ISMARA results: GLI3

Project

GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for GLI3

Z-value: 0.84

Motif logo

Transcription factors associated with GLI3

Gene Symbol	Gene ID	Gene Info
GLI3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000106571.8	GLI family zinc finger 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GLI3	hg19_v2_chr7_-_42276612_42276782	0.34	1.8e-07	Click!

Activity profile of GLI3 motif

Sorted Z-values of GLI3 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_153839149 Show fit	24.09	ENST00000465093.1 ENST00000465817.1	ARHGEF26 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho guanine nucleotide exchange factor (GEF) 26
chr8_-_27462822 Show fit	15.32	ENST00000522098.1	CLU Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin
chr22_+_23247030 Show fit	13.72	ENST00000390324.2	IGLJ3 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda joining 3
chr19_+_35521616 Show fit	13.29	ENST00000595652.1	SCN1B Ensembl NCBI GeneCards UniProt NextProt Show fit	sodium channel, voltage-gated, type I, beta subunit
chr8_-_27468842 Show fit	13.08	ENST00000523500.1	CLU Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin
chr19_+_45417921 Show fit	12.88	ENST00000252491.4 ENST00000592885.1 ENST00000589781.1	APOC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	apolipoprotein C-I
chr11_-_111783919 Show fit	12.13	ENST00000531198.1 ENST00000533879.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr19_+_45417812 Show fit	12.07	ENST00000592535.1	APOC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	apolipoprotein C-I
chr5_-_42825983 Show fit	11.40	ENST00000506577.1	SEPP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	selenoprotein P, plasma, 1
chr11_-_111784005 Show fit	11.39	ENST00000527899.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of GLI3

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
11.6	46.5	GO:0010900	negative regulation of phosphatidylcholine catabolic process(GO:0010900)
6.1	36.4	GO:1902847	macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.7	30.5	GO:0007021	tubulin complex assembly(GO:0007021)
2.0	23.8	GO:0001886	endothelial cell morphogenesis(GO:0001886)
6.7	20.1	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
0.2	17.1	GO:0031338	regulation of vesicle fusion(GO:0031338)
0.2	16.3	GO:0007286	spermatid development(GO:0007286)
0.2	15.8	GO:0006910	phagocytosis, recognition(GO:0006910)
5.0	15.1	GO:0071140	resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
1.0	14.4	GO:0070050	neuron cellular homeostasis(GO:0070050)

Showing 1 to 10 of 414 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.7	46.7	GO:0042627	chylomicron(GO:0042627)
2.4	40.5	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.2	36.5	GO:0001726	ruffle(GO:0001726)
2.1	33.7	GO:0097512	cardiac myofibril(GO:0097512)
1.2	20.3	GO:0031095	platelet dense tubular network membrane(GO:0031095)
1.2	20.2	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.4	19.7	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.4	16.7	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
2.0	14.0	GO:0001520	outer dense fiber(GO:0001520)
0.0	13.1	GO:0045202	synapse(GO:0045202)

Showing 1 to 10 of 167 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
6.4	50.8	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.8	36.4	GO:0051787	misfolded protein binding(GO:0051787)
0.3	33.1	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.9	27.6	GO:0005212	structural constituent of eye lens(GO:0005212)
7.0	21.1	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.4	19.7	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.4	18.6	GO:0030507	spectrin binding(GO:0030507)
0.1	18.3	GO:0017137	Rab GTPase binding(GO:0017137)
0.3	17.0	GO:0070063	RNA polymerase binding(GO:0070063)
0.1	15.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)

Showing 1 to 10 of 287 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	47.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.4	22.3	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	20.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	13.4	PID IFNG PATHWAY	IFN-gamma pathway
0.1	12.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	11.8	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.2	9.9	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.3	9.2	PID S1P S1P3 PATHWAY	S1P3 pathway
0.4	9.0	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.2	8.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Showing 1 to 10 of 77 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	39.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.8	27.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.2	21.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.6	17.0	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.9	12.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.4	12.0	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	10.9	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.2	10.2	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.4	10.0	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.1	9.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases

Showing 1 to 10 of 99 entries

Results for GLI3

Z-value: 0.84

Motif logo

Transcription factors associated with GLI3

Activity-expression correlation:

Activity profile of GLI3 motif

Sorted Z-values of GLI3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of GLI3

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: