GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)


Results for HINFP1

Z-value: 0.95

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Transcription factors associated with HINFP1

Gene Symbol Gene ID Gene Info

Activity profile of HINFP1 motif

Sorted Z-values of HINFP1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_12308046 18.44 ENST00000317702.5
tubulin, beta 6 class V
chr18_+_12308231 15.49 ENST00000590103.1
tubulin, beta 6 class V
chr17_-_79481666 13.24 ENST00000575659.1
actin, gamma 1
chr18_+_11981427 11.30 ENST00000269159.3
inositol(myo)-1(or 4)-monophosphatase 2
chr5_+_154393260 11.09 ENST00000435029.4
kinesin family member 4B
chr2_-_234763147 10.66 ENST00000411486.2
Holliday junction recognition protein
chr2_+_130939827 10.47 ENST00000409255.1
mitotic spindle organizing protein 2B
chr18_+_11981547 8.66 ENST00000588927.1
inositol(myo)-1(or 4)-monophosphatase 2
chr6_-_144416737 6.94 ENST00000367569.2
splicing factor 3b, subunit 5, 10kDa
chr3_+_133293278 6.73 ENST00000508481.1
CDV3 homolog (mouse)
chr2_-_130939115 5.87 ENST00000441135.1
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
chr1_+_42922173 5.57 ENST00000455780.1
phosphopantothenoylcysteine synthetase
chr1_+_42921761 5.56 ENST00000372562.1
phosphopantothenoylcysteine synthetase
chrX_-_153707246 5.39 ENST00000407062.1
L antigen family, member 3
chr9_-_94186131 5.06 ENST00000297689.3
nuclear factor, interleukin 3 regulated
chr2_+_130939235 5.06 ENST00000425361.1
mitotic spindle organizing protein 2B
chr3_+_133292851 4.98 ENST00000503932.1
CDV3 homolog (mouse)
chr3_+_133292759 4.68 ENST00000431519.2
CDV3 homolog (mouse)
chr6_-_52149475 4.40 ENST00000419835.2
minichromosome maintenance complex component 3
chr1_-_94147385 4.33 ENST00000260502.6
breast cancer anti-estrogen resistance 3
chr2_+_58655461 3.65 ENST00000429095.1
long intergenic non-protein coding RNA 1122
chr16_+_57279248 2.98 ENST00000562023.1
ADP-ribosylation factor-like 2 binding protein
chr11_-_61658853 2.95 ENST00000525588.1
fatty acid desaturase 3
chr9_-_86595503 2.58 ENST00000376281.4
heterogeneous nuclear ribonucleoprotein K
chr14_+_55033815 1.53 ENST00000554335.1
sterile alpha motif domain containing 4A
chr11_-_61659006 1.22 ENST00000278829.2
fatty acid desaturase 3
chr10_-_97453650 1.02 ENST00000371209.5
tectonic family member 3
chr21_+_35445827 0.62 ENST00000608209.1
sodium/myo-inositol cotransporter
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr6_-_56707943 0.31 ENST00000370769.4

Network of associatons between targets according to the STRING database.

First level regulatory network of HINFP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 20.0 GO:0006021 inositol biosynthetic process(GO:0006021)
0.7 11.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.6 2.6 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.6 5.9 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.5 11.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.3 10.7 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.2 13.2 GO:0045214 sarcomere organization(GO:0045214)
0.2 4.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 3.0 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.1 5.1 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.1 4.4 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.6 GO:0015791 polyol transport(GO:0015791)
0.1 4.2 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.0 5.4 GO:0008033 tRNA processing(GO:0008033)
0.0 34.2 GO:0007017 microtubule-based process(GO:0007017)
0.0 1.5 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 6.9 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 15.5 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
1.1 5.4 GO:0000408 EKC/KEOPS complex(GO:0000408)
1.0 13.2 GO:0097433 dense body(GO:0097433)
0.7 4.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.3 6.9 GO:0005686 U2 snRNP(GO:0005686)
0.2 11.1 GO:0005871 kinesin complex(GO:0005871)
0.1 10.7 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 34.2 GO:0005874 microtubule(GO:0005874)
0.0 3.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 5.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.0 GO:0060170 ciliary membrane(GO:0060170)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 20.0 GO:0052833 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.6 5.9 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.5 11.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.4 11.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 47.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.6 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.0 1.5 GO:0030371 translation repressor activity(GO:0030371)
0.0 5.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 10.7 GO:0042393 histone binding(GO:0042393)
0.0 4.4 GO:0004386 helicase activity(GO:0004386)
0.0 2.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 13.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 4.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 4.4 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 33.9 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.8 11.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.4 11.1 REACTOME KINESINS Genes involved in Kinesins
0.3 4.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 10.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 5.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 6.9 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 2.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing