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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GFI1B
Z-value: 0.48
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Transcription factors associated with GFI1B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GFI1B | hg19_v2_chr9_+_135854091_135854159 | -0.45 | 1.7e-12 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GFI1B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 64.3 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 4.5 | 40.3 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 2.3 | 32.4 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 7.3 | 21.9 | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 2.7 | 16.5 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 2.3 | 15.8 | GO:2000795 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.0 | 15.6 | GO:0006936 | muscle contraction(GO:0006936) |
| 2.2 | 15.2 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 2.4 | 14.1 | GO:0055129 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 0.5 | 14.0 | GO:0031639 | plasminogen activation(GO:0031639) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 64.3 | GO:0043195 | terminal bouton(GO:0043195) |
| 10.1 | 40.3 | GO:0031673 | H zone(GO:0031673) |
| 2.4 | 33.2 | GO:0008091 | spectrin(GO:0008091) |
| 1.6 | 23.5 | GO:0030478 | actin cap(GO:0030478) |
| 4.4 | 21.9 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 1.3 | 15.8 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 15.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.7 | 13.9 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 13.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 10.8 | GO:0001726 | ruffle(GO:0001726) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 64.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 1.6 | 42.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 2.8 | 27.8 | GO:0042731 | PH domain binding(GO:0042731) |
| 1.0 | 27.0 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 1.0 | 25.4 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 3.7 | 21.9 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.1 | 18.5 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 18.4 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 2.2 | 15.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.3 | 14.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 61.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 40.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 18.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 14.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.2 | 13.2 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.2 | 11.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.2 | 10.5 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 9.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 8.9 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.4 | 8.3 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 67.0 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.7 | 35.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.4 | 23.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.5 | 15.8 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.4 | 14.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 13.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 10.5 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.6 | 9.9 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.3 | 9.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.3 | 9.3 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |