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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HESX1

Z-value: 0.93

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Transcription factors associated with HESX1

Gene Symbol Gene ID Gene Info
HESX1
ENSG00000163666.4 HESX homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HESX1hg19_v2_chr3_-_57233966_57234014-0.073.3e-01Click!

Activity profile of HESX1 motif

Sorted Z-values of HESX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_106406090 31.91 ENST00000390593.2
IGHV6-1
immunoglobulin heavy variable 6-1
chr2_-_89292422 31.72 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr2_+_90198535 31.58 ENST00000390276.2
IGKV1D-12
immunoglobulin kappa variable 1D-12
chr2_+_90248739 26.58 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr2_-_89310012 25.51 ENST00000493819.1
IGKV1-9
immunoglobulin kappa variable 1-9
chr2_-_89399845 24.25 ENST00000479981.1
IGKV1-16
immunoglobulin kappa variable 1-16
chr2_-_89513402 23.59 ENST00000498435.1
IGKV1-27
immunoglobulin kappa variable 1-27
chr2_-_89340242 23.39 ENST00000480492.1
IGKV1-12
immunoglobulin kappa variable 1-12
chr2_+_89952792 14.44 ENST00000390265.2
IGKV1D-33
immunoglobulin kappa variable 1D-33
chr2_+_90192768 13.29 ENST00000390275.2
IGKV1D-13
immunoglobulin kappa variable 1D-13
chr2_-_89568263 12.36 ENST00000473726.1
IGKV1-33
immunoglobulin kappa variable 1-33
chr2_+_114163945 10.71 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr2_-_89247338 9.83 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr2_+_90458201 9.65 ENST00000603238.1
CH17-132F21.1
Uncharacterized protein
chr2_+_90259593 6.67 ENST00000471857.1
IGKV1D-8
immunoglobulin kappa variable 1D-8
chr8_-_98290087 6.45 ENST00000322128.3
TSPYL5
TSPY-like 5
chr4_-_2264015 5.89 ENST00000337190.2
MXD4
MAX dimerization protein 4
chr1_+_159175201 5.05 ENST00000368121.2
DARC
Duffy blood group, atypical chemokine receptor
chr7_-_37024665 4.91 ENST00000396040.2
ELMO1
engulfment and cell motility 1
chr14_-_25103472 4.69 ENST00000216341.4
ENST00000382542.1
ENST00000382540.1
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr18_+_54318616 4.62 ENST00000254442.3
WDR7
WD repeat domain 7
chr11_-_5276008 4.28 ENST00000336906.4
HBG2
hemoglobin, gamma G
chr18_+_54318566 4.16 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr10_-_101380121 4.12 ENST00000370495.4
SLC25A28
solute carrier family 25 (mitochondrial iron transporter), member 28
chr14_-_25103388 3.92 ENST00000526004.1
ENST00000415355.3
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr4_+_156588350 3.82 ENST00000296518.7
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr8_+_120885949 3.75 ENST00000523492.1
ENST00000286234.5
DEPTOR
DEP domain containing MTOR-interacting protein
chr1_-_203320617 3.75 ENST00000354955.4
FMOD
fibromodulin
chr20_-_590944 3.67 ENST00000246080.3
TCF15
transcription factor 15 (basic helix-loop-helix)
chr11_-_126138808 3.46 ENST00000332118.6
ENST00000532259.1
SRPR
signal recognition particle receptor (docking protein)
chr1_-_17216143 3.40 ENST00000457075.1
RP11-108M9.4
RP11-108M9.4
chr2_-_43823119 3.34 ENST00000403856.1
ENST00000404790.1
ENST00000405975.2
ENST00000415080.2
THADA
thyroid adenoma associated
chr2_-_160654745 3.27 ENST00000259053.4
ENST00000429078.2
CD302
CD302 molecule
chr8_-_110656995 3.21 ENST00000276646.9
ENST00000533065.1
SYBU
syntabulin (syntaxin-interacting)
chr6_-_29600832 3.10 ENST00000377016.4
ENST00000376977.3
ENST00000377034.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr2_-_43823093 3.06 ENST00000405006.4
THADA
thyroid adenoma associated
chr16_+_4784273 3.01 ENST00000299320.5
ENST00000586724.1
C16orf71
chromosome 16 open reading frame 71
chr14_+_61654271 2.96 ENST00000555185.1
ENST00000557294.1
ENST00000556778.1
PRKCH
protein kinase C, eta
chr4_+_71063641 2.95 ENST00000514097.1
ODAM
odontogenic, ameloblast asssociated
chr19_+_42388437 2.92 ENST00000378152.4
ENST00000337665.4
ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr19_+_19431490 2.91 ENST00000392313.6
ENST00000262815.8
ENST00000609122.1
MAU2
MAU2 sister chromatid cohesion factor
chr16_+_4784458 2.86 ENST00000590191.1
C16orf71
chromosome 16 open reading frame 71
chr11_-_71791435 2.85 ENST00000351960.6
ENST00000541719.1
ENST00000535111.1
NUMA1
nuclear mitotic apparatus protein 1
chr5_+_40679584 2.79 ENST00000302472.3
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr11_-_71791518 2.72 ENST00000537217.1
ENST00000366394.3
ENST00000358965.6
ENST00000546131.1
ENST00000543937.1
ENST00000368959.5
ENST00000541641.1
NUMA1
nuclear mitotic apparatus protein 1
chr2_-_197036289 2.72 ENST00000263955.4
STK17B
serine/threonine kinase 17b
chr1_+_47799446 2.61 ENST00000371873.5
CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr6_-_41888843 2.61 ENST00000434077.1
ENST00000409312.1
MED20
mediator complex subunit 20
chr4_+_144303093 2.58 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr7_+_72742178 2.52 ENST00000442793.1
ENST00000413573.2
ENST00000252037.4
FKBP6
FK506 binding protein 6, 36kDa
chr11_+_125774258 2.48 ENST00000263576.6
DDX25
DEAD (Asp-Glu-Ala-Asp) box helicase 25
chr1_-_40237020 2.45 ENST00000327582.5
OXCT2
3-oxoacid CoA transferase 2
chr4_+_6784401 2.37 ENST00000425103.1
ENST00000307659.5
KIAA0232
KIAA0232
chr16_-_57219966 2.28 ENST00000565760.1
ENST00000309137.8
ENST00000570184.1
ENST00000562324.1
FAM192A
family with sequence similarity 192, member A
chr18_-_54318353 2.25 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr7_-_95025661 2.25 ENST00000542556.1
ENST00000265627.5
ENST00000427422.1
ENST00000451904.1
PON1
PON3
paraoxonase 1
paraoxonase 3
chr5_-_176057518 2.23 ENST00000393693.2
SNCB
synuclein, beta
chr13_-_52378231 2.17 ENST00000280056.2
ENST00000444610.2
DHRS12
dehydrogenase/reductase (SDR family) member 12
chr16_-_1661988 2.09 ENST00000426508.2
IFT140
intraflagellar transport 140 homolog (Chlamydomonas)
chr14_-_90798418 2.08 ENST00000354366.3
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chr8_+_27182862 2.05 ENST00000521164.1
ENST00000346049.5
PTK2B
protein tyrosine kinase 2 beta
chr22_+_38453378 1.97 ENST00000437453.1
ENST00000356976.3
PICK1
protein interacting with PRKCA 1
chr16_-_70719925 1.97 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr16_+_1662326 1.97 ENST00000397412.3
CRAMP1L
Crm, cramped-like (Drosophila)
chr7_+_72742162 1.97 ENST00000431982.2
FKBP6
FK506 binding protein 6, 36kDa
chr1_-_20446020 1.88 ENST00000375105.3
PLA2G2D
phospholipase A2, group IID
chr11_+_73019282 1.82 ENST00000263674.3
ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chr6_-_167275991 1.81 ENST00000510118.1
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr12_+_13197218 1.80 ENST00000197268.8
KIAA1467
KIAA1467
chr6_+_31939608 1.78 ENST00000375331.2
ENST00000375333.2
STK19
serine/threonine kinase 19
chr22_+_31892373 1.75 ENST00000443011.1
ENST00000400289.1
ENST00000444859.1
ENST00000400288.2
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr16_+_66914264 1.73 ENST00000311765.2
ENST00000568869.1
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
PDP2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr2_-_128051670 1.73 ENST00000493187.2
ERCC3
excision repair cross-complementing rodent repair deficiency, complementation group 3
chr6_-_46703069 1.70 ENST00000538237.1
ENST00000274793.7
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr12_-_752786 1.69 ENST00000433832.2
ENST00000542920.1
NINJ2
ninjurin 2
chr21_+_38445539 1.56 ENST00000418766.1
ENST00000450533.1
ENST00000438055.1
ENST00000355666.1
ENST00000540756.1
ENST00000399010.1
TTC3
tetratricopeptide repeat domain 3
chr3_+_178253993 1.54 ENST00000420517.2
ENST00000452583.1
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr17_+_45286387 1.40 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr6_-_41888814 1.40 ENST00000409060.1
ENST00000265350.4
MED20
mediator complex subunit 20
chr11_-_57148619 1.39 ENST00000287143.2
PRG3
proteoglycan 3
chr22_+_38453207 1.34 ENST00000404072.3
ENST00000424694.1
PICK1
protein interacting with PRKCA 1
chr8_+_79428539 1.33 ENST00000352966.5
PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr7_+_74508372 1.30 ENST00000356115.5
ENST00000430511.2
ENST00000312575.7
GTF2IRD2B
GTF2I repeat domain containing 2B
chr17_+_18128896 1.30 ENST00000316843.4
LLGL1
lethal giant larvae homolog 1 (Drosophila)
chr10_-_75634326 1.28 ENST00000322635.3
ENST00000444854.2
ENST00000423381.1
ENST00000322680.3
ENST00000394762.2
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma
chr8_+_97274119 1.27 ENST00000455950.2
PTDSS1
phosphatidylserine synthase 1
chr3_+_158519654 1.27 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr19_+_38397839 1.26 ENST00000222345.6
SIPA1L3
signal-induced proliferation-associated 1 like 3
chr16_+_84733575 1.24 ENST00000219473.7
ENST00000563892.1
ENST00000562283.1
ENST00000570191.1
ENST00000569038.1
ENST00000570053.1
USP10
ubiquitin specific peptidase 10
chr1_-_205290865 1.23 ENST00000367157.3
NUAK2
NUAK family, SNF1-like kinase, 2
chr19_+_45312347 1.17 ENST00000270233.6
ENST00000591520.1
BCAM
basal cell adhesion molecule (Lutheran blood group)
chr21_-_38445443 1.17 ENST00000360525.4
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr2_-_96931679 1.13 ENST00000258439.3
ENST00000432959.1
TMEM127
transmembrane protein 127
chr10_+_26505594 1.13 ENST00000259271.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr7_+_4815238 1.09 ENST00000348624.4
ENST00000401897.1
AP5Z1
adaptor-related protein complex 5, zeta 1 subunit
chrX_-_7895479 1.04 ENST00000381042.4
PNPLA4
patatin-like phospholipase domain containing 4
chr2_+_176957619 0.99 ENST00000392539.3
HOXD13
homeobox D13
chr14_-_91884150 0.99 ENST00000553403.1
CCDC88C
coiled-coil domain containing 88C
chr4_-_48782259 0.98 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRYL
FRY-like
chr21_+_34398153 0.95 ENST00000382357.3
ENST00000430860.1
ENST00000333337.3
OLIG2
oligodendrocyte lineage transcription factor 2
chr8_-_101734308 0.94 ENST00000519004.1
ENST00000519363.1
ENST00000520142.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr7_-_74267836 0.85 ENST00000361071.5
ENST00000453619.2
ENST00000417115.2
ENST00000405086.2
GTF2IRD2
GTF2I repeat domain containing 2
chr2_+_233562015 0.85 ENST00000427233.1
ENST00000373566.3
ENST00000373563.4
ENST00000428883.1
ENST00000456491.1
ENST00000409480.1
ENST00000421433.1
ENST00000425040.1
ENST00000430720.1
ENST00000409547.1
ENST00000423659.1
ENST00000409196.3
ENST00000409451.3
ENST00000429187.1
ENST00000440945.1
GIGYF2
GRB10 interacting GYF protein 2
chr20_-_62587735 0.85 ENST00000354216.6
ENST00000369892.3
ENST00000358711.3
UCKL1
uridine-cytidine kinase 1-like 1
chr17_+_45286706 0.83 ENST00000393450.1
ENST00000572303.1
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr11_+_64323156 0.80 ENST00000377585.3
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr20_+_18269121 0.78 ENST00000377671.3
ENST00000360010.5
ENST00000396026.3
ENST00000402618.2
ENST00000401790.1
ENST00000434018.1
ENST00000538547.1
ENST00000535822.1
ZNF133
zinc finger protein 133
chr1_+_46016703 0.74 ENST00000481885.1
ENST00000351829.4
ENST00000471651.1
AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr3_+_155860751 0.74 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr7_+_115850547 0.72 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
TES
testis derived transcript (3 LIM domains)
chr14_+_45553296 0.71 ENST00000355765.6
ENST00000553605.1
PRPF39
pre-mRNA processing factor 39
chr15_+_32322709 0.71 ENST00000455693.2
CHRNA7
cholinergic receptor, nicotinic, alpha 7 (neuronal)
chr1_+_156338993 0.68 ENST00000368249.1
ENST00000368246.2
ENST00000537040.1
ENST00000400992.2
ENST00000255013.3
ENST00000451864.2
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chr2_+_234216454 0.66 ENST00000447536.1
ENST00000409110.1
SAG
S-antigen; retina and pineal gland (arrestin)
chr15_+_80351910 0.65 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr2_-_128399706 0.60 ENST00000426981.1
LIMS2
LIM and senescent cell antigen-like domains 2
chr1_-_26372602 0.55 ENST00000374278.3
ENST00000374276.3
SLC30A2
solute carrier family 30 (zinc transporter), member 2
chrX_+_135730373 0.55 ENST00000370628.2
CD40LG
CD40 ligand
chr22_+_26565440 0.51 ENST00000404234.3
ENST00000529632.2
ENST00000360929.3
ENST00000248933.6
ENST00000343706.4
SEZ6L
seizure related 6 homolog (mouse)-like
chr20_+_35807512 0.50 ENST00000373622.5
RPN2
ribophorin II
chr17_+_55163075 0.49 ENST00000571629.1
ENST00000570423.1
ENST00000575186.1
ENST00000573085.1
ENST00000572814.1
AKAP1
A kinase (PRKA) anchor protein 1
chr3_+_39851094 0.47 ENST00000302541.6
MYRIP
myosin VIIA and Rab interacting protein
chr2_+_32502952 0.44 ENST00000238831.4
YIPF4
Yip1 domain family, member 4
chr21_-_38445011 0.41 ENST00000464265.1
ENST00000399102.1
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr11_+_64323098 0.41 ENST00000301891.4
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr1_-_16302565 0.41 ENST00000537142.1
ENST00000448462.2
ZBTB17
zinc finger and BTB domain containing 17
chr21_-_34852304 0.36 ENST00000542230.2
TMEM50B
transmembrane protein 50B
chr19_-_50370799 0.35 ENST00000600910.1
ENST00000322344.3
ENST00000600573.1
PNKP
polynucleotide kinase 3'-phosphatase
chr11_+_118443098 0.32 ENST00000392859.3
ENST00000359415.4
ENST00000534182.2
ENST00000264028.4
ARCN1
archain 1
chr16_+_57279248 0.30 ENST00000562023.1
ENST00000563234.1
ARL2BP
ADP-ribosylation factor-like 2 binding protein
chr8_+_124084899 0.28 ENST00000287380.1
ENST00000309336.3
ENST00000519418.1
ENST00000327098.5
ENST00000522420.1
ENST00000521676.1
ENST00000378080.2
TBC1D31
TBC1 domain family, member 31
chr7_-_99679324 0.24 ENST00000292393.5
ENST00000413658.2
ENST00000412947.1
ENST00000441298.1
ENST00000449785.1
ENST00000299667.4
ENST00000424697.1
ZNF3
zinc finger protein 3
chrX_-_64754611 0.22 ENST00000374807.5
ENST00000374811.3
ENST00000374804.5
ENST00000312391.8
LAS1L
LAS1-like (S. cerevisiae)
chr13_-_108870623 0.22 ENST00000405925.1
LIG4
ligase IV, DNA, ATP-dependent
chrX_+_135730297 0.16 ENST00000370629.2
CD40LG
CD40 ligand
chr8_-_101734170 0.13 ENST00000522387.1
ENST00000518196.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr18_+_56892724 0.10 ENST00000456142.3
ENST00000530323.1
GRP
gastrin-releasing peptide
chr15_-_82824843 0.07 ENST00000560826.1
ENST00000559187.1
ENST00000330339.7
RPS17
ribosomal protein S17
chr1_+_169337172 0.06 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
BLZF1
basic leucine zipper nuclear factor 1
chr12_-_121476750 0.04 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr20_+_35807449 0.04 ENST00000237530.6
RPN2
ribophorin II
chr1_+_3614591 0.00 ENST00000378290.4
TP73
tumor protein p73

Network of associatons between targets according to the STRING database.

First level regulatory network of HESX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0032888 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
1.6 6.4 GO:1901895 negative regulation of calcium-transporting ATPase activity(GO:1901895)
1.4 4.1 GO:0048250 mitochondrial iron ion transport(GO:0048250)
1.2 3.7 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
1.2 8.6 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
1.0 147.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.9 2.8 GO:2000417 negative regulation of eosinophil migration(GO:2000417)
0.7 3.0 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.7 2.1 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.7 3.9 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.6 3.8 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.6 1.9 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.6 107.3 GO:0002377 immunoglobulin production(GO:0002377)
0.6 4.5 GO:0034587 piRNA metabolic process(GO:0034587)
0.5 2.5 GO:0046952 ketone body catabolic process(GO:0046952)
0.5 3.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.5 1.4 GO:0001694 histamine biosynthetic process(GO:0001694)
0.4 2.6 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.4 3.0 GO:0034350 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) positive regulation of B cell receptor signaling pathway(GO:0050861)
0.4 3.7 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.3 2.9 GO:0034086 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.3 0.9 GO:0021778 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.3 4.3 GO:0015671 oxygen transport(GO:0015671)
0.2 0.7 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.2 3.8 GO:0045792 negative regulation of cell size(GO:0045792)
0.2 0.7 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.2 2.7 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.2 2.1 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.2 1.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.2 1.0 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.2 1.3 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.7 GO:0050893 sensory processing(GO:0050893)
0.1 0.8 GO:0044211 CTP salvage(GO:0044211)
0.1 1.2 GO:0015747 urate transport(GO:0015747)
0.1 6.5 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.1 1.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 1.7 GO:0009650 UV protection(GO:0009650)
0.1 0.5 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.1 4.9 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.1 1.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 2.1 GO:0016246 RNA interference(GO:0016246)
0.1 1.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 31.1 GO:0002250 adaptive immune response(GO:0002250)
0.1 0.3 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 2.6 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.1 0.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 1.5 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 3.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 1.3 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.1 2.2 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 1.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.6 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 1.7 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 1.0 GO:0090527 actin filament reorganization(GO:0090527)
0.0 3.2 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 0.7 GO:1903817 diaphragm development(GO:0060539) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.5 GO:0060074 synapse maturation(GO:0060074)
0.0 2.2 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.8 GO:0061157 mRNA destabilization(GO:0061157)
0.0 1.0 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.5 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 2.2 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.0 1.4 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 2.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 1.2 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.9 GO:0031648 protein destabilization(GO:0031648)
0.0 1.6 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 2.5 GO:0007286 spermatid development(GO:0007286)
0.0 1.1 GO:0007032 endosome organization(GO:0007032)
0.0 0.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 1.2 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.2 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 1.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 4.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 1.3 GO:0006909 phagocytosis(GO:0006909)
0.0 0.4 GO:0001702 gastrulation with mouth forming second(GO:0001702)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 1.1 GO:0000725 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0 0.3 GO:0051457 maintenance of protein location in nucleus(GO:0051457)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0055028 cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673)
1.0 3.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.9 6.4 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.6 31.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.4 4.9 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.4 73.2 GO:0072562 blood microparticle(GO:0072562)
0.4 3.2 GO:0097433 dense body(GO:0097433)
0.3 2.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.3 2.5 GO:0033391 chromatoid body(GO:0033391)
0.2 1.6 GO:1990635 proximal dendrite(GO:1990635)
0.2 1.3 GO:0061689 tricellular tight junction(GO:0061689)
0.2 1.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.2 1.7 GO:0000439 core TFIIH complex(GO:0000439)
0.2 3.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 8.6 GO:0001772 immunological synapse(GO:0001772)
0.1 2.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 4.5 GO:0000795 synaptonemal complex(GO:0000795)
0.1 1.1 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.1 4.0 GO:0016592 mediator complex(GO:0016592)
0.1 123.9 GO:0005615 extracellular space(GO:0005615)
0.1 0.7 GO:0000243 commitment complex(GO:0000243)
0.0 3.3 GO:0005902 microvillus(GO:0005902)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 3.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.5 GO:0031045 dense core granule(GO:0031045)
0.0 0.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 2.2 GO:0031672 A band(GO:0031672)
0.0 5.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 2.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.1 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)
0.0 2.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 2.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.5 GO:0031514 motile cilium(GO:0031514)
0.0 0.7 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.9 GO:0005814 centriole(GO:0005814)
0.0 1.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 274.3 GO:0003823 antigen binding(GO:0003823)
1.0 3.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.7 2.2 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.7 2.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.6 2.5 GO:0008410 CoA-transferase activity(GO:0008410)
0.6 3.0 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.6 2.2 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.5 3.5 GO:0004849 uridine kinase activity(GO:0004849)
0.4 1.7 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.4 5.6 GO:0051011 microtubule minus-end binding(GO:0051011)
0.4 3.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.3 2.8 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.3 4.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 2.3 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.3 1.7 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.3 4.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.2 0.7 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.2 0.7 GO:0005174 CD40 receptor binding(GO:0005174)
0.2 1.7 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.2 1.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 2.2 GO:1903136 cuprous ion binding(GO:1903136)
0.2 4.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 3.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.7 GO:0002046 opsin binding(GO:0002046)
0.1 1.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 3.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 0.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 4.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 1.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 1.1 GO:0008494 translation activator activity(GO:0008494)
0.1 1.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 0.5 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.7 GO:0015643 toxic substance binding(GO:0015643)
0.0 2.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 2.6 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 1.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 3.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.9 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.0 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 8.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.7 GO:0070402 NADPH binding(GO:0070402)
0.0 4.9 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.2 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.5 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.3 GO:0019905 syntaxin binding(GO:0019905)
0.0 2.9 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 4.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 4.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 5.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.9 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 2.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 5.1 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 5.3 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 5.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 6.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 4.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 3.8 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.7 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.6 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.6 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3 2.8 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.2 3.7 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.2 3.1 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 4.9 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 1.9 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 6.9 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 3.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.7 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 5.1 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 2.6 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.1 3.0 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 1.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 3.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 1.8 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 3.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 4.2 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 4.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.7 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.1 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 2.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 4.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 3.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 1.1 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S