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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GGAAGAC
Z-value: 0.29
Motif logo
miRNA associated with seed GGAAGAC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-7-5p
|
MIMAT0000252 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_10979750 Show fit | 8.09 |
ENST00000339600.5
|
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa |
|
| chr5_-_111093406 Show fit | 7.05 |
ENST00000379671.3
|
neuronal regeneration related protein |
|
| chr2_-_161350305 Show fit | 6.78 |
ENST00000348849.3
|
RNA binding motif, single stranded interacting protein 1 |
|
| chr3_-_12705600 Show fit | 6.29 |
ENST00000542177.1
ENST00000442415.2 ENST00000251849.4 |
v-raf-1 murine leukemia viral oncogene homolog 1 |
|
| chr20_+_35202909 Show fit | 6.17 |
ENST00000558530.1
ENST00000558028.1 ENST00000560025.1 |
TGIF2-C20orf24 readthrough TGFB-induced factor homeobox 2 |
|
| chr1_+_113161778 Show fit | 6.06 |
ENST00000263168.3
|
capping protein (actin filament) muscle Z-line, alpha 1 |
|
| chr2_-_131850951 Show fit | 5.37 |
ENST00000409185.1
ENST00000389915.3 |
family with sequence similarity 168, member B |
|
| chr12_-_106641728 Show fit | 5.30 |
ENST00000378026.4
|
cytoskeleton-associated protein 4 |
|
| chr5_+_31532373 Show fit | 5.03 |
ENST00000325366.9
ENST00000355907.3 ENST00000507818.2 |
chromosome 5 open reading frame 22 |
|
| chr18_-_9614515 Show fit | 4.93 |
ENST00000400556.3
ENST00000400555.3 |
protein phosphatase 4, regulatory subunit 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GGAAGAC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.0 | GO:0006260 | DNA replication(GO:0006260) |
| 0.4 | 8.1 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.4 | 6.3 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
| 0.3 | 6.2 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.2 | 6.2 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.0 | 6.1 | GO:0048675 | axon extension(GO:0048675) |
| 0.5 | 5.3 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.0 | 5.0 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.5 | 4.6 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
| 0.2 | 4.4 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.1 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 7.0 | GO:0005874 | microtubule(GO:0005874) |
| 0.2 | 6.3 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.9 | 6.1 | GO:0071203 | WASH complex(GO:0071203) |
| 0.3 | 5.3 | GO:0042599 | lamellar body(GO:0042599) |
| 1.6 | 4.9 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
| 0.2 | 4.8 | GO:0046930 | pore complex(GO:0046930) |
| 0.4 | 4.6 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.3 | 4.5 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 4.5 | GO:0072562 | blood microparticle(GO:0072562) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.3 | 8.1 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.2 | 6.3 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.1 | 6.2 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 5.7 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.2 | 5.3 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.5 | 4.8 | GO:0015288 | porin activity(GO:0015288) |
| 0.2 | 4.8 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 1.6 | 4.7 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.1 | 4.6 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 6.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 5.5 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 5.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.7 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 3.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 3.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.9 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.6 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.2 | 10.0 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.2 | 8.2 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 8.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 7.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 6.1 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 5.4 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 5.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 4.7 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 4.5 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |