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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HIC2
Z-value: 0.59
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Transcription factors associated with HIC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC2 | hg19_v2_chr22_+_21771656_21771693 | -0.04 | 5.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_94856951 Show fit | 23.68 |
ENST00000553327.1
ENST00000556955.1 ENST00000557118.1 ENST00000440909.1 |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
|
| chr14_-_94856987 Show fit | 22.18 |
ENST00000449399.3
ENST00000404814.4 |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
|
| chr14_-_94857004 Show fit | 16.41 |
ENST00000557492.1
ENST00000448921.1 ENST00000437397.1 ENST00000355814.4 ENST00000393088.4 |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
|
| chr14_-_106092403 Show fit | 16.30 |
ENST00000390543.2
|
immunoglobulin heavy constant gamma 4 (G4m marker) |
|
| chr3_+_10206545 Show fit | 16.15 |
ENST00000256458.4
|
interleukin-1 receptor-associated kinase 2 |
|
| chr14_-_106209368 Show fit | 14.88 |
ENST00000390548.2
ENST00000390549.2 ENST00000390542.2 |
immunoglobulin heavy constant gamma 1 (G1m marker) |
|
| chr22_-_27620603 Show fit | 14.67 |
ENST00000418271.1
ENST00000444114.1 |
RP5-1172A22.1 |
|
| chr11_-_5248294 Show fit | 14.51 |
ENST00000335295.4
|
hemoglobin, beta |
|
| chr5_-_172198190 Show fit | 14.39 |
ENST00000239223.3
|
dual specificity phosphatase 1 |
|
| chr9_+_124088860 Show fit | 13.95 |
ENST00000373806.1
|
gelsolin |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 77.5 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.4 | 36.6 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.5 | 35.4 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 5.9 | 29.6 | GO:0044858 | plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906) |
| 7.1 | 28.3 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 3.1 | 28.0 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 2.1 | 27.7 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.8 | 20.0 | GO:0001502 | cartilage condensation(GO:0001502) |
| 3.2 | 19.4 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 1.0 | 19.1 | GO:0071850 | mitotic cell cycle arrest(GO:0071850) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 181.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.9 | 110.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 90.4 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.7 | 32.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 2.0 | 29.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.4 | 28.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.2 | 26.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.8 | 19.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.2 | 19.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 19.5 | GO:0008021 | synaptic vesicle(GO:0008021) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 131.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.8 | 89.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.8 | 39.6 | GO:0030546 | receptor activator activity(GO:0030546) |
| 0.7 | 36.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 2.5 | 29.6 | GO:0045159 | myosin II binding(GO:0045159) |
| 1.7 | 26.1 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.1 | 22.8 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.2 | 21.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.4 | 19.8 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.8 | 19.7 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 83.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 75.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.8 | 68.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 39.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 38.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.5 | 32.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.6 | 31.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.4 | 25.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.7 | 21.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.8 | 20.3 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 55.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 34.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.3 | 32.7 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.6 | 31.6 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.9 | 30.2 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 1.1 | 25.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.8 | 24.9 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 1.2 | 24.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 1.7 | 24.4 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.6 | 19.2 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |