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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GCM2
Z-value: 0.31
Motif logo
Transcription factors associated with GCM2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
GCM2
|
ENSG00000124827.6 | glial cells missing transcription factor 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GCM2 | hg19_v2_chr6_-_10882174_10882274 | 0.14 | 3.9e-02 | Click! |
Activity profile of GCM2 motif
Sorted Z-values of GCM2 motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_47105309 | 13.11 |
ENST00000599839.1
ENST00000596362.1 |
CALM3
|
calmodulin 3 (phosphorylase kinase, delta) |
| chrX_-_71526813 | 10.87 |
ENST00000246139.5
|
CITED1
|
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 |
| chr1_+_43824577 | 9.23 |
ENST00000310955.6
|
CDC20
|
cell division cycle 20 |
| chr1_+_43824669 | 9.19 |
ENST00000372462.1
|
CDC20
|
cell division cycle 20 |
| chr9_-_130635741 | 8.33 |
ENST00000223836.10
|
AK1
|
adenylate kinase 1 |
| chr14_-_60097524 | 8.16 |
ENST00000342503.4
|
RTN1
|
reticulon 1 |
| chrX_-_71526999 | 7.65 |
ENST00000453707.2
ENST00000373619.3 |
CITED1
|
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 |
| chr1_-_55352834 | 7.51 |
ENST00000371269.3
|
DHCR24
|
24-dehydrocholesterol reductase |
| chr14_-_60097297 | 7.44 |
ENST00000395090.1
|
RTN1
|
reticulon 1 |
| chr6_-_52859968 | 7.19 |
ENST00000370959.1
|
GSTA4
|
glutathione S-transferase alpha 4 |
| chr7_-_44365020 | 6.86 |
ENST00000395747.2
ENST00000347193.4 ENST00000346990.4 ENST00000258682.6 ENST00000353625.4 ENST00000421607.1 ENST00000424197.1 ENST00000502837.2 ENST00000350811.3 ENST00000395749.2 |
CAMK2B
|
calcium/calmodulin-dependent protein kinase II beta |
| chr22_-_20307532 | 6.83 |
ENST00000405465.3
ENST00000248879.3 |
DGCR6L
|
DiGeorge syndrome critical region gene 6-like |
| chr6_-_110500905 | 6.71 |
ENST00000392587.2
|
WASF1
|
WAS protein family, member 1 |
| chr2_+_73114489 | 6.45 |
ENST00000234454.5
|
SPR
|
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) |
| chr18_+_3449695 | 5.66 |
ENST00000343820.5
|
TGIF1
|
TGFB-induced factor homeobox 1 |
| chr6_+_31633902 | 5.58 |
ENST00000375865.2
ENST00000375866.2 |
CSNK2B
|
casein kinase 2, beta polypeptide |
| chr7_+_12727250 | 5.04 |
ENST00000404894.1
|
ARL4A
|
ADP-ribosylation factor-like 4A |
| chr6_+_31633833 | 4.97 |
ENST00000375882.2
ENST00000375880.2 |
CSNK2B
CSNK2B-LY6G5B-1181
|
casein kinase 2, beta polypeptide Uncharacterized protein |
| chr8_+_20054878 | 4.92 |
ENST00000276390.2
ENST00000519667.1 |
ATP6V1B2
|
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 |
| chr16_+_2564254 | 4.92 |
ENST00000565223.1
|
ATP6V0C
|
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c |
| chr7_+_6048856 | 4.81 |
ENST00000223029.3
ENST00000400479.2 ENST00000395236.2 |
AIMP2
|
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 |
| chr9_-_99417562 | 4.79 |
ENST00000375234.3
ENST00000446045.1 |
AAED1
|
AhpC/TSA antioxidant enzyme domain containing 1 |
| chr11_+_63448918 | 4.78 |
ENST00000341307.2
ENST00000356000.3 ENST00000542238.1 |
RTN3
|
reticulon 3 |
| chr17_-_10017864 | 4.75 |
ENST00000323816.4
|
GAS7
|
growth arrest-specific 7 |
| chr11_+_63448955 | 4.71 |
ENST00000377819.5
ENST00000339997.4 ENST00000540798.1 ENST00000545432.1 ENST00000543552.1 ENST00000537981.1 |
RTN3
|
reticulon 3 |
| chr15_-_41624685 | 4.40 |
ENST00000560640.1
ENST00000220514.3 |
OIP5
|
Opa interacting protein 5 |
| chr20_+_1115821 | 4.25 |
ENST00000435720.1
|
PSMF1
|
proteasome (prosome, macropain) inhibitor subunit 1 (PI31) |
| chr1_-_204116078 | 4.21 |
ENST00000367198.2
ENST00000452983.1 |
ETNK2
|
ethanolamine kinase 2 |
| chr15_-_75248954 | 4.11 |
ENST00000499788.2
|
RPP25
|
ribonuclease P/MRP 25kDa subunit |
| chr17_-_7197881 | 4.10 |
ENST00000007699.5
|
YBX2
|
Y box binding protein 2 |
| chr3_+_50712672 | 4.01 |
ENST00000266037.9
|
DOCK3
|
dedicator of cytokinesis 3 |
| chr19_+_19626531 | 3.98 |
ENST00000507754.4
|
NDUFA13
|
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 |
| chr9_+_131873659 | 3.93 |
ENST00000452489.2
ENST00000347048.4 ENST00000357197.4 ENST00000445241.1 ENST00000355007.3 ENST00000414331.1 |
PPP2R4
|
protein phosphatase 2A activator, regulatory subunit 4 |
| chr12_-_49582593 | 3.92 |
ENST00000295766.5
|
TUBA1A
|
tubulin, alpha 1a |
| chr18_+_3449821 | 3.86 |
ENST00000407501.2
ENST00000405385.3 ENST00000546979.1 |
TGIF1
|
TGFB-induced factor homeobox 1 |
| chr7_-_150754935 | 3.84 |
ENST00000297518.4
|
CDK5
|
cyclin-dependent kinase 5 |
| chr10_-_21786179 | 3.79 |
ENST00000377113.5
|
CASC10
|
cancer susceptibility candidate 10 |
| chr14_+_75536335 | 3.78 |
ENST00000554763.1
ENST00000439583.2 ENST00000526130.1 ENST00000525046.1 |
ZC2HC1C
|
zinc finger, C2HC-type containing 1C |
| chr19_+_35783047 | 3.68 |
ENST00000595791.1
ENST00000597035.1 ENST00000537831.2 |
MAG
|
myelin associated glycoprotein |
| chr2_-_33824336 | 3.67 |
ENST00000431950.1
ENST00000403368.1 ENST00000441530.2 |
FAM98A
|
family with sequence similarity 98, member A |
| chr14_+_75536280 | 3.65 |
ENST00000238686.8
|
ZC2HC1C
|
zinc finger, C2HC-type containing 1C |
| chr16_+_71392616 | 3.63 |
ENST00000349553.5
ENST00000302628.4 ENST00000562305.1 |
CALB2
|
calbindin 2 |
| chr19_+_35783028 | 3.59 |
ENST00000600291.1
ENST00000392213.3 |
MAG
|
myelin associated glycoprotein |
| chr1_-_167906277 | 3.54 |
ENST00000271373.4
|
MPC2
|
mitochondrial pyruvate carrier 2 |
| chr2_-_33824382 | 3.52 |
ENST00000238823.8
|
FAM98A
|
family with sequence similarity 98, member A |
| chr19_+_6361754 | 3.44 |
ENST00000597326.1
|
CLPP
|
caseinolytic mitochondrial matrix peptidase proteolytic subunit |
| chrX_-_77225135 | 3.42 |
ENST00000458128.1
|
PGAM4
|
phosphoglycerate mutase family member 4 |
| chr7_+_116139744 | 3.41 |
ENST00000343213.2
|
CAV2
|
caveolin 2 |
| chr19_+_35783037 | 3.34 |
ENST00000361922.4
|
MAG
|
myelin associated glycoprotein |
| chr5_+_82767284 | 3.31 |
ENST00000265077.3
|
VCAN
|
versican |
| chr13_-_45010939 | 3.29 |
ENST00000261489.2
|
TSC22D1
|
TSC22 domain family, member 1 |
| chr3_+_35681081 | 3.29 |
ENST00000428373.1
|
ARPP21
|
cAMP-regulated phosphoprotein, 21kDa |
| chr11_+_86511569 | 3.22 |
ENST00000441050.1
|
PRSS23
|
protease, serine, 23 |
| chr11_+_73882144 | 3.21 |
ENST00000328257.8
|
PPME1
|
protein phosphatase methylesterase 1 |
| chr2_-_220252603 | 3.17 |
ENST00000322176.7
ENST00000273075.4 |
DNPEP
|
aspartyl aminopeptidase |
| chr8_-_98290087 | 3.14 |
ENST00000322128.3
|
TSPYL5
|
TSPY-like 5 |
| chr15_-_45670924 | 3.10 |
ENST00000396659.3
|
GATM
|
glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
| chr7_+_148395959 | 3.06 |
ENST00000325222.4
|
CUL1
|
cullin 1 |
| chrX_+_128674213 | 3.03 |
ENST00000371113.4
ENST00000357121.5 |
OCRL
|
oculocerebrorenal syndrome of Lowe |
| chr2_-_179315786 | 2.96 |
ENST00000457633.1
ENST00000438687.3 ENST00000325748.4 |
PRKRA
|
protein kinase, interferon-inducible double stranded RNA dependent activator |
| chr2_-_44588624 | 2.93 |
ENST00000438314.1
ENST00000409936.1 |
PREPL
|
prolyl endopeptidase-like |
| chr2_-_44588694 | 2.93 |
ENST00000409957.1
|
PREPL
|
prolyl endopeptidase-like |
| chr3_-_79068594 | 2.91 |
ENST00000436010.2
|
ROBO1
|
roundabout, axon guidance receptor, homolog 1 (Drosophila) |
| chr3_+_126707437 | 2.90 |
ENST00000393409.2
ENST00000251772.4 |
PLXNA1
|
plexin A1 |
| chr2_-_44588679 | 2.87 |
ENST00000409411.1
|
PREPL
|
prolyl endopeptidase-like |
| chr7_+_148395733 | 2.83 |
ENST00000602748.1
|
CUL1
|
cullin 1 |
| chr5_+_140743859 | 2.69 |
ENST00000518069.1
|
PCDHGA5
|
protocadherin gamma subfamily A, 5 |
| chr1_+_15272271 | 2.68 |
ENST00000400797.3
|
KAZN
|
kazrin, periplakin interacting protein |
| chr11_-_6341724 | 2.66 |
ENST00000530979.1
|
PRKCDBP
|
protein kinase C, delta binding protein |
| chr3_+_130650738 | 2.66 |
ENST00000504612.1
|
ATP2C1
|
ATPase, Ca++ transporting, type 2C, member 1 |
| chr3_+_156008809 | 2.62 |
ENST00000302490.8
|
KCNAB1
|
potassium voltage-gated channel, shaker-related subfamily, beta member 1 |
| chr1_+_156105878 | 2.60 |
ENST00000508500.1
|
LMNA
|
lamin A/C |
| chr16_+_25123041 | 2.50 |
ENST00000399069.3
ENST00000380966.4 |
LCMT1
|
leucine carboxyl methyltransferase 1 |
| chr5_+_140345820 | 2.43 |
ENST00000289269.5
|
PCDHAC2
|
protocadherin alpha subfamily C, 2 |
| chr17_-_41132010 | 2.39 |
ENST00000409103.1
ENST00000360221.4 |
PTGES3L-AARSD1
|
PTGES3L-AARSD1 readthrough |
| chr2_-_179315490 | 2.39 |
ENST00000487082.1
|
PRKRA
|
protein kinase, interferon-inducible double stranded RNA dependent activator |
| chr1_+_44444865 | 2.36 |
ENST00000372324.1
|
B4GALT2
|
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 |
| chr2_-_220436248 | 2.36 |
ENST00000265318.4
|
OBSL1
|
obscurin-like 1 |
| chr2_-_220408430 | 2.27 |
ENST00000243776.6
|
CHPF
|
chondroitin polymerizing factor |
| chr5_-_137878887 | 2.26 |
ENST00000507939.1
ENST00000572514.1 ENST00000499810.2 ENST00000360541.5 |
ETF1
|
eukaryotic translation termination factor 1 |
| chr11_-_64410787 | 2.25 |
ENST00000301894.2
|
NRXN2
|
neurexin 2 |
| chr7_-_100808394 | 2.14 |
ENST00000445482.2
|
VGF
|
VGF nerve growth factor inducible |
| chr15_+_89010923 | 2.08 |
ENST00000353598.6
|
MRPS11
|
mitochondrial ribosomal protein S11 |
| chr8_+_66556936 | 2.08 |
ENST00000262146.4
|
MTFR1
|
mitochondrial fission regulator 1 |
| chr10_+_102790980 | 2.06 |
ENST00000393459.1
ENST00000224807.5 |
SFXN3
|
sideroflexin 3 |
| chr12_+_56618102 | 2.00 |
ENST00000267023.4
ENST00000380198.2 ENST00000341463.5 |
NABP2
|
nucleic acid binding protein 2 |
| chr9_-_13279589 | 1.99 |
ENST00000319217.7
|
MPDZ
|
multiple PDZ domain protein |
| chr15_-_89010607 | 1.99 |
ENST00000312475.4
|
MRPL46
|
mitochondrial ribosomal protein L46 |
| chr7_-_44365216 | 1.99 |
ENST00000358707.3
ENST00000457475.1 ENST00000440254.2 |
CAMK2B
|
calcium/calmodulin-dependent protein kinase II beta |
| chr19_+_6361795 | 1.95 |
ENST00000596149.1
|
CLPP
|
caseinolytic mitochondrial matrix peptidase proteolytic subunit |
| chrX_-_63005405 | 1.90 |
ENST00000374878.1
ENST00000437457.2 |
ARHGEF9
|
Cdc42 guanine nucleotide exchange factor (GEF) 9 |
| chr15_+_43809797 | 1.82 |
ENST00000399453.1
ENST00000300231.5 |
MAP1A
|
microtubule-associated protein 1A |
| chr19_+_6361440 | 1.78 |
ENST00000245816.4
|
CLPP
|
caseinolytic mitochondrial matrix peptidase proteolytic subunit |
| chr16_+_30759563 | 1.75 |
ENST00000563588.1
ENST00000565924.1 ENST00000424889.3 |
PHKG2
|
phosphorylase kinase, gamma 2 (testis) |
| chr15_+_40733387 | 1.73 |
ENST00000416165.1
|
BAHD1
|
bromo adjacent homology domain containing 1 |
| chr1_+_155179012 | 1.72 |
ENST00000609421.1
|
MTX1
|
metaxin 1 |
| chr15_+_78632666 | 1.72 |
ENST00000299529.6
|
CRABP1
|
cellular retinoic acid binding protein 1 |
| chr2_-_220435963 | 1.72 |
ENST00000373876.1
ENST00000404537.1 ENST00000603926.1 ENST00000373873.4 ENST00000289656.3 |
OBSL1
|
obscurin-like 1 |
| chr17_-_76899275 | 1.64 |
ENST00000322630.2
ENST00000586713.1 |
DDC8
|
Protein DDC8 homolog |
| chr5_+_157170703 | 1.61 |
ENST00000286307.5
|
LSM11
|
LSM11, U7 small nuclear RNA associated |
| chr5_+_134240588 | 1.59 |
ENST00000254908.6
|
PCBD2
|
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 |
| chr9_-_13279563 | 1.58 |
ENST00000541718.1
|
MPDZ
|
multiple PDZ domain protein |
| chr15_-_64665911 | 1.57 |
ENST00000606793.1
ENST00000561349.1 ENST00000560278.1 |
CTD-2116N17.1
|
Uncharacterized protein |
| chr19_+_6361841 | 1.48 |
ENST00000596605.1
|
CLPP
|
caseinolytic mitochondrial matrix peptidase proteolytic subunit |
| chr3_-_119813264 | 1.46 |
ENST00000264235.8
|
GSK3B
|
glycogen synthase kinase 3 beta |
| chr20_-_30795511 | 1.46 |
ENST00000246229.4
|
PLAGL2
|
pleiomorphic adenoma gene-like 2 |
| chr5_+_82767487 | 1.42 |
ENST00000343200.5
ENST00000342785.4 |
VCAN
|
versican |
| chr19_+_5823813 | 1.42 |
ENST00000303212.2
|
NRTN
|
neurturin |
| chr16_+_30759700 | 1.42 |
ENST00000328273.7
|
PHKG2
|
phosphorylase kinase, gamma 2 (testis) |
| chr2_+_234627424 | 1.41 |
ENST00000373409.3
|
UGT1A4
|
UDP glucuronosyltransferase 1 family, polypeptide A4 |
| chr5_+_82767583 | 1.34 |
ENST00000512590.2
ENST00000513960.1 ENST00000513984.1 ENST00000502527.2 |
VCAN
|
versican |
| chr15_+_40731920 | 1.33 |
ENST00000561234.1
|
BAHD1
|
bromo adjacent homology domain containing 1 |
| chr12_+_56360550 | 1.33 |
ENST00000266970.4
|
CDK2
|
cyclin-dependent kinase 2 |
| chr1_+_180601139 | 1.33 |
ENST00000367590.4
ENST00000367589.3 |
XPR1
|
xenotropic and polytropic retrovirus receptor 1 |
| chr15_+_41624892 | 1.32 |
ENST00000260359.6
ENST00000450318.1 ENST00000450592.2 ENST00000559596.1 ENST00000414849.2 ENST00000560747.1 ENST00000560177.1 |
NUSAP1
|
nucleolar and spindle associated protein 1 |
| chr3_-_11762202 | 1.23 |
ENST00000445411.1
ENST00000404339.1 ENST00000273038.3 |
VGLL4
|
vestigial like 4 (Drosophila) |
| chr10_-_102790852 | 1.22 |
ENST00000470414.1
ENST00000370215.3 |
PDZD7
|
PDZ domain containing 7 |
| chr17_+_53342311 | 1.20 |
ENST00000226067.5
|
HLF
|
hepatic leukemia factor |
| chr5_+_137774706 | 1.18 |
ENST00000378339.2
ENST00000254901.5 ENST00000506158.1 |
REEP2
|
receptor accessory protein 2 |
| chr12_+_56360605 | 1.18 |
ENST00000553376.1
ENST00000440311.2 ENST00000354056.4 |
CDK2
|
cyclin-dependent kinase 2 |
| chr9_-_127263265 | 1.17 |
ENST00000373587.3
|
NR5A1
|
nuclear receptor subfamily 5, group A, member 1 |
| chr17_+_7358889 | 1.16 |
ENST00000575379.1
|
CHRNB1
|
cholinergic receptor, nicotinic, beta 1 (muscle) |
| chr14_-_75536182 | 1.15 |
ENST00000555463.1
|
ACYP1
|
acylphosphatase 1, erythrocyte (common) type |
| chr18_-_29264669 | 1.12 |
ENST00000306851.5
|
B4GALT6
|
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 |
| chr11_+_92085707 | 1.12 |
ENST00000525166.1
|
FAT3
|
FAT atypical cadherin 3 |
| chr8_+_117950422 | 1.11 |
ENST00000378279.3
|
AARD
|
alanine and arginine rich domain containing protein |
| chr19_-_18653781 | 1.10 |
ENST00000596558.2
ENST00000453489.2 |
FKBP8
|
FK506 binding protein 8, 38kDa |
| chr11_+_92085262 | 1.08 |
ENST00000298047.6
ENST00000409404.2 ENST00000541502.1 |
FAT3
|
FAT atypical cadherin 3 |
| chr5_+_113697983 | 1.01 |
ENST00000264773.3
|
KCNN2
|
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 |
| chr4_-_74864386 | 1.00 |
ENST00000296027.4
|
CXCL5
|
chemokine (C-X-C motif) ligand 5 |
| chr2_-_179315453 | 1.00 |
ENST00000432031.2
|
PRKRA
|
protein kinase, interferon-inducible double stranded RNA dependent activator |
| chr7_-_6048650 | 0.99 |
ENST00000382321.4
ENST00000406569.3 |
PMS2
|
PMS2 postmeiotic segregation increased 2 (S. cerevisiae) |
| chr13_-_47471155 | 0.93 |
ENST00000543956.1
ENST00000542664.1 |
HTR2A
|
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled |
| chr19_-_14316980 | 0.92 |
ENST00000361434.3
ENST00000340736.6 |
LPHN1
|
latrophilin 1 |
| chrX_+_120181457 | 0.92 |
ENST00000328078.1
|
GLUD2
|
glutamate dehydrogenase 2 |
| chr16_+_69221028 | 0.92 |
ENST00000336278.4
|
SNTB2
|
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) |
| chr7_-_27169801 | 0.92 |
ENST00000511914.1
|
HOXA4
|
homeobox A4 |
| chr17_-_46703826 | 0.91 |
ENST00000550387.1
ENST00000311177.5 |
HOXB9
|
homeobox B9 |
| chrX_+_99839799 | 0.88 |
ENST00000373031.4
|
TNMD
|
tenomodulin |
| chr22_+_19710468 | 0.88 |
ENST00000366425.3
|
GP1BB
|
glycoprotein Ib (platelet), beta polypeptide |
| chr9_+_4490394 | 0.87 |
ENST00000262352.3
|
SLC1A1
|
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| chr16_+_28996364 | 0.87 |
ENST00000564277.1
|
LAT
|
linker for activation of T cells |
| chr19_+_2236509 | 0.86 |
ENST00000221494.5
|
SF3A2
|
splicing factor 3a, subunit 2, 66kDa |
| chr7_-_100808843 | 0.83 |
ENST00000249330.2
|
VGF
|
VGF nerve growth factor inducible |
| chr18_+_55102917 | 0.82 |
ENST00000491143.2
|
ONECUT2
|
one cut homeobox 2 |
| chr2_+_16080659 | 0.82 |
ENST00000281043.3
|
MYCN
|
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog |
| chr7_-_6048702 | 0.79 |
ENST00000265849.7
|
PMS2
|
PMS2 postmeiotic segregation increased 2 (S. cerevisiae) |
| chrX_-_119763835 | 0.78 |
ENST00000371313.2
ENST00000304661.5 |
C1GALT1C1
|
C1GALT1-specific chaperone 1 |
| chr1_-_21503337 | 0.75 |
ENST00000400422.1
ENST00000602326.1 ENST00000411888.1 ENST00000438975.1 |
EIF4G3
|
eukaryotic translation initiation factor 4 gamma, 3 |
| chr12_-_322504 | 0.74 |
ENST00000424061.2
|
SLC6A12
|
solute carrier family 6 (neurotransmitter transporter), member 12 |
| chr17_-_42908155 | 0.71 |
ENST00000426548.1
ENST00000590758.1 ENST00000591424.1 |
GJC1
|
gap junction protein, gamma 1, 45kDa |
| chr22_-_29457832 | 0.70 |
ENST00000216071.4
|
C22orf31
|
chromosome 22 open reading frame 31 |
| chr6_+_37787458 | 0.66 |
ENST00000373391.2
|
ZFAND3
|
zinc finger, AN1-type domain 3 |
| chr22_+_31489344 | 0.65 |
ENST00000404574.1
|
SMTN
|
smoothelin |
| chr14_-_105635090 | 0.65 |
ENST00000331782.3
ENST00000347004.2 |
JAG2
|
jagged 2 |
| chr12_+_56390964 | 0.65 |
ENST00000356124.4
ENST00000266971.3 ENST00000394115.2 ENST00000547586.1 ENST00000552258.1 ENST00000548274.1 ENST00000546833.1 |
SUOX
|
sulfite oxidase |
| chr14_-_59932044 | 0.64 |
ENST00000395116.1
|
GPR135
|
G protein-coupled receptor 135 |
| chr12_-_56122124 | 0.64 |
ENST00000552754.1
|
CD63
|
CD63 molecule |
| chr6_+_46761118 | 0.63 |
ENST00000230588.4
|
MEP1A
|
meprin A, alpha (PABA peptide hydrolase) |
| chr19_-_2236290 | 0.63 |
ENST00000591099.2
ENST00000586608.2 ENST00000326631.2 ENST00000587962.2 |
PLEKHJ1
|
pleckstrin homology domain containing, family J member 1 |
| chr12_+_5541267 | 0.60 |
ENST00000423158.3
|
NTF3
|
neurotrophin 3 |
| chr6_-_13621126 | 0.59 |
ENST00000600057.1
|
AL441883.1
|
Uncharacterized protein |
| chr1_+_156698708 | 0.57 |
ENST00000519086.1
|
RRNAD1
|
ribosomal RNA adenine dimethylase domain containing 1 |
| chr14_+_21359558 | 0.56 |
ENST00000304639.3
|
RNASE3
|
ribonuclease, RNase A family, 3 |
| chr17_-_7218631 | 0.56 |
ENST00000577040.2
ENST00000389167.5 ENST00000391950.3 |
GPS2
|
G protein pathway suppressor 2 |
| chr5_+_176560007 | 0.55 |
ENST00000510954.1
ENST00000354179.4 |
NSD1
|
nuclear receptor binding SET domain protein 1 |
| chrX_+_12156582 | 0.52 |
ENST00000380682.1
|
FRMPD4
|
FERM and PDZ domain containing 4 |
| chr6_-_138539627 | 0.51 |
ENST00000527246.2
|
PBOV1
|
prostate and breast cancer overexpressed 1 |
| chr17_+_79989500 | 0.50 |
ENST00000306897.4
|
RAC3
|
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
| chr19_+_42829702 | 0.50 |
ENST00000334370.4
|
MEGF8
|
multiple EGF-like-domains 8 |
| chr1_+_46640750 | 0.49 |
ENST00000372003.1
|
TSPAN1
|
tetraspanin 1 |
| chr15_-_34331243 | 0.48 |
ENST00000306730.3
|
AVEN
|
apoptosis, caspase activation inhibitor |
| chr17_-_7123021 | 0.47 |
ENST00000399510.2
|
DLG4
|
discs, large homolog 4 (Drosophila) |
| chr11_+_76778033 | 0.46 |
ENST00000456580.2
|
CAPN5
|
calpain 5 |
| chr13_-_44735393 | 0.45 |
ENST00000400419.1
|
SMIM2
|
small integral membrane protein 2 |
| chr6_+_7108210 | 0.45 |
ENST00000467782.1
ENST00000334984.6 ENST00000349384.6 |
RREB1
|
ras responsive element binding protein 1 |
| chr1_-_223537475 | 0.39 |
ENST00000344029.6
ENST00000494793.2 ENST00000366878.4 ENST00000366877.3 |
SUSD4
|
sushi domain containing 4 |
| chr19_+_36132631 | 0.39 |
ENST00000379026.2
ENST00000379023.4 ENST00000402764.2 ENST00000479824.1 |
ETV2
|
ets variant 2 |
| chrX_-_41782592 | 0.38 |
ENST00000378158.1
|
CASK
|
calcium/calmodulin-dependent serine protein kinase (MAGUK family) |
| chr12_+_5019061 | 0.36 |
ENST00000382545.3
|
KCNA1
|
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) |
| chr1_+_17944832 | 0.35 |
ENST00000167825.4
|
ARHGEF10L
|
Rho guanine nucleotide exchange factor (GEF) 10-like |
| chr1_+_17944806 | 0.35 |
ENST00000375408.3
|
ARHGEF10L
|
Rho guanine nucleotide exchange factor (GEF) 10-like |
| chr3_-_138553779 | 0.34 |
ENST00000461451.1
|
PIK3CB
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
| chr9_+_15422702 | 0.34 |
ENST00000380821.3
ENST00000421710.1 |
SNAPC3
|
small nuclear RNA activating complex, polypeptide 3, 50kDa |
| chr10_-_70092635 | 0.34 |
ENST00000309049.4
|
PBLD
|
phenazine biosynthesis-like protein domain containing |
| chr11_+_4116054 | 0.34 |
ENST00000423050.2
|
RRM1
|
ribonucleotide reductase M1 |
| chr5_+_122847781 | 0.34 |
ENST00000395412.1
ENST00000395411.1 ENST00000345990.4 |
CSNK1G3
|
casein kinase 1, gamma 3 |
| chr16_+_22825475 | 0.33 |
ENST00000261374.3
|
HS3ST2
|
heparan sulfate (glucosamine) 3-O-sulfotransferase 2 |
| chr19_-_51531210 | 0.30 |
ENST00000391804.3
|
KLK11
|
kallikrein-related peptidase 11 |
| chr11_+_64001962 | 0.29 |
ENST00000309422.2
|
VEGFB
|
vascular endothelial growth factor B |
| chr19_+_41222998 | 0.27 |
ENST00000263370.2
|
ITPKC
|
inositol-trisphosphate 3-kinase C |
| chr12_+_81110684 | 0.27 |
ENST00000228644.3
|
MYF5
|
myogenic factor 5 |
| chrX_+_46937745 | 0.24 |
ENST00000397180.1
ENST00000457380.1 ENST00000352078.4 |
RGN
|
regucalcin |
| chr7_-_8301768 | 0.24 |
ENST00000265577.7
|
ICA1
|
islet cell autoantigen 1, 69kDa |
| chr8_-_144897138 | 0.23 |
ENST00000377533.3
|
SCRIB
|
scribbled planar cell polarity protein |
| chr1_+_156698234 | 0.22 |
ENST00000368218.4
ENST00000368216.4 |
RRNAD1
|
ribosomal RNA adenine dimethylase domain containing 1 |
| chr11_+_64002292 | 0.22 |
ENST00000426086.2
|
VEGFB
|
vascular endothelial growth factor B |
| chr15_-_88799384 | 0.22 |
ENST00000540489.2
ENST00000557856.1 ENST00000558676.1 |
NTRK3
|
neurotrophic tyrosine kinase, receptor, type 3 |
| chr1_-_205313304 | 0.21 |
ENST00000539253.1
ENST00000607826.1 |
KLHDC8A
|
kelch domain containing 8A |
| chr1_-_223537401 | 0.21 |
ENST00000343846.3
ENST00000454695.2 ENST00000484758.2 |
SUSD4
|
sushi domain containing 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GCM2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 18.5 | GO:0071105 | response to interleukin-11(GO:0071105) |
| 1.7 | 5.1 | GO:1903630 | regulation of aminoacyl-tRNA ligase activity(GO:1903630) |
| 1.6 | 27.3 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 1.5 | 7.5 | GO:0033489 | cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490) |
| 1.3 | 10.6 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 1.1 | 2.2 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 1.1 | 1.1 | GO:0060541 | lung development(GO:0030324) respiratory system development(GO:0060541) |
| 1.1 | 9.5 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 1.0 | 4.1 | GO:0009386 | translational attenuation(GO:0009386) |
| 1.0 | 2.9 | GO:0021823 | cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
| 0.9 | 8.0 | GO:0046146 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.9 | 3.5 | GO:1902361 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
| 0.9 | 3.4 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.8 | 6.7 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.8 | 10.6 | GO:0048711 | positive regulation of astrocyte differentiation(GO:0048711) |
| 0.6 | 3.8 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.6 | 5.9 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 0.6 | 1.7 | GO:0034653 | diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653) |
| 0.6 | 3.4 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.5 | 4.9 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 0.5 | 3.2 | GO:0045819 | positive regulation of glycogen catabolic process(GO:0045819) |
| 0.5 | 2.6 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.5 | 6.4 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.5 | 1.5 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 0.4 | 2.7 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.4 | 4.0 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.4 | 2.5 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
| 0.4 | 1.2 | GO:0050916 | sensory perception of sweet taste(GO:0050916) |
| 0.3 | 1.6 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.3 | 4.1 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.3 | 2.9 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 0.3 | 3.1 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.2 | 6.1 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.2 | 1.4 | GO:0006789 | bilirubin conjugation(GO:0006789) |
| 0.2 | 4.1 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.2 | 0.9 | GO:0035992 | tendon cell differentiation(GO:0035990) tendon formation(GO:0035992) |
| 0.2 | 0.9 | GO:0007538 | primary sex determination(GO:0007538) |
| 0.2 | 7.2 | GO:1901685 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.2 | 3.1 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.2 | 8.7 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.2 | 4.2 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.2 | 1.3 | GO:0072502 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.2 | 0.9 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
| 0.2 | 0.9 | GO:0086021 | SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053) |
| 0.2 | 2.3 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.2 | 1.2 | GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) |
| 0.2 | 8.9 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.2 | 0.9 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.2 | 2.6 | GO:1902260 | diaphragm development(GO:0060539) negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.2 | 2.5 | GO:0090266 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.2 | 4.9 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.2 | 2.3 | GO:0006449 | regulation of translational termination(GO:0006449) |
| 0.1 | 3.0 | GO:0002021 | response to dietary excess(GO:0002021) |
| 0.1 | 4.4 | GO:0061641 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 5.0 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.1 | 0.9 | GO:0006537 | glutamate biosynthetic process(GO:0006537) |
| 0.1 | 0.5 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
| 0.1 | 0.9 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.1 | 0.5 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
| 0.1 | 0.7 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.1 | 0.5 | GO:0097688 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.1 | 1.5 | GO:0034378 | chylomicron assembly(GO:0034378) |
| 0.1 | 0.6 | GO:0019418 | sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221) |
| 0.1 | 1.2 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
| 0.1 | 1.0 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.1 | 3.0 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.1 | 2.0 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.1 | 1.8 | GO:0016446 | somatic hypermutation of immunoglobulin genes(GO:0016446) |
| 0.1 | 1.3 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.1 | 3.5 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.1 | 2.1 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 0.6 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.1 | 0.4 | GO:2000382 | positive regulation of mesoderm development(GO:2000382) |
| 0.1 | 0.4 | GO:0071286 | cellular response to magnesium ion(GO:0071286) |
| 0.1 | 0.2 | GO:0052026 | modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026) |
| 0.1 | 0.3 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.1 | 0.8 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.1 | 3.1 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.1 | 4.3 | GO:1901799 | negative regulation of proteasomal protein catabolic process(GO:1901799) |
| 0.1 | 2.1 | GO:0006482 | protein demethylation(GO:0006482) protein dealkylation(GO:0008214) |
| 0.1 | 0.5 | GO:0060754 | positive regulation of mast cell chemotaxis(GO:0060754) |
| 0.1 | 0.6 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.1 | 2.1 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.1 | 0.2 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.0 | 0.6 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.0 | 0.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.0 | 0.2 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.0 | 0.6 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 4.0 | GO:1990748 | cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748) |
| 0.0 | 0.7 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
| 0.0 | 0.8 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.0 | 0.5 | GO:0021894 | cerebral cortex GABAergic interneuron development(GO:0021894) |
| 0.0 | 0.2 | GO:0001826 | inner cell mass cell differentiation(GO:0001826) |
| 0.0 | 0.7 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.0 | 0.9 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.0 | 6.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 1.1 | GO:0021904 | dorsal/ventral neural tube patterning(GO:0021904) |
| 0.0 | 0.2 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.0 | 0.8 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 1.4 | GO:0001755 | neural crest cell migration(GO:0001755) |
| 0.0 | 2.0 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 0.0 | 0.8 | GO:0036344 | platelet morphogenesis(GO:0036344) |
| 0.0 | 0.4 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.0 | 4.7 | GO:0008213 | protein methylation(GO:0006479) protein alkylation(GO:0008213) |
| 0.0 | 1.5 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 2.7 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 3.3 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 2.1 | GO:0055072 | iron ion homeostasis(GO:0055072) |
| 0.0 | 3.4 | GO:0030705 | cytoskeleton-dependent intracellular transport(GO:0030705) |
| 0.0 | 0.6 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 0.6 | GO:0001881 | receptor recycling(GO:0001881) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 10.6 | GO:0097453 | mesaxon(GO:0097453) ensheathing process(GO:1990015) |
| 1.7 | 8.6 | GO:0009368 | endopeptidase Clp complex(GO:0009368) |
| 1.5 | 10.6 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 1.0 | 7.2 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 1.0 | 3.8 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.8 | 2.5 | GO:0000806 | Y chromosome(GO:0000806) cyclin A2-CDK2 complex(GO:0097124) cyclin E1-CDK2 complex(GO:0097134) |
| 0.8 | 4.1 | GO:1990393 | 3M complex(GO:1990393) |
| 0.7 | 4.9 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.7 | 18.4 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.6 | 4.1 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.5 | 4.9 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.5 | 2.0 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.5 | 6.4 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.4 | 1.2 | GO:0002139 | stereocilia coupling link(GO:0002139) |
| 0.4 | 4.9 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.4 | 2.6 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.4 | 3.2 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.3 | 3.1 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.3 | 2.6 | GO:0005638 | lamin filament(GO:0005638) |
| 0.3 | 2.9 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.2 | 3.6 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.2 | 4.8 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.2 | 1.8 | GO:0032389 | MutLalpha complex(GO:0032389) |
| 0.2 | 4.4 | GO:0010369 | chromocenter(GO:0010369) |
| 0.2 | 1.6 | GO:0071204 | U7 snRNP(GO:0005683) histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.2 | 2.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 8.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 4.5 | GO:0005921 | gap junction(GO:0005921) |
| 0.1 | 0.5 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.1 | 0.9 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 4.3 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 3.5 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.1 | 3.4 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 1.5 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.1 | 2.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 5.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 2.1 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 13.0 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 0.4 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.1 | 4.0 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 5.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 1.3 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 1.3 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 0.6 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.1 | 2.0 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 0.5 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.1 | 0.2 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.1 | 0.9 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 6.1 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 3.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 3.0 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 0.4 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 4.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 0.9 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 20.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.6 | GO:0098796 | membrane protein complex(GO:0098796) |
| 0.0 | 3.0 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 1.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 0.3 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.4 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 4.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.8 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.0 | 0.5 | GO:0012505 | endomembrane system(GO:0012505) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 18.4 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 1.3 | 18.1 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.9 | 3.4 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.8 | 10.6 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.8 | 2.3 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.7 | 6.4 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.7 | 8.3 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.6 | 3.8 | GO:0099602 | acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602) |
| 0.6 | 2.4 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.5 | 3.2 | GO:0043813 | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) |
| 0.5 | 1.6 | GO:0071209 | U7 snRNA binding(GO:0071209) |
| 0.5 | 2.5 | GO:0051998 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 0.5 | 2.9 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.5 | 4.2 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.4 | 3.5 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.4 | 2.4 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.4 | 1.6 | GO:0004505 | phenylalanine 4-monooxygenase activity(GO:0004505) |
| 0.4 | 9.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.4 | 8.7 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.4 | 3.2 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.4 | 9.8 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.3 | 1.3 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.3 | 9.1 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.3 | 4.1 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.3 | 1.8 | GO:0032138 | single base insertion or deletion binding(GO:0032138) |
| 0.3 | 8.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.2 | 0.9 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.2 | 2.7 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.2 | 1.0 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.2 | 6.1 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 4.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.2 | 1.1 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.2 | 0.6 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.2 | 0.9 | GO:0086020 | gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077) |
| 0.2 | 2.0 | GO:0043047 | single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505) |
| 0.2 | 4.1 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493) |
| 0.2 | 2.9 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.2 | 2.7 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.2 | 0.8 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.2 | 0.6 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.1 | 3.2 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 0.5 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 3.4 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 0.1 | 0.6 | GO:0030151 | molybdenum ion binding(GO:0030151) |
| 0.1 | 0.9 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 3.1 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
| 0.1 | 0.7 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.1 | 1.7 | GO:0016918 | retinal binding(GO:0016918) |
| 0.1 | 6.7 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 3.2 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.1 | 0.7 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.1 | 1.5 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.1 | 0.5 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.1 | 10.6 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.1 | 3.0 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.9 | GO:0043176 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.1 | 4.0 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 1.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 7.5 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.1 | 4.7 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
| 0.1 | 1.3 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 0.3 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.1 | 0.3 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.1 | 0.8 | GO:0048531 | beta-1,3-galactosyltransferase activity(GO:0048531) |
| 0.0 | 0.3 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 1.5 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 1.4 | GO:0001972 | retinoic acid binding(GO:0001972) glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.3 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.0 | 4.0 | GO:0016209 | antioxidant activity(GO:0016209) |
| 0.0 | 0.7 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 10.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.7 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.0 | 1.5 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 4.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.6 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 2.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.8 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 21.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.2 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.0 | 3.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 5.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.6 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.0 | 0.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.2 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 3.6 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.5 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 0.5 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 2.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 0.9 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.6 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.3 | 18.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 7.4 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.2 | 8.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 6.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 30.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 6.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 3.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 11.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 3.9 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 3.8 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 4.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 2.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.6 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 2.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.5 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.3 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 2.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 22.0 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.7 | 18.4 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.4 | 6.5 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.3 | 9.8 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.3 | 8.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.3 | 8.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.3 | 10.6 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.2 | 7.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 6.7 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 5.9 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.2 | 4.2 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.2 | 7.2 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 9.5 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 10.6 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.2 | 3.2 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.2 | 3.2 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 3.5 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 2.9 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 3.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 4.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 1.6 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.1 | 6.8 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.1 | 0.7 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 0.9 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 0.9 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 4.4 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 3.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.4 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 0.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 4.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 2.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.7 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.5 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 1.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.9 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 1.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 4.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 3.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 0.3 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.6 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |