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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GUAAACA
Z-value: 0.42
Motif logo
miRNA associated with seed GUAAACA
Network of associatons between targets according to the STRING database.
First level regulatory network of GUAAACA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.3 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 3.3 | 10.0 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 0.3 | 8.2 | GO:0035640 | exploration behavior(GO:0035640) |
| 0.1 | 8.2 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.1 | 8.2 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.2 | 7.9 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 7.5 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.1 | 7.3 | GO:0032411 | positive regulation of transporter activity(GO:0032411) |
| 0.1 | 6.1 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.5 | 6.0 | GO:0043249 | erythrocyte maturation(GO:0043249) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 79.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.3 | 14.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 14.2 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.6 | 10.1 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.3 | 10.0 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.2 | 9.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 9.8 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.2 | 9.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 9.3 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 1.6 | 7.9 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.0 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.2 | 15.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 12.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.5 | 10.0 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.2 | 8.5 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 1.1 | 8.0 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.7 | 7.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 7.6 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.2 | 7.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.3 | 7.1 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 7.9 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 6.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 6.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 5.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 4.9 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.2 | 4.8 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 4.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 4.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 4.1 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.0 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 9.1 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.2 | 8.8 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.2 | 8.0 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.3 | 7.9 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.4 | 6.3 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.2 | 6.1 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.3 | 5.9 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 5.8 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.2 | 5.6 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |