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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GCUGGUG
Z-value: 0.30
Motif logo
miRNA associated with seed GCUGGUG
| Name | miRBASE accession |
|---|---|
|
hsa-miR-138-5p
|
MIMAT0000430 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_10199468 Show fit | 10.83 |
ENST00000254976.2
ENST00000304886.2 |
synaptosomal-associated protein, 25kDa |
|
| chr19_-_49944806 Show fit | 7.31 |
ENST00000221485.3
|
solute carrier family 17 (vesicular glutamate transporter), member 7 |
|
| chr15_-_48470558 Show fit | 6.95 |
ENST00000324324.7
|
myelin expression factor 2 |
|
| chr5_-_176057365 Show fit | 6.77 |
ENST00000310112.3
|
synuclein, beta |
|
| chr3_-_13009168 Show fit | 6.18 |
ENST00000273221.4
|
IQ motif and Sec7 domain 1 |
|
| chr6_-_46293378 Show fit | 5.99 |
ENST00000330430.6
|
regulator of calcineurin 2 |
|
| chr17_-_78450398 Show fit | 5.36 |
ENST00000306773.4
|
neuronal pentraxin I |
|
| chr4_+_47033345 Show fit | 5.23 |
ENST00000295454.3
|
gamma-aminobutyric acid (GABA) A receptor, beta 1 |
|
| chr17_-_9929581 Show fit | 4.71 |
ENST00000437099.2
ENST00000396115.2 |
growth arrest-specific 7 |
|
| chr1_-_41131326 Show fit | 4.61 |
ENST00000372684.3
|
regulating synaptic membrane exocytosis 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GCUGGUG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 10.8 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 2.4 | 7.3 | GO:0042137 | sequestering of neurotransmitter(GO:0042137) |
| 0.1 | 7.1 | GO:0042417 | dopamine metabolic process(GO:0042417) |
| 0.2 | 6.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 6.1 | GO:0014902 | myotube differentiation(GO:0014902) |
| 0.1 | 5.9 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.3 | 5.7 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.5 | 5.4 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 0.3 | 5.2 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.4 | 4.2 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.4 | GO:0005730 | nucleolus(GO:0005730) |
| 2.7 | 10.8 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 7.9 | GO:0030425 | dendrite(GO:0030425) |
| 0.1 | 7.7 | GO:0016234 | inclusion body(GO:0016234) |
| 0.2 | 7.4 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 1.2 | 7.3 | GO:0060203 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
| 0.4 | 6.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 5.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 4.2 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 3.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 10.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 7.0 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 6.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.5 | 6.8 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 1.6 | 6.5 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 1.3 | 6.5 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 1.0 | 6.0 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.2 | 5.7 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.4 | 5.2 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.6 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 6.8 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 6.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.9 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.1 | 4.6 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 4.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.5 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 3.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 3.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 3.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 18.1 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.3 | 8.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 5.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 5.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 4.2 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.3 | 3.9 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.2 | 2.9 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 2.9 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 2.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.2 | REACTOME REGULATORY RNA PATHWAYS | Genes involved in Regulatory RNA pathways |