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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GGCUCAG
Z-value: 1.36
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miRNA associated with seed GGCUCAG
| Name | miRBASE accession |
|---|---|
|
hsa-miR-24-3p
|
MIMAT0000080 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GGCUCAG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 15.7 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 4.4 | 13.2 | GO:0072275 | metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
| 2.2 | 12.9 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
| 0.5 | 10.9 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
| 1.7 | 10.2 | GO:0030820 | regulation of cyclic nucleotide catabolic process(GO:0030805) regulation of cAMP catabolic process(GO:0030820) regulation of purine nucleotide catabolic process(GO:0033121) |
| 2.2 | 8.9 | GO:0009386 | translational attenuation(GO:0009386) |
| 0.3 | 8.3 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 2.0 | 8.0 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.3 | 8.0 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 8.0 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.3 | GO:0005730 | nucleolus(GO:0005730) |
| 1.0 | 15.7 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.2 | 12.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.4 | 12.0 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 11.5 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 1.6 | 11.2 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.0 | 10.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.1 | 10.3 | GO:0097425 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.0 | 10.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 10.0 | GO:0043202 | lysosomal lumen(GO:0043202) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 15.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 4.4 | 13.2 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.2 | 12.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 11.3 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 11.2 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.1 | 11.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 10.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 10.3 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.3 | 9.1 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 17.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.5 | 16.9 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.3 | 16.8 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.2 | 12.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 11.0 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.1 | 10.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 8.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 6.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 6.5 | PID FGF PATHWAY | FGF signaling pathway |
| 0.2 | 5.7 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.2 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.4 | 11.2 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.1 | 11.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.5 | 10.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.5 | 7.7 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.3 | 7.3 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.4 | 7.2 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 7.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 6.9 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.2 | 6.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |