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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HIF1A

Z-value: 0.82

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Transcription factors associated with HIF1A

Gene Symbol Gene ID Gene Info
HIF1A
ENSG00000100644.12 hypoxia inducible factor 1 subunit alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HIF1Ahg19_v2_chr14_+_62162258_621622690.617.8e-24Click!

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_8939265 51.74 ENST00000489867.1
ENO1
enolase 1, (alpha)
chr11_-_64014379 32.94 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr8_+_98656336 27.61 ENST00000336273.3
MTDH
metadherin
chr3_-_195808952 25.91 ENST00000540528.1
ENST00000392396.3
ENST00000535031.1
ENST00000420415.1
TFRC
transferrin receptor
chr1_-_8938736 25.30 ENST00000234590.4
ENO1
enolase 1, (alpha)
chr3_-_195808980 25.15 ENST00000360110.4
TFRC
transferrin receptor
chr11_-_14665163 24.64 ENST00000418988.2
PSMA1
proteasome (prosome, macropain) subunit, alpha type, 1
chr12_+_131356582 24.23 ENST00000448750.3
ENST00000541630.1
ENST00000392369.2
ENST00000254675.3
ENST00000535090.1
ENST00000392367.3
RAN
RAN, member RAS oncogene family
chr3_-_145878954 23.21 ENST00000282903.5
ENST00000360060.3
PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr12_+_6977258 22.36 ENST00000488464.2
ENST00000535434.1
ENST00000493987.1
TPI1
triosephosphate isomerase 1
chrX_+_77359671 21.54 ENST00000373316.4
PGK1
phosphoglycerate kinase 1
chrX_+_77359726 21.17 ENST00000442431.1
PGK1
phosphoglycerate kinase 1
chr14_+_56046990 19.04 ENST00000438792.2
ENST00000395314.3
ENST00000395308.1
KTN1
kinectin 1 (kinesin receptor)
chr5_+_49962495 18.83 ENST00000515175.1
PARP8
poly (ADP-ribose) polymerase family, member 8
chrX_+_69509927 18.49 ENST00000374403.3
KIF4A
kinesin family member 4A
chr5_+_138609441 18.22 ENST00000509990.1
ENST00000506147.1
ENST00000512107.1
MATR3
matrin 3
chr1_-_159894319 16.96 ENST00000320307.4
TAGLN2
transgelin 2
chr14_+_64970662 16.75 ENST00000556965.1
ENST00000554015.1
ZBTB1
zinc finger and BTB domain containing 1
chr1_-_26233423 16.68 ENST00000357865.2
STMN1
stathmin 1
chr15_+_74218787 16.66 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr12_-_21810726 16.62 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr12_-_21810765 16.17 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr14_+_56046914 15.89 ENST00000413890.2
ENST00000395309.3
ENST00000554567.1
ENST00000555498.1
KTN1
kinectin 1 (kinesin receptor)
chr3_-_81811312 15.61 ENST00000429644.2
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr12_-_58146128 15.00 ENST00000551800.1
ENST00000549606.1
ENST00000257904.6
CDK4
cyclin-dependent kinase 4
chr8_+_55047763 14.71 ENST00000260102.4
ENST00000519831.1
MRPL15
mitochondrial ribosomal protein L15
chr15_+_52311398 14.54 ENST00000261845.5
MAPK6
mitogen-activated protein kinase 6
chr16_-_81129951 14.40 ENST00000315467.3
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr4_-_104119528 14.15 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr12_-_58146048 13.99 ENST00000547281.1
ENST00000546489.1
ENST00000552388.1
ENST00000540325.1
ENST00000312990.6
CDK4
cyclin-dependent kinase 4
chr8_+_97274119 13.79 ENST00000455950.2
PTDSS1
phosphatidylserine synthase 1
chr16_-_81129845 13.73 ENST00000569885.1
ENST00000566566.1
GCSH
glycine cleavage system protein H (aminomethyl carrier)
chr8_-_54755459 13.73 ENST00000524234.1
ENST00000521275.1
ENST00000396774.2
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr14_-_64010046 13.71 ENST00000337537.3
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr11_-_122931881 13.70 ENST00000526110.1
ENST00000227378.3
HSPA8
heat shock 70kDa protein 8
chr11_-_64013663 13.55 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr14_-_54908043 13.25 ENST00000556113.1
ENST00000553660.1
ENST00000395573.4
ENST00000557690.1
ENST00000216416.4
CNIH1
cornichon family AMPA receptor auxiliary protein 1
chr17_-_57184260 13.16 ENST00000376149.3
ENST00000393066.3
TRIM37
tripartite motif containing 37
chr17_-_5342380 13.15 ENST00000225698.4
C1QBP
complement component 1, q subcomponent binding protein
chr8_+_98656693 13.11 ENST00000519934.1
MTDH
metadherin
chr2_+_216176540 13.04 ENST00000236959.9
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr17_-_57184064 13.03 ENST00000262294.7
TRIM37
tripartite motif containing 37
chr12_+_6643676 12.94 ENST00000396856.1
ENST00000396861.1
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr16_+_447209 12.48 ENST00000382940.4
ENST00000219479.2
NME4
NME/NM23 nucleoside diphosphate kinase 4
chr8_-_54755789 12.46 ENST00000359530.2
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr1_-_6269448 12.46 ENST00000465335.1
RPL22
ribosomal protein L22
chr2_+_187350883 12.33 ENST00000337859.6
ZC3H15
zinc finger CCCH-type containing 15
chr1_-_26232951 12.10 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr2_+_216176761 11.94 ENST00000540518.1
ENST00000435675.1
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr1_-_6269304 11.90 ENST00000471204.1
RPL22
ribosomal protein L22
chr3_+_25831567 11.86 ENST00000280701.3
ENST00000420173.2
OXSM
3-oxoacyl-ACP synthase, mitochondrial
chr13_-_31038370 11.86 ENST00000399489.1
ENST00000339872.4
HMGB1
high mobility group box 1
chr8_-_97273807 11.63 ENST00000517720.1
ENST00000287025.3
ENST00000523821.1
MTERFD1
MTERF domain containing 1
chr8_-_102218292 11.59 ENST00000518336.1
ENST00000520454.1
ZNF706
zinc finger protein 706
chr12_+_72148614 11.58 ENST00000261263.3
RAB21
RAB21, member RAS oncogene family
chr3_+_52719936 11.29 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr11_-_47664072 10.82 ENST00000542981.1
ENST00000530428.1
ENST00000302503.3
MTCH2
mitochondrial carrier 2
chr6_-_153304148 10.53 ENST00000229758.3
FBXO5
F-box protein 5
chr6_-_114292449 10.43 ENST00000519065.1
HDAC2
histone deacetylase 2
chr2_+_187350973 10.39 ENST00000544130.1
ZC3H15
zinc finger CCCH-type containing 15
chr4_-_24586140 10.32 ENST00000336812.4
DHX15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr4_-_39529049 10.25 ENST00000501493.2
ENST00000509391.1
ENST00000507089.1
UGDH
UDP-glucose 6-dehydrogenase
chr12_-_50677255 10.21 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr22_-_30987849 10.20 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr1_-_6259641 10.17 ENST00000234875.4
RPL22
ribosomal protein L22
chr17_+_73201754 10.11 ENST00000583569.1
ENST00000245544.4
ENST00000579324.1
ENST00000541827.1
ENST00000579298.1
ENST00000447371.2
NUP85
nucleoporin 85kDa
chr20_+_56964253 9.81 ENST00000395802.3
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr1_-_6259613 9.61 ENST00000465387.1
RPL22
ribosomal protein L22
chr2_+_242254507 9.56 ENST00000391973.2
SEPT2
septin 2
chr10_+_76969909 9.54 ENST00000298468.5
ENST00000543351.1
VDAC2
voltage-dependent anion channel 2
chr3_+_184080790 9.50 ENST00000430783.1
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr8_-_117768023 9.46 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
EIF3H
eukaryotic translation initiation factor 3, subunit H
chr13_+_27998681 9.46 ENST00000381140.4
GTF3A
general transcription factor IIIA
chr8_+_26240414 9.40 ENST00000380629.2
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr6_-_114292284 9.37 ENST00000520895.1
ENST00000521163.1
ENST00000524334.1
ENST00000368632.2
ENST00000398283.2
HDAC2
histone deacetylase 2
chr1_+_112162381 9.02 ENST00000433097.1
ENST00000369709.3
ENST00000436150.2
RAP1A
RAP1A, member of RAS oncogene family
chr8_+_109455845 8.83 ENST00000220853.3
EMC2
ER membrane protein complex subunit 2
chr1_-_43833628 8.81 ENST00000413844.2
ENST00000372458.3
ELOVL1
ELOVL fatty acid elongase 1
chr10_+_75910960 8.76 ENST00000539909.1
ENST00000286621.2
ADK
adenosine kinase
chrX_-_102941596 8.58 ENST00000441076.2
ENST00000422355.1
ENST00000442614.1
ENST00000422154.2
ENST00000451301.1
MORF4L2
mortality factor 4 like 2
chr9_+_100745615 8.47 ENST00000339399.4
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr1_+_193091080 8.44 ENST00000367435.3
CDC73
cell division cycle 73
chr19_-_5719860 8.42 ENST00000590729.1
LONP1
lon peptidase 1, mitochondrial
chr22_+_24236191 8.39 ENST00000215754.7
MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr1_+_230202936 8.33 ENST00000366672.4
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr15_+_89182178 8.31 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr12_-_49318715 8.23 ENST00000444214.2
FKBP11
FK506 binding protein 11, 19 kDa
chr22_-_30987837 8.17 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr16_+_447226 8.17 ENST00000433358.1
NME4
NME/NM23 nucleoside diphosphate kinase 4
chr5_+_134094461 7.86 ENST00000452510.2
ENST00000354283.4
DDX46
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
chr7_+_128095945 7.83 ENST00000257696.4
HILPDA
hypoxia inducible lipid droplet-associated
chr12_+_7023491 7.80 ENST00000541477.1
ENST00000229277.1
ENO2
enolase 2 (gamma, neuronal)
chr13_+_25875785 7.66 ENST00000381747.3
NUPL1
nucleoporin like 1
chrX_+_100663243 7.53 ENST00000316594.5
HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr19_+_50180409 7.39 ENST00000391851.4
PRMT1
protein arginine methyltransferase 1
chr5_-_131563501 7.30 ENST00000401867.1
ENST00000379086.1
ENST00000418055.1
ENST00000453286.1
ENST00000166534.4
P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
chr15_+_89181974 7.21 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr12_+_7023735 7.20 ENST00000538763.1
ENST00000544774.1
ENST00000545045.2
ENO2
enolase 2 (gamma, neuronal)
chr1_-_235324530 7.18 ENST00000447801.1
ENST00000366606.3
ENST00000429912.1
RBM34
RNA binding motif protein 34
chr1_-_26232522 7.18 ENST00000399728.1
STMN1
stathmin 1
chr10_-_16859361 7.13 ENST00000377921.3
RSU1
Ras suppressor protein 1
chr19_-_1568057 7.09 ENST00000402693.4
ENST00000388824.6
MEX3D
mex-3 RNA binding family member D
chr10_+_76970509 7.00 ENST00000332211.6
ENST00000535553.1
ENST00000313132.4
VDAC2
voltage-dependent anion channel 2
chr7_-_95951334 6.97 ENST00000265631.5
SLC25A13
solute carrier family 25 (aspartate/glutamate carrier), member 13
chr4_-_39529180 6.95 ENST00000515021.1
ENST00000510490.1
ENST00000316423.6
UGDH
UDP-glucose 6-dehydrogenase
chr7_-_95951432 6.84 ENST00000416240.2
SLC25A13
solute carrier family 25 (aspartate/glutamate carrier), member 13
chr3_-_58419537 6.84 ENST00000474765.1
ENST00000485460.1
ENST00000302746.6
ENST00000383714.4
PDHB
pyruvate dehydrogenase (lipoamide) beta
chr19_+_50180507 6.78 ENST00000454376.2
ENST00000524771.1
PRMT1
protein arginine methyltransferase 1
chr9_+_133569108 6.66 ENST00000372358.5
ENST00000546165.1
ENST00000372352.3
ENST00000372351.3
ENST00000372350.3
ENST00000495699.2
EXOSC2
exosome component 2
chr2_+_27435734 6.64 ENST00000419744.1
ATRAID
all-trans retinoic acid-induced differentiation factor
chr12_+_110906169 6.59 ENST00000377673.5
FAM216A
family with sequence similarity 216, member A
chr10_-_16859442 6.48 ENST00000602389.1
ENST00000345264.5
RSU1
Ras suppressor protein 1
chr1_-_32801825 6.46 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr17_+_45608430 6.38 ENST00000322157.4
NPEPPS
aminopeptidase puromycin sensitive
chr19_-_5720123 6.27 ENST00000587365.1
ENST00000585374.1
ENST00000593119.1
LONP1
lon peptidase 1, mitochondrial
chr20_+_48552908 6.22 ENST00000244061.2
RNF114
ring finger protein 114
chr1_+_100436065 6.14 ENST00000370153.1
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr5_+_70883117 6.13 ENST00000340941.6
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr9_+_115983808 6.03 ENST00000374210.6
ENST00000374212.4
SLC31A1
solute carrier family 31 (copper transporter), member 1
chr11_+_73498898 5.96 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr7_+_26331541 5.84 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
SNX10
sorting nexin 10
chr1_-_151319710 5.82 ENST00000290524.4
ENST00000437327.1
ENST00000452513.2
ENST00000368870.2
ENST00000452671.2
RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr4_+_17578815 5.78 ENST00000226299.4
LAP3
leucine aminopeptidase 3
chr5_+_61602055 5.66 ENST00000381103.2
KIF2A
kinesin heavy chain member 2A
chr12_+_28343353 5.60 ENST00000539107.1
CCDC91
coiled-coil domain containing 91
chr16_+_3070356 5.57 ENST00000341627.5
ENST00000575124.1
ENST00000575836.1
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr22_+_41347363 5.55 ENST00000216225.8
RBX1
ring-box 1, E3 ubiquitin protein ligase
chr1_+_231376941 5.52 ENST00000436239.1
ENST00000366647.4
ENST00000366646.3
ENST00000416000.1
GNPAT
glyceronephosphate O-acyltransferase
chr1_-_167522982 5.50 ENST00000370509.4
CREG1
cellular repressor of E1A-stimulated genes 1
chrX_-_57147748 5.49 ENST00000374910.3
SPIN2B
spindlin family, member 2B
chr1_+_214454492 5.46 ENST00000366957.5
ENST00000415093.2
SMYD2
SET and MYND domain containing 2
chr11_+_60609537 5.40 ENST00000227520.5
CCDC86
coiled-coil domain containing 86
chr16_+_3070313 5.29 ENST00000326577.4
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr2_+_242254679 5.27 ENST00000428282.1
ENST00000360051.3
SEPT2
septin 2
chr22_+_35653445 5.26 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr8_-_30515693 5.25 ENST00000355904.4
GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr15_+_89182156 5.24 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr6_-_153304697 5.16 ENST00000367241.3
FBXO5
F-box protein 5
chr2_+_88991162 5.14 ENST00000283646.4
RPIA
ribose 5-phosphate isomerase A
chr6_+_64281906 5.13 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr22_-_36424458 5.10 ENST00000438146.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_-_149688896 5.06 ENST00000239940.7
PFN2
profilin 2
chr3_+_133292851 5.03 ENST00000503932.1
CDV3
CDV3 homolog (mouse)
chr6_+_44191290 5.00 ENST00000371755.3
ENST00000371740.5
ENST00000371731.1
ENST00000393841.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr7_-_102985035 4.81 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr9_-_123605177 4.79 ENST00000373904.5
ENST00000210313.3
PSMD5
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
chr1_-_51425772 4.72 ENST00000371778.4
FAF1
Fas (TNFRSF6) associated factor 1
chr17_-_8534031 4.54 ENST00000411957.1
ENST00000396239.1
ENST00000379980.4
MYH10
myosin, heavy chain 10, non-muscle
chr5_+_126112794 4.49 ENST00000261366.5
ENST00000395354.1
LMNB1
lamin B1
chr17_+_57642886 4.48 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DHX40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chrX_-_57164058 4.47 ENST00000374906.3
SPIN2A
spindlin family, member 2A
chr6_+_30539153 4.43 ENST00000326195.8
ENST00000376545.3
ENST00000396515.4
ENST00000441867.1
ENST00000468958.1
ABCF1
ATP-binding cassette, sub-family F (GCN20), member 1
chr17_+_66508537 4.40 ENST00000392711.1
ENST00000585427.1
ENST00000589228.1
ENST00000536854.2
ENST00000588702.1
ENST00000589309.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr3_+_133292759 4.35 ENST00000431519.2
CDV3
CDV3 homolog (mouse)
chr8_-_103424986 4.32 ENST00000521922.1
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr14_+_96968707 4.23 ENST00000216277.8
ENST00000557320.1
ENST00000557471.1
PAPOLA
poly(A) polymerase alpha
chr5_+_70883178 4.19 ENST00000323375.8
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr11_+_6624970 4.16 ENST00000420936.2
ENST00000528995.1
ILK
integrin-linked kinase
chr8_-_101734308 4.15 ENST00000519004.1
ENST00000519363.1
ENST00000520142.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr8_-_101734907 4.14 ENST00000318607.5
ENST00000521865.1
ENST00000520804.1
ENST00000522720.1
ENST00000521067.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr19_+_17622415 4.13 ENST00000252603.2
ENST00000600923.1
PGLS
6-phosphogluconolactonase
chr16_-_18812746 4.09 ENST00000546206.2
ENST00000562819.1
ENST00000562234.2
ENST00000304414.7
ENST00000567078.2
ARL6IP1
RP11-1035H13.3
ADP-ribosylation factor-like 6 interacting protein 1
Uncharacterized protein
chr13_+_25670268 4.05 ENST00000281589.3
PABPC3
poly(A) binding protein, cytoplasmic 3
chr6_+_71377473 4.02 ENST00000370452.3
ENST00000316999.5
ENST00000370455.3
SMAP1
small ArfGAP 1
chr16_+_53164833 4.01 ENST00000564845.1
CHD9
chromodomain helicase DNA binding protein 9
chr11_+_6624955 4.01 ENST00000299421.4
ENST00000537806.1
ILK
integrin-linked kinase
chr17_-_8534067 3.95 ENST00000360416.3
ENST00000269243.4
MYH10
myosin, heavy chain 10, non-muscle
chr8_-_103424916 3.79 ENST00000220959.4
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr11_+_6625046 3.77 ENST00000396751.2
ILK
integrin-linked kinase
chr17_+_40985407 3.71 ENST00000586114.1
ENST00000590720.1
ENST00000585805.1
ENST00000541124.1
ENST00000441946.2
ENST00000591152.1
ENST00000589469.1
ENST00000293362.3
ENST00000592169.1
PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr2_+_178077477 3.67 ENST00000411529.2
ENST00000435711.1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3
chr10_-_96122682 3.65 ENST00000371361.3
NOC3L
nucleolar complex associated 3 homolog (S. cerevisiae)
chr1_-_246729544 3.52 ENST00000544618.1
ENST00000366514.4
TFB2M
transcription factor B2, mitochondrial
chr7_+_96747030 3.44 ENST00000360382.4
ACN9
ACN9 homolog (S. cerevisiae)
chr2_+_232575128 3.40 ENST00000412128.1
PTMA
prothymosin, alpha
chr17_+_42148225 3.40 ENST00000591696.1
G6PC3
glucose 6 phosphatase, catalytic, 3
chr8_-_95908902 3.27 ENST00000520509.1
CCNE2
cyclin E2
chr3_-_50329990 3.27 ENST00000417626.2
IFRD2
interferon-related developmental regulator 2
chrX_-_57147902 3.24 ENST00000275988.5
ENST00000434397.1
ENST00000333933.3
ENST00000374912.5
SPIN2B
spindlin family, member 2B
chrX_+_47077632 3.19 ENST00000457458.2
CDK16
cyclin-dependent kinase 16
chr3_+_63898275 3.10 ENST00000538065.1
ATXN7
ataxin 7
chr2_-_220118631 3.09 ENST00000248437.4
TUBA4A
tubulin, alpha 4a
chr19_+_1407517 3.04 ENST00000336761.6
ENST00000233078.4
DAZAP1
DAZ associated protein 1
chr15_-_59665062 3.03 ENST00000288235.4
MYO1E
myosin IE
chr8_-_103425047 2.94 ENST00000520539.1
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr2_+_85132749 2.94 ENST00000233143.4
TMSB10
thymosin beta 10
chr12_+_28343365 2.93 ENST00000545336.1
CCDC91
coiled-coil domain containing 91
chrX_-_41782683 2.92 ENST00000378163.1
ENST00000378154.1
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chr10_+_93558069 2.89 ENST00000371627.4
TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr4_+_83351715 2.83 ENST00000273920.3
ENOPH1
enolase-phosphatase 1
chr6_+_64282447 2.78 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr2_+_68384976 2.74 ENST00000263657.2
PNO1
partner of NOB1 homolog (S. cerevisiae)
chr18_+_9913977 2.71 ENST00000400000.2
ENST00000340541.4
VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr6_-_109702885 2.63 ENST00000504373.1
CD164
CD164 molecule, sialomucin
chr12_-_51422017 2.63 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr17_+_42148097 2.62 ENST00000269097.4
G6PC3
glucose 6 phosphatase, catalytic, 3
chr7_+_75931861 2.62 ENST00000248553.6
HSPB1
heat shock 27kDa protein 1
chr14_+_96968802 2.53 ENST00000556619.1
ENST00000392990.2
PAPOLA
poly(A) polymerase alpha
chr8_+_67341239 2.51 ENST00000320270.2
RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr17_+_80477571 2.46 ENST00000335255.5
FOXK2
forkhead box K2

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
11.0 77.0 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
8.7 26.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
7.7 23.2 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
7.5 22.4 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
7.2 36.0 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
6.9 20.8 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
6.2 25.0 GO:0046452 dihydrofolate metabolic process(GO:0046452)
5.8 29.0 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
5.6 28.1 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
5.2 15.7 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
4.9 14.6 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
4.6 13.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
4.2 16.7 GO:0002572 pro-T cell differentiation(GO:0002572)
4.0 19.8 GO:0061198 fungiform papilla formation(GO:0061198)
3.7 11.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
3.5 24.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
3.3 13.2 GO:1901165 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of trophoblast cell migration(GO:1901165)
3.0 9.0 GO:0097327 response to antineoplastic agent(GO:0097327)
3.0 9.0 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
3.0 11.9 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
2.9 8.8 GO:0044209 AMP salvage(GO:0044209)
2.9 17.2 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
2.8 8.5 GO:0021678 fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
2.7 13.7 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
2.7 51.1 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
2.4 11.9 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
2.4 14.2 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
2.2 32.8 GO:0006089 lactate metabolic process(GO:0006089)
2.1 8.3 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
2.0 42.7 GO:0031639 plasminogen activation(GO:0031639)
2.0 14.2 GO:0043985 histone H4-R3 methylation(GO:0043985) negative regulation of megakaryocyte differentiation(GO:0045653)
1.8 5.5 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
1.8 18.4 GO:0007000 nucleolus organization(GO:0007000)
1.7 13.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
1.7 20.7 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
1.7 8.4 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.6 4.8 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
1.6 11.1 GO:1902915 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
1.6 9.4 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
1.5 8.8 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
1.4 2.9 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
1.4 4.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
1.4 10.9 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
1.4 2.7 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
1.2 18.5 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.2 12.3 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
1.2 11.6 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
1.1 10.3 GO:0006552 leucine catabolic process(GO:0006552)
1.1 7.9 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
1.1 9.6 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
1.0 5.1 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
1.0 6.1 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
1.0 6.0 GO:0072719 cellular response to cisplatin(GO:0072719)
1.0 5.0 GO:0015862 uridine transport(GO:0015862)
1.0 4.8 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.9 8.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.9 3.5 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.9 26.2 GO:0007035 vacuolar acidification(GO:0007035)
0.8 5.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.8 4.1 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.8 2.4 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.8 6.8 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.8 11.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.7 8.5 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.7 8.4 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.7 2.6 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.6 7.1 GO:0008298 intracellular mRNA localization(GO:0008298)
0.6 8.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.6 2.5 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.6 1.8 GO:0060166 olfactory pit development(GO:0060166)
0.6 13.5 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.6 7.3 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.6 5.6 GO:0010265 SCF complex assembly(GO:0010265)
0.5 5.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.5 39.4 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.5 2.6 GO:0015692 lead ion transport(GO:0015692)
0.4 49.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.4 2.2 GO:0035672 oligopeptide transmembrane transport(GO:0035672)
0.4 5.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.4 1.5 GO:0043335 protein unfolding(GO:0043335)
0.4 16.5 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.4 4.7 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.4 1.4 GO:0035425 autocrine signaling(GO:0035425)
0.3 10.7 GO:0009303 rRNA transcription(GO:0009303)
0.3 6.6 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.3 4.4 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.3 2.8 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.3 13.2 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.3 1.2 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.3 28.3 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.3 8.5 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.3 8.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.3 0.9 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.3 12.1 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361) termination of RNA polymerase I transcription(GO:0006363)
0.3 20.7 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.3 3.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 10.1 GO:0048246 macrophage chemotaxis(GO:0048246)
0.3 16.7 GO:0035904 aorta development(GO:0035904)
0.2 1.0 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.2 0.9 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.2 5.8 GO:0071539 protein localization to centrosome(GO:0071539)
0.2 2.9 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.2 2.2 GO:0000733 DNA strand renaturation(GO:0000733)
0.2 3.0 GO:0072015 glomerular visceral epithelial cell development(GO:0072015)
0.2 0.6 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.2 0.8 GO:0015808 L-alanine transport(GO:0015808)
0.2 3.7 GO:0045444 fat cell differentiation(GO:0045444)
0.2 1.6 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.2 10.2 GO:0031529 ruffle organization(GO:0031529)
0.2 4.0 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.2 6.8 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.2 3.0 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2 1.8 GO:0032261 purine nucleotide salvage(GO:0032261)
0.2 8.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.2 3.4 GO:0000075 cell cycle checkpoint(GO:0000075)
0.2 10.4 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 1.3 GO:0070475 rRNA base methylation(GO:0070475)
0.2 37.5 GO:0007018 microtubule-based movement(GO:0007018)
0.1 6.4 GO:0043171 peptide catabolic process(GO:0043171)
0.1 2.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 9.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 20.1 GO:0002576 platelet degranulation(GO:0002576)
0.1 3.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 5.3 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 2.5 GO:0016579 protein deubiquitination(GO:0016579) protein modification by small protein removal(GO:0070646)
0.1 0.3 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.1 1.1 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 1.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 0.7 GO:0009249 protein lipoylation(GO:0009249)
0.1 0.3 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1 2.6 GO:0030252 growth hormone secretion(GO:0030252)
0.1 0.6 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 3.3 GO:0007129 synapsis(GO:0007129)
0.1 4.0 GO:0016569 covalent chromatin modification(GO:0016569)
0.1 14.8 GO:0060271 cilium morphogenesis(GO:0060271)
0.1 1.8 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.2 GO:0007097 nuclear migration(GO:0007097)
0.1 6.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.1 1.4 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 4.5 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 22.6 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.1 4.8 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 46.5 GO:0045087 innate immune response(GO:0045087)
0.1 2.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.5 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 1.5 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.9 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 11.4 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
15.3 92.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
9.4 28.1 GO:0005960 glycine cleavage complex(GO:0005960)
5.8 40.7 GO:0046581 intercellular canaliculus(GO:0046581)
5.2 26.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
4.8 29.0 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
3.9 51.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
3.1 18.4 GO:0070545 PeBoW complex(GO:0070545)
2.1 10.3 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
2.1 10.3 GO:1905202 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
2.1 24.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
2.0 13.7 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
1.9 5.6 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
1.8 46.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
1.7 8.5 GO:0097513 myosin II filament(GO:0097513)
1.6 24.2 GO:0090543 Flemming body(GO:0090543)
1.6 11.0 GO:0097452 GAIT complex(GO:0097452)
1.6 12.5 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
1.3 29.4 GO:0032156 septin cytoskeleton(GO:0032156)
1.2 14.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.1 5.3 GO:0016589 NURF complex(GO:0016589)
1.1 9.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
1.0 8.8 GO:0072546 ER membrane protein complex(GO:0072546)
1.0 27.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
1.0 5.8 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.8 8.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.8 3.3 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.8 9.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.8 14.5 GO:0034709 methylosome(GO:0034709)
0.7 16.5 GO:0046930 pore complex(GO:0046930)
0.7 10.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.6 12.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.6 3.7 GO:0008537 proteasome activator complex(GO:0008537)
0.5 9.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.5 2.6 GO:0070826 paraferritin complex(GO:0070826)
0.5 20.7 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.5 4.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.5 12.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.4 20.8 GO:1904115 axon cytoplasm(GO:1904115)
0.4 25.7 GO:0015030 Cajal body(GO:0015030)
0.4 44.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 13.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.4 18.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 22.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.3 8.6 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.3 2.6 GO:0000439 core TFIIH complex(GO:0000439)
0.3 4.8 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.2 20.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 0.7 GO:0044393 microspike(GO:0044393)
0.2 5.7 GO:0097228 sperm principal piece(GO:0097228)
0.2 4.4 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.2 20.7 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 47.0 GO:0043209 myelin sheath(GO:0043209)
0.2 0.9 GO:1990393 3M complex(GO:1990393)
0.1 2.9 GO:0000242 pericentriolar material(GO:0000242)
0.1 19.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 3.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 2.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 5.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.2 GO:0042641 actomyosin(GO:0042641)
0.1 6.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 5.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 21.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 5.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 1.5 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 17.3 GO:0045121 membrane raft(GO:0045121)
0.1 24.7 GO:0005635 nuclear envelope(GO:0005635)
0.1 21.3 GO:0005874 microtubule(GO:0005874)
0.0 8.0 GO:0001726 ruffle(GO:0001726)
0.0 2.0 GO:0098791 organelle subcompartment(GO:0031984) Golgi subcompartment(GO:0098791)
0.0 1.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 4.6 GO:0005770 late endosome(GO:0005770)
0.0 3.0 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 7.3 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 2.9 GO:0060170 ciliary membrane(GO:0060170)
0.0 2.4 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 2.4 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.4 GO:0031082 BLOC complex(GO:0031082)
0.0 5.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 75.8 GO:0070062 extracellular exosome(GO:0070062)
0.0 1.1 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
17.0 51.1 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
15.3 92.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
14.2 42.7 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
7.7 23.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
7.0 28.1 GO:0004047 aminomethyltransferase activity(GO:0004047)
6.9 20.8 GO:0008859 exoribonuclease II activity(GO:0008859)
4.9 14.6 GO:0070361 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
4.7 32.8 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
4.4 13.2 GO:0030984 kininogen binding(GO:0030984)
4.2 25.0 GO:0019238 cyclohydrolase activity(GO:0019238)
4.1 12.3 GO:0033149 FFAT motif binding(GO:0033149)
3.5 14.2 GO:0043515 kinetochore binding(GO:0043515)
2.8 13.8 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
2.8 11.0 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) aspartic-type endopeptidase inhibitor activity(GO:0019828) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
2.7 24.2 GO:0070883 pre-miRNA binding(GO:0070883)
2.5 27.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
2.4 14.2 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
2.3 20.7 GO:1901612 cardiolipin binding(GO:1901612)
2.1 10.3 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
2.0 11.9 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
1.9 20.7 GO:0004312 fatty acid synthase activity(GO:0004312)
1.8 16.5 GO:0015288 porin activity(GO:0015288)
1.7 6.8 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
1.6 63.4 GO:0051059 NF-kappaB binding(GO:0051059)
1.6 15.7 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
1.5 6.0 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.5 7.3 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
1.4 8.4 GO:0004167 dopachrome isomerase activity(GO:0004167)
1.4 4.1 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
1.2 13.7 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
1.2 12.0 GO:0008097 5S rRNA binding(GO:0008097)
1.1 5.6 GO:0019788 NEDD8 transferase activity(GO:0019788)
1.1 50.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
1.0 16.7 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.9 32.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.9 26.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.9 24.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 2.6 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.9 8.7 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.8 6.8 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.8 16.7 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.8 2.4 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.8 4.8 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.8 11.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.8 6.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.7 6.7 GO:0008312 7S RNA binding(GO:0008312)
0.7 2.2 GO:0015235 cobalamin transporter activity(GO:0015235)
0.7 3.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.6 34.9 GO:0019894 kinesin binding(GO:0019894)
0.6 19.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.6 1.9 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.6 18.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.6 3.7 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.6 5.5 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.6 17.8 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.6 8.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.6 2.2 GO:0000405 bubble DNA binding(GO:0000405)
0.5 26.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.5 3.7 GO:0061133 endopeptidase activator activity(GO:0061133)
0.5 9.5 GO:0001054 RNA polymerase I activity(GO:0001054)
0.5 8.3 GO:0008494 translation activator activity(GO:0008494)
0.5 8.8 GO:0019206 nucleoside kinase activity(GO:0019206)
0.5 5.5 GO:0016413 palmitoyl-CoA hydrolase activity(GO:0016290) O-acetyltransferase activity(GO:0016413)
0.4 1.3 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.4 9.0 GO:0004707 MAP kinase activity(GO:0004707)
0.4 5.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.4 18.2 GO:0003785 actin monomer binding(GO:0003785)
0.4 8.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.4 1.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.3 60.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 8.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.3 8.2 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 7.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.3 6.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.3 0.8 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.3 5.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 4.5 GO:0043274 phospholipase binding(GO:0043274)
0.2 5.0 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.2 4.1 GO:0008143 poly(A) binding(GO:0008143)
0.2 7.1 GO:0017091 AU-rich element binding(GO:0017091)
0.2 4.4 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 2.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 3.0 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 12.9 GO:0051287 NAD binding(GO:0051287)
0.2 1.8 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2 6.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 12.5 GO:0019003 GDP binding(GO:0019003)
0.2 0.5 GO:1901611 phosphatidylglycerol binding(GO:1901611)
0.2 1.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 5.8 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 2.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.6 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 2.2 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 10.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 1.0 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.1 9.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.6 GO:0035198 miRNA binding(GO:0035198)
0.1 5.7 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.4 GO:0030955 potassium ion binding(GO:0030955)
0.1 0.9 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 6.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 1.0 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 1.0 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 2.3 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.1 1.5 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 32.1 GO:0045296 cadherin binding(GO:0045296)
0.1 6.5 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 1.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 10.3 GO:0005178 integrin binding(GO:0005178)
0.1 0.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 0.8 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.3 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 1.7 GO:0030276 clathrin binding(GO:0030276)
0.0 3.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.6 GO:0042393 histone binding(GO:0042393)
0.0 3.0 GO:0035091 phosphatidylinositol binding(GO:0035091)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 36.0 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
1.6 24.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
1.5 213.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.8 58.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.7 34.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.5 30.0 PID PLK1 PATHWAY PLK1 signaling events
0.4 11.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.3 19.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.3 3.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 7.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 10.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 5.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 44.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 9.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 3.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 10.9 PID CMYB PATHWAY C-MYB transcription factor network
0.1 5.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 5.5 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 4.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.5 PID P53 REGULATION PATHWAY p53 pathway
0.1 4.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 4.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 166.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
2.4 77.3 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
1.5 25.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.3 15.7 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
1.2 33.7 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
1.0 9.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.9 24.1 REACTOME KINESINS Genes involved in Kinesins
0.9 25.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.8 13.7 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.7 17.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.7 13.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.6 5.6 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.6 20.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.6 55.7 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.6 11.9 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.5 26.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.5 29.4 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.4 22.8 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.4 10.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.4 8.8 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.4 9.0 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.4 6.8 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.4 3.3 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.4 12.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.4 23.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 58.9 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.3 16.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 6.0 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 20.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 6.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.2 8.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 8.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 4.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 4.9 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.2 2.6 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.2 7.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 2.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 3.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 5.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 16.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 9.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 1.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 4.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.0 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 9.3 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 1.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.1 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 2.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 3.5 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 1.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production