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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HES7_HES5
Z-value: 0.01
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Transcription factors associated with HES7_HES5
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_26233423 Show fit | 21.07 |
ENST00000357865.2
|
stathmin 1 |
|
| chr1_-_26232951 Show fit | 10.56 |
ENST00000426559.2
ENST00000455785.2 |
stathmin 1 |
|
| chr1_-_26232522 Show fit | 10.24 |
ENST00000399728.1
|
stathmin 1 |
|
| chr17_-_41465674 Show fit | 7.97 |
ENST00000592135.1
ENST00000587874.1 ENST00000588654.1 ENST00000592094.1 |
long intergenic non-protein coding RNA 910 |
|
| chr19_+_4304632 Show fit | 7.47 |
ENST00000597590.1
|
fibronectin type III and SPRY domain containing 1 |
|
| chr2_-_175870085 Show fit | 7.41 |
ENST00000409156.3
|
chimerin 1 |
|
| chr19_+_4304585 Show fit | 7.18 |
ENST00000221856.6
|
fibronectin type III and SPRY domain containing 1 |
|
| chr17_+_30813576 Show fit | 7.15 |
ENST00000313401.3
|
cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
|
| chr14_+_65879437 Show fit | 6.95 |
ENST00000394585.1
|
fucosyltransferase 8 (alpha (1,6) fucosyltransferase) |
|
| chr8_+_38089198 Show fit | 6.50 |
ENST00000528358.1
ENST00000529642.1 ENST00000532222.1 ENST00000520272.2 |
DDHD domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HES7_HES5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 42.6 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.0 | 18.3 | GO:0051301 | cell division(GO:0051301) |
| 4.9 | 14.7 | GO:0036071 | N-glycan fucosylation(GO:0036071) |
| 0.2 | 7.4 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 2.4 | 7.2 | GO:0021722 | superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 0.3 | 6.5 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.8 | 6.3 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 0.1 | 5.8 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.1 | 5.4 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.3 | 5.1 | GO:0033623 | regulation of integrin activation(GO:0033623) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 59.6 | GO:0005874 | microtubule(GO:0005874) |
| 0.2 | 15.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 8.1 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 1.8 | 7.2 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.1 | 6.5 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 6.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 1.3 | 6.3 | GO:0044308 | axonal spine(GO:0044308) |
| 0.3 | 5.4 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 5.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 1.5 | 4.6 | GO:0005960 | glycine cleavage complex(GO:0005960) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 45.7 | GO:0015631 | tubulin binding(GO:0015631) |
| 4.9 | 14.7 | GO:0046921 | glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921) |
| 2.4 | 7.2 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 0.1 | 6.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.2 | 6.5 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.8 | 6.3 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.0 | 5.7 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 1.3 | 5.4 | GO:0052812 | phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) |
| 0.2 | 5.1 | GO:0031005 | filamin binding(GO:0031005) |
| 1.1 | 4.6 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 41.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 7.4 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 7.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 6.3 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 5.3 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 2.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 2.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.9 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.6 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 16.1 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 7.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.5 | 7.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.3 | 6.3 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.2 | 4.9 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 4.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 4.4 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 3.0 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 3.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 2.9 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |