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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GCUACAU
Z-value: 0.21
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miRNA associated with seed GCUACAU
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_176923483 Show fit | 5.01 |
ENST00000280187.7
ENST00000512509.1 |
glycoprotein M6A |
|
| chr12_+_12870055 Show fit | 4.22 |
ENST00000228872.4
|
cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
|
| chr1_-_41131326 Show fit | 4.11 |
ENST00000372684.3
|
regulating synaptic membrane exocytosis 3 |
|
| chr5_+_140254884 Show fit | 3.42 |
ENST00000398631.2
|
protocadherin alpha 12 |
|
| chr4_-_69215699 Show fit | 3.40 |
ENST00000510746.1
ENST00000344157.4 ENST00000355665.3 |
YTH domain containing 1 |
|
| chr5_+_140306478 Show fit | 3.28 |
ENST00000253807.2
|
protocadherin alpha subfamily C, 1 |
|
| chr5_+_140220769 Show fit | 3.15 |
ENST00000531613.1
ENST00000378123.3 |
protocadherin alpha 8 |
|
| chr5_+_140213815 Show fit | 3.11 |
ENST00000525929.1
ENST00000378125.3 |
protocadherin alpha 7 |
|
| chr5_+_140248518 Show fit | 3.04 |
ENST00000398640.2
|
protocadherin alpha 11 |
|
| chr9_-_111929560 Show fit | 2.80 |
ENST00000561981.2
|
ferric-chelate reductase 1-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of GCUACAU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 26.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 5.0 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.1 | 4.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.6 | 4.2 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.1 | 4.2 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 3.0 | GO:1900449 | regulation of glutamate receptor signaling pathway(GO:1900449) |
| 0.8 | 2.5 | GO:0048170 | response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162) positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.8 | 2.4 | GO:0048294 | negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 0.1 | 2.4 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
| 0.2 | 2.1 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 5.0 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.4 | 4.2 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.1 | 4.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 2.8 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 2.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.5 | 1.9 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.1 | 1.8 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 1.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 1.5 | GO:0043235 | receptor complex(GO:0043235) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 4.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.2 | 4.2 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 3.8 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.3 | 3.4 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.2 | 3.2 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.1 | 2.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 2.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.2 | 1.9 | GO:0043559 | insulin binding(GO:0043559) |
| 0.2 | 1.8 | GO:1904315 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 3.7 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 3.2 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.2 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.6 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.5 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.2 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 2.9 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 2.5 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 1.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 1.4 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 1.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.9 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 0.9 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |