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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HINFP
Z-value: 0.55
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Transcription factors associated with HINFP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HINFP | hg19_v2_chr11_+_118992269_118992334 | 0.05 | 4.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_94023873 Show fit | 13.67 |
ENST00000297268.6
|
collagen, type I, alpha 2 |
|
| chr8_-_27462822 Show fit | 8.97 |
ENST00000522098.1
|
clusterin |
|
| chr5_-_136834982 Show fit | 8.58 |
ENST00000510689.1
ENST00000394945.1 |
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 |
|
| chr1_+_6845384 Show fit | 6.60 |
ENST00000303635.7
|
calmodulin binding transcription activator 1 |
|
| chr11_-_66336060 Show fit | 6.53 |
ENST00000310325.5
|
cathepsin F |
|
| chr9_+_130965651 Show fit | 6.49 |
ENST00000475805.1
ENST00000341179.7 ENST00000372923.3 |
dynamin 1 |
|
| chr9_+_130965677 Show fit | 6.33 |
ENST00000393594.3
ENST00000486160.1 |
dynamin 1 |
|
| chr20_-_35492048 Show fit | 6.22 |
ENST00000237536.4
|
suppressor of glucose, autophagy associated 1 |
|
| chr4_-_492891 Show fit | 5.91 |
ENST00000338977.5
ENST00000511833.2 |
zinc finger protein 721 |
|
| chr20_-_32031680 Show fit | 5.83 |
ENST00000217381.2
|
syntrophin, alpha 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HINFP
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 13.7 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 4.3 | 12.8 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 1.5 | 9.0 | GO:0061518 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.1 | 8.6 | GO:0010812 | negative regulation of cell-substrate adhesion(GO:0010812) |
| 2.1 | 8.2 | GO:2001151 | regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153) |
| 1.6 | 7.9 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.1 | 7.5 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.4 | 7.3 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 2.4 | 7.1 | GO:0050760 | negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 1.4 | 7.1 | GO:0032377 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 16.3 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 14.2 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 13.3 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.2 | 12.8 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 12.1 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.1 | 10.2 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.7 | 9.0 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.3 | 8.4 | GO:0033268 | node of Ranvier(GO:0033268) |
| 1.6 | 7.9 | GO:0045298 | tubulin complex(GO:0045298) |
| 1.9 | 7.6 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 16.3 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.4 | 9.0 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 8.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.3 | 8.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 1.4 | 8.2 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 2.0 | 7.9 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.0 | 7.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.4 | 7.1 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 7.1 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.0 | 6.7 | GO:0047485 | protein N-terminus binding(GO:0047485) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.8 | 13.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 12.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 12.8 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.5 | 10.4 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 8.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 8.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 7.9 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.2 | 7.6 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 7.3 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 13.7 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.7 | 12.8 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 9.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 8.2 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.2 | 7.9 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.4 | 7.1 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 6.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 6.1 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.2 | 5.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 4.5 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |