1 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 10.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 4.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 19.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 5.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.1 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.0 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.4 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 1.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 21.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 5.1 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.2 3.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 7.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 3.9 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 5.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 6.0 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 15.0 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 20.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.5 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 6.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.0 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.5 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.0 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis