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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GUAGUGU
Z-value: 0.46
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miRNA associated with seed GUAGUGU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-142-3p.1
|
MIMAT0000434 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_38869410 Show fit | 19.03 |
ENST00000358869.2
|
family with sequence similarity 114, member A1 |
|
| chr2_+_187454749 Show fit | 18.54 |
ENST00000261023.3
ENST00000374907.3 |
integrin, alpha V |
|
| chr22_-_36236265 Show fit | 13.89 |
ENST00000414461.2
ENST00000416721.2 ENST00000449924.2 ENST00000262829.7 ENST00000397305.3 |
RNA binding protein, fox-1 homolog (C. elegans) 2 |
|
| chr2_+_198365122 Show fit | 13.31 |
ENST00000604458.1
|
HSPE1-MOB4 readthrough |
|
| chr12_+_66217911 Show fit | 12.60 |
ENST00000403681.2
|
high mobility group AT-hook 2 |
|
| chr2_-_86790593 Show fit | 12.42 |
ENST00000263856.4
ENST00000409225.2 |
charged multivesicular body protein 3 |
|
| chr11_+_9406169 Show fit | 12.07 |
ENST00000379719.3
ENST00000527431.1 |
importin 7 |
|
| chr6_+_114178512 Show fit | 12.01 |
ENST00000368635.4
|
myristoylated alanine-rich protein kinase C substrate |
|
| chr6_+_13615554 Show fit | 11.93 |
ENST00000451315.2
|
nucleolar protein 7, 27kDa |
|
| chr19_+_16187085 Show fit | 11.56 |
ENST00000300933.4
|
tropomyosin 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GUAGUGU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 18.5 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 2.3 | 13.9 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.0 | 13.3 | GO:0006457 | protein folding(GO:0006457) |
| 4.2 | 12.6 | GO:2000685 | mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685) |
| 1.6 | 12.4 | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) |
| 0.1 | 12.2 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.6 | 12.0 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 11.8 | GO:2001020 | regulation of response to DNA damage stimulus(GO:2001020) |
| 0.1 | 11.6 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.1 | 11.3 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.2 | 18.5 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.1 | 15.3 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.2 | 15.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 14.7 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 2.6 | 13.0 | GO:0097513 | myosin II filament(GO:0097513) |
| 1.1 | 12.6 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 1.0 | 12.4 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.8 | 12.0 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.1 | 11.9 | GO:0030175 | filopodium(GO:0030175) |
| 0.6 | 11.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.6 | 13.0 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 12.9 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 4.2 | 12.6 | GO:0035501 | MH1 domain binding(GO:0035501) |
| 2.5 | 12.6 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.7 | 12.4 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.3 | 12.1 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 11.8 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.2 | 11.6 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.1 | 11.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 24.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.4 | 21.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.5 | 14.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 12.0 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 11.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 8.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 6.7 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 6.7 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 6.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 5.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 23.5 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.5 | 22.3 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.4 | 21.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.0 | 18.5 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 1.1 | 11.7 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.3 | 11.2 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 1.0 | 11.1 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.4 | 8.1 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 7.3 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 6.7 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |