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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HIVEP1
Z-value: 0.43
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Transcription factors associated with HIVEP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIVEP1 | hg19_v2_chr6_+_12012536_12012571 | 0.06 | 3.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_32605195 Show fit | 47.63 |
ENST00000374949.2
|
major histocompatibility complex, class II, DQ alpha 1 |
|
| chr6_+_32709119 Show fit | 34.13 |
ENST00000374940.3
|
major histocompatibility complex, class II, DQ alpha 2 |
|
| chr22_+_22930626 Show fit | 31.15 |
ENST00000390302.2
|
immunoglobulin lambda variable 2-33 (non-functional) |
|
| chr6_+_32407619 Show fit | 29.00 |
ENST00000395388.2
ENST00000374982.5 |
major histocompatibility complex, class II, DR alpha |
|
| chr14_-_106322288 Show fit | 26.02 |
ENST00000390559.2
|
immunoglobulin heavy constant mu |
|
| chr6_+_32605134 Show fit | 25.50 |
ENST00000343139.5
ENST00000395363.1 ENST00000496318.1 |
major histocompatibility complex, class II, DQ alpha 1 |
|
| chr17_+_40440481 Show fit | 24.75 |
ENST00000590726.2
ENST00000452307.2 ENST00000444283.1 ENST00000588868.1 |
signal transducer and activator of transcription 5A |
|
| chr5_-_149792295 Show fit | 24.56 |
ENST00000518797.1
ENST00000524315.1 ENST00000009530.7 ENST00000377795.3 |
CD74 molecule, major histocompatibility complex, class II invariant chain |
|
| chr6_+_29691198 Show fit | 24.50 |
ENST00000440587.2
ENST00000434407.2 |
major histocompatibility complex, class I, F |
|
| chr14_-_35873856 Show fit | 23.89 |
ENST00000553342.1
ENST00000216797.5 ENST00000557140.1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIVEP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 125.0 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 11.8 | 117.8 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 1.0 | 116.2 | GO:0031295 | T cell costimulation(GO:0031295) |
| 1.0 | 91.1 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 5.5 | 71.6 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.6 | 60.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 12.5 | 50.0 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.3 | 46.5 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 6.5 | 38.7 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
| 2.7 | 34.5 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.7 | 181.8 | GO:0042611 | MHC protein complex(GO:0042611) |
| 2.5 | 125.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 10.7 | 117.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 63.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 4.8 | 57.6 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.3 | 45.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 42.8 | GO:0031965 | nuclear membrane(GO:0031965) |
| 1.8 | 41.1 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.4 | 27.5 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.1 | 20.5 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.7 | 136.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 2.4 | 133.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 2.7 | 65.9 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.5 | 62.6 | GO:0003823 | antigen binding(GO:0003823) |
| 8.0 | 47.8 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.2 | 36.7 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
| 0.7 | 33.7 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.2 | 29.2 | GO:0005178 | integrin binding(GO:0005178) |
| 1.4 | 25.2 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 6.1 | 24.6 | GO:0042289 | MHC class II protein binding(GO:0042289) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 83.6 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 1.4 | 72.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.5 | 56.6 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.8 | 38.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.5 | 27.9 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.7 | 25.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 1.3 | 24.7 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 3.9 | 23.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 19.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 15.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.8 | 117.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 4.7 | 107.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.7 | 57.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.9 | 45.4 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.3 | 40.0 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.3 | 28.7 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 1.7 | 25.7 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 1.2 | 24.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.7 | 23.0 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.7 | 21.5 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |