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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HESX1
Z-value: 0.93
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Transcription factors associated with HESX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HESX1 | hg19_v2_chr3_-_57233966_57234014 | -0.07 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106406090 Show fit | 31.91 |
ENST00000390593.2
|
immunoglobulin heavy variable 6-1 |
|
| chr2_-_89292422 Show fit | 31.72 |
ENST00000495489.1
|
immunoglobulin kappa variable 1-8 |
|
| chr2_+_90198535 Show fit | 31.58 |
ENST00000390276.2
|
immunoglobulin kappa variable 1D-12 |
|
| chr2_+_90248739 Show fit | 26.58 |
ENST00000468879.1
|
immunoglobulin kappa variable 1D-43 |
|
| chr2_-_89310012 Show fit | 25.51 |
ENST00000493819.1
|
immunoglobulin kappa variable 1-9 |
|
| chr2_-_89399845 Show fit | 24.25 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
|
| chr2_-_89513402 Show fit | 23.59 |
ENST00000498435.1
|
immunoglobulin kappa variable 1-27 |
|
| chr2_-_89340242 Show fit | 23.39 |
ENST00000480492.1
|
immunoglobulin kappa variable 1-12 |
|
| chr2_+_89952792 Show fit | 14.44 |
ENST00000390265.2
|
immunoglobulin kappa variable 1D-33 |
|
| chr2_+_90192768 Show fit | 13.29 |
ENST00000390275.2
|
immunoglobulin kappa variable 1D-13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HESX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 147.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.6 | 107.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 31.1 | GO:0002250 | adaptive immune response(GO:0002250) |
| 1.2 | 8.6 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.1 | 6.5 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 1.6 | 6.4 | GO:1901895 | negative regulation of calcium-transporting ATPase activity(GO:1901895) |
| 1.9 | 5.6 | GO:0032888 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 0.1 | 4.9 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.6 | 4.5 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.3 | 4.3 | GO:0015671 | oxygen transport(GO:0015671) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 123.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 73.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.6 | 31.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 8.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.9 | 6.4 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.0 | 5.9 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 1.9 | 5.6 | GO:0055028 | cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673) |
| 0.4 | 4.9 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 4.5 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.1 | 4.0 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 274.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 8.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 5.6 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 4.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 4.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 4.7 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.2 | 4.5 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.3 | 4.3 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.3 | 4.1 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 0.1 | 4.0 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 6.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 5.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.3 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.1 | 5.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.1 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 4.9 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 4.3 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 3.8 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 2.1 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.3 | 5.6 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 5.1 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 4.9 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 4.2 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 4.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 4.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 3.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 3.7 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 3.3 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |