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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GLI2
Z-value: 0.50
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Transcription factors associated with GLI2
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 52.6 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 1.3 | 41.8 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.8 | 36.8 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 1.9 | 33.7 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.7 | 31.4 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 0.4 | 29.7 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.3 | 28.0 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 2.7 | 27.2 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.2 | 24.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.3 | 23.3 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 66.6 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.7 | 62.7 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 47.8 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.8 | 37.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 6.1 | 36.9 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.2 | 32.6 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 5.8 | 29.1 | GO:0017102 | methionyl glutamyl tRNA synthetase complex(GO:0017102) |
| 0.2 | 26.8 | GO:0016605 | PML body(GO:0016605) |
| 1.5 | 26.4 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.2 | 23.1 | GO:0005903 | brush border(GO:0005903) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 39.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 5.3 | 36.9 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 1.6 | 33.9 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 3.0 | 33.5 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.7 | 32.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 6.4 | 32.0 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.1 | 31.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 30.5 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.3 | 28.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.6 | 27.8 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 79.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.6 | 53.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.6 | 33.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.7 | 32.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.5 | 32.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.6 | 30.0 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 1.9 | 27.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.5 | 25.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.4 | 25.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 23.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 67.6 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 1.8 | 44.5 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 1.4 | 33.9 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.8 | 30.2 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 1.2 | 29.6 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 1.0 | 28.8 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.6 | 28.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 27.7 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 1.0 | 27.2 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.2 | 24.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |