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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for GATA6

Z-value: 0.29

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.4 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19749386_197494040.152.6e-02Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_118958689 14.34 ENST00000535253.1
ENST00000392841.1
HMBS
hydroxymethylbilane synthase
chr12_-_54689532 13.63 ENST00000540264.2
ENST00000312156.4
NFE2
nuclear factor, erythroid 2
chr7_-_100239132 8.61 ENST00000223051.3
ENST00000431692.1
TFR2
transferrin receptor 2
chr5_+_159848807 8.50 ENST00000352433.5
PTTG1
pituitary tumor-transforming 1
chr1_-_158656488 8.47 ENST00000368147.4
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr16_+_202686 7.60 ENST00000252951.2
HBZ
hemoglobin, zeta
chr1_+_206317450 7.53 ENST00000358184.2
ENST00000361052.3
ENST00000360218.2
CTSE
cathepsin E
chr19_-_13213662 6.88 ENST00000264824.4
LYL1
lymphoblastic leukemia derived sequence 1
chr1_+_161136180 6.73 ENST00000352210.5
ENST00000367999.4
ENST00000544598.1
ENST00000535223.1
ENST00000432542.2
PPOX
protoporphyrinogen oxidase
chr15_-_43513187 6.46 ENST00000540029.1
ENST00000441366.2
EPB42
erythrocyte membrane protein band 4.2
chr7_+_130020180 6.08 ENST00000481342.1
ENST00000011292.3
ENST00000604896.1
CPA1
carboxypeptidase A1 (pancreatic)
chr7_+_142457315 5.58 ENST00000486171.1
ENST00000311737.7
PRSS1
protease, serine, 1 (trypsin 1)
chr8_+_21823726 5.56 ENST00000433566.4
XPO7
exportin 7
chr10_+_118305435 5.43 ENST00000369221.2
PNLIP
pancreatic lipase
chr12_-_120765565 5.12 ENST00000423423.3
ENST00000308366.4
PLA2G1B
phospholipase A2, group IB (pancreas)
chr10_+_118350468 4.41 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr18_+_19749386 4.34 ENST00000269216.3
GATA6
GATA binding protein 6
chr10_+_118350522 4.23 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chr9_+_33795533 3.95 ENST00000379405.3
PRSS3
protease, serine, 3
chr20_-_54967187 3.92 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA
aurora kinase A
chr3_+_69812877 3.79 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr19_+_10397621 3.74 ENST00000380770.3
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397648 3.68 ENST00000340992.4
ENST00000393717.2
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr1_+_25599018 3.54 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
RHD
Rh blood group, D antigen
chr1_+_25598989 3.51 ENST00000454452.2
RHD
Rh blood group, D antigen
chr6_-_30128657 3.40 ENST00000449742.2
ENST00000376704.3
TRIM10
tripartite motif containing 10
chr1_+_25598872 3.38 ENST00000328664.4
RHD
Rh blood group, D antigen
chr11_-_66206260 2.94 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
MRPL11
mitochondrial ribosomal protein L11
chr19_-_11494975 2.85 ENST00000222139.6
ENST00000592375.2
EPOR
erythropoietin receptor
chr8_-_95449155 2.78 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr12_+_111843749 2.45 ENST00000341259.2
SH2B3
SH2B adaptor protein 3
chr4_-_103266219 2.08 ENST00000394833.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr6_+_31674639 2.07 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F
MEGT1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr2_+_109237717 2.01 ENST00000409441.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr11_-_116708302 1.83 ENST00000375320.1
ENST00000359492.2
ENST00000375329.2
ENST00000375323.1
APOA1
apolipoprotein A-I
chr13_-_46716969 1.67 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr20_+_51588873 1.63 ENST00000371497.5
TSHZ2
teashirt zinc finger homeobox 2
chr4_-_103266355 1.62 ENST00000424970.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr3_+_69812701 1.57 ENST00000472437.1
MITF
microphthalmia-associated transcription factor
chr2_-_69098566 1.57 ENST00000295379.1
BMP10
bone morphogenetic protein 10
chr6_+_12290586 1.57 ENST00000379375.5
EDN1
endothelin 1
chr9_+_118950325 1.41 ENST00000534838.1
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr14_+_53173910 1.37 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr16_+_333152 1.30 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
PDIA2
protein disulfide isomerase family A, member 2
chr2_+_87565634 1.29 ENST00000421835.2
IGKV3OR2-268
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr14_+_53173890 1.21 ENST00000445930.2
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr1_-_24469602 1.12 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr2_-_44065889 1.10 ENST00000543989.1
ENST00000405322.1
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr2_-_90538397 1.07 ENST00000443397.3
RP11-685N3.1
Uncharacterized protein
chr18_-_28742813 1.06 ENST00000257197.3
ENST00000257198.5
DSC1
desmocollin 1
chr2_-_44065946 1.02 ENST00000260645.1
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr17_-_4806369 0.98 ENST00000293780.4
CHRNE
cholinergic receptor, nicotinic, epsilon (muscle)
chr8_+_70378852 0.96 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
SULF1
sulfatase 1
chr5_-_33984741 0.96 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
SLC45A2
solute carrier family 45, member 2
chr3_+_88188254 0.95 ENST00000309495.5
ZNF654
zinc finger protein 654
chr1_-_27240455 0.94 ENST00000254227.3
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr4_+_100495864 0.92 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr14_-_23285011 0.90 ENST00000397532.3
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr5_-_135290705 0.89 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr1_+_171217677 0.89 ENST00000402921.2
FMO1
flavin containing monooxygenase 1
chr5_-_33984786 0.87 ENST00000296589.4
SLC45A2
solute carrier family 45, member 2
chr8_-_20040638 0.86 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr7_+_155090271 0.85 ENST00000476756.1
INSIG1
insulin induced gene 1
chr8_-_20040601 0.83 ENST00000265808.7
ENST00000522513.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr17_+_4835580 0.81 ENST00000329125.5
GP1BA
glycoprotein Ib (platelet), alpha polypeptide
chr2_-_214014959 0.81 ENST00000442445.1
ENST00000457361.1
ENST00000342002.2
IKZF2
IKAROS family zinc finger 2 (Helios)
chr19_-_51522955 0.80 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr14_-_23285069 0.79 ENST00000554758.1
ENST00000397528.4
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr12_+_53818855 0.76 ENST00000550839.1
AMHR2
anti-Mullerian hormone receptor, type II
chr3_+_137717571 0.74 ENST00000343735.4
CLDN18
claudin 18
chr17_-_62084241 0.73 ENST00000449662.2
ICAM2
intercellular adhesion molecule 2
chr8_-_93107696 0.73 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_+_75988768 0.63 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr10_-_127505167 0.59 ENST00000368786.1
UROS
uroporphyrinogen III synthase
chr8_-_38008783 0.57 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr2_+_138722028 0.56 ENST00000280096.5
HNMT
histamine N-methyltransferase
chr11_-_26743546 0.50 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr14_-_21945057 0.50 ENST00000397762.1
RAB2B
RAB2B, member RAS oncogene family
chr2_+_220436917 0.50 ENST00000243786.2
INHA
inhibin, alpha
chr18_+_43304092 0.47 ENST00000321925.4
ENST00000587601.1
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr5_+_131409476 0.44 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr17_+_74381343 0.44 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr9_+_125796806 0.43 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chr15_+_49715293 0.36 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr5_+_131892603 0.33 ENST00000378823.3
ENST00000265335.6
RAD50
RAD50 homolog (S. cerevisiae)
chr6_-_46048116 0.33 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr17_+_43224684 0.32 ENST00000332499.2
HEXIM1
hexamethylene bis-acetamide inducible 1
chr2_-_40739501 0.32 ENST00000403092.1
ENST00000402441.1
ENST00000448531.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr5_+_135496675 0.32 ENST00000507637.1
SMAD5
SMAD family member 5
chr18_+_43304137 0.31 ENST00000502059.2
ENST00000586951.1
ENST00000589322.2
ENST00000415427.3
ENST00000535474.1
ENST00000402943.2
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr16_+_4475806 0.31 ENST00000262375.6
ENST00000355296.4
ENST00000431375.2
ENST00000574895.1
DNAJA3
DnaJ (Hsp40) homolog, subfamily A, member 3
chr2_+_169757750 0.30 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
G6PC2
glucose-6-phosphatase, catalytic, 2
chr10_-_99531709 0.29 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr1_+_12524965 0.29 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr11_+_10326612 0.29 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
ADM
adrenomedullin
chr18_-_45663666 0.24 ENST00000535628.2
ZBTB7C
zinc finger and BTB domain containing 7C
chr21_-_39870339 0.20 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chr2_+_102928009 0.19 ENST00000404917.2
ENST00000447231.1
IL1RL1
interleukin 1 receptor-like 1
chr22_-_29784519 0.19 ENST00000357586.2
ENST00000356015.2
ENST00000432560.2
ENST00000317368.7
AP1B1
adaptor-related protein complex 1, beta 1 subunit
chr19_+_36132631 0.13 ENST00000379026.2
ENST00000379023.4
ENST00000402764.2
ENST00000479824.1
ETV2
ets variant 2
chr12_-_10151773 0.12 ENST00000298527.6
ENST00000348658.4
CLEC1B
C-type lectin domain family 1, member B
chr7_+_128379346 0.12 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
CALU
calumenin
chr1_+_171217622 0.11 ENST00000433267.1
ENST00000367750.3
FMO1
flavin containing monooxygenase 1
chr14_+_21945335 0.09 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
TOX4
TOX high mobility group box family member 4
chr19_-_55549624 0.04 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
GP6
glycoprotein VI (platelet)

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 21.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
1.4 4.3 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
1.4 8.6 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
1.4 2.8 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
1.3 3.9 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
1.3 5.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
1.2 14.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.8 3.9 GO:1904729 regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal lipid absorption(GO:1904729)
0.8 3.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.7 6.9 GO:0001955 blood vessel maturation(GO:0001955)
0.5 13.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.4 5.4 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.4 7.5 GO:0016540 protein autoprocessing(GO:0016540)
0.4 3.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.4 9.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 8.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.3 10.4 GO:0015695 organic cation transport(GO:0015695)
0.3 1.7 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.3 1.7 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
0.3 0.8 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 0.8 GO:1902612 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.2 0.6 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.2 8.5 GO:0045143 homologous chromosome segregation(GO:0045143)
0.2 0.3 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.2 0.8 GO:0071918 urea transmembrane transport(GO:0071918)
0.2 0.9 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 7.9 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 0.4 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.3 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 1.0 GO:0070995 NADPH oxidation(GO:0070995)
0.1 0.5 GO:0046882 negative regulation of B cell differentiation(GO:0045578) negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.1 3.4 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 0.4 GO:0060437 lung growth(GO:0060437)
0.1 1.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 1.7 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.6 GO:0001692 histamine metabolic process(GO:0001692)
0.1 0.4 GO:0045918 positive regulation of interleukin-23 production(GO:0032747) negative regulation of cytolysis(GO:0045918)
0.1 0.8 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.1 2.5 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.1 0.3 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 2.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.7 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.1 0.3 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.1 5.6 GO:0006611 protein export from nucleus(GO:0006611)
0.1 1.4 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.1 0.5 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.1 1.8 GO:0042438 melanin biosynthetic process(GO:0042438)
0.1 2.0 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 0.2 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.3 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.3 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.8 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.3 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 1.0 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.2 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 1.1 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.2 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.3 GO:1901798 positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 2.1 GO:0002576 platelet degranulation(GO:0002576)
0.0 6.1 GO:0030198 extracellular matrix organization(GO:0030198)
0.0 0.4 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.0 0.9 GO:0032024 positive regulation of insulin secretion(GO:0032024)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 8.5 GO:0032437 cuticular plate(GO:0032437)
0.7 8.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.6 1.8 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.5 7.6 GO:0005833 hemoglobin complex(GO:0005833)
0.5 3.9 GO:0032133 chromosome passenger complex(GO:0032133)
0.4 1.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 6.7 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.2 2.6 GO:0031595 nuclear proteasome complex(GO:0031595)
0.2 0.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 1.7 GO:0070083 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.2 2.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.2 0.5 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.8 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.7 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.6 GO:0030061 mitochondrial crista(GO:0030061)
0.1 10.9 GO:0016605 PML body(GO:0016605)
0.1 2.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 2.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.7 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 5.6 GO:0005643 nuclear pore(GO:0005643)
0.0 4.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 6.5 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 1.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.1 GO:0005921 gap junction(GO:0005921)
0.0 5.6 GO:0072562 blood microparticle(GO:0072562)
0.0 29.8 GO:0005615 extracellular space(GO:0005615)
0.0 3.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 26.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 4.3 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.3 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.3 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.6 GO:0004998 transferrin receptor activity(GO:0004998)
0.8 6.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.6 7.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.6 1.7 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.6 6.7 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.5 14.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.5 5.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.5 5.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.5 1.8 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.4 3.9 GO:0035174 histone serine kinase activity(GO:0035174)
0.4 1.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.4 10.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.3 7.5 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 1.6 GO:0031708 endothelin B receptor binding(GO:0031708)
0.3 13.6 GO:0050699 WW domain binding(GO:0050699)
0.2 2.6 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.2 0.8 GO:0015265 urea channel activity(GO:0015265)
0.2 3.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 0.8 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.2 14.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 1.6 GO:0031433 telethonin binding(GO:0031433)
0.2 1.7 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 4.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.8 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 2.7 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 1.8 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.1 1.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 1.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.4 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.1 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 4.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 8.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 5.4 GO:0070888 E-box binding(GO:0070888)
0.1 0.3 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.4 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.5 GO:0034711 inhibin binding(GO:0034711)
0.1 0.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 2.9 GO:0019843 rRNA binding(GO:0019843)
0.0 0.3 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 1.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 9.7 GO:0051015 actin filament binding(GO:0051015)
0.0 6.1 GO:0005178 integrin binding(GO:0005178)
0.0 9.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 2.1 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 10.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 4.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 19.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 5.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.1 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.0 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.4 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 1.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 21.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 5.1 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.2 3.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 7.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 3.9 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 5.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 6.0 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 15.0 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 20.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.5 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 6.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.0 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.5 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.0 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis