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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HAND1
Z-value: 0.07
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Transcription factors associated with HAND1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HAND1 | hg19_v2_chr5_-_153857819_153857824 | 0.16 | 2.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_36359341 Show fit | 9.08 |
ENST00000221891.4
|
amyloid beta (A4) precursor-like protein 1 |
|
| chr1_+_65775204 Show fit | 8.10 |
ENST00000371069.4
|
DnaJ (Hsp40) homolog, subfamily C, member 6 |
|
| chr5_+_36608422 Show fit | 4.44 |
ENST00000381918.3
|
solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
|
| chr19_-_37701386 Show fit | 3.93 |
ENST00000527838.1
ENST00000591492.1 ENST00000532828.2 |
zinc finger protein 585B |
|
| chr16_+_6069586 Show fit | 3.23 |
ENST00000547372.1
|
RNA binding protein, fox-1 homolog (C. elegans) 1 |
|
| chr4_+_41614909 Show fit | 2.97 |
ENST00000509454.1
ENST00000396595.3 ENST00000381753.4 |
LIM and calponin homology domains 1 |
|
| chr16_-_28621312 Show fit | 2.43 |
ENST00000314752.7
|
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
|
| chr16_-_28621353 Show fit | 2.26 |
ENST00000567512.1
|
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
|
| chr14_-_65409438 Show fit | 2.10 |
ENST00000557049.1
|
glutathione peroxidase 2 (gastrointestinal) |
|
| chr1_+_174846570 Show fit | 2.06 |
ENST00000392064.2
|
RAB GTPase activating protein 1-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of HAND1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.8 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 1.8 | 9.1 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
| 0.9 | 8.1 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.1 | 4.9 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.6 | 4.4 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.5 | 4.4 | GO:0045959 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027) |
| 0.0 | 4.3 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.4 | 3.9 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.3 | 3.3 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.1 | 2.7 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.6 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.1 | 9.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 4.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 4.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 4.4 | GO:0044216 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.1 | 3.7 | GO:0098636 | protein complex involved in cell adhesion(GO:0098636) |
| 0.2 | 2.7 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 1.5 | GO:0032982 | myosin filament(GO:0032982) |
| 0.2 | 1.4 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 1.3 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 9.8 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 2.3 | 9.1 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.1 | 7.4 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 4.9 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.6 | 4.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.3 | 3.3 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 3.1 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 2.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 2.1 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 2.0 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 2.0 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.7 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.6 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.3 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 1.0 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.2 | 8.1 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.2 | 4.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 4.4 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 3.9 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.0 | 3.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 2.7 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 2.0 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.6 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.3 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |