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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for GFI1B

Z-value: 0.48

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Transcription factors associated with GFI1B

Gene Symbol Gene ID Gene Info
ENSG00000165702.8 growth factor independent 1B transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GFI1Bhg19_v2_chr9_+_135854091_135854159-0.451.7e-12Click!

Activity profile of GFI1B motif

Sorted Z-values of GFI1B motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_149688655 33.32 ENST00000461930.1
ENST00000423691.2
ENST00000490975.1
ENST00000461868.1
ENST00000452853.2
profilin 2
chr3_-_149688896 31.00 ENST00000239940.7
profilin 2
chr6_-_56707943 23.67 ENST00000370769.4
ENST00000421834.2
ENST00000312431.6
ENST00000361203.3
ENST00000523817.1
dystonin
chr6_-_56708459 16.59 ENST00000370788.2
dystonin
chr9_-_14180778 15.76 ENST00000380924.1
ENST00000543693.1
nuclear factor I/B
chr5_+_36608422 15.18 ENST00000381918.3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_-_176733897 13.86 ENST00000393658.2
glycoprotein M6A
chr1_-_23886285 11.83 ENST00000374561.5
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr4_+_41362796 11.75 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
LIM and calponin homology domains 1
chr4_+_154125565 11.32 ENST00000338700.5
tripartite motif containing 2
chr12_+_48513570 11.15 ENST00000551804.1
phosphofructokinase, muscle
chr12_+_48513009 10.76 ENST00000359794.5
ENST00000551339.1
ENST00000395233.2
ENST00000548345.1
phosphofructokinase, muscle
chr22_+_24204375 10.53 ENST00000433835.3
Uncharacterized protein
chr12_-_123752624 9.96 ENST00000542174.1
ENST00000535796.1
cyclin-dependent kinase 2 associated protein 1
chr10_+_124221036 9.78 ENST00000368984.3
HtrA serine peptidase 1
chr7_+_134576317 9.69 ENST00000424922.1
ENST00000495522.1
caldesmon 1
chr14_-_53417732 9.26 ENST00000399304.3
ENST00000395631.2
ENST00000341590.3
ENST00000343279.4
fermitin family member 2
chr17_-_79827808 8.92 ENST00000580685.1
Rho GDP dissociation inhibitor (GDI) alpha
chr7_+_134576151 8.86 ENST00000393118.2
caldesmon 1
chr11_+_32112431 8.42 ENST00000054950.3
reticulocalbin 1, EF-hand calcium binding domain
chr17_+_49230897 8.26 ENST00000393196.3
ENST00000336097.3
ENST00000480143.1
ENST00000511355.1
ENST00000013034.3
ENST00000393198.3
ENST00000608447.1
ENST00000393193.2
ENST00000376392.6
ENST00000555572.1
NME/NM23 nucleoside diphosphate kinase 1
NME1-NME2 readthrough
NME/NM23 nucleoside diphosphate kinase 2
chr15_+_32933866 8.08 ENST00000300175.4
ENST00000413748.2
ENST00000494364.1
ENST00000497208.1
secretogranin V (7B2 protein)
chr6_-_131384347 7.99 ENST00000530481.1
erythrocyte membrane protein band 4.1-like 2
chr19_-_44123734 7.66 ENST00000598676.1
zinc finger protein 428
chr17_-_46688334 7.57 ENST00000239165.7
homeobox B7
chr8_-_49834299 7.44 ENST00000396822.1
snail family zinc finger 2
chr6_+_123100620 7.32 ENST00000368444.3
fatty acid binding protein 7, brain
chr13_-_67802549 7.31 ENST00000328454.5
ENST00000377865.2
protocadherin 9
chr17_+_70117153 7.30 ENST00000245479.2
SRY (sex determining region Y)-box 9
chr17_-_79895097 7.25 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
pyrroline-5-carboxylate reductase 1
chr3_-_165555200 7.14 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
butyrylcholinesterase
chr6_-_131384373 7.13 ENST00000392427.3
ENST00000525271.1
ENST00000527411.1
erythrocyte membrane protein band 4.1-like 2
chr9_-_95056010 7.09 ENST00000443024.2
isoleucyl-tRNA synthetase
chrX_+_77359726 7.08 ENST00000442431.1
phosphoglycerate kinase 1
chr5_-_146461027 7.03 ENST00000394410.2
ENST00000508267.1
ENST00000504198.1
protein phosphatase 2, regulatory subunit B, beta
chr6_-_131384412 6.94 ENST00000445890.2
ENST00000368128.2
ENST00000337057.3
erythrocyte membrane protein band 4.1-like 2
chr7_+_79765071 6.90 ENST00000457358.2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chrX_+_77359671 6.89 ENST00000373316.4
phosphoglycerate kinase 1
chr17_-_79895154 6.88 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
pyrroline-5-carboxylate reductase 1
chr11_-_61582579 6.85 ENST00000539419.1
ENST00000545245.1
ENST00000545405.1
ENST00000542506.1
fatty acid desaturase 1
chr2_-_9563469 6.77 ENST00000484735.1
ENST00000456913.2
integrin beta 1 binding protein 1
chr7_+_39663061 6.70 ENST00000005257.2
v-ral simian leukemia viral oncogene homolog A (ras related)
chr14_-_103523745 6.68 ENST00000361246.2
CDC42 binding protein kinase beta (DMPK-like)
chr1_-_94703118 6.33 ENST00000260526.6
ENST00000370217.3
Rho GTPase activating protein 29
chr10_+_31610064 6.30 ENST00000446923.2
ENST00000559476.1
zinc finger E-box binding homeobox 1
chr14_-_68162464 6.24 ENST00000553384.1
ENST00000557726.1
ENST00000381346.4
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr1_-_230513367 6.22 ENST00000321327.2
ENST00000525115.1
piggyBac transposable element derived 5
chr4_-_102268484 6.15 ENST00000394853.4
protein phosphatase 3, catalytic subunit, alpha isozyme
chr7_+_112063192 5.94 ENST00000005558.4
interferon-related developmental regulator 1
chr5_-_125930929 5.88 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
aldehyde dehydrogenase 7 family, member A1
chr8_-_49833978 5.81 ENST00000020945.1
snail family zinc finger 2
chr2_-_110371720 5.80 ENST00000356688.4
septin 10
chr2_-_10978103 5.78 ENST00000404824.2
protein disulfide isomerase family A, member 6
chr6_-_131321863 5.73 ENST00000528282.1
erythrocyte membrane protein band 4.1-like 2
chr17_+_34848049 5.68 ENST00000588902.1
ENST00000591067.1
zinc finger, HIT-type containing 3
chr7_+_150758304 5.63 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
solute carrier family 4 (anion exchanger), member 2
chr19_-_44124019 5.55 ENST00000300811.3
zinc finger protein 428
chr19_+_33071974 5.47 ENST00000590247.2
ENST00000419343.3
ENST00000592786.1
ENST00000379316.3
programmed cell death 5
chr2_+_54683419 5.46 ENST00000356805.4
spectrin, beta, non-erythrocytic 1
chr2_-_110371777 5.45 ENST00000397712.2
septin 10
chr2_-_9563319 5.32 ENST00000497105.1
ENST00000360635.3
ENST00000359712.3
integrin beta 1 binding protein 1
chr7_+_141438393 5.27 ENST00000484178.1
ENST00000473783.1
ENST00000481508.1
single-stranded DNA binding protein 1, mitochondrial
chr2_-_96874553 5.27 ENST00000337288.5
ENST00000443962.1
StAR-related lipid transfer (START) domain containing 7
chr10_+_63661053 5.20 ENST00000279873.7
AT rich interactive domain 5B (MRF1-like)
chr1_+_39796810 5.17 ENST00000289893.4
microtubule-actin crosslinking factor 1
chr16_-_18441131 5.15 ENST00000339303.5
nuclear pore complex interacting protein family, member A8
chr17_-_9929581 5.11 ENST00000437099.2
ENST00000396115.2
growth arrest-specific 7
chr6_+_44215603 5.11 ENST00000371554.1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr12_+_117176090 5.10 ENST00000257575.4
ENST00000407967.3
ENST00000392549.2
ring finger protein, transmembrane 2
chr2_-_110371412 5.06 ENST00000415095.1
ENST00000334001.6
ENST00000437928.1
ENST00000493445.1
ENST00000397714.2
ENST00000461295.1
septin 10
chr1_+_164528866 4.99 ENST00000420696.2
pre-B-cell leukemia homeobox 1
chr1_-_237167718 4.96 ENST00000464121.2
metallothionein 1H-like 1
chr7_+_134551583 4.96 ENST00000435928.1
caldesmon 1
chr5_+_79703823 4.94 ENST00000338008.5
ENST00000510158.1
ENST00000505560.1
zinc finger, FYVE domain containing 16
chr1_+_162602244 4.90 ENST00000367922.3
ENST00000367921.3
discoidin domain receptor tyrosine kinase 2
chr3_-_33759699 4.89 ENST00000399362.4
ENST00000359576.5
ENST00000307312.7
cytoplasmic linker associated protein 2
chr17_-_19281203 4.87 ENST00000487415.2
B9 protein domain 1
chr10_+_17272608 4.80 ENST00000421459.2
vimentin
chr2_+_201754050 4.77 ENST00000426253.1
ENST00000416651.1
ENST00000454952.1
ENST00000409020.1
ENST00000359683.4
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr7_-_108096765 4.71 ENST00000379024.4
ENST00000351718.4
neuronal cell adhesion molecule
chr7_+_141438118 4.64 ENST00000265304.6
ENST00000498107.1
ENST00000467681.1
ENST00000465582.1
ENST00000463093.1
single-stranded DNA binding protein 1, mitochondrial
chr6_-_116601044 4.62 ENST00000368608.3
TSPY-like 1
chr11_-_117748138 4.54 ENST00000527717.1
FXYD domain containing ion transport regulator 6
chr2_+_201754135 4.54 ENST00000409357.1
ENST00000409129.2
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr18_-_5419797 4.47 ENST00000542146.1
ENST00000427684.2
erythrocyte membrane protein band 4.1-like 3
chr19_-_14945933 4.47 ENST00000322301.3
olfactory receptor, family 7, subfamily A, member 5
chr2_-_9563575 4.38 ENST00000488451.1
ENST00000238091.4
ENST00000355346.4
integrin beta 1 binding protein 1
chr2_+_11752379 4.31 ENST00000396123.1
growth regulation by estrogen in breast cancer 1
chr12_+_117176113 4.30 ENST00000319176.7
ring finger protein, transmembrane 2
chr2_-_190044480 4.30 ENST00000374866.3
collagen, type V, alpha 2
chr1_-_143767881 4.28 ENST00000419275.1
peptidylprolyl isomerase A (cyclophilin A)-like 4G
chr11_-_33774944 4.25 ENST00000532057.1
ENST00000531080.1
F-box protein 3
chr2_-_55496344 4.23 ENST00000403721.1
ENST00000263629.4
mitochondrial translational initiation factor 2
chr7_+_56119323 3.99 ENST00000275603.4
ENST00000335503.3
ENST00000540286.1
chaperonin containing TCP1, subunit 6A (zeta 1)
chr2_-_55496174 3.94 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
mitochondrial translational initiation factor 2
chr1_-_144364246 3.92 ENST00000540273.1
peptidylprolyl isomerase A (cyclophilin A)-like 4B
chr2_+_47630108 3.88 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
mutS homolog 2
chr7_-_108096822 3.88 ENST00000379028.3
ENST00000413765.2
ENST00000379022.4
neuronal cell adhesion molecule
chr18_-_24445729 3.85 ENST00000383168.4
aquaporin 4
chr7_+_39663485 3.81 ENST00000436179.1
v-ral simian leukemia viral oncogene homolog A (ras related)
chr2_+_171785012 3.79 ENST00000234160.4
golgi reassembly stacking protein 2, 55kDa
chr14_+_78870030 3.67 ENST00000553631.1
ENST00000554719.1
neurexin 3
chr6_+_12290586 3.67 ENST00000379375.5
endothelin 1
chr10_-_129924468 3.63 ENST00000368653.3
marker of proliferation Ki-67
chr9_+_12693336 3.56 ENST00000381137.2
ENST00000388918.5
tyrosinase-related protein 1
chr7_-_87856280 3.56 ENST00000490437.1
ENST00000431660.1
sorcin
chr22_+_38864041 3.55 ENST00000216014.4
ENST00000409006.3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr19_-_55660561 3.52 ENST00000587758.1
ENST00000356783.5
ENST00000291901.8
ENST00000588426.1
ENST00000588147.1
ENST00000536926.1
ENST00000588981.1
troponin T type 1 (skeletal, slow)
chr11_-_61659006 3.51 ENST00000278829.2
fatty acid desaturase 3
chrX_+_119737806 3.39 ENST00000371317.5
malignant T cell amplified sequence 1
chr11_+_93861993 3.38 ENST00000227638.3
ENST00000436171.2
pannexin 1
chr17_-_79481666 3.37 ENST00000575659.1
actin, gamma 1
chr4_+_41937131 3.32 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
transmembrane protein 33
chr1_-_148202536 3.30 ENST00000544708.1
peptidylprolyl isomerase A (cyclophilin A)-like 4D
chr5_+_150591678 3.19 ENST00000523466.1
GM2 ganglioside activator
chr1_+_149553003 3.17 ENST00000369222.3
peptidylprolyl isomerase A (cyclophilin A)-like 4C
chr20_-_33999766 3.14 ENST00000349714.5
ENST00000438533.1
ENST00000359226.2
ENST00000374384.2
ENST00000374377.5
ENST00000407996.2
ENST00000424405.1
ENST00000542501.1
ENST00000397554.1
ENST00000540457.1
ENST00000374380.2
ENST00000374385.5
ubiquinol-cytochrome c reductase complex assembly factor 1
chr7_-_100808394 3.11 ENST00000445482.2
VGF nerve growth factor inducible
chr10_-_129924611 3.07 ENST00000368654.3
marker of proliferation Ki-67
chr10_+_88516396 3.06 ENST00000372037.3
bone morphogenetic protein receptor, type IA
chr18_+_11857439 2.96 ENST00000602628.1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr1_+_150337144 2.94 ENST00000539519.1
ENST00000369067.3
ENST00000369068.4
regulation of nuclear pre-mRNA domain containing 2
chr1_-_115300579 2.91 ENST00000358528.4
ENST00000525132.1
cold shock domain containing E1, RNA-binding
chr7_+_73106926 2.89 ENST00000453316.1
Williams Beuren syndrome chromosome region 22
chr2_-_158732340 2.87 ENST00000539637.1
ENST00000413751.1
ENST00000434821.1
ENST00000424669.1
activin A receptor, type I
chrX_+_129473916 2.84 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr20_-_32262165 2.83 ENST00000606690.1
ENST00000246190.6
ENST00000439478.1
ENST00000375238.4
N-terminal EF-hand calcium binding protein 3
chr16_+_4526341 2.81 ENST00000458134.3
ENST00000219700.6
ENST00000575120.1
ENST00000572812.1
ENST00000574466.1
ENST00000576827.1
ENST00000570445.1
heme oxygenase (decycling) 2
chr6_+_71122974 2.77 ENST00000418814.2
family with sequence similarity 135, member A
chr5_+_159436120 2.75 ENST00000522793.1
ENST00000231238.5
tetratricopeptide repeat domain 1
chr12_+_95867919 2.74 ENST00000261220.9
ENST00000549502.1
ENST00000553151.1
ENST00000550777.1
ENST00000551840.1
methionyl aminopeptidase 2
chr1_+_206516200 2.71 ENST00000295713.5
SLIT-ROBO Rho GTPase activating protein 2
chr11_-_102595681 2.70 ENST00000236826.3
matrix metallopeptidase 8 (neutrophil collagenase)
chr1_+_226736446 2.70 ENST00000366788.3
ENST00000366789.4
chromosome 1 open reading frame 95
chr11_+_101785727 2.69 ENST00000263468.8
KIAA1377
chr12_+_54447637 2.64 ENST00000609810.1
ENST00000430889.2
homeobox C4
Homeobox protein Hox-C4
chr1_+_150337100 2.63 ENST00000401000.4
regulation of nuclear pre-mRNA domain containing 2
chr15_-_34331243 2.62 ENST00000306730.3
apoptosis, caspase activation inhibitor
chr9_-_70488865 2.60 ENST00000377392.5
COBW domain containing 5
chr15_+_67458357 2.58 ENST00000537194.2
SMAD family member 3
chr1_-_21377383 2.55 ENST00000374935.3
eukaryotic translation initiation factor 4 gamma, 3
chrX_+_7137475 2.54 ENST00000217961.4
steroid sulfatase (microsomal), isozyme S
chr1_-_147955419 2.54 ENST00000539781.1
peptidylprolyl isomerase A (cyclophilin A)-like 4A
chr17_-_1395954 2.53 ENST00000359786.5
myosin IC
chr11_+_27076764 2.50 ENST00000525090.1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr1_-_21377447 2.50 ENST00000374937.3
ENST00000264211.8
eukaryotic translation initiation factor 4 gamma, 3
chr1_-_68698222 2.46 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
wntless Wnt ligand secretion mediator
chr20_-_35274548 2.40 ENST00000262866.4
Src-like-adaptor 2
chr11_+_35684288 2.40 ENST00000299413.5
tripartite motif containing 44
chr1_-_115300592 2.38 ENST00000261443.5
ENST00000534699.1
ENST00000339438.6
ENST00000529046.1
ENST00000525970.1
ENST00000369530.1
ENST00000530886.1
cold shock domain containing E1, RNA-binding
chr19_+_21265028 2.36 ENST00000291770.7
zinc finger protein 714
chr19_-_10687907 2.32 ENST00000589348.1
adaptor-related protein complex 1, mu 2 subunit
chr5_+_15500280 2.30 ENST00000504595.1
F-box and leucine-rich repeat protein 7
chr12_+_93861264 2.28 ENST00000549982.1
ENST00000361630.2
mitochondrial ribosomal protein L42
chr2_-_130886795 2.23 ENST00000409914.2
POTE ankyrin domain family, member F
chr8_-_22926623 2.20 ENST00000276431.4
tumor necrosis factor receptor superfamily, member 10b
chr1_-_220220000 2.20 ENST00000366923.3
glutamyl-prolyl-tRNA synthetase
chr3_-_49466686 2.16 ENST00000273598.3
ENST00000436744.2
nicolin 1
chr2_+_110371905 2.16 ENST00000356454.3
sosondowah ankyrin repeat domain family member C
chr14_+_29236269 2.15 ENST00000313071.4
forkhead box G1
chr19_-_43708378 2.11 ENST00000599746.1
pregnancy specific beta-1-glycoprotein 4
chr12_+_6603253 2.11 ENST00000382457.4
ENST00000545962.1
non-SMC condensin I complex, subunit D2
chr1_+_15272271 2.07 ENST00000400797.3
kazrin, periplakin interacting protein
chr9_-_127263265 2.05 ENST00000373587.3
nuclear receptor subfamily 5, group A, member 1
chr11_-_102595512 2.00 ENST00000438475.2
matrix metallopeptidase 8 (neutrophil collagenase)
chr17_-_9862772 1.99 ENST00000580865.1
ENST00000583882.1
growth arrest-specific 7
chr6_+_116601265 1.96 ENST00000452085.3
dermatan sulfate epimerase
chr12_-_82153087 1.93 ENST00000547623.1
ENST00000549396.1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr1_+_35544968 1.92 ENST00000359858.4
ENST00000373330.1
zinc finger, MYM-type 1
chr7_-_14029515 1.91 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
ets variant 1
chr19_+_41770269 1.88 ENST00000378215.4
heterogeneous nuclear ribonucleoprotein U-like 1
chr5_+_140261703 1.87 ENST00000409494.1
ENST00000289272.2
protocadherin alpha 13
chr16_-_18468926 1.86 ENST00000545114.1
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr14_-_106069247 1.77 ENST00000479229.1
RP11-731F5.1
chr19_+_41770349 1.76 ENST00000602130.1
heterogeneous nuclear ribonucleoprotein U-like 1
chrM_+_4431 1.76 ENST00000361453.3
mitochondrially encoded NADH dehydrogenase 2
chr2_-_110371664 1.75 ENST00000545389.1
ENST00000423520.1
septin 10
chr1_+_95616933 1.73 ENST00000604203.1
TMEM56-RWDD3 readthrough
chr5_+_14143728 1.69 ENST00000344204.4
ENST00000537187.1
trio Rho guanine nucleotide exchange factor
chr2_-_85788652 1.68 ENST00000430215.3
gamma-glutamyl carboxylase
chr22_+_19951192 1.68 ENST00000428707.1
catechol-O-methyltransferase
chr6_-_13621126 1.65 ENST00000600057.1
Uncharacterized protein
chr20_-_57607347 1.64 ENST00000395663.1
ENST00000395659.1
ENST00000243997.3
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
chr15_-_83378638 1.55 ENST00000261722.3
adaptor-related protein complex 3, beta 2 subunit
chr9_+_35490101 1.52 ENST00000361226.3
RUN and SH3 domain containing 2
chr11_-_26743546 1.52 ENST00000280467.6
ENST00000396005.3
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr20_-_48330377 1.49 ENST00000371711.4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
chr3_+_173116225 1.45 ENST00000457714.1
neuroligin 1
chr6_+_71123107 1.40 ENST00000370479.3
ENST00000505769.1
ENST00000515323.1
ENST00000515280.1
ENST00000507085.1
ENST00000457062.2
ENST00000361499.3
family with sequence similarity 135, member A
chr19_-_4831701 1.39 ENST00000248244.5
toll-like receptor adaptor molecule 1
chr11_+_30253410 1.39 ENST00000533718.1
follicle stimulating hormone, beta polypeptide
chr19_+_57862622 1.39 ENST00000391705.3
ENST00000443917.2
ENST00000598744.1
zinc finger protein 304
chr14_-_93214915 1.34 ENST00000553918.1
ENST00000555699.1
ENST00000553802.1
ENST00000554397.1
ENST00000554919.1
ENST00000554080.1
ENST00000553371.1
legumain
chr22_+_41865109 1.33 ENST00000216254.4
ENST00000396512.3
aconitase 2, mitochondrial
chr4_-_159080806 1.32 ENST00000590648.1
family with sequence similarity 198, member B
chr7_-_100808843 1.32 ENST00000249330.2
VGF nerve growth factor inducible
chr11_+_76571911 1.30 ENST00000534206.1
ENST00000532485.1
ENST00000526597.1
ENST00000533873.1
ENST00000538157.1
alkaline ceramidase 3
chr10_+_72575643 1.29 ENST00000373202.3
sphingosine-1-phosphate lyase 1
chr14_-_93214988 1.28 ENST00000557434.1
ENST00000393218.2
ENST00000334869.4
legumain
chr15_-_42500351 1.25 ENST00000348544.4
ENST00000318006.5
vacuolar protein sorting 39 homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of GFI1B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 21.9 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
5.4 64.3 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
4.5 40.3 GO:0008090 retrograde axonal transport(GO:0008090)
4.4 13.2 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
2.7 16.5 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
2.4 7.3 GO:0060018 astrocyte fate commitment(GO:0060018) retinal rod cell differentiation(GO:0060221)
2.4 7.1 GO:0014016 neuroblast differentiation(GO:0014016)
2.4 7.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
2.4 14.1 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
2.3 32.4 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
2.3 15.8 GO:2000795 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
2.2 15.2 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
2.1 6.2 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
2.0 5.9 GO:0007518 myoblast fate determination(GO:0007518)
2.0 9.8 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
1.4 11.6 GO:0032790 ribosome disassembly(GO:0032790)
1.4 8.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.4 13.8 GO:0051096 positive regulation of helicase activity(GO:0051096)
1.4 5.5 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
1.4 5.5 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
1.3 5.1 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
1.2 3.7 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
1.2 3.5 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
1.1 3.3 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
1.1 4.3 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
1.1 5.3 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
1.0 2.0 GO:0007538 primary sex determination(GO:0007538)
1.0 3.1 GO:0048382 mesendoderm development(GO:0048382)
1.0 2.9 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
0.9 2.8 GO:0006788 heme oxidation(GO:0006788)
0.9 10.5 GO:0051665 membrane raft localization(GO:0051665)
0.9 2.6 GO:0006624 vacuolar protein processing(GO:0006624)
0.8 3.4 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.8 5.9 GO:0042426 choline catabolic process(GO:0042426)
0.8 8.3 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.8 9.8 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.7 4.5 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.7 6.3 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.7 11.8 GO:0030903 notochord development(GO:0030903)
0.6 3.1 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.5 6.2 GO:0009642 response to light intensity(GO:0009642)
0.5 2.6 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.5 3.6 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.5 14.0 GO:0031639 plasminogen activation(GO:0031639)
0.5 1.0 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.5 1.5 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.5 4.8 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.5 1.4 GO:1900114 positive regulation of histone H3-K9 trimethylation(GO:1900114)
0.4 1.7 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.4 2.5 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.4 13.9 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.4 3.6 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.4 3.5 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.4 6.9 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.3 2.7 GO:0006689 ganglioside catabolic process(GO:0006689)
0.3 1.7 GO:0050666 cellular response to phosphate starvation(GO:0016036) regulation of sulfur amino acid metabolic process(GO:0031335) positive regulation of sulfur amino acid metabolic process(GO:0031337) regulation of homocysteine metabolic process(GO:0050666) positive regulation of homocysteine metabolic process(GO:0050668)
0.3 3.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.3 8.4 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.3 1.3 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.3 4.0 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.3 7.0 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.3 3.4 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.3 1.1 GO:0006668 sphinganine-1-phosphate metabolic process(GO:0006668)
0.3 5.2 GO:0002021 response to dietary excess(GO:0002021)
0.3 2.7 GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.3 7.6 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.3 1.3 GO:0035900 response to isolation stress(GO:0035900)
0.3 2.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.3 2.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 2.3 GO:0010265 SCF complex assembly(GO:0010265)
0.2 3.0 GO:0030321 transepithelial chloride transport(GO:0030321)
0.2 8.2 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.2 2.8 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2 3.7 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.2 10.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 1.1 GO:0080009 mRNA methylation(GO:0080009)
0.2 1.4 GO:0045080 positive regulation of chemokine biosynthetic process(GO:0045080)
0.2 7.9 GO:0016486 peptide hormone processing(GO:0016486)
0.2 0.9 GO:0072719 cellular response to cisplatin(GO:0072719)
0.2 1.5 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.2 2.8 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.1 3.3 GO:0033622 integrin activation(GO:0033622)
0.1 5.2 GO:0016577 histone demethylation(GO:0016577)
0.1 4.9 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 5.2 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 3.0 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 2.0 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.5 GO:0032906 transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.1 5.3 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 6.7 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 2.5 GO:0006833 water transport(GO:0006833)
0.1 1.3 GO:0046520 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.1 2.9 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 5.6 GO:0015701 bicarbonate transport(GO:0015701)
0.1 1.5 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 2.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 1.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 5.3 GO:0043277 apoptotic cell clearance(GO:0043277)
0.1 2.5 GO:0006706 steroid catabolic process(GO:0006706)
0.1 2.2 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 1.3 GO:0030149 sphingolipid catabolic process(GO:0030149)
0.1 1.9 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.2 GO:0061743 motor learning(GO:0061743)
0.1 5.6 GO:0001895 retina homeostasis(GO:0001895)
0.1 0.2 GO:0060577 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung development(GO:0060459) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.1 4.5 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 1.2 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1 9.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 3.4 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.1 4.7 GO:0030574 collagen catabolic process(GO:0030574)
0.1 0.8 GO:0046415 urate metabolic process(GO:0046415)
0.1 3.5 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.1 0.7 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 0.3 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.1 2.3 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.1 2.7 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 0.4 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 5.1 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 0.6 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 8.1 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 2.9 GO:0043039 amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.0 0.4 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.4 GO:0044241 lipid digestion(GO:0044241)
0.0 1.9 GO:0014047 glutamate secretion(GO:0014047)
0.0 1.2 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 7.0 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 10.2 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 1.5 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)
0.0 3.1 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.3 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.0 0.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.9 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 15.6 GO:0006936 muscle contraction(GO:0006936)
0.0 2.3 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 4.5 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.9 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.2 GO:0046498 S-adenosylmethionine cycle(GO:0033353) S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.8 GO:0006308 DNA catabolic process(GO:0006308)
0.0 2.8 GO:0007030 Golgi organization(GO:0007030)
0.0 2.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 11.6 GO:0051301 cell division(GO:0051301)
0.0 0.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 2.6 GO:0015992 proton transport(GO:0015992)
0.0 0.4 GO:0043161 proteasomal protein catabolic process(GO:0010498) proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)
0.0 1.2 GO:0090002 establishment of protein localization to plasma membrane(GO:0090002)
0.0 0.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 2.7 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.0 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.8 GO:0006968 cellular defense response(GO:0006968)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
10.1 40.3 GO:0031673 H zone(GO:0031673)
4.4 21.9 GO:0005945 6-phosphofructokinase complex(GO:0005945)
2.4 33.2 GO:0008091 spectrin(GO:0008091)
1.6 23.5 GO:0030478 actin cap(GO:0030478)
1.4 4.3 GO:0005588 collagen type V trimer(GO:0005588)
1.3 15.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.3 3.9 GO:0032302 MutSbeta complex(GO:0032302)
1.3 5.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.8 3.2 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.7 2.2 GO:0005874 microtubule(GO:0005874)
0.7 6.2 GO:0005955 calcineurin complex(GO:0005955)
0.7 13.9 GO:0044295 axonal growth cone(GO:0044295)
0.6 7.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.6 64.3 GO:0043195 terminal bouton(GO:0043195)
0.6 2.5 GO:0045160 myosin I complex(GO:0045160)
0.5 8.6 GO:0043194 axon initial segment(GO:0043194)
0.5 5.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.5 2.1 GO:0000799 nuclear condensin complex(GO:0000799)
0.5 3.6 GO:0042584 chromaffin granule membrane(GO:0042584) dendritic spine neck(GO:0044326)
0.5 4.9 GO:0045180 basal cortex(GO:0045180)
0.4 9.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.4 2.8 GO:0000137 Golgi cis cisterna(GO:0000137)
0.4 3.6 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.4 2.6 GO:0036021 endolysosome lumen(GO:0036021)
0.4 1.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.3 2.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 3.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 2.8 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.3 4.5 GO:0033270 paranode region of axon(GO:0033270)
0.3 2.7 GO:0044327 dendritic spine head(GO:0044327)
0.3 3.4 GO:0097433 dense body(GO:0097433)
0.2 9.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 3.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 1.6 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.2 5.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 4.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 7.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 3.4 GO:0032059 bleb(GO:0032059)
0.2 9.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 9.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.2 GO:0036157 outer dynein arm(GO:0036157)
0.1 3.5 GO:0005861 troponin complex(GO:0005861)
0.1 1.2 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 6.2 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 3.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 10.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 13.1 GO:0005882 intermediate filament(GO:0005882)
0.1 1.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.9 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 2.1 GO:0030057 desmosome(GO:0030057)
0.1 0.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 4.8 GO:1990904 intracellular ribonucleoprotein complex(GO:0030529) ribonucleoprotein complex(GO:1990904)
0.1 7.3 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 2.3 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 2.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 7.6 GO:0042641 actomyosin(GO:0042641)
0.1 9.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 4.8 GO:0035580 specific granule lumen(GO:0035580)
0.1 10.8 GO:0001726 ruffle(GO:0001726)
0.1 3.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.1 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 0.6 GO:0097342 ripoptosome(GO:0097342)
0.0 2.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.7 GO:0000242 pericentriolar material(GO:0000242)
0.0 2.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 7.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 15.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.9 GO:1902554 serine/threonine protein kinase complex(GO:1902554)
0.0 10.1 GO:0043025 neuronal cell body(GO:0043025)
0.0 5.1 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 2.8 GO:0035579 specific granule membrane(GO:0035579)
0.0 1.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.4 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 8.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.9 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 3.4 GO:0098793 presynapse(GO:0098793)
0.0 5.8 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.5 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.4 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.9 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 2.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 5.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.4 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.0 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
3.7 21.9 GO:0003872 6-phosphofructokinase activity(GO:0003872)
3.5 14.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
2.8 27.8 GO:0042731 PH domain binding(GO:0042731)
2.4 7.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
2.2 15.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.8 5.5 GO:0010698 acetyltransferase activator activity(GO:0010698)
1.8 7.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
1.7 5.1 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
1.6 42.9 GO:0051010 microtubule plus-end binding(GO:0051010)
1.4 64.3 GO:0003785 actin monomer binding(GO:0003785)
1.4 6.9 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
1.3 3.9 GO:0032181 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
1.2 8.3 GO:0004673 protein histidine kinase activity(GO:0004673)
1.0 25.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.0 27.0 GO:0005523 tropomyosin binding(GO:0005523)
1.0 4.0 GO:0071987 WD40-repeat domain binding(GO:0071987)
1.0 4.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.9 2.8 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.9 6.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.8 3.4 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.8 7.3 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.8 4.8 GO:1990254 keratin filament binding(GO:1990254)
0.7 3.7 GO:0031708 endothelin B receptor binding(GO:0031708)
0.7 2.9 GO:0016361 activin receptor activity, type I(GO:0016361)
0.7 8.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.7 2.0 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.6 8.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.6 2.5 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.6 6.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.6 6.9 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.5 4.9 GO:0008158 hedgehog receptor activity(GO:0008158)
0.5 2.6 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.4 1.3 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.4 3.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.4 3.5 GO:0046923 ER retention sequence binding(GO:0046923)
0.4 2.2 GO:0045569 TRAIL binding(GO:0045569)
0.4 1.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.3 1.3 GO:0017040 ceramidase activity(GO:0017040)
0.3 3.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.3 1.3 GO:0098821 BMP receptor activity(GO:0098821)
0.3 5.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 10.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 14.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 9.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 5.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2 5.9 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 5.1 GO:0000339 RNA cap binding(GO:0000339)
0.2 3.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 5.5 GO:0030506 ankyrin binding(GO:0030506)
0.2 3.8 GO:0015250 water channel activity(GO:0015250)
0.2 0.7 GO:0004040 amidase activity(GO:0004040)
0.2 11.8 GO:0005504 fatty acid binding(GO:0005504)
0.2 10.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.2 3.0 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.2 0.7 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.2 7.1 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2 2.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.2 1.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 3.0 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2 5.2 GO:0032452 histone demethylase activity(GO:0032452)
0.1 2.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 1.5 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 5.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 9.8 GO:0019003 GDP binding(GO:0019003)
0.1 0.4 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.1 3.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 18.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.0 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.1 2.2 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 6.3 GO:0070888 E-box binding(GO:0070888)
0.1 2.5 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 0.9 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 1.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 11.5 GO:0005262 calcium channel activity(GO:0005262)
0.1 3.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 4.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.8 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.4 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 0.8 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 8.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 10.7 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.6 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.1 7.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 0.8 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 18.5 GO:0005525 GTP binding(GO:0005525)
0.1 3.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 6.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 9.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 2.7 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 3.6 GO:0005507 copper ion binding(GO:0005507)
0.1 3.4 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.3 GO:0032451 demethylase activity(GO:0032451)
0.0 1.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 4.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.1 GO:0003682 chromatin binding(GO:0003682)
0.0 0.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 2.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 2.9 GO:0046332 SMAD binding(GO:0046332)
0.0 6.0 GO:0008017 microtubule binding(GO:0008017)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 2.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0097602 cullin family protein binding(GO:0097602)
0.0 9.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 2.6 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 12.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 3.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.8 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 3.6 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 61.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.7 7.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.4 40.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 7.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.4 8.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.3 2.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.3 14.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 2.9 PID ALK2 PATHWAY ALK2 signaling events
0.2 10.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.2 8.9 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.2 11.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 13.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 18.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 6.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 6.6 PID ENDOTHELIN PATHWAY Endothelins
0.1 7.9 PID ATR PATHWAY ATR signaling pathway
0.1 9.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 6.9 PID AURORA B PATHWAY Aurora B signaling
0.1 2.2 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 4.3 NABA COLLAGENS Genes encoding collagen proteins
0.1 3.1 PID BMP PATHWAY BMP receptor signaling
0.1 5.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 4.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 1.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 4.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 4.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 3.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.7 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 2.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 6.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.2 SIG CHEMOTAXIS Genes related to chemotaxis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 67.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.7 35.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.6 9.9 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.5 15.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.4 8.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.4 7.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.4 14.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 23.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.4 10.5 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.4 6.9 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.3 9.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 3.8 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 9.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 8.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 9.3 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.2 2.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 2.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 8.3 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.1 6.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 2.0 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 4.0 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 4.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 4.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.4 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 3.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 2.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.0 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 13.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.7 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.1 1.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 4.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 5.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 2.2 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 2.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 3.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.7 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 1.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase