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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GSC_GSC2
Z-value: 0.51
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Transcription factors associated with GSC_GSC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GSC2 | hg19_v2_chr22_-_19137796_19137796 | 0.50 | 3.2e-15 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_169079823 Show fit | 26.71 |
ENST00000367813.3
|
ATPase, Na+/K+ transporting, beta 1 polypeptide |
|
| chr2_-_175711133 Show fit | 21.32 |
ENST00000409597.1
ENST00000413882.1 |
chimerin 1 |
|
| chr11_-_111794446 Show fit | 16.48 |
ENST00000527950.1
|
crystallin, alpha B |
|
| chr11_-_111783595 Show fit | 14.66 |
ENST00000528628.1
|
crystallin, alpha B |
|
| chr6_+_111580508 Show fit | 14.01 |
ENST00000368847.4
|
KIAA1919 |
|
| chr14_-_101034407 Show fit | 12.03 |
ENST00000443071.2
ENST00000557378.1 |
brain-enriched guanylate kinase-associated |
|
| chr11_-_76155618 Show fit | 11.94 |
ENST00000530759.1
|
RP11-111M22.3 |
|
| chr11_-_76155700 Show fit | 11.85 |
ENST00000572035.1
|
RP11-111M22.3 |
|
| chr9_+_17134980 Show fit | 9.82 |
ENST00000380647.3
|
centlein, centrosomal protein |
|
| chrX_-_54384425 Show fit | 9.67 |
ENST00000375169.3
ENST00000354646.2 |
WNK lysine deficient protein kinase 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GSC_GSC2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 31.1 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 6.7 | 26.7 | GO:1903288 | protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288) |
| 0.6 | 21.3 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 1.1 | 19.1 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.8 | 14.4 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 13.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 4.3 | 12.8 | GO:0003383 | apical constriction(GO:0003383) mesoderm migration involved in gastrulation(GO:0007509) |
| 0.2 | 11.8 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.3 | 10.2 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.8 | 10.0 | GO:0035372 | protein localization to microtubule(GO:0035372) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 31.1 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.3 | 26.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 24.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 16.2 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 14.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 14.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.4 | 14.4 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.7 | 14.3 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 9.3 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.2 | 7.9 | GO:0000421 | autophagosome membrane(GO:0000421) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 40.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 1.7 | 26.7 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.4 | 21.3 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 16.2 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 14.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.4 | 13.4 | GO:0015301 | anion:anion antiporter activity(GO:0015301) |
| 0.1 | 12.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 11.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 1.4 | 11.3 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.1 | 10.0 | GO:0051219 | phosphoprotein binding(GO:0051219) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 7.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 6.3 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 5.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 4.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.7 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 2.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 2.3 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 26.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 24.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.5 | 14.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.6 | 13.4 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.5 | 8.2 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.2 | 8.2 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.4 | 7.7 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 6.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 5.3 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.2 | 5.1 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |