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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GUGCAAA
Z-value: 0.09
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miRNA associated with seed GUGCAAA
Network of associatons between targets according to the STRING database.
First level regulatory network of GUGCAAA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 31.5 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 7.5 | 22.6 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.2 | 21.6 | GO:0010812 | negative regulation of cell-substrate adhesion(GO:0010812) |
| 1.9 | 19.1 | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) |
| 6.2 | 18.5 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 4.6 | 18.5 | GO:0010645 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 0.1 | 17.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.7 | 16.8 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
| 3.1 | 15.5 | GO:0097338 | response to clozapine(GO:0097338) |
| 4.8 | 14.3 | GO:2000681 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 27.8 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.8 | 23.8 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.2 | 23.2 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.2 | 22.5 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.2 | 21.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.8 | 19.2 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 3.7 | 18.5 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 1.2 | 18.5 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.5 | 18.4 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 16.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 35.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.4 | 30.4 | GO:0019003 | GDP binding(GO:0019003) |
| 1.0 | 25.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 5.0 | 20.2 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.0 | 19.9 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 18.7 | GO:0005525 | GTP binding(GO:0005525) |
| 3.7 | 18.5 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 3.1 | 18.5 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 0.4 | 18.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 18.0 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.9 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.4 | 25.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.4 | 19.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 18.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.4 | 17.8 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.4 | 17.7 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.4 | 15.2 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.4 | 14.7 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.2 | 14.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.3 | 13.8 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 23.9 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 1.2 | 21.0 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.6 | 20.4 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.7 | 15.7 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 15.0 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.5 | 14.4 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 13.2 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.5 | 12.1 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.5 | 10.4 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 10.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |