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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HMBOX1

Z-value: 0.61

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Transcription factors associated with HMBOX1

Gene Symbol Gene ID Gene Info
HMBOX1
ENSG00000147421.13 homeobox containing 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMBOX1hg19_v2_chr8_+_28747884_28747938-0.221.3e-03Click!

Activity profile of HMBOX1 motif

Sorted Z-values of HMBOX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_149095652 22.75 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr6_+_27114861 20.54 ENST00000377459.1
HIST1H2AH
histone cluster 1, H2ah
chr3_+_33155525 16.37 ENST00000449224.1
CRTAP
cartilage associated protein
chr8_-_63951730 15.51 ENST00000260118.6
GGH
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
chr1_-_152009460 14.64 ENST00000271638.2
S100A11
S100 calcium binding protein A11
chr9_+_75766652 13.03 ENST00000257497.6
ANXA1
annexin A1
chrX_-_10851762 12.82 ENST00000380785.1
ENST00000380787.1
MID1
midline 1 (Opitz/BBB syndrome)
chr6_-_27114577 12.39 ENST00000356950.1
ENST00000396891.4
HIST1H2BK
histone cluster 1, H2bk
chr19_+_16178317 10.99 ENST00000344824.6
ENST00000538887.1
TPM4
tropomyosin 4
chrX_-_10588459 10.43 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr8_-_67977178 9.88 ENST00000517736.1
COPS5
COP9 signalosome subunit 5
chr14_+_56078695 9.69 ENST00000416613.1
KTN1
kinectin 1 (kinesin receptor)
chrX_-_10588595 8.92 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chrX_-_20236970 8.79 ENST00000379548.4
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr8_+_30244580 8.07 ENST00000523115.1
ENST00000519647.1
RBPMS
RNA binding protein with multiple splicing
chr2_-_99952769 7.89 ENST00000409434.1
ENST00000434323.1
ENST00000264255.3
TXNDC9
thioredoxin domain containing 9
chr1_+_45212051 7.76 ENST00000372222.3
KIF2C
kinesin family member 2C
chr7_-_102985288 7.33 ENST00000379263.3
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr13_+_48611665 7.27 ENST00000258662.2
NUDT15
nudix (nucleoside diphosphate linked moiety X)-type motif 15
chr8_-_67525473 7.16 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr6_-_8102714 7.04 ENST00000502429.1
ENST00000429723.2
ENST00000507463.1
ENST00000379715.5
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr7_+_135242652 6.66 ENST00000285968.6
ENST00000440390.2
NUP205
nucleoporin 205kDa
chr7_+_134576317 6.57 ENST00000424922.1
ENST00000495522.1
CALD1
caldesmon 1
chr11_+_19798964 6.34 ENST00000527559.2
NAV2
neuron navigator 2
chr1_-_150669500 6.22 ENST00000271732.3
GOLPH3L
golgi phosphoprotein 3-like
chr7_+_128379449 6.21 ENST00000479257.1
CALU
calumenin
chr17_-_3571934 6.13 ENST00000225525.3
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr3_-_141747439 6.06 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr8_+_11666649 6.05 ENST00000528643.1
ENST00000525777.1
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chrX_+_70503037 5.97 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chr7_+_134576151 5.92 ENST00000393118.2
CALD1
caldesmon 1
chr8_-_101734170 5.91 ENST00000522387.1
ENST00000518196.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr9_+_101984577 5.77 ENST00000223641.4
SEC61B
Sec61 beta subunit
chr4_-_47465666 5.70 ENST00000381571.4
COMMD8
COMM domain containing 8
chr10_+_35484793 5.25 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr11_-_57194948 5.15 ENST00000533235.1
ENST00000526621.1
ENST00000352187.1
SLC43A3
solute carrier family 43, member 3
chr3_+_69928256 5.11 ENST00000394355.2
MITF
microphthalmia-associated transcription factor
chr5_-_77844974 5.07 ENST00000515007.2
LHFPL2
lipoma HMGIC fusion partner-like 2
chr17_-_40134339 4.84 ENST00000587727.1
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr1_+_207943667 4.78 ENST00000462968.2
CD46
CD46 molecule, complement regulatory protein
chr22_+_19419425 4.75 ENST00000333130.3
MRPL40
mitochondrial ribosomal protein L40
chr1_+_117602925 4.72 ENST00000369466.4
TTF2
transcription termination factor, RNA polymerase II
chr7_-_99699538 4.70 ENST00000343023.6
ENST00000303887.5
MCM7
minichromosome maintenance complex component 7
chr12_-_77272765 4.58 ENST00000547435.1
ENST00000552330.1
ENST00000546966.1
ENST00000311083.5
CSRP2
cysteine and glycine-rich protein 2
chr1_-_32384693 4.42 ENST00000602683.1
ENST00000470404.1
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr3_+_37035289 4.38 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr10_-_112678904 4.37 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBIP1
BBSome interacting protein 1
chr7_+_107220899 4.33 ENST00000379117.2
ENST00000473124.1
BCAP29
B-cell receptor-associated protein 29
chrX_+_109246285 4.32 ENST00000372073.1
ENST00000372068.2
ENST00000288381.4
TMEM164
transmembrane protein 164
chr10_-_94257512 4.17 ENST00000371581.5
IDE
insulin-degrading enzyme
chr6_+_138725343 4.10 ENST00000607197.1
ENST00000367697.3
HEBP2
heme binding protein 2
chr20_-_48770244 4.06 ENST00000371650.5
ENST00000371652.4
ENST00000557021.1
TMEM189
transmembrane protein 189
chr7_+_128095945 3.92 ENST00000257696.4
HILPDA
hypoxia inducible lipid droplet-associated
chr17_+_3572087 3.91 ENST00000248378.5
ENST00000397133.2
EMC6
ER membrane protein complex subunit 6
chr7_+_99006550 3.82 ENST00000222969.5
BUD31
BUD31 homolog (S. cerevisiae)
chr3_+_33155444 3.80 ENST00000320954.6
CRTAP
cartilage associated protein
chr10_+_89419370 3.74 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr11_+_65769550 3.73 ENST00000312175.2
ENST00000445560.2
ENST00000530204.1
BANF1
barrier to autointegration factor 1
chr19_-_19051103 3.71 ENST00000542541.2
ENST00000433218.2
HOMER3
homer homolog 3 (Drosophila)
chr12_+_75874580 3.70 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr12_-_57113333 3.52 ENST00000550920.1
NACA
nascent polypeptide-associated complex alpha subunit
chrX_+_70503433 3.49 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO
non-POU domain containing, octamer-binding
chr2_+_27994567 3.33 ENST00000379666.3
ENST00000296102.3
MRPL33
mitochondrial ribosomal protein L33
chr16_-_67281413 3.17 ENST00000258201.4
FHOD1
formin homology 2 domain containing 1
chr4_-_10117949 3.16 ENST00000508079.1
WDR1
WD repeat domain 1
chr1_-_27216729 3.09 ENST00000431781.2
ENST00000374135.4
GPN2
GPN-loop GTPase 2
chr12_+_4758264 3.06 ENST00000266544.5
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr11_-_58345569 2.96 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr6_+_30585486 2.94 ENST00000259873.4
ENST00000506373.2
MRPS18B
mitochondrial ribosomal protein S18B
chr2_+_68384976 2.93 ENST00000263657.2
PNO1
partner of NOB1 homolog (S. cerevisiae)
chr10_+_124913793 2.93 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3
BUB3 mitotic checkpoint protein
chr14_-_50999307 2.89 ENST00000013125.4
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr10_+_75936444 2.88 ENST00000372734.3
ENST00000541550.1
ADK
adenosine kinase
chr14_+_90422239 2.86 ENST00000393452.3
ENST00000554180.1
ENST00000393454.2
ENST00000553617.1
ENST00000335725.4
ENST00000357382.3
ENST00000556867.1
ENST00000553527.1
TDP1
tyrosyl-DNA phosphodiesterase 1
chr5_-_137667459 2.82 ENST00000415130.2
ENST00000356505.3
ENST00000357274.3
ENST00000348983.3
ENST00000323760.6
CDC25C
cell division cycle 25C
chr1_+_174844645 2.81 ENST00000486220.1
RABGAP1L
RAB GTPase activating protein 1-like
chrX_-_74376108 2.80 ENST00000339447.4
ENST00000373394.3
ENST00000529949.1
ENST00000534524.1
ENST00000253577.3
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr12_+_117013656 2.74 ENST00000556529.1
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
chr20_-_43133491 2.72 ENST00000411544.1
SERINC3
serine incorporator 3
chr3_-_49142504 2.71 ENST00000306125.6
ENST00000420147.2
QARS
glutaminyl-tRNA synthetase
chr7_-_47579188 2.65 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr1_-_110283138 2.62 ENST00000256594.3
GSTM3
glutathione S-transferase mu 3 (brain)
chr4_-_114900831 2.51 ENST00000315366.7
ARSJ
arylsulfatase family, member J
chr3_-_141747459 2.50 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr15_+_79166065 2.41 ENST00000559690.1
ENST00000559158.1
MORF4L1
mortality factor 4 like 1
chr3_+_52444651 2.40 ENST00000327906.3
PHF7
PHD finger protein 7
chr11_-_47447970 2.26 ENST00000298852.3
ENST00000530912.1
PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr2_+_204193129 2.18 ENST00000417864.1
ABI2
abl-interactor 2
chr2_-_27632390 2.07 ENST00000350803.4
ENST00000344034.4
PPM1G
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr2_+_204193149 2.04 ENST00000422511.2
ABI2
abl-interactor 2
chr3_+_101504200 2.03 ENST00000422132.1
NXPE3
neurexophilin and PC-esterase domain family, member 3
chr2_+_204193101 2.02 ENST00000430418.1
ENST00000424558.1
ENST00000261016.6
ABI2
abl-interactor 2
chr1_+_198126093 1.98 ENST00000367385.4
ENST00000442588.1
ENST00000538004.1
NEK7
NIMA-related kinase 7
chr17_-_10452929 1.94 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2
myosin, heavy chain 2, skeletal muscle, adult
chr2_+_162087577 1.91 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr2_+_127782787 1.86 ENST00000564121.1
RP11-521O16.2
RP11-521O16.2
chr1_+_206643806 1.79 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr4_+_74347400 1.75 ENST00000226355.3
AFM
afamin
chr7_+_101460882 1.71 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr11_+_10772534 1.68 ENST00000361367.2
CTR9
CTR9, Paf1/RNA polymerase II complex component
chr16_-_71842941 1.68 ENST00000423132.2
ENST00000433195.2
ENST00000569748.1
ENST00000570017.1
AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chrX_-_77225135 1.65 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr1_+_89246647 1.60 ENST00000544045.1
PKN2
protein kinase N2
chr10_-_54531406 1.60 ENST00000373968.3
MBL2
mannose-binding lectin (protein C) 2, soluble
chrX_+_66764375 1.58 ENST00000374690.3
AR
androgen receptor
chr16_+_89696692 1.44 ENST00000261615.4
DPEP1
dipeptidase 1 (renal)
chr11_+_65343494 1.44 ENST00000309295.4
ENST00000533237.1
EHBP1L1
EH domain binding protein 1-like 1
chr8_-_95449155 1.41 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr1_+_100436065 1.41 ENST00000370153.1
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr14_+_21458127 1.40 ENST00000382985.4
ENST00000556670.2
ENST00000553564.1
ENST00000554751.1
ENST00000554283.1
ENST00000555670.1
METTL17
methyltransferase like 17
chr22_-_37172111 1.40 ENST00000417951.2
ENST00000430701.1
ENST00000433985.2
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
chr17_-_56494713 1.39 ENST00000407977.2
RNF43
ring finger protein 43
chr2_+_127413481 1.32 ENST00000259254.4
GYPC
glycophorin C (Gerbich blood group)
chr12_-_25348007 1.30 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
CASC1
cancer susceptibility candidate 1
chr1_-_93257951 1.28 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
EVI5
ecotropic viral integration site 5
chr19_-_41903161 1.27 ENST00000602129.1
ENST00000593771.1
ENST00000596905.1
ENST00000221233.4
EXOSC5
exosome component 5
chr14_+_32030582 1.24 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr17_-_1395954 1.24 ENST00000359786.5
MYO1C
myosin IC
chr4_-_110723134 1.24 ENST00000510800.1
ENST00000512148.1
CFI
complement factor I
chr10_+_112679301 1.23 ENST00000265277.5
ENST00000369452.4
SHOC2
soc-2 suppressor of clear homolog (C. elegans)
chr6_+_26199737 1.19 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr3_-_126327398 1.17 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr14_-_21566731 1.10 ENST00000360947.3
ZNF219
zinc finger protein 219
chr16_-_18908196 1.09 ENST00000565324.1
ENST00000561947.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr4_-_110723194 1.07 ENST00000394635.3
CFI
complement factor I
chr6_-_52668605 1.07 ENST00000334575.5
GSTA1
glutathione S-transferase alpha 1
chr22_-_37172191 1.07 ENST00000340630.5
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
chr7_-_120498357 1.02 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
TSPAN12
tetraspanin 12
chr2_-_183387064 1.02 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr16_-_71843047 0.95 ENST00000299980.4
ENST00000393512.3
AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr2_+_109335929 0.88 ENST00000283195.6
RANBP2
RAN binding protein 2
chr14_-_23623577 0.88 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr1_-_217250231 0.87 ENST00000493748.1
ENST00000463665.1
ESRRG
estrogen-related receptor gamma
chr17_-_56494908 0.87 ENST00000577716.1
RNF43
ring finger protein 43
chr17_-_56494882 0.87 ENST00000584437.1
RNF43
ring finger protein 43
chr6_-_165989936 0.79 ENST00000354448.4
PDE10A
phosphodiesterase 10A
chr4_-_159080806 0.74 ENST00000590648.1
FAM198B
family with sequence similarity 198, member B
chr7_-_122840015 0.73 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr20_-_2644832 0.73 ENST00000380851.5
ENST00000380843.4
IDH3B
isocitrate dehydrogenase 3 (NAD+) beta
chr1_+_206643787 0.72 ENST00000367120.3
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr11_-_59950519 0.71 ENST00000528851.1
MS4A6A
membrane-spanning 4-domains, subfamily A, member 6A
chr11_-_59950486 0.71 ENST00000426738.2
ENST00000533023.1
ENST00000420732.2
MS4A6A
membrane-spanning 4-domains, subfamily A, member 6A
chr1_-_169396666 0.71 ENST00000456107.1
ENST00000367805.3
CCDC181
coiled-coil domain containing 181
chr1_+_24286287 0.70 ENST00000334351.7
ENST00000374468.1
PNRC2
proline-rich nuclear receptor coactivator 2
chr5_+_176561129 0.68 ENST00000511258.1
ENST00000347982.4
NSD1
nuclear receptor binding SET domain protein 1
chr12_-_68619586 0.67 ENST00000229134.4
IL26
interleukin 26
chr1_+_175036966 0.66 ENST00000239462.4
TNN
tenascin N
chr17_-_10372875 0.64 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr4_+_187187098 0.61 ENST00000403665.2
ENST00000264692.4
F11
coagulation factor XI
chr12_+_28343353 0.59 ENST00000539107.1
CCDC91
coiled-coil domain containing 91
chr20_+_43211149 0.56 ENST00000372886.1
PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chrX_-_21776281 0.54 ENST00000379494.3
SMPX
small muscle protein, X-linked
chr9_-_114246635 0.53 ENST00000338205.5
KIAA0368
KIAA0368
chr4_+_9172135 0.51 ENST00000512047.1
FAM90A26
family with sequence similarity 90, member A26
chr3_-_45837959 0.51 ENST00000353278.4
ENST00000456124.2
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr5_+_138629417 0.47 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
MATR3
matrin 3
chr4_+_74301880 0.47 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr14_+_75536280 0.46 ENST00000238686.8
ZC2HC1C
zinc finger, C2HC-type containing 1C
chr5_-_157079372 0.45 ENST00000311371.5
SOX30
SRY (sex determining region Y)-box 30
chr5_+_176560742 0.45 ENST00000439151.2
NSD1
nuclear receptor binding SET domain protein 1
chr18_-_19283649 0.44 ENST00000584464.1
ENST00000578270.1
ABHD3
abhydrolase domain containing 3
chr14_+_75536335 0.40 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
ZC2HC1C
zinc finger, C2HC-type containing 1C
chrX_+_70752917 0.38 ENST00000373719.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr9_-_123555655 0.36 ENST00000340778.5
ENST00000453291.1
ENST00000608872.1
FBXW2
F-box and WD repeat domain containing 2
chr14_+_22748980 0.35 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr10_+_115312766 0.30 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr12_+_51633061 0.27 ENST00000551313.1
DAZAP2
DAZ associated protein 2
chr8_+_67976593 0.25 ENST00000262210.5
ENST00000412460.1
CSPP1
centrosome and spindle pole associated protein 1
chrX_+_16964985 0.24 ENST00000303843.7
REPS2
RALBP1 associated Eps domain containing 2
chr18_-_31803435 0.24 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
NOL4
nucleolar protein 4
chr5_+_110559784 0.24 ENST00000282356.4
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr5_+_178977546 0.23 ENST00000319449.4
ENST00000377001.2
RUFY1
RUN and FYVE domain containing 1
chr10_+_124320195 0.22 ENST00000359586.6
DMBT1
deleted in malignant brain tumors 1
chr9_-_21202204 0.21 ENST00000239347.3
IFNA7
interferon, alpha 7
chr1_-_173176452 0.20 ENST00000281834.3
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr21_+_45725050 0.19 ENST00000403390.1
PFKL
phosphofructokinase, liver
chr5_+_131705438 0.18 ENST00000245407.3
SLC22A5
solute carrier family 22 (organic cation/carnitine transporter), member 5
chr12_-_10962767 0.18 ENST00000240691.2
TAS2R9
taste receptor, type 2, member 9
chr8_+_27491572 0.18 ENST00000301904.3
SCARA3
scavenger receptor class A, member 3
chr1_-_169396646 0.17 ENST00000367806.3
CCDC181
coiled-coil domain containing 181
chr10_-_5046042 0.16 ENST00000421196.3
ENST00000455190.1
AKR1C2
aldo-keto reductase family 1, member C2
chr3_-_45838011 0.15 ENST00000358525.4
ENST00000413781.1
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr19_+_38826415 0.13 ENST00000410018.1
ENST00000409235.3
CATSPERG
catsper channel auxiliary subunit gamma
chr2_+_106468204 0.12 ENST00000425756.1
ENST00000393349.2
NCK2
NCK adaptor protein 2
chr14_+_64854958 0.10 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr12_+_81101277 0.10 ENST00000228641.3
MYF6
myogenic factor 6 (herculin)
chr5_+_110559603 0.05 ENST00000512453.1
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr1_-_21113105 0.03 ENST00000375000.1
ENST00000419490.1
ENST00000414993.1
ENST00000443615.1
ENST00000312239.5
HP1BP3
heterochromatin protein 1, binding protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of HMBOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 20.2 GO:1901873 regulation of post-translational protein modification(GO:1901873)
5.2 15.5 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
4.3 13.0 GO:1900138 negative regulation of phospholipase A2 activity(GO:1900138)
2.5 32.2 GO:0035372 protein localization to microtubule(GO:0035372)
2.4 7.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
2.0 7.9 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
1.8 7.3 GO:0006203 dGTP catabolic process(GO:0006203)
1.6 6.3 GO:0021564 vagus nerve development(GO:0021564)
1.6 9.5 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
1.5 4.4 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
1.4 4.2 GO:1901143 insulin catabolic process(GO:1901143)
1.2 6.0 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
1.2 5.8 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
1.0 3.1 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
1.0 2.9 GO:0044209 AMP salvage(GO:0044209)
0.9 3.7 GO:0000103 sulfate assimilation(GO:0000103)
0.9 2.7 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.8 3.2 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.8 3.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.8 7.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.7 5.9 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.7 2.6 GO:0043323 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.7 12.4 GO:0002227 innate immune response in mucosa(GO:0002227)
0.6 6.2 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.6 9.9 GO:0000338 protein deneddylation(GO:0000338)
0.6 4.1 GO:0010940 positive regulation of necrotic cell death(GO:0010940)
0.6 1.7 GO:2000653 regulation of genetic imprinting(GO:2000653) regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
0.5 1.6 GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599)
0.5 2.6 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.5 1.4 GO:0016999 antibiotic metabolic process(GO:0016999) cellular amide catabolic process(GO:0043605)
0.5 4.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.5 7.0 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.4 4.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.4 1.3 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.4 1.7 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.4 8.1 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.4 2.7 GO:0009597 detection of virus(GO:0009597)
0.4 3.0 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.4 4.8 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.4 6.1 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.4 1.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.4 6.7 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.3 4.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.3 1.9 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 3.2 GO:0051660 establishment of centrosome localization(GO:0051660)
0.3 3.7 GO:0015074 DNA integration(GO:0015074)
0.3 3.0 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.3 8.9 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.3 2.8 GO:0015886 heme transport(GO:0015886)
0.2 3.9 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 2.5 GO:0048194 Golgi vesicle budding(GO:0048194)
0.2 1.6 GO:0000012 single strand break repair(GO:0000012)
0.2 21.4 GO:0006342 chromatin silencing(GO:0006342)
0.2 0.7 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.2 1.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 1.4 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.2 8.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 1.9 GO:0001778 plasma membrane repair(GO:0001778)
0.2 2.7 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 3.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2 1.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.2 10.7 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.2 0.6 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.1 11.0 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 3.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 1.6 GO:0051852 disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.1 2.5 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.1 2.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 10.2 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 2.5 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.1 2.0 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.1 1.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.7 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.2 GO:0035712 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.1 5.1 GO:0030318 melanocyte differentiation(GO:0030318)
0.1 2.9 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 0.7 GO:0015824 proline transport(GO:0015824)
0.1 2.3 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.7 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.7 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.1 7.8 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.1 2.6 GO:0048286 lung alveolus development(GO:0048286)
0.1 0.2 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 1.1 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.1 1.6 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 4.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 4.1 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.7 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.3 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.0 1.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 9.7 GO:0007018 microtubule-based movement(GO:0007018)
0.0 1.0 GO:0010842 retina layer formation(GO:0010842)
0.0 4.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.9 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 12.6 GO:0006936 muscle contraction(GO:0006936)
0.0 0.7 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.6 GO:0042448 progesterone metabolic process(GO:0042448)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 1.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.2 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.0 1.1 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 0.1 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0 1.1 GO:0001505 regulation of neurotransmitter levels(GO:0001505)
0.0 0.1 GO:0035425 autocrine signaling(GO:0035425)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.2 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 0.2 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.0 0.2 GO:0009650 UV protection(GO:0009650)
0.0 2.1 GO:0002576 platelet degranulation(GO:0002576)
0.0 3.8 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 2.9 GO:0006364 rRNA processing(GO:0006364)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 13.0 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232) extrinsic component of endosome membrane(GO:0031313)
1.7 6.7 GO:0044611 nuclear pore inner ring(GO:0044611)
1.6 4.8 GO:0002079 inner acrosomal membrane(GO:0002079)
1.5 4.4 GO:0005715 late recombination nodule(GO:0005715)
1.3 3.9 GO:1903349 omegasome membrane(GO:1903349)
1.2 9.5 GO:0042382 paraspeckles(GO:0042382)
1.1 5.6 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
1.0 2.9 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.8 12.5 GO:0030478 actin cap(GO:0030478)
0.6 1.9 GO:0005826 actomyosin contractile ring(GO:0005826)
0.6 3.2 GO:0042643 actomyosin, actin portion(GO:0042643)
0.6 39.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.6 11.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.6 6.3 GO:0005614 interstitial matrix(GO:0005614)
0.6 6.2 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.6 31.4 GO:0000786 nucleosome(GO:0000786)
0.5 3.5 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.5 9.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.4 6.2 GO:0031209 SCAR complex(GO:0031209)
0.4 9.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.4 4.7 GO:0042555 MCM complex(GO:0042555)
0.4 3.2 GO:0032059 bleb(GO:0032059)
0.3 6.4 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.3 3.0 GO:0034464 BBSome(GO:0034464)
0.3 1.2 GO:0045160 myosin I complex(GO:0045160)
0.3 5.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.3 8.1 GO:0005685 U1 snRNP(GO:0005685)
0.2 2.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 8.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 4.0 GO:0097228 sperm principal piece(GO:0097228)
0.2 18.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.2 1.7 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 0.9 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.9 GO:0002177 manchette(GO:0002177)
0.1 2.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 16.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.5 GO:0005927 muscle tendon junction(GO:0005927)
0.1 4.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 2.4 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 31.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 2.7 GO:0000421 autophagosome membrane(GO:0000421)
0.1 3.0 GO:0002102 podosome(GO:0002102)
0.1 3.7 GO:0045178 basal part of cell(GO:0045178)
0.1 1.4 GO:0031528 microvillus membrane(GO:0031528)
0.1 2.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 3.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 3.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 9.5 GO:0030496 midbody(GO:0030496)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.0 2.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 4.3 GO:0001650 fibrillar center(GO:0001650)
0.0 0.6 GO:0032982 myosin filament(GO:0032982)
0.0 2.2 GO:0000922 spindle pole(GO:0000922)
0.0 5.0 GO:0005769 early endosome(GO:0005769)
0.0 2.5 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 1.3 GO:0005819 spindle(GO:0005819)
0.0 1.4 GO:0005840 ribosome(GO:0005840)
0.0 9.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.5 GO:0010008 endosome membrane(GO:0010008)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 GO:0035539 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) NADH pyrophosphatase activity(GO:0035529) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
2.2 13.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
1.6 7.9 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
1.5 6.0 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
1.2 3.7 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
1.2 7.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
1.2 8.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
1.1 4.4 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
1.0 9.9 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.9 2.7 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.8 2.5 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.8 5.8 GO:0048408 epidermal growth factor binding(GO:0048408)
0.8 7.8 GO:0019237 centromeric DNA binding(GO:0019237)
0.8 14.6 GO:0044548 S100 protein binding(GO:0044548)
0.7 4.4 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.7 2.9 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.7 15.5 GO:0008242 omega peptidase activity(GO:0008242)
0.7 7.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.5 4.2 GO:0043559 insulin binding(GO:0043559)
0.4 1.7 GO:0008431 vitamin E binding(GO:0008431)
0.4 1.7 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.4 11.1 GO:0005523 tropomyosin binding(GO:0005523)
0.4 1.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.4 5.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 5.9 GO:0008494 translation activator activity(GO:0008494)
0.3 1.9 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 2.8 GO:0015232 heme transporter activity(GO:0015232)
0.3 10.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 1.6 GO:0004882 androgen receptor activity(GO:0004882)
0.2 3.7 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.2 12.3 GO:0019894 kinesin binding(GO:0019894)
0.2 6.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 2.7 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.2 6.2 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 27.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 2.3 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.2 0.7 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.2 2.5 GO:0004065 arylsulfatase activity(GO:0004065)
0.2 1.4 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.2 2.9 GO:0019206 nucleoside kinase activity(GO:0019206)
0.2 2.9 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 2.6 GO:0043295 glutathione binding(GO:0043295)
0.1 4.8 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.0 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.8 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1 2.5 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 1.1 GO:0004969 histamine receptor activity(GO:0004969)
0.1 4.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 3.8 GO:0000146 microfilament motor activity(GO:0000146)
0.1 3.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 4.7 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.1 0.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 8.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.4 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 9.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 3.1 GO:0005109 frizzled binding(GO:0005109)
0.1 1.6 GO:0005537 mannose binding(GO:0005537)
0.1 0.9 GO:0019534 toxin transporter activity(GO:0019534)
0.1 1.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 1.6 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.2 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 1.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 3.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 3.2 GO:0043621 protein self-association(GO:0043621)
0.1 4.8 GO:0001618 virus receptor activity(GO:0001618)
0.0 2.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.9 GO:0050699 WW domain binding(GO:0050699)
0.0 1.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.9 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 5.6 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 3.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.7 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 1.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 5.6 GO:0008201 heparin binding(GO:0008201)
0.0 6.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 12.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.2 GO:0047115 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.0 2.3 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 9.1 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 2.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 2.4 GO:0051015 actin filament binding(GO:0051015)
0.0 0.8 GO:0070888 E-box binding(GO:0070888)
0.0 13.0 GO:0032403 protein complex binding(GO:0032403)
0.0 4.1 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 9.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 8.8 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 4.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 6.3 PID ATR PATHWAY ATR signaling pathway
0.1 4.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 5.6 PID AURORA B PATHWAY Aurora B signaling
0.1 4.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 14.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 0.9 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 8.6 PID E2F PATHWAY E2F transcription factor network
0.1 5.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 7.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 1.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.6 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 1.6 PID RHOA PATHWAY RhoA signaling pathway
0.0 2.9 PID TNF PATHWAY TNF receptor signaling pathway
0.0 15.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 4.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.7 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.4 23.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 20.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 7.8 REACTOME KINESINS Genes involved in Kinesins
0.3 4.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 9.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 12.0 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.2 8.8 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.2 2.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 5.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 6.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 2.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 6.6 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 5.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.3 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.1 1.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 3.7 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.5 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 2.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 2.9 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 2.0 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 8.0 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.1 1.6 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.6 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.1 3.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 12.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 9.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 1.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 3.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis