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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HIC1

Z-value: 1.14

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Transcription factors associated with HIC1

Gene Symbol Gene ID Gene Info
HIC1
ENSG00000177374.8 HIC ZBTB transcriptional repressor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HIC1hg19_v2_chr17_+_1959369_1959604,
hg19_v2_chr17_+_1958388_1958404		0.401.0e-09Click!

Activity profile of HIC1 motif

Sorted Z-values of HIC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_6845384 77.19 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr15_+_68871308 47.32 ENST00000261861.5
CORO2B
coronin, actin binding protein, 2B
chr16_+_58497567 43.51 ENST00000258187.5
NDRG4
NDRG family member 4
chr19_+_709101 43.51 ENST00000338448.5
PALM
paralemmin
chr19_+_708910 42.23 ENST00000264560.7
PALM
paralemmin
chr16_+_1662326 41.01 ENST00000397412.3
CRAMP1L
Crm, cramped-like (Drosophila)
chr18_-_74844727 40.67 ENST00000355994.2
ENST00000579129.1
MBP
myelin basic protein
chr9_-_101471479 40.29 ENST00000259455.2
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr9_+_137979506 39.96 ENST00000539529.1
ENST00000392991.4
ENST00000371793.3
OLFM1
olfactomedin 1
chr20_+_44034804 39.96 ENST00000357275.2
ENST00000372720.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr4_-_109684120 39.96 ENST00000512646.1
ENST00000411864.2
ENST00000296486.3
ENST00000510706.1
ETNPPL
ethanolamine-phosphate phospho-lyase
chr19_+_35521572 36.67 ENST00000262631.5
SCN1B
sodium channel, voltage-gated, type I, beta subunit
chr2_-_224903995 36.07 ENST00000409304.1
ENST00000454956.1
ENST00000258405.4
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr16_+_226658 35.77 ENST00000320868.5
ENST00000397797.1
HBA1
hemoglobin, alpha 1
chr19_+_35521616 35.23 ENST00000595652.1
SCN1B
sodium channel, voltage-gated, type I, beta subunit
chrX_+_38420783 34.83 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chr6_-_84419101 34.37 ENST00000520302.1
ENST00000520213.1
ENST00000439399.2
ENST00000428679.2
ENST00000437520.1
SNAP91
synaptosomal-associated protein, 91kDa
chr12_-_45270151 32.53 ENST00000429094.2
NELL2
NEL-like 2 (chicken)
chr7_-_44365020 32.37 ENST00000395747.2
ENST00000347193.4
ENST00000346990.4
ENST00000258682.6
ENST00000353625.4
ENST00000421607.1
ENST00000424197.1
ENST00000502837.2
ENST00000350811.3
ENST00000395749.2
CAMK2B
calcium/calmodulin-dependent protein kinase II beta
chr17_-_15903002 31.94 ENST00000399277.1
ZSWIM7
zinc finger, SWIM-type containing 7
chr6_-_84418841 31.90 ENST00000369694.2
ENST00000195649.6
SNAP91
synaptosomal-associated protein, 91kDa
chr11_-_2160611 31.86 ENST00000416167.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_-_45270077 31.75 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NELL2
NEL-like 2 (chicken)
chrX_+_38420623 31.70 ENST00000378482.2
TSPAN7
tetraspanin 7
chr18_+_77439775 31.31 ENST00000299543.7
ENST00000075430.7
CTDP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr10_+_121485588 31.04 ENST00000361976.2
ENST00000369083.3
INPP5F
inositol polyphosphate-5-phosphatase F
chr12_+_121078355 29.84 ENST00000316803.3
CABP1
calcium binding protein 1
chr10_+_124221036 29.56 ENST00000368984.3
HTRA1
HtrA serine peptidase 1
chr11_-_12030905 28.85 ENST00000326932.4
DKK3
dickkopf WNT signaling pathway inhibitor 3
chr16_-_1661988 28.76 ENST00000426508.2
IFT140
intraflagellar transport 140 homolog (Chlamydomonas)
chr20_+_44034676 28.62 ENST00000372723.3
ENST00000372722.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr8_-_120685608 28.50 ENST00000427067.2
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr5_+_134240588 28.14 ENST00000254908.6
PCBD2
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
chr6_-_46459099 27.97 ENST00000371374.1
RCAN2
regulator of calcineurin 2
chr13_+_42031679 27.78 ENST00000379359.3
RGCC
regulator of cell cycle
chr9_+_130374537 27.64 ENST00000373302.3
ENST00000373299.1
STXBP1
syntaxin binding protein 1
chr15_+_80696666 27.13 ENST00000303329.4
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr11_+_70244510 25.13 ENST00000346329.3
ENST00000301843.8
ENST00000376561.3
CTTN
cortactin
chr11_-_777467 24.81 ENST00000397472.2
ENST00000524550.1
ENST00000319863.8
ENST00000526325.1
ENST00000442059.2
PDDC1
Parkinson disease 7 domain containing 1
chr15_+_68871569 24.61 ENST00000566799.1
CORO2B
coronin, actin binding protein, 2B
chr2_+_241938255 24.46 ENST00000401884.1
ENST00000405547.3
ENST00000310397.8
ENST00000342631.6
SNED1
sushi, nidogen and EGF-like domains 1
chr2_-_99552620 23.85 ENST00000428096.1
ENST00000397899.2
ENST00000420294.1
KIAA1211L
KIAA1211-like
chr8_+_104152922 23.67 ENST00000309982.5
ENST00000438105.2
ENST00000297574.6
BAALC
brain and acute leukemia, cytoplasmic
chr14_+_102027688 23.43 ENST00000510508.4
ENST00000359323.3
DIO3
deiodinase, iodothyronine, type III
chr7_+_45613958 23.32 ENST00000297323.7
ADCY1
adenylate cyclase 1 (brain)
chr6_-_109330702 22.97 ENST00000356644.7
SESN1
sestrin 1
chr2_-_38604398 22.43 ENST00000443098.1
ENST00000449130.1
ENST00000378954.4
ENST00000539122.1
ENST00000419554.2
ENST00000451483.1
ENST00000406122.1
ATL2
atlastin GTPase 2
chr17_-_15165854 22.31 ENST00000395936.1
ENST00000395938.2
PMP22
peripheral myelin protein 22
chr1_+_169075554 22.24 ENST00000367815.4
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr20_+_44035200 22.06 ENST00000372717.1
ENST00000360981.4
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr6_+_107811162 22.05 ENST00000317357.5
SOBP
sine oculis binding protein homolog (Drosophila)
chr1_+_10270863 22.04 ENST00000377093.4
ENST00000263934.6
KIF1B
kinesin family member 1B
chr12_+_53440753 21.82 ENST00000379902.3
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr4_-_57522598 21.36 ENST00000553379.2
HOPX
HOP homeobox
chr3_+_53528659 21.30 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr8_-_101571964 21.22 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ANKRD46
ankyrin repeat domain 46
chr6_+_43543864 21.19 ENST00000372236.4
ENST00000535400.1
POLH
polymerase (DNA directed), eta
chr4_-_57522673 21.06 ENST00000381255.3
ENST00000317745.7
ENST00000555760.2
ENST00000556614.2
HOPX
HOP homeobox
chr22_+_33197683 21.04 ENST00000266085.6
TIMP3
TIMP metallopeptidase inhibitor 3
chr17_+_30813576 20.93 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr20_-_50384864 20.80 ENST00000311637.5
ENST00000402822.1
ATP9A
ATPase, class II, type 9A
chr20_-_50385138 20.74 ENST00000338821.5
ATP9A
ATPase, class II, type 9A
chr8_-_101571933 20.56 ENST00000520311.1
ANKRD46
ankyrin repeat domain 46
chrX_-_2418596 20.55 ENST00000381218.3
ZBED1
zinc finger, BED-type containing 1
chr1_-_241520525 20.47 ENST00000366565.1
RGS7
regulator of G-protein signaling 7
chr7_+_4721885 20.46 ENST00000328914.4
FOXK1
forkhead box K1
chr9_+_17579084 20.29 ENST00000380607.4
SH3GL2
SH3-domain GRB2-like 2
chr2_+_46524537 20.21 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr6_-_56819385 20.19 ENST00000370754.5
ENST00000449297.2
DST
dystonin
chr10_-_81205373 20.09 ENST00000372336.3
ZCCHC24
zinc finger, CCHC domain containing 24
chr9_+_137967366 20.05 ENST00000252854.4
OLFM1
olfactomedin 1
chr17_-_74236382 20.02 ENST00000592271.1
ENST00000319945.6
ENST00000269391.6
RNF157
ring finger protein 157
chr22_-_21213029 19.96 ENST00000572273.1
ENST00000255882.6
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr11_-_66336060 19.81 ENST00000310325.5
CTSF
cathepsin F
chr16_+_84002234 19.81 ENST00000305202.4
NECAB2
N-terminal EF-hand calcium binding protein 2
chr2_-_175870085 19.78 ENST00000409156.3
CHN1
chimerin 1
chr10_+_126150369 19.66 ENST00000392757.4
ENST00000368842.5
ENST00000368839.1
LHPP
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr19_-_460996 19.62 ENST00000264554.6
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr17_-_79139817 19.34 ENST00000326724.4
AATK
apoptosis-associated tyrosine kinase
chr4_-_57522470 19.33 ENST00000503639.3
HOPX
HOP homeobox
chr19_-_19006890 19.32 ENST00000247005.6
GDF1
growth differentiation factor 1
chr8_+_1922024 19.22 ENST00000320248.3
KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr19_-_42746714 19.16 ENST00000222330.3
GSK3A
glycogen synthase kinase 3 alpha
chr22_-_45559642 19.05 ENST00000426282.2
CTA-217C2.1
CTA-217C2.1
chr2_+_20646824 18.86 ENST00000272233.4
RHOB
ras homolog family member B
chr6_-_84418860 18.84 ENST00000521743.1
SNAP91
synaptosomal-associated protein, 91kDa
chr16_+_66914264 18.81 ENST00000311765.2
ENST00000568869.1
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
PDP2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr19_-_49944806 18.74 ENST00000221485.3
SLC17A7
solute carrier family 17 (vesicular glutamate transporter), member 7
chr17_+_38083977 18.60 ENST00000578802.1
ENST00000578478.1
ENST00000582263.1
RP11-387H17.4
RP11-387H17.4
chr7_-_99756293 18.54 ENST00000316937.3
ENST00000456769.1
C7orf43
chromosome 7 open reading frame 43
chr3_+_32147997 18.48 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr4_+_3768075 18.45 ENST00000509482.1
ENST00000330055.5
ADRA2C
adrenoceptor alpha 2C
chr17_-_80656528 18.37 ENST00000538809.2
ENST00000269347.6
ENST00000571995.1
RAB40B
RAB40B, member RAS oncogene family
chr2_-_175869936 18.35 ENST00000409900.3
CHN1
chimerin 1
chr4_+_1795012 18.18 ENST00000481110.2
ENST00000340107.4
ENST00000440486.2
ENST00000412135.2
FGFR3
fibroblast growth factor receptor 3
chr19_+_18718214 17.77 ENST00000600490.1
TMEM59L
transmembrane protein 59-like
chr3_+_49027308 17.76 ENST00000383729.4
ENST00000343546.4
P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr5_+_76506706 17.60 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
PDE8B
phosphodiesterase 8B
chrX_+_110187513 17.56 ENST00000446737.1
ENST00000425146.1
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr12_-_124457371 17.49 ENST00000238156.3
ENST00000545037.1
CCDC92
coiled-coil domain containing 92
chr21_-_34100244 17.47 ENST00000382491.3
ENST00000357345.3
ENST00000429236.1
SYNJ1
synaptojanin 1
chr9_-_139922631 17.46 ENST00000341511.6
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr4_+_2965307 17.41 ENST00000398051.4
ENST00000503518.2
ENST00000398052.4
ENST00000345167.6
ENST00000504933.1
ENST00000442472.2
GRK4
G protein-coupled receptor kinase 4
chr7_-_22396533 17.38 ENST00000344041.6
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr3_-_149688502 17.17 ENST00000481767.1
ENST00000475518.1
PFN2
profilin 2
chr1_-_6240183 17.14 ENST00000262450.3
ENST00000378021.1
CHD5
chromodomain helicase DNA binding protein 5
chr7_-_124405681 17.13 ENST00000303921.2
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr22_-_39239987 17.05 ENST00000333039.2
NPTXR
neuronal pentraxin receptor
chr6_+_147830063 16.93 ENST00000367474.1
SAMD5
sterile alpha motif domain containing 5
chr12_-_53574376 16.90 ENST00000267085.4
ENST00000379850.3
ENST00000379846.1
ENST00000424990.1
CSAD
cysteine sulfinic acid decarboxylase
chr11_-_108369101 16.90 ENST00000323468.5
KDELC2
KDEL (Lys-Asp-Glu-Leu) containing 2
chr14_+_65171099 16.87 ENST00000247226.7
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr6_+_43543942 16.87 ENST00000372226.1
ENST00000443535.1
POLH
polymerase (DNA directed), eta
chr15_-_71146480 16.87 ENST00000299213.8
LARP6
La ribonucleoprotein domain family, member 6
chr2_+_220379052 16.78 ENST00000347842.3
ENST00000358078.4
ASIC4
acid-sensing (proton-gated) ion channel family member 4
chr6_+_31865552 16.68 ENST00000469372.1
ENST00000497706.1
C2
complement component 2
chr2_-_86564776 16.66 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1
receptor accessory protein 1
chr1_+_184356188 16.63 ENST00000235307.6
C1orf21
chromosome 1 open reading frame 21
chr14_+_73704201 16.60 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr9_+_124030338 16.53 ENST00000449773.1
ENST00000432226.1
ENST00000436847.1
ENST00000394353.2
ENST00000449733.1
ENST00000412819.1
ENST00000341272.2
ENST00000373808.2
GSN
gelsolin
chr8_+_136469684 16.52 ENST00000355849.5
KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr16_+_3096638 16.44 ENST00000336577.4
MMP25
matrix metallopeptidase 25
chr1_+_24882560 16.31 ENST00000374392.2
NCMAP
noncompact myelin associated protein
chr20_-_48532019 16.13 ENST00000289431.5
SPATA2
spermatogenesis associated 2
chr14_+_96505659 16.11 ENST00000555004.1
C14orf132
chromosome 14 open reading frame 132
chr3_-_149688655 16.08 ENST00000461930.1
ENST00000423691.2
ENST00000490975.1
ENST00000461868.1
ENST00000452853.2
PFN2
profilin 2
chr5_-_146889619 16.05 ENST00000343218.5
DPYSL3
dihydropyrimidinase-like 3
chr12_-_53574418 16.01 ENST00000379843.3
ENST00000453446.2
ENST00000437073.1
CSAD
cysteine sulfinic acid decarboxylase
chr18_-_72265035 15.94 ENST00000585279.1
ENST00000580048.1
LINC00909
long intergenic non-protein coding RNA 909
chr8_-_110703819 15.93 ENST00000532779.1
ENST00000534578.1
SYBU
syntabulin (syntaxin-interacting)
chr19_-_18717627 15.74 ENST00000392386.3
CRLF1
cytokine receptor-like factor 1
chr1_+_9599540 15.74 ENST00000302692.6
SLC25A33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr4_-_5890145 15.48 ENST00000397890.2
CRMP1
collapsin response mediator protein 1
chr11_-_62389449 15.47 ENST00000534026.1
B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr9_-_91793675 15.41 ENST00000375835.4
ENST00000375830.1
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr21_-_38338773 15.40 ENST00000399120.1
ENST00000419461.1
HLCS
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr9_-_139922726 15.31 ENST00000265662.5
ENST00000371605.3
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr20_+_23016057 15.20 ENST00000255008.3
SSTR4
somatostatin receptor 4
chr4_+_4388805 15.16 ENST00000504171.1
NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr4_-_5894777 15.07 ENST00000324989.7
CRMP1
collapsin response mediator protein 1
chr19_+_33685490 15.07 ENST00000253193.7
LRP3
low density lipoprotein receptor-related protein 3
chr13_+_27131887 14.92 ENST00000335327.5
WASF3
WAS protein family, member 3
chr1_+_3569072 14.87 ENST00000378295.4
ENST00000604074.1
TP73
tumor protein p73
chr1_-_11865982 14.86 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr21_-_34100341 14.78 ENST00000382499.2
ENST00000433931.2
SYNJ1
synaptojanin 1
chr15_-_72410350 14.71 ENST00000356056.5
ENST00000424560.1
ENST00000444904.1
MYO9A
myosin IXA
chr9_-_140353748 14.57 ENST00000371472.2
ENST00000371475.3
ENST00000265663.7
ENST00000437259.1
ENST00000392812.4
ENST00000371474.3
ENST00000371473.3
NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor
chr15_+_29131103 14.49 ENST00000558402.1
ENST00000558330.1
APBA2
amyloid beta (A4) precursor protein-binding, family A, member 2
chr19_+_16999654 14.49 ENST00000248076.3
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr19_-_19006920 14.44 ENST00000429504.2
ENST00000427170.2
CERS1
ceramide synthase 1
chr16_+_85061367 14.41 ENST00000538274.1
ENST00000258180.3
KIAA0513
KIAA0513
chr6_+_19837592 14.28 ENST00000378700.3
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr12_+_12878829 14.24 ENST00000326765.6
APOLD1
apolipoprotein L domain containing 1
chr19_-_2236290 14.21 ENST00000591099.2
ENST00000586608.2
ENST00000326631.2
ENST00000587962.2
PLEKHJ1
pleckstrin homology domain containing, family J member 1
chr1_+_3569129 14.14 ENST00000354437.4
ENST00000357733.3
ENST00000346387.4
TP73
tumor protein p73
chr19_+_10541462 14.13 ENST00000293683.5
PDE4A
phosphodiesterase 4A, cAMP-specific
chr8_+_124194752 14.06 ENST00000318462.6
FAM83A
family with sequence similarity 83, member A
chr3_-_52001448 14.05 ENST00000461554.1
ENST00000395013.3
ENST00000428823.2
ENST00000483411.1
ENST00000461544.1
ENST00000355852.2
PCBP4
poly(rC) binding protein 4
chrX_-_153363188 14.05 ENST00000303391.6
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr9_-_136857403 14.03 ENST00000406606.3
ENST00000371850.3
VAV2
vav 2 guanine nucleotide exchange factor
chr8_+_26435359 14.02 ENST00000311151.5
DPYSL2
dihydropyrimidinase-like 2
chr1_-_21948906 13.94 ENST00000374761.2
ENST00000599760.1
RAP1GAP
RAP1 GTPase activating protein
chr16_+_1756162 13.90 ENST00000250894.4
ENST00000356010.5
MAPK8IP3
mitogen-activated protein kinase 8 interacting protein 3
chr1_-_54872059 13.85 ENST00000371320.3
SSBP3
single stranded DNA binding protein 3
chr17_-_10101868 13.74 ENST00000432992.2
ENST00000540214.1
GAS7
growth arrest-specific 7
chrX_-_8700171 13.72 ENST00000262648.3
KAL1
Kallmann syndrome 1 sequence
chr5_+_149109825 13.71 ENST00000360453.4
ENST00000394320.3
ENST00000309241.5
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr7_+_98246588 13.71 ENST00000265634.3
NPTX2
neuronal pentraxin II
chr1_-_21995794 13.70 ENST00000542643.2
ENST00000374765.4
ENST00000317967.7
RAP1GAP
RAP1 GTPase activating protein
chr17_+_18163848 13.68 ENST00000323019.4
ENST00000578174.1
ENST00000395704.4
ENST00000395703.4
ENST00000578621.1
ENST00000579341.1
MIEF2
mitochondrial elongation factor 2
chr12_+_113376249 13.62 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr9_-_13279563 13.58 ENST00000541718.1
MPDZ
multiple PDZ domain protein
chr1_+_156611704 13.56 ENST00000329117.5
BCAN
brevican
chr12_+_119616447 13.54 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr16_-_75498308 13.52 ENST00000569540.1
TMEM170A
transmembrane protein 170A
chr2_-_183903133 13.49 ENST00000361354.4
NCKAP1
NCK-associated protein 1
chr7_-_122526799 13.33 ENST00000334010.7
ENST00000313070.7
CADPS2
Ca++-dependent secretion activator 2
chr14_+_33408449 13.30 ENST00000346562.2
ENST00000341321.4
ENST00000548645.1
ENST00000356141.4
ENST00000357798.5
NPAS3
neuronal PAS domain protein 3
chr11_+_121322832 13.29 ENST00000260197.7
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr20_-_35492048 13.27 ENST00000237536.4
SOGA1
suppressor of glucose, autophagy associated 1
chr3_-_127541679 13.25 ENST00000265052.5
MGLL
monoglyceride lipase
chr3_+_14989186 13.19 ENST00000435454.1
ENST00000323373.6
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr7_+_2559399 13.17 ENST00000222725.5
ENST00000359574.3
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_-_85930823 13.16 ENST00000284031.8
ENST00000539042.1
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr20_+_4667094 13.16 ENST00000424424.1
ENST00000457586.1
PRNP
prion protein
chr9_+_129089088 13.15 ENST00000361171.3
ENST00000545391.1
MVB12B
multivesicular body subunit 12B
chr7_-_73133959 13.07 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A
syntaxin 1A (brain)
chr8_+_104513086 13.06 ENST00000406091.3
RIMS2
regulating synaptic membrane exocytosis 2
chr3_-_149688896 13.04 ENST00000239940.7
PFN2
profilin 2
chr8_-_33424636 13.03 ENST00000256257.1
RNF122
ring finger protein 122
chr12_-_53574671 13.01 ENST00000444623.1
CSAD
cysteine sulfinic acid decarboxylase
chr14_-_101034407 12.92 ENST00000443071.2
ENST00000557378.1
BEGAIN
brain-enriched guanylate kinase-associated
chr17_-_4167142 12.88 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr19_-_49140609 12.87 ENST00000601104.1
DBP
D site of albumin promoter (albumin D-box) binding protein
chr10_-_120514720 12.87 ENST00000369151.3
ENST00000340214.4
CACUL1
CDK2-associated, cullin domain 1
chr21_+_47878757 12.78 ENST00000400274.1
ENST00000427143.2
ENST00000318711.7
ENST00000457905.3
ENST00000466639.1
ENST00000435722.3
ENST00000417564.2
DIP2A
DIP2 disco-interacting protein 2 homolog A (Drosophila)
chr9_-_130742792 12.77 ENST00000373095.1
FAM102A
family with sequence similarity 102, member A
chr1_-_241520385 12.76 ENST00000366564.1
RGS7
regulator of G-protein signaling 7
chr12_-_112819896 12.73 ENST00000377560.5
ENST00000430131.2
ENST00000550722.1
ENST00000550724.1
HECTD4
HECT domain containing E3 ubiquitin protein ligase 4
chr12_+_125478241 12.67 ENST00000341446.8
BRI3BP
BRI3 binding protein

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
24.0 71.9 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
11.5 45.9 GO:0042412 taurine biosynthetic process(GO:0042412)
11.0 88.3 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
10.4 31.3 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
10.2 30.5 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
10.1 50.4 GO:0061107 seminal vesicle development(GO:0061107)
9.4 18.7 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
9.3 27.8 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
9.2 27.7 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
9.2 27.6 GO:1903697 negative regulation of microvillus assembly(GO:1903697)
9.2 27.6 GO:0007412 axon target recognition(GO:0007412) regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
9.0 36.0 GO:1904978 regulation of endosome organization(GO:1904978)
8.7 78.7 GO:0003190 atrioventricular valve formation(GO:0003190)
7.4 22.2 GO:0014807 regulation of somitogenesis(GO:0014807)
7.3 22.0 GO:1904647 response to rotenone(GO:1904647)
7.2 28.8 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
7.2 21.5 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
7.2 14.4 GO:0072134 nephrogenic mesenchyme morphogenesis(GO:0072134)
7.0 34.9 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
6.8 87.8 GO:2001135 regulation of endocytic recycling(GO:2001135)
6.6 19.8 GO:0060168 positive regulation of adenosine receptor signaling pathway(GO:0060168)
6.6 32.8 GO:0032377 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
6.5 91.3 GO:0070050 neuron cellular homeostasis(GO:0070050)
6.4 19.2 GO:0006258 UDP-glucose catabolic process(GO:0006258)
6.1 12.2 GO:1990523 bone regeneration(GO:1990523)
6.0 18.1 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
5.9 29.6 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
5.6 22.2 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
5.5 22.2 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
5.4 38.1 GO:0071494 cellular response to UV-C(GO:0071494)
5.4 16.3 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
5.4 16.3 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
5.3 21.0 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
5.2 15.7 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
5.1 15.4 GO:0070781 response to biotin(GO:0070781)
4.9 19.6 GO:0060594 mammary gland specification(GO:0060594)
4.7 56.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
4.6 60.4 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
4.6 18.5 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072) negative regulation of protein kinase C signaling(GO:0090038)
4.6 18.4 GO:0032811 negative regulation of epinephrine secretion(GO:0032811) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
4.5 4.5 GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
4.4 39.5 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
4.2 46.1 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
4.2 12.5 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
4.2 12.5 GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233)
4.1 20.6 GO:1990504 dense core granule exocytosis(GO:1990504)
4.1 8.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
4.1 12.2 GO:0003383 apical constriction(GO:0003383) mesoderm migration involved in gastrulation(GO:0007509)
4.1 20.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
4.1 12.2 GO:1990502 dense core granule maturation(GO:1990502)
3.9 7.7 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
3.8 11.5 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
3.7 22.4 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
3.7 29.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
3.7 106.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
3.7 25.6 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
3.6 14.4 GO:0071492 cellular response to UV-A(GO:0071492)
3.5 17.5 GO:0097338 response to clozapine(GO:0097338)
3.5 27.6 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
3.3 23.4 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
3.3 10.0 GO:0048511 rhythmic process(GO:0048511)
3.3 9.9 GO:0071529 cementum mineralization(GO:0071529)
3.3 16.5 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
3.3 13.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
3.2 9.7 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
3.2 28.8 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
3.2 28.4 GO:0008090 retrograde axonal transport(GO:0008090)
3.1 12.5 GO:0003219 cardiac right ventricle formation(GO:0003219)
3.1 9.4 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
3.1 6.2 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
3.1 15.3 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
3.1 12.2 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
3.0 15.2 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
3.0 14.9 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
2.9 11.7 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
2.9 20.4 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
2.9 5.8 GO:0021586 pons maturation(GO:0021586)
2.9 11.4 GO:2001151 regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
2.9 11.4 GO:1901162 primary amino compound biosynthetic process(GO:1901162)
2.8 8.5 GO:1900369 transcription, RNA-templated(GO:0001172) regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369) positive regulation of protein localization to nucleolus(GO:1904751)
2.8 11.3 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
2.8 11.2 GO:0060024 rhythmic synaptic transmission(GO:0060024)
2.7 8.2 GO:1900063 regulation of peroxisome organization(GO:1900063)
2.7 10.9 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
2.7 8.1 GO:0060437 lung growth(GO:0060437)
2.7 8.0 GO:0031052 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
2.7 5.3 GO:1990164 histone H2A phosphorylation(GO:1990164)
2.7 13.3 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
2.6 13.2 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
2.6 18.2 GO:0060992 response to fungicide(GO:0060992)
2.6 23.0 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
2.5 20.2 GO:0043129 surfactant homeostasis(GO:0043129)
2.5 12.6 GO:0043654 recognition of apoptotic cell(GO:0043654)
2.5 22.2 GO:0038007 netrin-activated signaling pathway(GO:0038007)
2.5 12.3 GO:1904139 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141)
2.5 7.4 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
2.4 4.9 GO:0070256 negative regulation of circadian sleep/wake cycle, sleep(GO:0042321) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
2.4 2.4 GO:0007497 posterior midgut development(GO:0007497)
2.4 35.8 GO:0015671 oxygen transport(GO:0015671)
2.4 7.1 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
2.4 9.4 GO:0006114 glycerol biosynthetic process(GO:0006114)
2.3 11.4 GO:0071321 cellular response to cGMP(GO:0071321)
2.3 27.2 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
2.3 9.0 GO:0022027 interkinetic nuclear migration(GO:0022027)
2.2 6.6 GO:0071373 luteinizing hormone signaling pathway(GO:0042700) cellular response to luteinizing hormone stimulus(GO:0071373)
2.2 24.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
2.2 13.2 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
2.2 6.5 GO:0046952 ketone body catabolic process(GO:0046952)
2.2 10.9 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
2.1 12.9 GO:0048549 positive regulation of pinocytosis(GO:0048549)
2.1 8.5 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
2.1 6.3 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
2.1 10.5 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
2.0 10.1 GO:0030035 microspike assembly(GO:0030035)
2.0 44.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
2.0 30.2 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
2.0 8.0 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
2.0 5.9 GO:1900073 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
2.0 17.8 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
2.0 41.4 GO:0001829 trophectodermal cell differentiation(GO:0001829)
1.9 5.8 GO:0006566 threonine metabolic process(GO:0006566)
1.9 11.7 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
1.9 5.8 GO:0072177 mesonephric duct development(GO:0072177)
1.9 9.7 GO:0036016 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
1.9 9.6 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.9 9.5 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
1.9 5.7 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
1.9 13.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.9 35.8 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
1.9 20.6 GO:0060022 hard palate development(GO:0060022)
1.9 7.5 GO:0001826 inner cell mass cell differentiation(GO:0001826)
1.9 13.1 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
1.9 5.6 GO:0010265 SCF complex assembly(GO:0010265)
1.8 12.9 GO:0007256 activation of JNKK activity(GO:0007256)
1.8 9.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
1.8 14.5 GO:0060155 platelet dense granule organization(GO:0060155)
1.8 5.4 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
1.8 19.9 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
1.8 10.7 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
1.8 5.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
1.8 5.3 GO:0100009 circadian temperature homeostasis(GO:0060086) regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009)
1.8 22.9 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
1.7 45.1 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
1.7 5.2 GO:2000173 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
1.7 6.9 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
1.7 13.7 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
1.7 5.1 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
1.7 17.1 GO:0045964 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
1.7 29.0 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
1.7 5.0 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
1.7 6.7 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
1.7 16.6 GO:0042118 endothelial cell activation(GO:0042118)
1.7 52.8 GO:0008045 motor neuron axon guidance(GO:0008045)
1.6 9.9 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
1.6 8.2 GO:0090650 rRNA transport(GO:0051029) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
1.6 4.9 GO:0043615 astrocyte cell migration(GO:0043615)
1.6 19.5 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
1.6 8.0 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
1.6 4.8 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
1.6 9.5 GO:0052422 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
1.5 6.2 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
1.5 12.4 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
1.5 47.4 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
1.5 4.6 GO:0097359 UDP-glucosylation(GO:0097359)
1.5 4.6 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
1.5 9.1 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
1.5 16.7 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
1.5 7.6 GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development(GO:0061051)
1.5 6.0 GO:0032074 negative regulation of nuclease activity(GO:0032074)
1.5 14.9 GO:0070830 bicellular tight junction assembly(GO:0070830)
1.5 11.9 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
1.5 14.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
1.4 1.4 GO:0003343 proepicardium development(GO:0003342) septum transversum development(GO:0003343)
1.4 8.6 GO:0021819 layer formation in cerebral cortex(GO:0021819)
1.4 50.0 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
1.4 2.9 GO:0070307 lens fiber cell development(GO:0070307)
1.4 8.5 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
1.4 8.5 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
1.4 6.9 GO:0099538 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
1.4 9.7 GO:0051639 actin filament network formation(GO:0051639)
1.4 13.7 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
1.4 6.8 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
1.3 9.4 GO:0043634 polyadenylation-dependent RNA catabolic process(GO:0043633) polyadenylation-dependent ncRNA catabolic process(GO:0043634)
1.3 9.4 GO:0042126 nitrate metabolic process(GO:0042126)
1.3 10.7 GO:0061314 Notch signaling involved in heart development(GO:0061314)
1.3 17.4 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
1.3 6.7 GO:0034334 adherens junction maintenance(GO:0034334)
1.3 8.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
1.3 4.0 GO:0090298 negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859)
1.3 7.8 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
1.3 7.8 GO:0098722 asymmetric neuroblast division(GO:0055059) asymmetric stem cell division(GO:0098722)
1.3 23.3 GO:0032060 bleb assembly(GO:0032060)
1.3 6.4 GO:1990034 calcium ion export from cell(GO:1990034)
1.3 6.4 GO:0000189 MAPK import into nucleus(GO:0000189)
1.3 19.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
1.3 3.8 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
1.3 46.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
1.3 12.5 GO:0030322 stabilization of membrane potential(GO:0030322)
1.3 6.3 GO:0018125 peptidyl-cysteine methylation(GO:0018125) minus-end-directed organelle transport along microtubule(GO:0072385)
1.2 7.4 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
1.2 3.7 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
1.2 7.1 GO:0046929 negative regulation of neurotransmitter secretion(GO:0046929)
1.2 3.5 GO:0036071 N-glycan fucosylation(GO:0036071)
1.2 3.5 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
1.2 10.6 GO:1903140 regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
1.2 8.2 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
1.1 3.4 GO:0043068 positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
1.1 17.0 GO:0071318 cellular response to ATP(GO:0071318)
1.1 6.5 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
1.1 8.7 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
1.1 11.9 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
1.1 3.2 GO:1902490 regulation of sperm capacitation(GO:1902490)
1.1 2.1 GO:0003348 cardiac endothelial cell differentiation(GO:0003348) endocardial cell differentiation(GO:0060956)
1.1 2.1 GO:0031133 regulation of axon diameter(GO:0031133)
1.1 6.4 GO:0060013 righting reflex(GO:0060013)
1.1 10.6 GO:0060700 regulation of ribonuclease activity(GO:0060700)
1.1 2.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
1.1 10.6 GO:0010457 centriole-centriole cohesion(GO:0010457)
1.0 19.8 GO:0035988 chondrocyte proliferation(GO:0035988)
1.0 5.2 GO:0009636 response to toxic substance(GO:0009636)
1.0 7.2 GO:0016322 neuron remodeling(GO:0016322)
1.0 59.3 GO:0050885 neuromuscular process controlling balance(GO:0050885)
1.0 6.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
1.0 2.0 GO:0098868 endochondral bone growth(GO:0003416) bone growth(GO:0098868)
1.0 9.0 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
1.0 5.0 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
1.0 8.9 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
1.0 3.9 GO:0016198 axon choice point recognition(GO:0016198)
1.0 4.9 GO:0061511 centriole elongation(GO:0061511)
1.0 13.7 GO:0000725 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
1.0 24.4 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
1.0 6.8 GO:0035897 proteolysis in other organism(GO:0035897)
1.0 23.2 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
1.0 1.0 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
1.0 11.6 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
1.0 6.7 GO:0046618 drug export(GO:0046618)
1.0 5.7 GO:0072364 regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter(GO:0072364)
1.0 11.5 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
1.0 3.8 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
1.0 10.5 GO:0042711 maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.9 32.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.9 7.4 GO:0046325 negative regulation of glucose import(GO:0046325)
0.9 21.2 GO:0031643 positive regulation of myelination(GO:0031643)
0.9 3.7 GO:0019086 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) late viral transcription(GO:0019086) positive regulation of transcription by glucose(GO:0046016)
0.9 9.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.9 0.9 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.9 16.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.9 11.7 GO:0008089 anterograde axonal transport(GO:0008089)
0.9 7.2 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.9 7.2 GO:0034086 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.9 5.3 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.9 16.0 GO:0051764 actin crosslink formation(GO:0051764)
0.9 8.9 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.9 9.7 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.9 2.6 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.8 6.8 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.8 8.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.8 8.5 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.8 1.7 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.8 7.5 GO:0006338 chromatin remodeling(GO:0006338)
0.8 5.0 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.8 2.5 GO:0033184 positive regulation of histone ubiquitination(GO:0033184) regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.8 7.4 GO:0090037 positive regulation of protein kinase C signaling(GO:0090037)
0.8 5.7 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.8 9.7 GO:0014848 urinary bladder smooth muscle contraction(GO:0014832) urinary tract smooth muscle contraction(GO:0014848)
0.8 3.9 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.8 6.2 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.8 14.7 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.8 4.6 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.7 19.4 GO:0097503 sialylation(GO:0097503)
0.7 3.7 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.7 14.7 GO:0005513 detection of calcium ion(GO:0005513)
0.7 7.3 GO:0030913 paranodal junction assembly(GO:0030913)
0.7 5.1 GO:0040032 post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.7 2.2 GO:1903401 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine transmembrane transport(GO:1903401) L-lysine import into cell(GO:1903410)
0.7 11.5 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.7 11.4 GO:0032836 glomerular basement membrane development(GO:0032836)
0.7 2.1 GO:0050720 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720)
0.7 3.6 GO:0070166 enamel mineralization(GO:0070166)
0.7 3.5 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.7 5.6 GO:0003338 metanephros morphogenesis(GO:0003338)
0.7 2.1 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.7 4.8 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.7 22.0 GO:0006783 heme biosynthetic process(GO:0006783)
0.7 10.9 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.7 11.5 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.7 3.3 GO:0060004 reflex(GO:0060004)
0.7 15.2 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.7 2.0 GO:0075071 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.7 9.3 GO:0097264 self proteolysis(GO:0097264)
0.7 5.3 GO:0016926 protein desumoylation(GO:0016926)
0.7 2.6 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.7 9.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.7 3.9 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.6 1.9 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.6 1.9 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.6 1.9 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.6 1.2 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.6 7.7 GO:0048820 hair follicle maturation(GO:0048820)
0.6 5.9 GO:0048102 autophagic cell death(GO:0048102)
0.6 11.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.6 5.9 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.6 5.3 GO:0046578 regulation of Ras protein signal transduction(GO:0046578)
0.6 1.7 GO:0021997 neural plate axis specification(GO:0021997)
0.6 5.7 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.6 2.3 GO:0015808 L-alanine transport(GO:0015808)
0.6 5.7 GO:0060841 venous blood vessel development(GO:0060841)
0.6 1.7 GO:0009447 putrescine catabolic process(GO:0009447)
0.6 3.4 GO:0098535 de novo centriole assembly(GO:0098535)
0.6 2.2 GO:0007018 microtubule-based movement(GO:0007018)
0.6 6.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.5 1.6 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.5 3.8 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.5 7.6 GO:0021854 hypothalamus development(GO:0021854)
0.5 5.4 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.5 4.3 GO:0021904 dorsal/ventral neural tube patterning(GO:0021904)
0.5 3.7 GO:0006572 tyrosine catabolic process(GO:0006572)
0.5 1.6 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.5 9.9 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
0.5 3.6 GO:0048104 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.5 2.6 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.5 4.1 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.5 31.9 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.5 9.2 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.5 9.2 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.5 4.5 GO:0033127 regulation of histone phosphorylation(GO:0033127)
0.5 8.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.5 10.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.5 4.0 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.5 12.3 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.5 2.0 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.5 0.5 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.5 4.9 GO:0008038 neuron recognition(GO:0008038)
0.5 12.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.5 3.3 GO:0034453 microtubule anchoring(GO:0034453)
0.5 12.3 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.5 15.5 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.5 1.9 GO:0075509 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.5 0.5 GO:0072178 nephric duct development(GO:0072176) nephric duct morphogenesis(GO:0072178)
0.5 8.7 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.5 1.4 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.5 4.1 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.4 13.9 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.4 1.8 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.4 1.8 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.4 4.4 GO:0055123 digestive system development(GO:0055123)
0.4 3.0 GO:0090344 negative regulation of cell aging(GO:0090344)
0.4 6.7 GO:0030030 cell projection organization(GO:0030030)
0.4 1.3 GO:0072284 thyroid-stimulating hormone secretion(GO:0070460) comma-shaped body morphogenesis(GO:0072049) S-shaped body morphogenesis(GO:0072050) metanephric comma-shaped body morphogenesis(GO:0072278) metanephric S-shaped body morphogenesis(GO:0072284) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.4 6.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.4 2.5 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.4 1.2 GO:0071267 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.4 5.7 GO:0009650 UV protection(GO:0009650)
0.4 3.3 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.4 3.2 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.4 2.8 GO:0048710 regulation of astrocyte differentiation(GO:0048710)
0.4 2.4 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.4 9.0 GO:0009435 NAD biosynthetic process(GO:0009435)
0.4 3.1 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.4 8.5 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.4 2.3 GO:0006196 AMP catabolic process(GO:0006196)
0.4 2.7 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.4 3.0 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.4 20.7 GO:0030516 regulation of axon extension(GO:0030516)
0.4 12.5 GO:0090102 cochlea development(GO:0090102)
0.4 5.1 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.4 9.7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.4 9.3 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.4 1.4 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.3 4.2 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.3 2.4 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.3 15.0 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.3 1.3 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.3 2.3 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.3 1.6 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.3 3.9 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.3 2.2 GO:0070459 prolactin secretion(GO:0070459)
0.3 19.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.3 4.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.3 0.9 GO:0001955 blood vessel maturation(GO:0001955)
0.3 7.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.3 2.2 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.3 2.4 GO:0006600 creatine metabolic process(GO:0006600)
0.3 2.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.3 6.3 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.3 2.4 GO:1990403 embryonic brain development(GO:1990403)
0.3 3.0 GO:0071539 protein localization to centrosome(GO:0071539)
0.3 20.1 GO:0042308 negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein import(GO:1904590)
0.3 2.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.3 2.9 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.3 1.4 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.3 1.7 GO:0006006 glucose metabolic process(GO:0006006)
0.3 1.9 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.3 3.6 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.3 3.0 GO:0050909 sensory perception of taste(GO:0050909)
0.3 2.9 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.3 5.6 GO:0016577 histone demethylation(GO:0016577)
0.3 5.0 GO:0003091 renal water homeostasis(GO:0003091)
0.3 2.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.3 4.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.3 5.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.3 1.8 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.3 6.8 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151) phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.3 12.7 GO:0015701 bicarbonate transport(GO:0015701)
0.2 7.2 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.2 1.5 GO:0007296 vitellogenesis(GO:0007296)
0.2 4.7 GO:0009395 phospholipid catabolic process(GO:0009395)
0.2 4.7 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.2 6.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 1.9 GO:0007368 determination of left/right symmetry(GO:0007368)
0.2 4.3 GO:0043507 positive regulation of JUN kinase activity(GO:0043507)
0.2 12.0 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.2 3.6 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.2 17.4 GO:0032273 positive regulation of protein polymerization(GO:0032273)
0.2 5.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.2 2.6 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.2 1.9 GO:0009798 axis specification(GO:0009798)
0.2 1.9 GO:0050769 positive regulation of neurogenesis(GO:0050769)
0.2 2.8 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.2 29.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 42.9 GO:0050953 visual perception(GO:0007601) sensory perception of light stimulus(GO:0050953)
0.2 3.7 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.2 2.3 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.2 0.7 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.2 6.7 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.2 5.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 7.0 GO:0001942 hair follicle development(GO:0001942)
0.2 0.8 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.2 1.4 GO:0010002 cardioblast differentiation(GO:0010002)
0.2 2.4 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.2 3.8 GO:0032570 response to progesterone(GO:0032570)
0.2 3.0 GO:0060113 inner ear receptor cell differentiation(GO:0060113)
0.2 2.3 GO:0045475 locomotor rhythm(GO:0045475)
0.2 5.7 GO:0009268 response to pH(GO:0009268)
0.2 1.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.2 0.5 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.2 4.8 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.2 5.2 GO:0008306 associative learning(GO:0008306)
0.2 7.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.2 2.2 GO:0018345 protein palmitoylation(GO:0018345)
0.2 2.1 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.2 1.9 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.2 2.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 6.7 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.2 0.2 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.2 0.5 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.1 1.9 GO:0032988 ribonucleoprotein complex disassembly(GO:0032988)
0.1 3.7 GO:0021954 central nervous system neuron development(GO:0021954)
0.1 1.0 GO:0007020 microtubule nucleation(GO:0007020)
0.1 1.4 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.1 0.8 GO:0015732 prostaglandin transport(GO:0015732)
0.1 2.5 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.1 1.4 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 1.9 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 0.6 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 3.0 GO:0006379 mRNA cleavage(GO:0006379)
0.1 2.0 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 12.3 GO:1903509 glycolipid metabolic process(GO:0006664) liposaccharide metabolic process(GO:1903509)
0.1 1.6 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.1 0.5 GO:0030432 peristalsis(GO:0030432)
0.1 0.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.2 GO:0033008 positive regulation of myeloid leukocyte mediated immunity(GO:0002888) positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.1 1.0 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 1.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 1.9 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.1 0.4 GO:0002024 diet induced thermogenesis(GO:0002024)
0.1 5.5 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.1 1.8 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 7.1 GO:0030593 neutrophil chemotaxis(GO:0030593)
0.1 2.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 12.2 GO:2000257 regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257)
0.1 4.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 3.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 0.8 GO:0097178 ruffle assembly(GO:0097178)
0.1 0.3 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 1.8 GO:0007605 sensory perception of sound(GO:0007605)
0.1 1.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 1.5 GO:0070207 protein homotrimerization(GO:0070207)
0.1 4.3 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.1 0.4 GO:0045861 negative regulation of proteolysis(GO:0045861)
0.1 1.3 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 6.2 GO:0007219 Notch signaling pathway(GO:0007219)
0.1 4.8 GO:0006901 vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 0.3 GO:1901906 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 1.0 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 7.4 GO:0016197 endosomal transport(GO:0016197)
0.1 1.6 GO:0048599 oocyte development(GO:0048599)
0.1 0.6 GO:0010962 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.1 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 5.8 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 8.0 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.6 GO:0002431 Fc receptor mediated stimulatory signaling pathway(GO:0002431)
0.0 0.2 GO:0035810 positive regulation of urine volume(GO:0035810)
0.0 1.8 GO:0002576 platelet degranulation(GO:0002576)
0.0 2.2 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.2 GO:0097205 glomerular filtration(GO:0003094) renal filtration(GO:0097205)
0.0 0.4 GO:0006069 ethanol oxidation(GO:0006069)
0.0 1.3 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.5 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 1.9 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 1.1 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 0.2 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.2 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.3 GO:0090398 cellular senescence(GO:0090398)
0.0 2.6 GO:0007586 digestion(GO:0007586)
0.0 5.4 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.5 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.3 GO:0035411 catenin import into nucleus(GO:0035411)
0.0 2.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.4 GO:0035264 multicellular organism growth(GO:0035264)
0.0 0.1 GO:0048747 muscle fiber development(GO:0048747)
0.0 0.2 GO:0031102 neuron projection regeneration(GO:0031102)
0.0 0.1 GO:0000305 response to oxygen radical(GO:0000305)
0.0 1.0 GO:0030203 glycosaminoglycan metabolic process(GO:0030203)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
13.4 40.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
8.9 35.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
8.1 40.7 GO:0048787 presynaptic active zone membrane(GO:0048787)
7.1 28.4 GO:0031673 H zone(GO:0031673)
6.9 27.7 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
6.7 20.0 GO:0019034 viral replication complex(GO:0019034)
6.0 36.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
5.2 15.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
5.0 34.9 GO:0033269 internode region of axon(GO:0033269)
4.8 38.4 GO:0098845 postsynaptic endosome(GO:0098845)
4.8 28.8 GO:0030991 intraciliary transport particle A(GO:0030991)
4.3 12.9 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
4.2 71.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
4.0 87.6 GO:0032591 dendritic spine membrane(GO:0032591)
3.7 78.0 GO:0044295 axonal growth cone(GO:0044295)
3.3 23.0 GO:0061700 GATOR2 complex(GO:0061700)
3.1 6.3 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
3.1 18.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
3.0 9.1 GO:0031251 PAN complex(GO:0031251)
3.0 18.1 GO:0005927 muscle tendon junction(GO:0005927)
2.9 35.0 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
2.5 9.9 GO:0031417 NatC complex(GO:0031417)
2.4 16.7 GO:0044326 dendritic spine neck(GO:0044326)
2.4 31.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
2.3 18.7 GO:0060203 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
2.3 254.2 GO:0005905 clathrin-coated pit(GO:0005905)
2.3 9.0 GO:0070695 FHF complex(GO:0070695)
2.2 4.4 GO:0044308 axonal spine(GO:0044308)
2.2 17.5 GO:0031083 BLOC-1 complex(GO:0031083)
2.1 8.5 GO:0000333 telomerase catalytic core complex(GO:0000333)
2.1 12.3 GO:1990682 CSF1-CSF1R complex(GO:1990682)
2.0 8.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
1.9 5.7 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
1.9 26.4 GO:0016461 unconventional myosin complex(GO:0016461)
1.9 13.1 GO:0000813 ESCRT I complex(GO:0000813)
1.9 9.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
1.8 7.3 GO:1990246 uniplex complex(GO:1990246)
1.8 12.8 GO:0070852 cell body fiber(GO:0070852)
1.8 27.0 GO:0030877 beta-catenin destruction complex(GO:0030877)
1.8 21.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
1.7 9.9 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
1.5 119.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.5 7.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.5 11.9 GO:0005683 U7 snRNP(GO:0005683)
1.5 37.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.4 2.8 GO:0000125 PCAF complex(GO:0000125)
1.4 7.1 GO:0008275 gamma-tubulin small complex(GO:0008275)
1.4 38.2 GO:0043218 compact myelin(GO:0043218)
1.3 26.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.3 18.5 GO:0043194 axon initial segment(GO:0043194)
1.3 6.6 GO:0036398 TCR signalosome(GO:0036398)
1.3 11.7 GO:0099634 postsynaptic specialization membrane(GO:0099634)
1.3 23.9 GO:0097381 photoreceptor disc membrane(GO:0097381)
1.2 53.3 GO:1904115 axon cytoplasm(GO:1904115)
1.2 11.0 GO:0097427 microtubule bundle(GO:0097427)
1.2 3.6 GO:0060187 cell pole(GO:0060187)
1.2 31.3 GO:0051233 spindle midzone(GO:0051233)
1.1 9.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
1.1 20.4 GO:0031089 platelet dense granule lumen(GO:0031089)
1.1 11.1 GO:0031045 dense core granule(GO:0031045)
1.1 16.5 GO:0030478 actin cap(GO:0030478)
1.1 11.7 GO:0033391 chromatoid body(GO:0033391)
1.1 12.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
1.0 17.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
1.0 31.4 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
1.0 7.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
1.0 49.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
1.0 3.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.9 2.7 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.9 12.6 GO:0035102 PRC1 complex(GO:0035102)
0.9 7.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.8 58.1 GO:0043195 terminal bouton(GO:0043195)
0.8 4.2 GO:0035859 Seh1-associated complex(GO:0035859) Iml1 complex(GO:1990130)
0.8 20.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.8 28.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.8 3.9 GO:0005594 collagen type IX trimer(GO:0005594)
0.8 4.6 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.8 15.2 GO:0071565 nBAF complex(GO:0071565)
0.8 4.5 GO:0001939 female pronucleus(GO:0001939)
0.7 4.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.7 9.4 GO:0031209 SCAR complex(GO:0031209)
0.7 36.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 6.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.7 4.1 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.7 20.3 GO:0030057 desmosome(GO:0030057)
0.7 14.6 GO:0097440 apical dendrite(GO:0097440)
0.6 25.2 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.6 3.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.6 2.5 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.6 3.6 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.6 13.9 GO:0071141 SMAD protein complex(GO:0071141)
0.6 3.0 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.6 7.6 GO:0008091 spectrin(GO:0008091)
0.6 6.8 GO:0005642 annulate lamellae(GO:0005642)
0.6 5.1 GO:0034464 BBSome(GO:0034464)
0.6 9.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.6 12.2 GO:0031527 filopodium membrane(GO:0031527)
0.5 40.0 GO:0042734 presynaptic membrane(GO:0042734)
0.5 1.6 GO:0005960 glycine cleavage complex(GO:0005960)
0.5 43.8 GO:0070382 exocytic vesicle(GO:0070382)
0.5 16.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.5 4.2 GO:0043219 lateral loop(GO:0043219)
0.5 7.8 GO:0005869 dynactin complex(GO:0005869)
0.5 1.9 GO:0055087 Ski complex(GO:0055087)
0.5 44.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.5 26.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.5 8.1 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.5 1.0 GO:0031201 SNARE complex(GO:0031201)
0.5 6.2 GO:0042555 MCM complex(GO:0042555)
0.5 15.9 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.5 5.1 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.5 3.7 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.5 12.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.4 29.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.4 95.1 GO:0060076 excitatory synapse(GO:0060076)
0.4 43.0 GO:0032587 ruffle membrane(GO:0032587)
0.4 4.1 GO:0045180 basal cortex(GO:0045180)
0.4 1.9 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.4 16.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.4 6.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.4 36.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 15.0 GO:0014704 intercalated disc(GO:0014704)
0.4 5.0 GO:0036038 MKS complex(GO:0036038)
0.4 42.5 GO:0031225 anchored component of membrane(GO:0031225)
0.3 38.2 GO:0031901 early endosome membrane(GO:0031901)
0.3 2.4 GO:0005614 interstitial matrix(GO:0005614)
0.3 4.6 GO:0032590 dendrite membrane(GO:0032590)
0.3 2.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.3 4.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.3 3.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.3 2.1 GO:0030870 Mre11 complex(GO:0030870)
0.3 5.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.3 2.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.3 20.8 GO:0001726 ruffle(GO:0001726)
0.3 4.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.3 9.1 GO:0005902 microvillus(GO:0005902)
0.3 8.1 GO:0005605 basal lamina(GO:0005605)
0.3 2.5 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.3 7.7 GO:0031256 leading edge membrane(GO:0031256)
0.3 28.0 GO:0031253 cell projection membrane(GO:0031253)
0.3 9.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 8.7 GO:0055037 recycling endosome(GO:0055037)
0.3 6.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 3.0 GO:0005922 connexon complex(GO:0005922)
0.2 9.1 GO:0016592 mediator complex(GO:0016592)
0.2 37.1 GO:0001650 fibrillar center(GO:0001650)
0.2 2.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 13.8 GO:0005604 basement membrane(GO:0005604)
0.2 5.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 5.2 GO:0009925 basal plasma membrane(GO:0009925)
0.2 15.4 GO:0019898 extrinsic component of membrane(GO:0019898)
0.2 14.8 GO:0005581 collagen trimer(GO:0005581)
0.2 2.2 GO:0030175 filopodium(GO:0030175)
0.2 1.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 3.4 GO:0031594 neuromuscular junction(GO:0031594)
0.2 11.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 18.1 GO:0005814 centriole(GO:0005814)
0.2 1.3 GO:0060077 inhibitory synapse(GO:0060077)
0.2 9.8 GO:0098793 presynapse(GO:0098793)
0.2 4.6 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.2 11.1 GO:0000792 heterochromatin(GO:0000792)
0.2 3.8 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.2 1.7 GO:0005652 nuclear lamina(GO:0005652)
0.2 0.5 GO:0032009 early phagosome(GO:0032009)
0.1 2.9 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.3 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1 4.3 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 2.3 GO:0005801 cis-Golgi network(GO:0005801)
0.1 18.4 GO:0010008 endosome membrane(GO:0010008)
0.1 6.1 GO:0015030 Cajal body(GO:0015030)
0.1 10.1 GO:0045177 apical part of cell(GO:0045177)
0.1 9.7 GO:0005923 bicellular tight junction(GO:0005923)
0.1 2.1 GO:0002080 acrosomal membrane(GO:0002080)
0.1 1.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 21.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 5.5 GO:0005796 Golgi lumen(GO:0005796)
0.1 9.2 GO:0031514 motile cilium(GO:0031514)
0.1 9.3 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 0.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1 4.2 GO:0043204 perikaryon(GO:0043204)
0.1 2.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 98.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 2.4 GO:0044438 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.1 1.9 GO:0001533 cornified envelope(GO:0001533)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 1.5 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.5 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 51.6 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
23.7 71.0 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
15.3 45.8 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
13.4 40.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
9.2 27.7 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
8.2 8.2 GO:0032794 GTPase activating protein binding(GO:0032794)
8.1 32.2 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
7.3 22.0 GO:0032184 SUMO polymer binding(GO:0032184)
7.0 28.0 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
6.6 19.9 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
6.5 19.6 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
6.2 31.0 GO:0052833 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
6.1 18.4 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
6.0 18.1 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
5.6 16.9 GO:0004157 dihydropyrimidinase activity(GO:0004157)
5.5 21.8 GO:0004803 transposase activity(GO:0004803)
5.4 32.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
5.3 5.3 GO:0030226 apolipoprotein receptor activity(GO:0030226)
5.3 21.1 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
5.2 15.7 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
5.0 19.8 GO:0031685 adenosine receptor binding(GO:0031685)
4.8 19.4 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
4.7 23.7 GO:0070728 leucine binding(GO:0070728)
4.7 18.7 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
4.3 17.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
4.3 51.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
4.3 12.8 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
4.3 21.3 GO:0008420 CTD phosphatase activity(GO:0008420)
4.2 37.4 GO:0032051 clathrin light chain binding(GO:0032051)
4.0 11.9 GO:0071209 U7 snRNA binding(GO:0071209)
3.9 23.4 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
3.9 89.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
3.7 3.7 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
3.6 14.5 GO:0015057 thrombin receptor activity(GO:0015057)
3.6 21.5 GO:1903135 cupric ion binding(GO:1903135)
3.6 28.5 GO:0035374 chondroitin sulfate binding(GO:0035374)
3.5 17.4 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
3.4 37.9 GO:0031681 G-protein beta-subunit binding(GO:0031681)
3.4 92.1 GO:0050780 dopamine receptor binding(GO:0050780)
3.4 10.2 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
3.4 16.9 GO:0070097 delta-catenin binding(GO:0070097)
3.3 13.3 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
3.3 13.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
3.2 12.9 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
3.2 19.2 GO:0003998 acylphosphatase activity(GO:0003998)
3.2 31.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
3.2 9.5 GO:0004488 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
3.1 15.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
3.1 12.6 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
3.1 9.4 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
3.1 18.8 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
3.0 15.2 GO:0004994 somatostatin receptor activity(GO:0004994)
3.0 14.9 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
3.0 14.9 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
2.8 8.5 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
2.8 35.8 GO:0005344 oxygen transporter activity(GO:0005344)
2.7 8.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
2.7 8.0 GO:0035501 MH1 domain binding(GO:0035501)
2.6 13.2 GO:0016403 dimethylargininase activity(GO:0016403)
2.6 10.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
2.5 34.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
2.4 17.0 GO:0050682 AF-2 domain binding(GO:0050682)
2.4 7.3 GO:0052831 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol tetrakisphosphate kinase activity(GO:0051765) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
2.4 9.4 GO:0008940 nitrate reductase activity(GO:0008940)
2.4 4.7 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
2.3 30.5 GO:0031005 filamin binding(GO:0031005)
2.3 11.7 GO:0010465 nerve growth factor receptor activity(GO:0010465)
2.3 9.0 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
2.3 13.5 GO:0048039 ubiquinone binding(GO:0048039)
2.2 29.0 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
2.1 12.9 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
2.1 36.1 GO:0008432 JUN kinase binding(GO:0008432)
2.1 8.5 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
2.1 16.5 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
2.1 12.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
2.0 20.2 GO:0009374 biotin binding(GO:0009374)
2.0 19.6 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
1.9 15.4 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
1.9 11.5 GO:0016015 morphogen activity(GO:0016015)
1.9 11.4 GO:0043237 laminin-1 binding(GO:0043237)
1.9 5.7 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
1.9 11.3 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
1.9 7.4 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
1.9 20.4 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
1.9 51.8 GO:0017075 syntaxin-1 binding(GO:0017075)
1.8 10.9 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
1.8 45.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
1.8 21.5 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
1.8 24.9 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
1.8 7.0 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
1.8 5.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.7 12.0 GO:0045159 myosin II binding(GO:0045159)
1.7 10.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
1.7 5.0 GO:0070984 SET domain binding(GO:0070984)
1.6 6.6 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
1.6 1.6 GO:0004924 oncostatin-M receptor activity(GO:0004924)
1.6 6.5 GO:0008410 CoA-transferase activity(GO:0008410)
1.6 47.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
1.6 15.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
1.6 14.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
1.5 4.6 GO:0004103 choline kinase activity(GO:0004103)
1.5 32.1 GO:0005112 Notch binding(GO:0005112)
1.5 4.6 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
1.5 51.4 GO:0030742 GTP-dependent protein binding(GO:0030742)
1.5 37.1 GO:0004383 guanylate cyclase activity(GO:0004383)
1.5 30.8 GO:0030552 cAMP binding(GO:0030552)
1.5 7.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.4 9.9 GO:0004035 alkaline phosphatase activity(GO:0004035)
1.4 4.2 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
1.4 9.8 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
1.4 52.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.4 6.9 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
1.4 17.6 GO:0070700 BMP receptor binding(GO:0070700)
1.3 6.7 GO:0015307 drug:proton antiporter activity(GO:0015307)
1.3 2.7 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
1.3 61.2 GO:0003785 actin monomer binding(GO:0003785)
1.3 37.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
1.3 8.0 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
1.3 15.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
1.3 13.1 GO:0032036 myosin heavy chain binding(GO:0032036)
1.3 16.9 GO:0046527 glucosyltransferase activity(GO:0046527)
1.3 6.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
1.3 8.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
1.3 3.8 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
1.3 11.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
1.3 22.6 GO:0005522 profilin binding(GO:0005522)
1.3 12.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
1.2 26.0 GO:0050321 tau-protein kinase activity(GO:0050321)
1.2 12.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
1.2 4.9 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
1.2 19.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
1.2 7.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.2 25.1 GO:0030955 potassium ion binding(GO:0030955)
1.2 15.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
1.2 54.5 GO:0046875 ephrin receptor binding(GO:0046875)
1.2 3.5 GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
1.2 11.8 GO:0043236 laminin binding(GO:0043236)
1.1 9.0 GO:0051959 dynein light intermediate chain binding(GO:0051959)
1.1 49.5 GO:0030507 spectrin binding(GO:0030507)
1.1 6.7 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
1.1 6.6 GO:0004522 ribonuclease A activity(GO:0004522)
1.1 8.8 GO:0048495 Roundabout binding(GO:0048495)
1.1 29.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
1.1 8.7 GO:0005534 galactose binding(GO:0005534)
1.1 24.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.1 5.3 GO:0044736 acid-sensing ion channel activity(GO:0044736)
1.1 3.2 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
1.1 28.4 GO:0051010 microtubule plus-end binding(GO:0051010)
1.0 7.2 GO:0017002 activin-activated receptor activity(GO:0017002)
1.0 10.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.0 10.9 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
1.0 4.9 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
1.0 18.5 GO:0048156 tau protein binding(GO:0048156)
1.0 9.7 GO:0046870 cadmium ion binding(GO:0046870)
1.0 13.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
1.0 3.8 GO:0048763 calcium-induced calcium release activity(GO:0048763)
1.0 6.7 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.9 26.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.9 21.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.9 7.5 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.9 6.6 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.9 36.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.9 8.3 GO:0043426 MRF binding(GO:0043426)
0.9 9.2 GO:0015232 heme transporter activity(GO:0015232)
0.9 4.5 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.9 9.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.9 8.5 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.9 2.6 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.8 21.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.8 3.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.8 2.4 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.8 22.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.8 8.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.8 4.7 GO:0008240 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241)
0.8 10.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.8 5.4 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.8 10.5 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.8 8.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.7 14.4 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.7 5.8 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.7 2.2 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.7 2.2 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.7 2.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.7 12.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.7 2.1 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.7 8.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.7 72.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.7 5.3 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.6 2.6 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.6 3.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.6 1.9 GO:0070026 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitric oxide binding(GO:0070026) nitrite reductase activity(GO:0098809)
0.6 8.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.6 1.9 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.6 8.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.6 5.3 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.6 8.2 GO:0050700 CARD domain binding(GO:0050700)
0.6 15.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.6 2.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.6 2.3 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.6 3.9 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.6 1.7 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.5 73.2 GO:0003774 motor activity(GO:0003774)
0.5 38.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 28.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.5 18.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.5 14.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.5 11.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 10.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.5 6.0 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.5 4.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.5 3.0 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.5 11.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.5 0.5 GO:0030551 cyclic nucleotide binding(GO:0030551)
0.5 2.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.5 55.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.5 4.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.5 23.4 GO:0070412 R-SMAD binding(GO:0070412)
0.5 21.2 GO:0030276 clathrin binding(GO:0030276)
0.5 6.7 GO:0045499 chemorepellent activity(GO:0045499)
0.5 4.7 GO:0004707 MAP kinase activity(GO:0004707)
0.5 1.4 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.5 4.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.5 0.9 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.5 14.6 GO:0005272 sodium channel activity(GO:0005272)
0.4 1.3 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.4 12.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 10.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.4 5.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.4 1.7 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
0.4 5.5 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.4 1.7 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.4 1.2 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.4 3.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.4 10.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.4 2.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.4 8.4 GO:0030275 LRR domain binding(GO:0030275)
0.4 4.0 GO:0022821 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.4 4.3 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.4 2.7 GO:0071837 HMG box domain binding(GO:0071837)
0.4 5.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.4 4.2 GO:0097016 L27 domain binding(GO:0097016)
0.4 7.1 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.4 5.9 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.4 6.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.4 1.8 GO:0046790 virion binding(GO:0046790)
0.3 1.7 GO:0097108 hedgehog family protein binding(GO:0097108)
0.3 1.7 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.3 2.9 GO:0004969 histamine receptor activity(GO:0004969)
0.3 8.0 GO:0005523 tropomyosin binding(GO:0005523)
0.3 6.3 GO:0031489 myosin V binding(GO:0031489)
0.3 2.5 GO:0097322 7SK snRNA binding(GO:0097322)
0.3 52.8 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.3 3.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 2.6 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.3 2.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3 2.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 3.0 GO:0016594 glycine binding(GO:0016594)
0.3 5.6 GO:0032452 histone demethylase activity(GO:0032452)
0.3 8.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.3 5.8 GO:0016805 dipeptidase activity(GO:0016805)
0.3 5.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.3 28.0 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.3 3.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.2 4.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.2 2.7 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.2 13.2 GO:0005262 calcium channel activity(GO:0005262)
0.2 8.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 0.7 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.2 0.7 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.2 7.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 133.3 GO:0005509 calcium ion binding(GO:0005509)
0.2 2.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 3.0 GO:0005243 gap junction channel activity(GO:0005243)
0.2 2.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 12.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 7.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 6.6 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.2 1.6 GO:0019955 cytokine binding(GO:0019955)
0.2 10.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.2 8.5 GO:0008013 beta-catenin binding(GO:0008013)
0.2 3.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 1.3 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.2 9.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 5.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 7.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 2.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 2.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 19.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 0.5 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 2.5 GO:0050811 GABA receptor binding(GO:0050811)
0.1 4.1 GO:0017091 AU-rich element binding(GO:0017091)
0.1 1.4 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 3.7 GO:0030371 translation repressor activity(GO:0030371)
0.1 1.5 GO:0032183 SUMO binding(GO:0032183)
0.1 0.5 GO:0004102 choline O-acetyltransferase activity(GO:0004102)
0.1 1.1 GO:0000150 recombinase activity(GO:0000150)
0.1 18.1 GO:0008017 microtubule binding(GO:0008017)
0.1 2.7 GO:0005109 frizzled binding(GO:0005109)
0.1 29.3 GO:0003924 GTPase activity(GO:0003924)
0.1 1.0 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.1 1.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 3.2 GO:0016859 cis-trans isomerase activity(GO:0016859)
0.1 23.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 0.5 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 0.3 GO:0052844 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1 0.2 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.1 4.1 GO:0005319 lipid transporter activity(GO:0005319)
0.1 1.4 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.4 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 4.3 GO:0022843 voltage-gated cation channel activity(GO:0022843)
0.1 27.3 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.2 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 2.6 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 12.2 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 5.1 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0035325 Toll-like receptor binding(GO:0035325)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 1.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.3 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 1.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.3 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.4 GO:0030170 pyridoxal phosphate binding(GO:0030170)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 29.6 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
2.0 71.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
1.5 10.6 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
1.5 28.6 PID ALK2 PATHWAY ALK2 signaling events
1.5 26.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
1.4 4.3 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
1.4 60.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
1.4 34.2 PID LPA4 PATHWAY LPA4-mediated signaling events
1.3 10.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
1.1 13.6 PID GLYPICAN 1PATHWAY Glypican 1 network
1.1 45.9 PID NCADHERIN PATHWAY N-cadherin signaling events
1.1 24.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
1.1 92.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
1.0 4.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
1.0 42.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
1.0 52.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.9 9.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.9 14.5 ST GA12 PATHWAY G alpha 12 Pathway
0.9 50.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.8 33.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.7 34.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.7 7.4 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.7 13.2 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.7 59.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.7 3.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.6 19.9 PID S1P S1P3 PATHWAY S1P3 pathway
0.6 158.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6 34.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.6 9.2 PID ATR PATHWAY ATR signaling pathway
0.6 132.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.5 7.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.5 9.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.5 6.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.5 17.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.5 20.0 PID FGF PATHWAY FGF signaling pathway
0.5 4.5 PID ALK1 PATHWAY ALK1 signaling events
0.4 19.8 PID ARF6 PATHWAY Arf6 signaling events
0.4 7.9 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.4 3.9 PID EPHB FWD PATHWAY EPHB forward signaling
0.4 25.2 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.4 29.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 9.6 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.4 14.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.4 22.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 6.6 ST ADRENERGIC Adrenergic Pathway
0.3 8.9 PID EPHA FWDPATHWAY EPHA forward signaling
0.3 8.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.3 6.0 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.3 6.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.3 3.0 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.2 23.2 PID P73PATHWAY p73 transcription factor network
0.2 7.4 PID SHP2 PATHWAY SHP2 signaling
0.2 4.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 3.8 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.2 2.6 ST G ALPHA I PATHWAY G alpha i Pathway
0.2 5.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 3.6 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.2 12.0 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.2 5.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.2 2.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 2.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 1.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 9.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.4 PID ENDOTHELIN PATHWAY Endothelins
0.1 3.5 PID RAS PATHWAY Regulation of Ras family activation
0.1 3.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 0.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 0.6 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 4.0 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 1.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.8 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 1.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.0 PID AURORA A PATHWAY Aurora A signaling
0.1 3.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 2.3 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 4.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 100.1 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
2.7 13.6 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
2.7 90.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
2.5 45.7 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
2.5 7.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
2.5 44.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
2.4 28.9 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
2.3 48.8 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
2.1 53.7 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.7 64.0 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
1.7 45.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.6 32.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
1.5 39.9 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
1.4 7.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
1.4 26.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
1.4 18.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
1.4 31.9 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
1.3 50.6 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
1.2 22.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.2 49.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
1.2 22.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.2 14.0 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
1.2 55.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
1.1 12.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
1.1 7.6 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
1.1 41.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
1.0 7.3 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
1.0 12.8 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
1.0 23.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
1.0 6.8 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
1.0 16.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.9 15.8 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.8 16.7 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.8 15.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.7 20.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.7 29.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.7 13.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.7 15.0 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.7 17.9 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.7 29.3 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.7 26.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.6 20.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.6 9.1 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.6 30.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.6 7.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.6 5.1 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.6 11.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.5 15.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.5 10.1 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.5 15.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.5 6.6 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.5 6.4 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.5 9.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.5 12.7 REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK
0.5 8.6 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.4 6.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.4 2.7 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.4 15.6 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.4 19.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 4.7 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.4 18.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.4 12.9 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.4 83.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.4 12.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.4 21.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.3 8.2 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 10.6 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.3 5.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.3 5.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 4.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.3 6.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 11.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 4.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.3 1.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 2.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.3 8.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 31.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.2 9.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 4.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 18.8 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.2 36.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 7.7 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 2.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 5.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 15.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.2 4.0 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.2 3.7 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2 20.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 3.0 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 4.5 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.2 10.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 1.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 3.2 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.1 2.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 9.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 6.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 3.6 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.1 2.7 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 2.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 4.3 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 1.6 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.1 2.1 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.5 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 0.5 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.7 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 4.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.9 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.6 REACTOME PKB MEDIATED EVENTS Genes involved in PKB-mediated events
0.0 2.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.6 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling