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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HLF_TEF
Z-value: 0.88
Motif logo
Transcription factors associated with HLF_TEF
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HLF
|
ENSG00000108924.9 | HLF transcription factor, PAR bZIP family member |
|
TEF
|
ENSG00000167074.10 | TEF transcription factor, PAR bZIP family member |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEF | hg19_v2_chr22_+_41777927_41777971, hg19_v2_chr22_+_41763274_41763337 | -0.52 | 2.4e-16 | Click! |
| HLF | hg19_v2_chr17_+_53344945_53344977 | -0.25 | 2.0e-04 | Click! |
Activity profile of HLF_TEF motif
Sorted Z-values of HLF_TEF motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HLF_TEF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.1 | 27.3 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 8.9 | 89.2 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 5.5 | 22.0 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288) |
| 5.1 | 15.3 | GO:0042822 | pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) |
| 4.0 | 16.0 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 3.7 | 37.2 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 3.1 | 21.6 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 3.0 | 8.9 | GO:0036509 | trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512) |
| 2.3 | 11.6 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 2.2 | 15.5 | GO:0033484 | nitric oxide homeostasis(GO:0033484) |
| 1.9 | 20.5 | GO:0006983 | ER overload response(GO:0006983) |
| 1.9 | 7.4 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 1.7 | 22.4 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 1.7 | 10.1 | GO:0061517 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 1.6 | 15.8 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 1.3 | 9.3 | GO:1902915 | negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
| 1.3 | 3.8 | GO:0060557 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
| 1.2 | 6.1 | GO:1901896 | positive regulation of calcium-transporting ATPase activity(GO:1901896) |
| 1.1 | 3.4 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
| 1.0 | 3.0 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
| 0.9 | 2.8 | GO:0000412 | histone peptidyl-prolyl isomerization(GO:0000412) |
| 0.9 | 2.6 | GO:0039534 | regulation of MDA-5 signaling pathway(GO:0039533) negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.9 | 2.6 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.8 | 4.8 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.7 | 2.2 | GO:0042700 | luteinizing hormone signaling pathway(GO:0042700) |
| 0.7 | 2.7 | GO:0032690 | negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712) |
| 0.6 | 27.7 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.5 | 2.4 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.5 | 3.8 | GO:0070487 | monocyte aggregation(GO:0070487) |
| 0.4 | 2.0 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202) |
| 0.4 | 2.0 | GO:2000638 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.4 | 6.4 | GO:0090344 | negative regulation of cell aging(GO:0090344) |
| 0.4 | 3.1 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.4 | 5.8 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.4 | 4.3 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 0.3 | 1.9 | GO:0006561 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 0.3 | 1.8 | GO:1903286 | regulation of potassium ion import(GO:1903286) |
| 0.3 | 5.8 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
| 0.3 | 3.2 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.3 | 5.4 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.3 | 26.9 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.3 | 8.9 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.3 | 20.4 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 0.2 | 0.9 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.2 | 1.9 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.2 | 1.0 | GO:0048880 | sensory system development(GO:0048880) |
| 0.2 | 7.2 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.2 | 9.1 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.2 | 1.0 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 0.1 | 2.4 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.1 | 6.8 | GO:0048255 | mRNA stabilization(GO:0048255) |
| 0.1 | 2.3 | GO:0090005 | negative regulation of establishment of protein localization to plasma membrane(GO:0090005) |
| 0.1 | 0.7 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.1 | 4.0 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.1 | 0.5 | GO:0015722 | canalicular bile acid transport(GO:0015722) glycerol transport(GO:0015793) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823) |
| 0.1 | 0.4 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 0.1 | 6.3 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.1 | 0.2 | GO:0006145 | purine nucleobase catabolic process(GO:0006145) |
| 0.1 | 7.0 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.1 | 1.0 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.1 | 6.4 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.1 | 1.8 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 1.1 | GO:1901663 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 8.4 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 12.7 | GO:0051495 | positive regulation of cytoskeleton organization(GO:0051495) |
| 0.0 | 0.5 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
| 0.0 | 0.6 | GO:0033189 | response to vitamin A(GO:0033189) |
| 0.0 | 0.4 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.0 | 12.7 | GO:0001558 | regulation of cell growth(GO:0001558) |
| 0.0 | 0.1 | GO:0050961 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.0 | 4.4 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 14.2 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.0 | 0.5 | GO:0030817 | regulation of cAMP biosynthetic process(GO:0030817) positive regulation of cAMP biosynthetic process(GO:0030819) |
| 0.0 | 0.4 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.4 | GO:0035902 | response to immobilization stress(GO:0035902) |
| 0.0 | 0.9 | GO:0006081 | cellular aldehyde metabolic process(GO:0006081) |
| 0.0 | 1.0 | GO:0010975 | regulation of neuron projection development(GO:0010975) |
| 0.0 | 1.2 | GO:0070268 | cornification(GO:0070268) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 21.6 | GO:0070552 | BRISC complex(GO:0070552) |
| 1.9 | 13.1 | GO:0016272 | prefoldin complex(GO:0016272) |
| 1.8 | 7.2 | GO:0070695 | FHF complex(GO:0070695) |
| 1.8 | 16.0 | GO:0005827 | polar microtubule(GO:0005827) |
| 1.5 | 6.1 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 1.3 | 21.5 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 1.1 | 22.0 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.6 | 1.9 | GO:0009330 | DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330) |
| 0.6 | 10.1 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.6 | 10.4 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
| 0.5 | 3.8 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.5 | 20.4 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.4 | 5.8 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.3 | 2.6 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.3 | 32.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.3 | 19.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.3 | 2.0 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.3 | 8.9 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.3 | 8.9 | GO:0033176 | proton-transporting V-type ATPase complex(GO:0033176) |
| 0.3 | 8.9 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.3 | 4.8 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.2 | 24.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 29.2 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.2 | 0.8 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.2 | 2.6 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 4.4 | GO:0099738 | cell cortex region(GO:0099738) |
| 0.1 | 7.0 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 13.0 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 7.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 1.0 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 8.9 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 9.3 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.1 | 4.0 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 8.1 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 2.3 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.1 | 0.4 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.0 | 3.4 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 3.2 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 12.3 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 16.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 1.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 19.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 7.5 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 28.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 0.7 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 7.9 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 5.7 | GO:0000139 | Golgi membrane(GO:0000139) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 27.3 | GO:1903135 | cupric ion binding(GO:1903135) |
| 4.0 | 16.0 | GO:0031208 | POZ domain binding(GO:0031208) |
| 3.7 | 22.4 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 3.1 | 50.3 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 3.1 | 21.6 | GO:0004372 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 1.8 | 37.3 | GO:0030955 | potassium ion binding(GO:0030955) |
| 1.6 | 15.8 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 1.0 | 3.0 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
| 1.0 | 38.0 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.8 | 22.5 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
| 0.8 | 8.9 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.8 | 2.3 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.6 | 6.4 | GO:0016312 | inositol bisphosphate phosphatase activity(GO:0016312) |
| 0.6 | 9.3 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.6 | 10.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.5 | 2.7 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.5 | 6.8 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.5 | 1.9 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 0.4 | 13.1 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.4 | 7.4 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.3 | 7.3 | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups(GO:0016780) |
| 0.3 | 15.5 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.3 | 1.9 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.3 | 5.4 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.3 | 4.4 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.3 | 10.4 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.3 | 2.0 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.2 | 4.8 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.2 | 2.6 | GO:0089720 | caspase binding(GO:0089720) |
| 0.2 | 0.6 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 0.2 | 1.1 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.2 | 0.9 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.2 | 4.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 2.8 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 0.5 | GO:0015254 | glycerol channel activity(GO:0015254) urea channel activity(GO:0015265) |
| 0.1 | 9.1 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 3.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 1.0 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 1.1 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 20.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 3.1 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 32.4 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 1.0 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 8.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 29.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 2.8 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.1 | 0.4 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 1.0 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 2.7 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 2.2 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.5 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
| 0.0 | 15.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.2 | GO:0043546 | molybdopterin cofactor binding(GO:0043546) |
| 0.0 | 1.6 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 16.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.4 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.0 | 2.0 | GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity(GO:0008757) |
| 0.0 | 0.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.6 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 3.5 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 16.0 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.5 | 27.3 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.4 | 6.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.4 | 10.6 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.3 | 45.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 22.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.3 | 22.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 15.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 7.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 2.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 8.3 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 1.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 2.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.8 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.8 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 37.2 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.6 | 5.8 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.6 | 15.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.5 | 8.9 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.5 | 7.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.4 | 17.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.4 | 26.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.4 | 10.4 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.3 | 26.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.3 | 13.1 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.3 | 8.9 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.3 | 15.3 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.3 | 6.1 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.2 | 3.8 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 6.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 4.8 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.1 | 2.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 2.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 5.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 4.4 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 3.0 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 1.8 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 1.0 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 1.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 2.2 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 15.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 7.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.6 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 1.0 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.5 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 2.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.4 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 3.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 3.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.4 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |