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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HINFP1
Z-value: 0.95
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Transcription factors associated with HINFP1
| Gene Symbol | Gene ID | Gene Info |
|---|
Network of associatons between targets according to the STRING database.
First level regulatory network of HINFP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.2 | GO:0007017 | microtubule-based process(GO:0007017) |
| 3.3 | 20.0 | GO:0006021 | inositol biosynthetic process(GO:0006021) |
| 0.2 | 13.2 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.7 | 11.1 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.5 | 11.1 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.3 | 10.7 | GO:0061641 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.0 | 6.9 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.6 | 5.9 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.0 | 5.4 | GO:0008033 | tRNA processing(GO:0008033) |
| 0.1 | 5.1 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 34.2 | GO:0005874 | microtubule(GO:0005874) |
| 1.7 | 15.5 | GO:0008274 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 1.0 | 13.2 | GO:0097433 | dense body(GO:0097433) |
| 0.2 | 11.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 10.7 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.3 | 6.9 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 5.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 1.1 | 5.4 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 0.7 | 4.4 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.0 | 3.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 47.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 4.0 | 20.0 | GO:0052833 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834) |
| 0.5 | 11.1 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.4 | 11.1 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 10.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.6 | 5.9 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 5.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 4.4 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 2.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 1.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 4.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 4.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 33.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.8 | 11.1 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.4 | 11.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 10.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 6.9 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.1 | 5.9 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.3 | 4.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 2.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |