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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for GSC_GSC2

Z-value: 0.51

Motif logo

Transcription factors associated with GSC_GSC2

Gene Symbol Gene ID Gene Info
ENSG00000133937.3 goosecoid homeobox
ENSG00000063515.2 goosecoid homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GSC2hg19_v2_chr22_-_19137796_191377960.503.2e-15Click!

Activity profile of GSC_GSC2 motif

Sorted Z-values of GSC_GSC2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_169079823 26.71 ENST00000367813.3
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_-_175711133 21.32 ENST00000409597.1
ENST00000413882.1
chimerin 1
chr11_-_111794446 16.48 ENST00000527950.1
crystallin, alpha B
chr11_-_111783595 14.66 ENST00000528628.1
crystallin, alpha B
chr6_+_111580508 14.01 ENST00000368847.4
KIAA1919
chr14_-_101034407 12.03 ENST00000443071.2
ENST00000557378.1
brain-enriched guanylate kinase-associated
chr11_-_76155618 11.94 ENST00000530759.1
RP11-111M22.3
chr11_-_76155700 11.85 ENST00000572035.1
RP11-111M22.3
chr9_+_17134980 9.82 ENST00000380647.3
centlein, centrosomal protein
chrX_-_54384425 9.67 ENST00000375169.3
ENST00000354646.2
WNK lysine deficient protein kinase 3
chr19_-_36247910 9.36 ENST00000587965.1
ENST00000004982.3
heat shock protein, alpha-crystallin-related, B6
chrX_+_135279179 8.24 ENST00000370676.3
four and a half LIM domains 1
chrX_+_100333709 8.23 ENST00000372930.4
transmembrane protein 35
chr1_+_20396649 8.15 ENST00000375108.3
phospholipase A2, group V
chr20_-_18774614 8.10 ENST00000412553.1
long intergenic non-protein coding RNA 652
chr9_-_13279563 8.07 ENST00000541718.1
multiple PDZ domain protein
chr7_-_97881429 7.88 ENST00000420697.1
ENST00000379795.3
ENST00000415086.1
ENST00000542604.1
ENST00000447648.2
tectonin beta-propeller repeat containing 1
chr9_+_103204553 7.88 ENST00000502978.1
ENST00000334943.6
MSANTD3-TMEFF1 readthrough
transmembrane protein with EGF-like and two follistatin-like domains 1
chr3_-_170626418 7.78 ENST00000474096.1
ENST00000295822.2
eukaryotic translation initiation factor 5A2
chr6_+_121756809 7.71 ENST00000282561.3
gap junction protein, alpha 1, 43kDa
chr18_-_64271363 7.38 ENST00000262150.2
cadherin 19, type 2
chr11_+_61522844 7.29 ENST00000265460.5
myelin regulatory factor
chr11_+_76156045 7.21 ENST00000533988.1
ENST00000524490.1
ENST00000334736.3
ENST00000343878.3
ENST00000533972.1
chromosome 11 open reading frame 30
chr2_+_120770645 6.93 ENST00000443902.2
erythrocyte membrane protein band 4.1 like 5
chr9_+_17135016 6.41 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
centlein, centrosomal protein
chr10_+_74451883 6.33 ENST00000373053.3
ENST00000357157.6
mitochondrial calcium uniporter
chr9_-_13279589 6.26 ENST00000319217.7
multiple PDZ domain protein
chr17_-_26903900 6.16 ENST00000395319.3
ENST00000581807.1
ENST00000584086.1
ENST00000395321.2
aldolase C, fructose-bisphosphate
chr2_+_120770581 5.82 ENST00000263713.5
erythrocyte membrane protein band 4.1 like 5
chr5_+_140868717 5.67 ENST00000252087.1
protocadherin gamma subfamily C, 5
chrX_-_6146876 5.21 ENST00000381095.3
neuroligin 4, X-linked
chr11_-_62783303 5.16 ENST00000336232.2
ENST00000430500.2
solute carrier family 22 (organic anion transporter), member 8
chr3_-_10547192 5.10 ENST00000360273.2
ENST00000343816.4
ATPase, Ca++ transporting, plasma membrane 2
chr17_-_48207157 5.06 ENST00000330175.4
ENST00000503131.1
sterile alpha motif domain containing 14
chr11_-_62783276 5.04 ENST00000535878.1
ENST00000545207.1
solute carrier family 22 (organic anion transporter), member 8
chr3_-_98241358 4.97 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
claudin domain containing 1
chrX_-_10588595 4.91 ENST00000423614.1
ENST00000317552.4
midline 1 (Opitz/BBB syndrome)
chrX_-_48931648 4.87 ENST00000376386.3
ENST00000376390.4
PRA1 domain family, member 2
chr8_-_133123406 4.72 ENST00000434736.2
HERV-H LTR-associating 1
chr10_+_102222798 4.53 ENST00000343737.5
wingless-type MMTV integration site family, member 8B
chr13_+_73632897 4.46 ENST00000377687.4
Kruppel-like factor 5 (intestinal)
chrX_-_10588459 4.37 ENST00000380782.2
midline 1 (Opitz/BBB syndrome)
chr14_+_96722152 4.25 ENST00000216629.6
bradykinin receptor B1
chr5_+_161274940 4.25 ENST00000393943.4
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_+_70916119 4.20 ENST00000246896.3
ENST00000511674.1
histatin 1
chr5_+_161274685 4.11 ENST00000428797.2
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_-_40021656 4.00 ENST00000319121.3
kelch-like family member 11
chr17_+_44668035 3.98 ENST00000398238.4
ENST00000225282.8
N-ethylmaleimide-sensitive factor
chr4_-_16077741 3.96 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
prominin 1
chr18_+_32290218 3.96 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
dystrobrevin, alpha
chr4_+_70894130 3.87 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
histatin 3
chr5_-_149324306 3.82 ENST00000255266.5
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr19_-_48547294 3.74 ENST00000293255.2
calcium binding protein 5
chr8_-_87755878 3.72 ENST00000320005.5
cyclic nucleotide gated channel beta 3
chr6_+_35310391 3.71 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
peroxisome proliferator-activated receptor delta
chr10_-_104178857 3.66 ENST00000020673.5
pleckstrin and Sec7 domain containing
chrX_+_135278908 3.53 ENST00000539015.1
ENST00000370683.1
four and a half LIM domains 1
chr7_-_128415844 3.49 ENST00000249389.2
opsin 1 (cone pigments), short-wave-sensitive
chr2_+_189156638 3.39 ENST00000410051.1
GULP, engulfment adaptor PTB domain containing 1
chr3_-_49058479 3.20 ENST00000440857.1
DALR anticodon binding domain containing 3
chr1_-_47655686 3.17 ENST00000294338.2
PDZK1 interacting protein 1
chr15_-_27184664 3.16 ENST00000541819.2
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr7_+_138482695 3.15 ENST00000422794.2
ENST00000397602.3
ENST00000442682.2
ENST00000458494.1
ENST00000413208.1
transmembrane protein 213
chr12_+_7941989 3.01 ENST00000229307.4
Nanog homeobox
chr5_+_161275320 2.91 ENST00000437025.2
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_-_19651654 2.89 ENST00000395555.3
aldehyde dehydrogenase 3 family, member A1
chr1_+_17248418 2.85 ENST00000375541.5
ciliary rootlet coiled-coil, rootletin
chr6_+_35310312 2.77 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
peroxisome proliferator-activated receptor delta
chr11_-_128712362 2.75 ENST00000392664.2
potassium inwardly-rectifying channel, subfamily J, member 1
chr5_-_33984741 2.73 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
solute carrier family 45, member 2
chr12_-_77272765 2.72 ENST00000547435.1
ENST00000552330.1
ENST00000546966.1
ENST00000311083.5
cysteine and glycine-rich protein 2
chr4_+_170541678 2.71 ENST00000360642.3
ENST00000512813.1
chloride channel, voltage-sensitive 3
chr19_-_55866061 2.69 ENST00000588572.2
ENST00000593184.1
ENST00000589467.1
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr17_-_40264692 2.67 ENST00000591220.1
ENST00000251642.3
DEXH (Asp-Glu-X-His) box polypeptide 58
chr22_-_19137796 2.67 ENST00000086933.2
goosecoid homeobox 2
chr17_-_19651668 2.66 ENST00000494157.2
ENST00000225740.6
aldehyde dehydrogenase 3 family, member A1
chr19_-_49520338 2.63 ENST00000221421.2
luteinizing hormone beta polypeptide
chr2_-_30144432 2.63 ENST00000389048.3
anaplastic lymphoma receptor tyrosine kinase
chr16_-_3074231 2.62 ENST00000572355.1
ENST00000248089.3
ENST00000574980.1
ENST00000354679.3
ENST00000396916.1
ENST00000573842.1
host cell factor C1 regulator 1 (XPO1 dependent)
chr19_-_49560987 2.59 ENST00000596965.1
chorionic gonadotropin, beta polypeptide 7
chr16_-_68269971 2.59 ENST00000565858.1
epithelial splicing regulatory protein 2
chr17_+_68100989 2.59 ENST00000585558.1
ENST00000392670.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr19_-_10121144 2.56 ENST00000264828.3
collagen, type V, alpha 3
chr5_-_33984786 2.48 ENST00000296589.4
solute carrier family 45, member 2
chr4_+_169552748 2.46 ENST00000504519.1
ENST00000512127.1
palladin, cytoskeletal associated protein
chr5_-_146461027 2.38 ENST00000394410.2
ENST00000508267.1
ENST00000504198.1
protein phosphatase 2, regulatory subunit B, beta
chr19_-_42931567 2.25 ENST00000244289.4
lipase, hormone-sensitive
chr17_+_77020325 2.22 ENST00000311661.4
C1q and tumor necrosis factor related protein 1
chr12_-_13248598 2.14 ENST00000337630.6
ENST00000545699.1
germ cell associated 1
chr1_+_114447763 2.08 ENST00000369563.3
DNA cross-link repair 1B
chr11_-_35440579 2.03 ENST00000606205.1
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr17_+_77020224 1.96 ENST00000339142.2
C1q and tumor necrosis factor related protein 1
chr3_+_36421826 1.92 ENST00000273183.3
SH3 and cysteine rich domain
chrX_+_15767971 1.90 ENST00000479740.1
ENST00000454127.2
carbonic anhydrase VB, mitochondrial
chr1_+_197237352 1.85 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
crumbs homolog 1 (Drosophila)
chr16_-_58004992 1.83 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
cyclic nucleotide gated channel beta 1
chr1_+_244816237 1.82 ENST00000302550.11
desumoylating isopeptidase 2
chr19_+_2476116 1.80 ENST00000215631.4
ENST00000587345.1
growth arrest and DNA-damage-inducible, beta
chr12_+_81101277 1.78 ENST00000228641.3
myogenic factor 6 (herculin)
chr12_-_113574028 1.77 ENST00000546530.1
ENST00000261729.5
RAS protein activator like 1 (GAP1 like)
chrX_-_138724994 1.74 ENST00000536274.1
MCF.2 cell line derived transforming sequence
chr1_+_18957500 1.73 ENST00000375375.3
paired box 7
chr14_+_21785693 1.72 ENST00000382933.4
ENST00000557351.1
retinitis pigmentosa GTPase regulator interacting protein 1
chr18_-_24443151 1.69 ENST00000440832.3
aquaporin 4
chr2_+_189156389 1.66 ENST00000409843.1
GULP, engulfment adaptor PTB domain containing 1
chr14_-_24551195 1.63 ENST00000560550.1
neural retina leucine zipper
chr11_-_35440796 1.62 ENST00000278379.3
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_-_86001210 1.62 ENST00000372105.3
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr6_+_31588478 1.56 ENST00000376007.4
ENST00000376033.2
proline-rich coiled-coil 2A
chrX_-_138724677 1.49 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF.2 cell line derived transforming sequence
chr1_-_21606013 1.47 ENST00000357071.4
endothelin converting enzyme 1
chr14_-_24551137 1.47 ENST00000396995.1
neural retina leucine zipper
chr8_+_70378852 1.42 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
sulfatase 1
chr1_+_11751748 1.41 ENST00000294485.5
dorsal inhibitory axon guidance protein
chr17_-_9808887 1.37 ENST00000226193.5
recoverin
chr15_-_31453359 1.29 ENST00000542188.1
transient receptor potential cation channel, subfamily M, member 1
chr6_-_35480640 1.29 ENST00000428978.1
ENST00000322263.4
tubby like protein 1
chr10_-_126849588 1.29 ENST00000411419.2
C-terminal binding protein 2
chr1_+_244816371 1.26 ENST00000263831.7
desumoylating isopeptidase 2
chr22_-_40929812 1.22 ENST00000422851.1
megakaryoblastic leukemia (translocation) 1
chr11_-_62752455 1.20 ENST00000360421.4
solute carrier family 22 (organic anion transporter), member 6
chr7_-_138482933 1.14 ENST00000310018.2
ATPase, H+ transporting, lysosomal V0 subunit a4
chr12_-_13248562 1.11 ENST00000457134.2
ENST00000537302.1
germ cell associated 1
chr11_-_62752429 1.10 ENST00000377871.3
solute carrier family 22 (organic anion transporter), member 6
chr16_+_69373323 1.08 ENST00000254940.5
NIP7, nucleolar pre-rRNA processing protein
chr4_+_170541660 1.07 ENST00000513761.1
ENST00000347613.4
chloride channel, voltage-sensitive 3
chr22_-_29663954 1.00 ENST00000216085.7
rhomboid domain containing 3
chr10_-_76868931 1.00 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
dual specificity phosphatase 13
chr12_+_53818855 0.98 ENST00000550839.1
anti-Mullerian hormone receptor, type II
chrX_-_24665353 0.98 ENST00000379144.2
phosphate cytidylyltransferase 1, choline, beta
chr15_-_43559055 0.97 ENST00000220420.5
ENST00000349114.4
transglutaminase 5
chr4_-_76823681 0.96 ENST00000286719.7
protein phosphatase, EF-hand calcium binding domain 2
chr4_+_170541835 0.95 ENST00000504131.2
chloride channel, voltage-sensitive 3
chr8_-_116681221 0.94 ENST00000395715.3
trichorhinophalangeal syndrome I
chrX_-_49089771 0.94 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr6_-_41130841 0.88 ENST00000373122.4
triggering receptor expressed on myeloid cells 2
chr11_-_62752162 0.88 ENST00000458333.2
ENST00000421062.2
solute carrier family 22 (organic anion transporter), member 6
chr6_-_41130914 0.85 ENST00000373113.3
ENST00000338469.3
triggering receptor expressed on myeloid cells 2
chr12_-_13248705 0.83 ENST00000396310.2
germ cell associated 1
chr7_-_138482849 0.76 ENST00000353492.4
ATPase, H+ transporting, lysosomal V0 subunit a4
chrX_+_107069063 0.76 ENST00000262843.6
midline 2
chr1_+_114522049 0.75 ENST00000369551.1
ENST00000320334.4
olfactomedin-like 3
chr11_+_44587141 0.73 ENST00000227155.4
ENST00000342935.3
ENST00000532544.1
CD82 molecule
chr3_-_54962100 0.73 ENST00000273286.5
leucine-rich repeats and transmembrane domains 1
chr1_+_202431859 0.65 ENST00000391959.3
ENST00000367270.4
protein phosphatase 1, regulatory subunit 12B
chr2_+_189156586 0.63 ENST00000409830.1
GULP, engulfment adaptor PTB domain containing 1
chr2_+_189156721 0.61 ENST00000409927.1
ENST00000409805.1
GULP, engulfment adaptor PTB domain containing 1
chr1_-_165414414 0.60 ENST00000359842.5
retinoid X receptor, gamma
chrY_+_16634483 0.55 ENST00000382872.1
neuroligin 4, Y-linked
chr19_+_40877583 0.49 ENST00000596470.1
phospholipase D family, member 3
chrX_+_99899180 0.48 ENST00000373004.3
sushi-repeat containing protein, X-linked 2
chr10_+_118350468 0.46 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
pancreatic lipase-related protein 1
chr2_+_128175997 0.45 ENST00000234071.3
ENST00000429925.1
ENST00000442644.1
ENST00000453608.2
protein C (inactivator of coagulation factors Va and VIIIa)
chr6_-_35480705 0.43 ENST00000229771.6
tubby like protein 1
chr15_+_96876340 0.36 ENST00000453270.2
nuclear receptor subfamily 2, group F, member 2
chr15_+_48498480 0.33 ENST00000380993.3
ENST00000396577.3
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr12_-_13248732 0.32 ENST00000396302.3
germ cell associated 1
chr10_+_52750930 0.25 ENST00000401604.2
protein kinase, cGMP-dependent, type I
chrX_+_41306575 0.25 ENST00000342595.2
ENST00000378220.1
nyctalopin
chr5_-_16738451 0.20 ENST00000274203.9
ENST00000515803.1
myosin X
chr13_-_36050819 0.17 ENST00000379919.4
mab-21-like 1 (C. elegans)
chr11_+_124735282 0.13 ENST00000397801.1
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr6_-_42690312 0.09 ENST00000230381.5
peripherin 2 (retinal degeneration, slow)
chr16_+_87636474 0.04 ENST00000284262.2
junctophilin 3
chr1_+_159409512 0.01 ENST00000423932.3
olfactory receptor, family 10, subfamily J, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of GSC_GSC2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 26.7 GO:1903288 protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288)
4.3 12.8 GO:0003383 apical constriction(GO:0003383) mesoderm migration involved in gastrulation(GO:0007509)
2.4 9.7 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
2.0 8.2 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
1.9 7.7 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
1.7 31.1 GO:0007021 tubulin complex assembly(GO:0007021)
1.1 3.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
1.1 19.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
1.1 3.2 GO:0097254 renal tubular secretion(GO:0097254)
1.1 6.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
1.0 4.2 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
1.0 4.0 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
1.0 7.8 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.9 4.7 GO:0048388 endosomal lumen acidification(GO:0048388)
0.8 14.4 GO:0071420 cellular response to histamine(GO:0071420)
0.8 3.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.8 10.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.7 8.2 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.7 5.2 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.7 7.3 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.7 2.1 GO:0031627 telomeric loop formation(GO:0031627)
0.7 2.7 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of MDA-5 signaling pathway(GO:1900245)
0.7 2.6 GO:0036269 swimming behavior(GO:0036269)
0.6 3.2 GO:0048066 developmental pigmentation(GO:0048066)
0.6 21.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.6 1.7 GO:0032499 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499)
0.5 3.0 GO:0001714 endodermal cell fate specification(GO:0001714)
0.5 4.5 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.5 3.7 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.5 4.5 GO:0048263 determination of dorsal identity(GO:0048263)
0.4 2.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.4 1.5 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.3 6.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 2.6 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.3 4.5 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.3 9.4 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.3 10.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 1.0 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.2 1.0 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.2 11.8 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.2 7.9 GO:0097352 autophagosome maturation(GO:0097352)
0.2 3.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.2 4.9 GO:0015813 L-glutamate transport(GO:0015813)
0.2 1.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.2 8.1 GO:0050832 defense response to fungus(GO:0050832)
0.2 3.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 1.9 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 4.0 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.2 1.8 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.2 5.3 GO:0010107 potassium ion import(GO:0010107)
0.2 1.4 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.2 1.4 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.2 0.5 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.1 3.8 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 4.3 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.1 3.7 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 2.5 GO:0003334 keratinocyte development(GO:0003334)
0.1 2.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 2.6 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 1.4 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 0.5 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.1 1.8 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.1 0.4 GO:0060849 radial pattern formation(GO:0009956) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 13.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.6 GO:0030199 collagen fibril organization(GO:0030199)
0.1 6.2 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 1.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 2.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 3.6 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.0 1.9 GO:0006730 one-carbon metabolic process(GO:0006730) bicarbonate transport(GO:0015701)
0.0 1.7 GO:0003091 renal water homeostasis(GO:0003091)
0.0 5.5 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 0.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.4 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 1.0 GO:0018149 peptide cross-linking(GO:0018149)
0.0 2.6 GO:0007292 female gamete generation(GO:0007292)
0.0 3.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.0 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 1.1 GO:0042255 ribosome assembly(GO:0042255)
0.0 4.0 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 1.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 3.7 GO:0042391 regulation of membrane potential(GO:0042391)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 31.1 GO:0097512 cardiac myofibril(GO:0097512)
1.6 6.3 GO:1990246 uniplex complex(GO:1990246)
1.3 26.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.9 2.6 GO:0005588 collagen type V trimer(GO:0005588)
0.7 14.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.6 7.7 GO:0005916 fascia adherens(GO:0005916)
0.4 14.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.4 2.7 GO:0030061 mitochondrial crista(GO:0030061)
0.4 1.5 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.3 4.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 6.7 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.2 2.9 GO:0035253 ciliary rootlet(GO:0035253)
0.2 1.9 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 7.9 GO:0000421 autophagosome membrane(GO:0000421)
0.2 0.7 GO:0035838 growing cell tip(GO:0035838)
0.1 16.2 GO:0005814 centriole(GO:0005814)
0.1 9.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 3.7 GO:0030673 axolemma(GO:0030673)
0.1 6.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 14.8 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 4.0 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 2.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 6.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 7.8 GO:0005643 nuclear pore(GO:0005643)
0.1 5.4 GO:0005901 caveola(GO:0005901)
0.1 2.5 GO:0002102 podosome(GO:0002102)
0.0 5.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 4.2 GO:0005581 collagen trimer(GO:0005581)
0.0 4.7 GO:0031902 late endosome membrane(GO:0031902)
0.0 2.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 5.9 GO:0042383 sarcolemma(GO:0042383)
0.0 1.8 GO:0005902 microvillus(GO:0005902)
0.0 3.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 14.5 GO:0005925 focal adhesion(GO:0005925)
0.0 0.7 GO:0031672 A band(GO:0031672)
0.0 4.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 24.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 2.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.0 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.7 GO:0005912 adherens junction(GO:0005912)
0.0 1.4 GO:0005795 Golgi stack(GO:0005795)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 26.7 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
1.4 4.3 GO:0004947 bradykinin receptor activity(GO:0004947)
1.4 11.3 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.3 40.5 GO:0005212 structural constituent of eye lens(GO:0005212)
1.3 7.7 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
1.1 5.5 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
1.1 3.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.9 9.7 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.8 8.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.8 5.6 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.8 4.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.7 2.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.6 6.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.5 3.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 2.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.4 21.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.4 13.4 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.4 5.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 2.6 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.4 1.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 5.2 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.3 3.5 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.3 3.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.3 7.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 1.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.3 7.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 2.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.2 1.7 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.2 1.0 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.2 6.5 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.2 5.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 3.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 2.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 3.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 4.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 4.5 GO:0005109 frizzled binding(GO:0005109)
0.1 0.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 1.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 2.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 10.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 12.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 16.2 GO:0030674 protein binding, bridging(GO:0030674)
0.1 11.8 GO:0044325 ion channel binding(GO:0044325)
0.1 2.6 GO:0043394 proteoglycan binding(GO:0043394)
0.1 1.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 8.0 GO:0005262 calcium channel activity(GO:0005262)
0.1 2.9 GO:0019894 kinesin binding(GO:0019894)
0.1 1.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 4.1 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 4.2 GO:0005518 collagen binding(GO:0005518)
0.0 1.7 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 2.7 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.0 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 3.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 4.3 GO:0005179 hormone activity(GO:0005179)
0.0 1.8 GO:0070888 E-box binding(GO:0070888)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 5.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 14.1 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 21.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 7.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 5.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 6.3 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 2.2 ST GA12 PATHWAY G alpha 12 Pathway
0.1 2.6 NABA COLLAGENS Genes encoding collagen proteins
0.1 1.0 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 2.4 PID ATR PATHWAY ATR signaling pathway
0.0 2.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 4.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 4.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.6 26.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.5 8.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.5 14.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.4 7.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.3 3.5 REACTOME OPSINS Genes involved in Opsins
0.2 8.2 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 5.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.2 5.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 2.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 1.7 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.2 4.0 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 24.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.9 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 6.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 5.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 4.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors