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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GRHL1
Z-value: 0.52
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Transcription factors associated with GRHL1
Network of associatons between targets according to the STRING database.
First level regulatory network of GRHL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 9.7 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 2.7 | 8.1 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 1.0 | 7.9 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 2.6 | 7.8 | GO:0006425 | glutaminyl-tRNA aminoacylation(GO:0006425) |
| 0.3 | 7.1 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.7 | 6.8 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.4 | 6.6 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.1 | 5.8 | GO:0070125 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 0.2 | 5.7 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.2 | 5.2 | GO:0050961 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 8.1 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.2 | 7.9 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.4 | 7.8 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.5 | 7.1 | GO:0008290 | F-actin capping protein complex(GO:0008290) Flemming body(GO:0090543) |
| 0.8 | 6.8 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.5 | 6.6 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.1 | 6.3 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 5.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.6 | 5.7 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.7 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 2.7 | 8.1 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 0.1 | 7.9 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 2.6 | 7.8 | GO:0004819 | glutamine-tRNA ligase activity(GO:0004819) |
| 0.0 | 7.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 6.6 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 6.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 5.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 5.7 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 5.2 | GO:0016887 | ATPase activity(GO:0016887) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 8.8 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 5.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 3.4 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 3.1 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 2.5 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 2.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.9 | PID P53 REGULATION PATHWAY | p53 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.3 | 8.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 8.1 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 7.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.4 | 7.8 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 6.8 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.2 | 5.7 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 5.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 5.0 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.1 | 4.3 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |