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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HBP1
Z-value: 0.97
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Transcription factors associated with HBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HBP1 | hg19_v2_chr7_+_106809406_106809460 | -0.37 | 2.7e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HBP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 36.8 | GO:0006903 | vesicle targeting(GO:0006903) |
| 11.7 | 35.1 | GO:0019242 | methylglyoxal biosynthetic process(GO:0019242) |
| 6.5 | 25.8 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.2 | 23.1 | GO:0032392 | DNA geometric change(GO:0032392) |
| 0.8 | 21.5 | GO:0046653 | tetrahydrofolate metabolic process(GO:0046653) |
| 1.4 | 18.4 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 3.0 | 17.8 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.2 | 16.4 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 1.2 | 16.3 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 3.1 | 15.3 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 55.0 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.3 | 33.2 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.8 | 25.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.8 | 23.7 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 19.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 17.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.2 | 17.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.9 | 16.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.5 | 16.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 2.6 | 15.3 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.9 | 39.6 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 11.7 | 35.1 | GO:0004347 | glucose-6-phosphate isomerase activity(GO:0004347) |
| 5.2 | 25.8 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.9 | 25.5 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 7.2 | 21.5 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488) |
| 6.1 | 18.4 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.0 | 18.4 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 18.0 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.7 | 17.7 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.8 | 16.4 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 42.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 17.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.6 | 15.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.6 | 14.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 14.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.5 | 11.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.2 | 11.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 11.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.2 | 11.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 10.7 | PID IL1 PATHWAY | IL1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 35.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.7 | 23.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.3 | 19.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 16.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.9 | 13.1 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.3 | 11.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.7 | 11.5 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.1 | 11.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.4 | 11.0 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.4 | 10.1 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |