Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for HMBOX1
Z-value: 0.61
Motif logo
Transcription factors associated with HMBOX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMBOX1 | hg19_v2_chr8_+_28747884_28747938 | -0.22 | 1.3e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_149095652 Show fit | 22.75 |
ENST00000305366.3
|
transmembrane 4 L six family member 1 |
|
| chr6_+_27114861 Show fit | 20.54 |
ENST00000377459.1
|
histone cluster 1, H2ah |
|
| chr3_+_33155525 Show fit | 16.37 |
ENST00000449224.1
|
cartilage associated protein |
|
| chr8_-_63951730 Show fit | 15.51 |
ENST00000260118.6
|
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
|
| chr1_-_152009460 Show fit | 14.64 |
ENST00000271638.2
|
S100 calcium binding protein A11 |
|
| chr9_+_75766652 Show fit | 13.03 |
ENST00000257497.6
|
annexin A1 |
|
| chrX_-_10851762 Show fit | 12.82 |
ENST00000380785.1
ENST00000380787.1 |
midline 1 (Opitz/BBB syndrome) |
|
| chr6_-_27114577 Show fit | 12.39 |
ENST00000356950.1
ENST00000396891.4 |
histone cluster 1, H2bk |
|
| chr19_+_16178317 Show fit | 10.99 |
ENST00000344824.6
ENST00000538887.1 |
tropomyosin 4 |
|
| chrX_-_10588459 Show fit | 10.43 |
ENST00000380782.2
|
midline 1 (Opitz/BBB syndrome) |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMBOX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 32.2 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.2 | 21.4 | GO:0006342 | chromatin silencing(GO:0006342) |
| 6.7 | 20.2 | GO:1901873 | regulation of post-translational protein modification(GO:1901873) |
| 5.2 | 15.5 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 4.3 | 13.0 | GO:1900138 | negative regulation of phospholipase A2 activity(GO:1900138) |
| 0.0 | 12.6 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.7 | 12.4 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 11.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 0.2 | 10.7 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.1 | 10.2 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 39.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.6 | 31.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 31.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 18.5 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 16.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 2.2 | 13.0 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) extrinsic component of endosome membrane(GO:0031313) |
| 0.8 | 12.5 | GO:0030478 | actin cap(GO:0030478) |
| 0.6 | 11.0 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.4 | 9.9 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 9.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.3 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.7 | 15.5 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.8 | 14.6 | GO:0044548 | S100 protein binding(GO:0044548) |
| 2.2 | 13.0 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 13.0 | GO:0032403 | protein complex binding(GO:0032403) |
| 0.2 | 12.3 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 12.3 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.4 | 11.1 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.3 | 10.2 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 1.0 | 9.9 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 14.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 9.9 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.4 | 9.5 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.2 | 8.8 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 8.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 7.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 6.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 6.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 5.6 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 20.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 12.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 12.0 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.3 | 9.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 9.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 8.8 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.1 | 8.0 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.3 | 7.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 6.6 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |