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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GCM1
Z-value: 0.55
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Transcription factors associated with GCM1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GCM1 | hg19_v2_chr6_-_53013620_53013644 | 0.10 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_90108504 Show fit | 32.22 |
ENST00000390271.2
|
immunoglobulin kappa variable 6D-41 (non-functional) |
|
| chr2_-_89459813 Show fit | 27.17 |
ENST00000390256.2
|
immunoglobulin kappa variable 6-21 (non-functional) |
|
| chr2_+_90060377 Show fit | 26.35 |
ENST00000436451.2
|
immunoglobulin kappa variable 6D-21 (non-functional) |
|
| chr3_+_10206545 Show fit | 26.14 |
ENST00000256458.4
|
interleukin-1 receptor-associated kinase 2 |
|
| chr22_+_23165153 Show fit | 24.57 |
ENST00000390317.2
|
immunoglobulin lambda variable 2-8 |
|
| chr22_+_22930626 Show fit | 24.03 |
ENST00000390302.2
|
immunoglobulin lambda variable 2-33 (non-functional) |
|
| chr22_+_23077065 Show fit | 23.10 |
ENST00000390310.2
|
immunoglobulin lambda variable 2-18 |
|
| chr22_+_22786288 Show fit | 22.10 |
ENST00000390301.2
|
immunoglobulin lambda variable 1-36 |
|
| chr2_-_89385283 Show fit | 21.00 |
ENST00000390252.2
|
immunoglobulin kappa variable 3-15 |
|
| chr22_+_23040274 Show fit | 19.93 |
ENST00000390306.2
|
immunoglobulin lambda variable 2-23 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GCM1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 174.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.9 | 124.8 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 1.2 | 26.1 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 6.4 | 19.2 | GO:0033212 | iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308) |
| 2.5 | 17.5 | GO:0039663 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.5 | 16.6 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.0 | 15.7 | GO:0002250 | adaptive immune response(GO:0002250) |
| 2.2 | 13.5 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.7 | 9.8 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.0 | 9.0 | GO:0071897 | DNA biosynthetic process(GO:0071897) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 192.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 39.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 21.9 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 19.4 | GO:0005770 | late endosome(GO:0005770) |
| 2.7 | 19.2 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
| 0.8 | 16.6 | GO:0044453 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.2 | 13.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 2.4 | 12.1 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.0 | 11.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 9.9 | GO:1990391 | DNA repair complex(GO:1990391) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 242.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 28.0 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.7 | 22.2 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 1.6 | 17.5 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 1.5 | 16.6 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 16.5 | GO:0005125 | cytokine activity(GO:0005125) |
| 1.7 | 13.5 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.6 | 12.2 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.4 | 12.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.6 | 11.7 | GO:0019992 | diacylglycerol binding(GO:0019992) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 26.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.5 | 21.6 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.2 | 11.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 8.9 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 7.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 6.8 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 6.4 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 5.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 5.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.2 | 4.9 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 26.1 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.4 | 19.2 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 3.5 | 17.5 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.2 | 13.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 11.1 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.3 | 8.9 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.2 | 7.1 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.4 | 6.8 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 6.4 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.2 | 5.5 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |