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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HAND1

Z-value: 0.07

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Transcription factors associated with HAND1

Gene Symbol Gene ID Gene Info
HAND1
ENSG00000113196.2 heart and neural crest derivatives expressed 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HAND1hg19_v2_chr5_-_153857819_1538578240.162.1e-02Click!

Activity profile of HAND1 motif

Sorted Z-values of HAND1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_36359341 9.08 ENST00000221891.4
APLP1
amyloid beta (A4) precursor-like protein 1
chr1_+_65775204 8.10 ENST00000371069.4
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr5_+_36608422 4.44 ENST00000381918.3
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr19_-_37701386 3.93 ENST00000527838.1
ENST00000591492.1
ENST00000532828.2
ZNF585B
zinc finger protein 585B
chr16_+_6069586 3.23 ENST00000547372.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr4_+_41614909 2.97 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIMCH1
LIM and calponin homology domains 1
chr16_-_28621312 2.43 ENST00000314752.7
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr16_-_28621353 2.26 ENST00000567512.1
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr14_-_65409438 2.10 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_+_174846570 2.06 ENST00000392064.2
RABGAP1L
RAB GTPase activating protein 1-like
chr6_+_6588902 1.99 ENST00000230568.4
LY86
lymphocyte antigen 86
chr16_-_28608364 1.99 ENST00000533150.1
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr8_+_79428539 1.99 ENST00000352966.5
PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr6_+_6588316 1.90 ENST00000379953.2
LY86
lymphocyte antigen 86
chr16_-_28621298 1.84 ENST00000566189.1
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr14_-_65409502 1.81 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_-_32210275 1.78 ENST00000440175.2
BAI2
brain-specific angiogenesis inhibitor 2
chr3_+_123813509 1.71 ENST00000460856.1
ENST00000240874.3
KALRN
kalirin, RhoGEF kinase
chr1_+_28261533 1.69 ENST00000411604.1
ENST00000373888.4
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr4_+_41614720 1.67 ENST00000509277.1
LIMCH1
LIM and calponin homology domains 1
chr16_+_6069664 1.65 ENST00000422070.4
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr10_+_118350468 1.58 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr12_+_98909260 1.55 ENST00000556029.1
TMPO
thymopoietin
chr5_-_41870621 1.54 ENST00000196371.5
OXCT1
3-oxoacid CoA transferase 1
chr10_+_118350522 1.54 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chr3_-_9811595 1.54 ENST00000256460.3
CAMK1
calcium/calmodulin-dependent protein kinase I
chr11_-_2323290 1.48 ENST00000381153.3
C11orf21
chromosome 11 open reading frame 21
chr1_-_52870059 1.41 ENST00000371566.1
ORC1
origin recognition complex, subunit 1
chr11_+_2323349 1.39 ENST00000381121.3
TSPAN32
tetraspanin 32
chr1_+_164528866 1.39 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr2_+_210444142 1.38 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chr10_-_99393242 1.32 ENST00000370635.3
ENST00000478953.1
ENST00000335628.3
MORN4
MORN repeat containing 4
chr16_-_28608424 1.30 ENST00000335715.4
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr2_-_27718052 1.29 ENST00000264703.3
FNDC4
fibronectin type III domain containing 4
chr1_-_52870104 1.25 ENST00000371568.3
ORC1
origin recognition complex, subunit 1
chr19_-_36304201 1.21 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr1_+_207262170 1.20 ENST00000367078.3
C4BPB
complement component 4 binding protein, beta
chr10_-_99393208 1.20 ENST00000307450.6
MORN4
MORN repeat containing 4
chr1_+_207262540 1.18 ENST00000452902.2
C4BPB
complement component 4 binding protein, beta
chr2_+_204732487 1.15 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr17_+_11924129 1.12 ENST00000353533.5
ENST00000415385.3
MAP2K4
mitogen-activated protein kinase kinase 4
chrX_+_15767971 1.07 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr7_-_142583506 1.05 ENST00000359396.3
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr4_-_40631859 1.05 ENST00000295971.7
ENST00000319592.4
RBM47
RNA binding motif protein 47
chr17_+_53342311 1.01 ENST00000226067.5
HLF
hepatic leukemia factor
chr1_+_207262578 1.00 ENST00000243611.5
ENST00000367076.3
C4BPB
complement component 4 binding protein, beta
chr17_-_56358287 0.98 ENST00000225275.3
ENST00000340482.3
MPO
myeloperoxidase
chr1_+_207262627 0.97 ENST00000391923.1
C4BPB
complement component 4 binding protein, beta
chr10_+_103113840 0.97 ENST00000393441.4
ENST00000408038.2
BTRC
beta-transducin repeat containing E3 ubiquitin protein ligase
chr7_-_2883928 0.96 ENST00000275364.3
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr7_-_150754935 0.94 ENST00000297518.4
CDK5
cyclin-dependent kinase 5
chrX_+_70364667 0.94 ENST00000536169.1
ENST00000395855.2
ENST00000374051.3
ENST00000358741.3
NLGN3
neuroligin 3
chr7_+_96634850 0.91 ENST00000518156.2
DLX6
distal-less homeobox 6
chr12_-_57630873 0.91 ENST00000556732.1
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr2_+_113816215 0.91 ENST00000346807.3
IL36RN
interleukin 36 receptor antagonist
chr18_+_12407895 0.90 ENST00000590956.1
ENST00000336990.4
ENST00000440960.1
ENST00000588729.1
SLMO1
slowmo homolog 1 (Drosophila)
chr10_-_118032979 0.89 ENST00000355422.6
GFRA1
GDNF family receptor alpha 1
chr6_-_53013620 0.88 ENST00000259803.7
GCM1
glial cells missing homolog 1 (Drosophila)
chr2_-_208031943 0.85 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr1_+_44444865 0.85 ENST00000372324.1
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr14_+_96722152 0.84 ENST00000216629.6
BDKRB1
bradykinin receptor B1
chr1_+_28261621 0.84 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr10_+_99344104 0.82 ENST00000555577.1
ENST00000370649.3
PI4K2A
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein
chr9_-_115095123 0.81 ENST00000458258.1
PTBP3
polypyrimidine tract binding protein 3
chr6_+_44191507 0.81 ENST00000371724.1
ENST00000371713.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr7_+_110731062 0.81 ENST00000308478.5
ENST00000451085.1
ENST00000422987.3
ENST00000421101.1
LRRN3
leucine rich repeat neuronal 3
chr1_+_28261492 0.76 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr20_-_56286479 0.71 ENST00000265626.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr10_-_118032697 0.69 ENST00000439649.3
GFRA1
GDNF family receptor alpha 1
chr16_+_90089008 0.69 ENST00000268699.4
GAS8
growth arrest-specific 8
chr14_+_96722539 0.69 ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr8_+_1993152 0.68 ENST00000262113.4
MYOM2
myomesin 2
chr20_-_1165117 0.63 ENST00000381894.3
TMEM74B
transmembrane protein 74B
chr6_+_35996859 0.62 ENST00000472333.1
MAPK14
mitogen-activated protein kinase 14
chr2_+_201997595 0.60 ENST00000470178.2
CFLAR
CASP8 and FADD-like apoptosis regulator
chr17_-_64216748 0.59 ENST00000585162.1
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr7_-_142207004 0.59 ENST00000426318.2
TRBV10-2
T cell receptor beta variable 10-2
chr12_+_54379569 0.58 ENST00000513209.1
RP11-834C11.12
RP11-834C11.12
chr12_+_49717019 0.58 ENST00000549275.1
ENST00000551245.1
ENST00000380327.5
ENST00000548311.1
ENST00000550346.1
ENST00000550709.1
ENST00000549534.1
ENST00000257909.3
TROAP
trophinin associated protein
chr2_+_204732666 0.56 ENST00000295854.6
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr11_+_2323236 0.56 ENST00000182290.4
TSPAN32
tetraspanin 32
chr21_+_34602377 0.56 ENST00000342101.3
ENST00000413881.1
ENST00000443073.1
IFNAR2
interferon (alpha, beta and omega) receptor 2
chr16_-_89556942 0.55 ENST00000301030.4
ANKRD11
ankyrin repeat domain 11
chr8_+_1993173 0.54 ENST00000523438.1
MYOM2
myomesin 2
chr12_+_68042495 0.53 ENST00000344096.3
DYRK2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr11_-_63330842 0.51 ENST00000255695.1
HRASLS2
HRAS-like suppressor 2
chr10_-_104211294 0.49 ENST00000239125.1
C10orf95
chromosome 10 open reading frame 95
chr22_+_24999114 0.49 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
GGT1
gamma-glutamyltransferase 1
chr2_-_42588338 0.49 ENST00000234301.2
COX7A2L
cytochrome c oxidase subunit VIIa polypeptide 2 like
chr17_-_43025005 0.49 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
KIF18B
kinesin family member 18B
chr21_+_34602200 0.48 ENST00000382264.3
ENST00000382241.3
ENST00000404220.3
ENST00000342136.4
IFNAR2
interferon (alpha, beta and omega) receptor 2
chr17_+_66624280 0.48 ENST00000585484.1
RP11-118B18.1
RP11-118B18.1
chr1_+_52870227 0.48 ENST00000257181.9
PRPF38A
pre-mRNA processing factor 38A
chr16_+_70328680 0.47 ENST00000563206.1
ENST00000451014.3
ENST00000568625.1
DDX19B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
chr7_+_76139833 0.47 ENST00000257632.5
UPK3B
uroplakin 3B
chr7_-_116963334 0.45 ENST00000265441.3
WNT2
wingless-type MMTV integration site family member 2
chr20_-_56285595 0.41 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr17_+_6347761 0.40 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
FAM64A
family with sequence similarity 64, member A
chr22_+_25003626 0.39 ENST00000451366.1
ENST00000406383.2
ENST00000428855.1
GGT1
gamma-glutamyltransferase 1
chr17_+_6347729 0.38 ENST00000572447.1
FAM64A
family with sequence similarity 64, member A
chr10_+_103113802 0.37 ENST00000370187.3
BTRC
beta-transducin repeat containing E3 ubiquitin protein ligase
chrX_+_149531524 0.37 ENST00000370401.2
MAMLD1
mastermind-like domain containing 1
chr1_+_202091980 0.37 ENST00000367282.5
GPR37L1
G protein-coupled receptor 37 like 1
chr12_-_110271178 0.36 ENST00000261740.2
ENST00000392719.2
ENST00000346520.2
TRPV4
transient receptor potential cation channel, subfamily V, member 4
chr7_-_81399329 0.34 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr10_+_72972281 0.32 ENST00000335350.6
UNC5B
unc-5 homolog B (C. elegans)
chr3_+_123813543 0.31 ENST00000360013.3
KALRN
kalirin, RhoGEF kinase
chr12_+_26111823 0.31 ENST00000381352.3
ENST00000535907.1
ENST00000405154.2
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr17_-_10372875 0.30 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr1_+_11249398 0.30 ENST00000376819.3
ANGPTL7
angiopoietin-like 7
chr3_+_112051994 0.28 ENST00000473539.1
ENST00000315711.8
ENST00000383681.3
CD200
CD200 molecule
chr19_+_12862486 0.27 ENST00000549706.1
BEST2
bestrophin 2
chr3_-_49131013 0.26 ENST00000424300.1
QRICH1
glutamine-rich 1
chr1_+_215747118 0.25 ENST00000448333.1
KCTD3
potassium channel tetramerization domain containing 3
chr7_-_81399355 0.18 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr2_-_25475120 0.17 ENST00000380746.4
ENST00000402667.1
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr3_+_148415571 0.17 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
AGTR1
angiotensin II receptor, type 1
chr2_-_228582709 0.15 ENST00000541617.1
ENST00000409456.2
ENST00000409287.1
ENST00000258403.3
SLC19A3
solute carrier family 19 (thiamine transporter), member 3
chr11_-_102496063 0.13 ENST00000260228.2
MMP20
matrix metallopeptidase 20
chr11_+_118826999 0.12 ENST00000264031.2
UPK2
uroplakin 2
chr7_-_81399438 0.12 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_81399411 0.11 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr12_+_68042517 0.10 ENST00000393555.3
DYRK2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr1_-_205601064 0.10 ENST00000357992.4
ENST00000289703.4
ELK4
ELK4, ETS-domain protein (SRF accessory protein 1)
chr2_+_3642545 0.07 ENST00000382062.2
ENST00000236693.7
ENST00000349077.4
COLEC11
collectin sub-family member 11
chr1_+_27719148 0.06 ENST00000374024.3
GPR3
G protein-coupled receptor 3
chr14_-_106642049 0.04 ENST00000390605.2
IGHV1-18
immunoglobulin heavy variable 1-18
chr2_+_201997676 0.04 ENST00000462763.1
ENST00000479953.2
CFLAR
CASP8 and FADD-like apoptosis regulator
chr19_-_55866061 0.02 ENST00000588572.2
ENST00000593184.1
ENST00000589467.1
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr2_-_197791441 0.01 ENST00000409475.1
ENST00000354764.4
ENST00000374738.3
PGAP1
post-GPI attachment to proteins 1
chr16_-_70729496 0.01 ENST00000567648.1
VAC14
Vac14 homolog (S. cerevisiae)
chr2_+_98262497 0.01 ENST00000258424.2
COX5B
cytochrome c oxidase subunit Vb

Network of associatons between targets according to the STRING database.

First level regulatory network of HAND1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 9.1 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.9 8.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.7 2.0 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.6 4.4 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.5 4.4 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.4 3.9 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.4 2.0 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.4 9.8 GO:0006068 ethanol catabolic process(GO:0006068)
0.4 1.5 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.4 1.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.3 1.7 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.3 3.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.3 1.5 GO:0046952 ketone body catabolic process(GO:0046952)
0.3 0.9 GO:0060018 astrocyte fate commitment(GO:0060018)
0.3 0.8 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.2 0.9 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.2 1.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.2 1.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 0.8 GO:0015862 uridine transport(GO:0015862)
0.2 0.9 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 1.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 0.9 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.1 1.6 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 0.6 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 0.9 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.1 2.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.6 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.4 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.1 1.0 GO:0001878 response to yeast(GO:0001878)
0.1 0.7 GO:0060294 cilium movement involved in cell motility(GO:0060294) regulation of microtubule binding(GO:1904526)
0.1 1.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.7 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.4 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.1 4.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.8 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.0 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 0.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 1.4 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.1 0.3 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 2.7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.6 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.1 1.3 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.1 GO:0071934 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.0 0.4 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0 0.4 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 1.0 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 1.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.8 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 0.2 GO:1901538 DNA methylation involved in embryo development(GO:0043045) C-5 methylation of cytosine(GO:0090116) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.3 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 1.0 GO:0010762 regulation of fibroblast migration(GO:0010762)
0.0 1.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 1.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.0 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.5 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 1.6 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 2.1 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.0 0.6 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0070166 enamel mineralization(GO:0070166)
0.0 4.3 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.5 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.9 GO:0042472 inner ear morphogenesis(GO:0042472)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.2 1.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 2.7 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.8 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.1 9.1 GO:0005604 basement membrane(GO:0005604)
0.1 3.7 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.1 0.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.5 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 1.5 GO:0032982 myosin filament(GO:0032982)
0.0 4.4 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.4 GO:1990909 Wnt signalosome(GO:1990909)
0.0 1.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.6 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 10.6 GO:0060076 excitatory synapse(GO:0060076)
0.0 4.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0097342 ripoptosome(GO:0097342)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 4.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.5 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.2 GO:0001741 XY body(GO:0001741)
0.0 0.8 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
1.4 9.8 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.6 4.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 1.5 GO:0004947 bradykinin receptor activity(GO:0004947)
0.4 1.5 GO:0008410 CoA-transferase activity(GO:0008410)
0.3 3.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.3 1.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.2 1.6 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2 0.8 GO:0004461 lactose synthase activity(GO:0004461)
0.2 1.0 GO:0004905 type I interferon receptor activity(GO:0004905)
0.2 0.8 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.2 0.9 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.2 0.9 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 3.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.4 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 0.6 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 2.0 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 2.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 2.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.9 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 1.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.4 GO:0002162 dystroglycan binding(GO:0002162)
0.1 7.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.6 GO:0005521 lamin binding(GO:0005521)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 1.2 GO:0051371 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 1.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.0 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 1.0 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.1 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0048018 receptor agonist activity(GO:0048018)
0.0 1.3 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.0 0.7 GO:0042056 chemoattractant activity(GO:0042056)
0.0 4.9 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 1.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 4.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 4.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.6 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.8 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 2.7 PID E2F PATHWAY E2F transcription factor network
0.0 0.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.0 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.6 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 2.7 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 8.1 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 4.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 4.4 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 0.8 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.1 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.6 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 2.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.2 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 1.0 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 1.1 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.4 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 3.9 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 1.0 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 3.9 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway