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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HDX

Z-value: 0.38

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.9 highly divergent homeobox

Activity profile of HDX motif

Sorted Z-values of HDX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_153363452 8.65 ENST00000368732.1
ENST00000368733.3
S100A8
S100 calcium binding protein A8
chr1_-_169680745 5.86 ENST00000236147.4
SELL
selectin L
chr6_+_144471643 2.21 ENST00000367568.4
STX11
syntaxin 11
chr12_+_10460549 1.91 ENST00000543420.1
ENST00000543777.1
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr2_-_113594279 1.87 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr2_-_89399845 1.68 ENST00000479981.1
IGKV1-16
immunoglobulin kappa variable 1-16
chr12_+_10460417 1.63 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr6_+_42584847 1.52 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr1_+_84630053 1.43 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr18_+_29027696 1.27 ENST00000257189.4
DSG3
desmoglein 3
chr12_-_118797475 1.24 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr1_+_21880560 1.22 ENST00000425315.2
ALPL
alkaline phosphatase, liver/bone/kidney
chr3_+_54157480 1.22 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr5_-_41213607 0.89 ENST00000337836.5
ENST00000433294.1
C6
complement component 6
chr5_-_35230434 0.87 ENST00000504500.1
PRLR
prolactin receptor
chr22_+_40440804 0.85 ENST00000441751.1
ENST00000301923.9
TNRC6B
trinucleotide repeat containing 6B
chr2_-_40657397 0.82 ENST00000408028.2
ENST00000332839.4
ENST00000406391.2
ENST00000542024.1
ENST00000542756.1
ENST00000405901.3
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr2_+_169926047 0.80 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr5_-_135290705 0.71 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr13_+_97928395 0.55 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr7_-_135412925 0.42 ENST00000354042.4
SLC13A4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr11_+_9685604 0.37 ENST00000447399.2
ENST00000318950.6
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr3_-_165555200 0.31 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE
butyrylcholinesterase
chr14_+_79746249 0.24 ENST00000428277.2
NRXN3
neurexin 3
chr5_-_35230649 0.24 ENST00000382002.5
PRLR
prolactin receptor
chr5_-_35230771 0.23 ENST00000342362.5
PRLR
prolactin receptor
chr8_+_110098850 0.12 ENST00000518632.1
TRHR
thyrotropin-releasing hormone receptor
chr8_+_24151620 0.05 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr14_+_79745682 0.03 ENST00000557594.1
NRXN3
neurexin 3
chr1_-_159684371 0.01 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr14_+_79745746 0.01 ENST00000281127.7
NRXN3
neurexin 3
chr7_+_99954224 0.01 ENST00000608825.1
PILRB
paired immunoglobin-like type 2 receptor beta

Network of associatons between targets according to the STRING database.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 8.6 GO:0032119 sequestering of zinc ion(GO:0032119)
0.6 1.9 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.4 1.2 GO:0071529 cementum mineralization(GO:0071529)
0.3 1.4 GO:0097338 response to clozapine(GO:0097338)
0.3 1.5 GO:0071233 cellular response to leucine(GO:0071233)
0.2 1.3 GO:0038161 prolactin signaling pathway(GO:0038161)
0.2 0.9 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.2 6.7 GO:0033198 response to ATP(GO:0033198)
0.1 0.4 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 2.2 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 0.3 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 0.8 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.8 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0 1.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 3.5 GO:0002228 natural killer cell mediated immunity(GO:0002228)
0.0 0.4 GO:0008272 sulfate transport(GO:0008272)
0.0 0.3 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 1.7 GO:0030449 regulation of complement activation(GO:0030449)
0.0 1.3 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 0.9 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.3 GO:0030057 desmosome(GO:0030057)
0.0 8.6 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 2.2 GO:0031201 SNARE complex(GO:0031201)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 9.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.3 GO:0031904 endosome lumen(GO:0031904)
0.0 0.8 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.8 5.9 GO:0043208 glycosphingolipid binding(GO:0043208)
0.7 3.5 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.3 1.5 GO:0070728 leucine binding(GO:0070728)
0.3 0.8 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.3 1.3 GO:0004925 prolactin receptor activity(GO:0004925)
0.2 1.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 1.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 0.3 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 1.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.4 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 2.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 7.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.4 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.3 PID ERBB4 PATHWAY ErbB4 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.8 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.8 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade