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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GAUUGUC
Z-value: 0.39
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miRNA associated with seed GAUUGUC
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_113033164 Show fit | 6.59 |
ENST00000409871.1
ENST00000343936.4 |
zinc finger CCCH-type containing 6 |
|
| chr1_-_31230650 Show fit | 5.98 |
ENST00000294507.3
|
lysosomal protein transmembrane 5 |
|
| chr4_-_109089573 Show fit | 4.98 |
ENST00000265165.1
|
lymphoid enhancer-binding factor 1 |
|
| chr3_-_18466787 Show fit | 4.91 |
ENST00000338745.6
ENST00000450898.1 |
SATB homeobox 1 |
|
| chr16_-_89007491 Show fit | 4.81 |
ENST00000327483.5
ENST00000564416.1 |
core-binding factor, runt domain, alpha subunit 2; translocated to, 3 |
|
| chr3_-_53080047 Show fit | 4.17 |
ENST00000482396.1
ENST00000358080.2 ENST00000296295.6 ENST00000394752.3 |
Scm-like with four mbt domains 1 |
|
| chr17_-_29151794 Show fit | 4.14 |
ENST00000324238.6
|
cytokine receptor-like factor 3 |
|
| chr12_+_94542459 Show fit | 3.96 |
ENST00000258526.4
|
plexin C1 |
|
| chr15_+_74833518 Show fit | 3.93 |
ENST00000346246.5
|
AT rich interactive domain 3B (BRIGHT-like) |
|
| chr17_-_40021656 Show fit | 3.91 |
ENST00000319121.3
|
kelch-like family member 11 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GAUUGUC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 5.1 | GO:0030099 | myeloid cell differentiation(GO:0030099) |
| 1.0 | 5.0 | GO:0071895 | odontoblast differentiation(GO:0071895) |
| 0.3 | 4.9 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.6 | 4.8 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.1 | 4.2 | GO:0048635 | negative regulation of muscle organ development(GO:0048635) |
| 0.0 | 4.1 | GO:0046427 | positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894) |
| 0.1 | 4.0 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.0 | 3.9 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.5 | 3.7 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.0 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 4.9 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.1 | 4.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 4.6 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 4.2 | GO:0031461 | cullin-RING ubiquitin ligase complex(GO:0031461) |
| 0.0 | 4.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 3.9 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 3.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 3.6 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.1 | 3.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 6.9 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 6.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.3 | 5.4 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.1 | 4.9 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.2 | 4.0 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 3.9 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.5 | 3.7 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.0 | 3.7 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 3.5 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 5.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 4.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 3.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 3.1 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 3.1 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.1 | 2.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 2.0 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 5.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.2 | 4.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.2 | 3.5 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 3.0 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.7 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 2.5 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 2.5 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 2.2 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 2.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |