Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for GMEB2
Z-value: 1.40
Motif logo
Transcription factors associated with GMEB2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GMEB2 | hg19_v2_chr20_-_62258394_62258464 | 0.26 | 1.1e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GMEB2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 446.6 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 4.8 | 344.3 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 1.6 | 250.4 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 1.1 | 236.3 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 16.4 | 213.4 | GO:0000492 | box C/D snoRNP assembly(GO:0000492) |
| 3.1 | 150.3 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 3.3 | 145.0 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 14.5 | 116.1 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 1.0 | 104.9 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 17.4 | 104.3 | GO:0007296 | vitellogenesis(GO:0007296) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 330.5 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 25.7 | 308.0 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 8.8 | 238.5 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 26.7 | 213.4 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 1.5 | 161.9 | GO:0000776 | kinetochore(GO:0000776) |
| 8.3 | 149.2 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 6.5 | 129.9 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 2.0 | 105.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 11.5 | 103.3 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 23.5 | 94.0 | GO:1990423 | RZZ complex(GO:1990423) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 384.3 | GO:0003723 | RNA binding(GO:0003723) |
| 12.8 | 383.1 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.7 | 371.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 15.4 | 200.4 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 12.9 | 181.3 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 8.3 | 149.2 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 3.4 | 109.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 9.0 | 99.4 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 6.5 | 91.6 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 5.7 | 91.5 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 278.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 4.1 | 213.4 | PID MYC PATHWAY | C-MYC pathway |
| 1.5 | 138.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 2.1 | 128.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 3.1 | 107.0 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.9 | 68.3 | PID E2F PATHWAY | E2F transcription factor network |
| 1.0 | 63.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 1.6 | 61.4 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.9 | 60.5 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 1.6 | 58.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 450.6 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 2.7 | 362.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 3.2 | 340.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 2.0 | 211.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 7.9 | 181.6 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 2.1 | 158.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.3 | 144.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 8.1 | 128.9 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 3.7 | 119.2 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 2.0 | 109.5 | REACTOME TRNA AMINOACYLATION | Genes involved in tRNA Aminoacylation |