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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GGCAGUG
Z-value: 0.97
Motif logo
miRNA associated with seed GGCAGUG
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_10199468 Show fit | 29.59 |
ENST00000254976.2
ENST00000304886.2 |
synaptosomal-associated protein, 25kDa |
|
| chrX_+_64708615 Show fit | 27.91 |
ENST00000338957.4
ENST00000423889.3 |
zinc finger CCCH-type containing 12B |
|
| chr12_+_79258547 Show fit | 25.87 |
ENST00000457153.2
|
synaptotagmin I |
|
| chr10_+_105036909 Show fit | 22.72 |
ENST00000369849.4
|
internexin neuronal intermediate filament protein, alpha |
|
| chr17_-_8066250 Show fit | 18.46 |
ENST00000488857.1
ENST00000481878.1 ENST00000316509.6 ENST00000498285.1 |
vesicle-associated membrane protein 2 (synaptobrevin 2) Uncharacterized protein |
|
| chr2_+_203499901 Show fit | 17.65 |
ENST00000303116.6
ENST00000392238.2 |
family with sequence similarity 117, member B |
|
| chr9_-_104249319 Show fit | 17.02 |
ENST00000374847.1
|
transmembrane protein 246 |
|
| chr8_+_11141925 Show fit | 16.88 |
ENST00000221086.3
|
myotubularin related protein 9 |
|
| chr16_+_56225248 Show fit | 15.66 |
ENST00000262493.6
|
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O |
|
| chr17_+_43971643 Show fit | 15.42 |
ENST00000344290.5
ENST00000262410.5 ENST00000351559.5 ENST00000340799.5 ENST00000535772.1 ENST00000347967.5 |
microtubule-associated protein tau |
Network of associatons between targets according to the STRING database.
First level regulatory network of GGCAGUG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 29.2 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 8.6 | 25.9 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 2.3 | 22.7 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.1 | 20.3 | GO:0006661 | phosphatidylinositol biosynthetic process(GO:0006661) |
| 0.5 | 20.0 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.4 | 19.9 | GO:0014072 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 1.7 | 19.0 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 2.6 | 18.5 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 3.4 | 16.9 | GO:0051946 | regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920) |
| 3.1 | 15.4 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.5 | 50.2 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.1 | 33.1 | GO:0030425 | dendrite(GO:0030425) |
| 5.2 | 25.9 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 1.5 | 22.7 | GO:0005883 | neurofilament(GO:0005883) |
| 1.1 | 18.3 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.3 | 16.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.8 | 15.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 3.1 | 15.4 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.1 | 14.8 | GO:0043204 | perikaryon(GO:0043204) |
| 0.3 | 14.0 | GO:0031430 | M band(GO:0031430) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 52.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 41.4 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.3 | 32.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.6 | 29.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 5.2 | 25.9 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.2 | 22.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 22.3 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 1.4 | 18.8 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 1.4 | 15.7 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 3.9 | 15.4 | GO:0099609 | microtubule lateral binding(GO:0099609) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 25.9 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.5 | 18.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.9 | 18.1 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.6 | 11.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 11.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 10.0 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 8.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 6.3 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.2 | 6.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 5.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 76.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.7 | 24.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.4 | 17.2 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.5 | 16.1 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.3 | 15.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.5 | 15.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 14.9 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.8 | 14.7 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 10.8 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 9.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |