ISMARA results: GFI1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for GFI1

Z-value: 0.74

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Transcription factors associated with GFI1

Gene Symbol	Gene ID	Gene Info
GFI1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000162676.7	growth factor independent 1 transcriptional repressor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GFI1	hg19_v2_chr1_-_92951607_92951661, hg19_v2_chr1_-_92949505_92949543, hg19_v2_chr1_-_92952433_92952489	0.14	3.6e-02	Click!

Activity profile of GFI1 motif

Sorted Z-values of GFI1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_26694979 Show fit	11.66	ENST00000438614.1	VTN Ensembl NCBI GeneCards UniProt NextProt Show fit	vitronectin
chr17_+_1665345 Show fit	11.48	ENST00000576406.1 ENST00000571149.1	SERPINF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_-_26695013 Show fit	10.84	ENST00000555059.2	CTB-96E2.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	Homeobox protein SEBOX
chr6_+_31982539 Show fit	9.61	ENST00000435363.2 ENST00000425700.2	C4B Ensembl NCBI GeneCards UniProt NextProt Show fit	complement component 4B (Chido blood group)
chr6_+_31949801 Show fit	9.60	ENST00000428956.2 ENST00000498271.1	C4A Ensembl NCBI GeneCards UniProt NextProt Show fit	complement component 4A (Rodgers blood group)
chr11_-_117748138 Show fit	9.42	ENST00000527717.1	FXYD6 Ensembl NCBI GeneCards UniProt NextProt Show fit	FXYD domain containing ion transport regulator 6
chr6_+_31795506 Show fit	7.51	ENST00000375650.3	HSPA1B Ensembl NCBI GeneCards UniProt NextProt Show fit	heat shock 70kDa protein 1B
chr17_+_1665253 Show fit	7.43	ENST00000254722.4	SERPINF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_22005062 Show fit	7.21	ENST00000317492.5	SALL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	spalt-like transcription factor 2
chr14_-_22005343 Show fit	7.20	ENST00000327430.3	SALL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	spalt-like transcription factor 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GFI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	19.2	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
3.8	18.9	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.1	13.5	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4	12.8	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
1.3	11.7	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
2.3	11.3	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.9	9.6	GO:0033227	dsRNA transport(GO:0033227)
0.3	9.5	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
1.1	8.9	GO:0002051	osteoblast fate commitment(GO:0002051)
0.1	8.9	GO:0050672	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)

Showing 1 to 10 of 232 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	39.6	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	28.7	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	26.4	GO:0005667	transcription factor complex(GO:0005667)
1.6	18.9	GO:0043203	axon hillock(GO:0043203)
0.0	16.4	GO:0030424	axon(GO:0030424)
0.1	13.1	GO:0030426	growth cone(GO:0030426)
0.0	13.1	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	12.2	GO:0000139	Golgi membrane(GO:0000139)
2.9	11.7	GO:0071062	rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.8	11.3	GO:0097227	sperm annulus(GO:0097227)

Showing 1 to 10 of 90 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	35.8	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2	18.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	13.4	GO:0005509	calcium ion binding(GO:0005509)
1.5	11.9	GO:0001849	complement component C1q binding(GO:0001849)
0.8	11.7	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
1.6	9.6	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.4	9.6	GO:0001848	complement binding(GO:0001848)
0.0	8.4	GO:0015631	tubulin binding(GO:0015631)
1.2	8.2	GO:0016206	catechol O-methyltransferase activity(GO:0016206)
0.4	7.8	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)

Showing 1 to 10 of 168 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	31.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	13.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	12.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	9.6	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	9.0	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.1	8.9	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	5.8	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	4.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	4.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	4.0	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway

Showing 1 to 10 of 36 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	15.9	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	13.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	11.5	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.2	10.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.7	10.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.5	9.6	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.3	9.1	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2	8.9	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3	7.6	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.4	7.3	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway

Showing 1 to 10 of 82 entries

Results for GFI1

Z-value: 0.74

Motif logo

Transcription factors associated with GFI1

Activity-expression correlation:

Activity profile of GFI1 motif

Sorted Z-values of GFI1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GFI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: