ISMARA results: HMGA1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for HMGA1

Z-value: 0.16

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Transcription factors associated with HMGA1

Gene Symbol	Gene ID	Gene Info
HMGA1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000137309.15	high mobility group AT-hook 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HMGA1	hg19_v2_chr6_+_34204642_34204664	-0.23	5.5e-04	Click!

Activity profile of HMGA1 motif

Sorted Z-values of HMGA1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_91539918 Show fit	12.44	ENST00000548218.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr4_+_155484155 Show fit	11.57	ENST00000509493.1	FGB Ensembl NCBI GeneCards UniProt NextProt Show fit	fibrinogen beta chain
chr1_+_196621002 Show fit	11.32	ENST00000367429.4 ENST00000439155.2	CFH Ensembl NCBI GeneCards UniProt NextProt Show fit	complement factor H
chr3_-_195310802 Show fit	10.20	ENST00000421243.1 ENST00000453131.1	APOD Ensembl NCBI GeneCards UniProt NextProt Show fit	apolipoprotein D
chr12_-_91546926 Show fit	9.75	ENST00000550758.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr2_+_189839046 Show fit	8.60	ENST00000304636.3 ENST00000317840.5	COL3A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	collagen, type III, alpha 1
chr4_-_143226979 Show fit	8.57	ENST00000514525.1	INPP4B Ensembl NCBI GeneCards UniProt NextProt Show fit	inositol polyphosphate-4-phosphatase, type II, 105kDa
chr12_-_91573249 Show fit	7.83	ENST00000550099.1 ENST00000546391.1 ENST00000551354.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr1_+_196621156 Show fit	7.64	ENST00000359637.2	CFH Ensembl NCBI GeneCards UniProt NextProt Show fit	complement factor H
chr12_-_71551652 Show fit	7.51	ENST00000546561.1	TSPAN8 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 8

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	37.1	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.9	22.7	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	18.3	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.7	16.6	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.4	13.1	GO:0003298	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
4.0	12.1	GO:0044179	hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
2.0	11.9	GO:0010751	negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.2	10.7	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
3.4	10.2	GO:2000097	regulation of smooth muscle cell-matrix adhesion(GO:2000097)
1.0	9.7	GO:0051581	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)

Showing 1 to 10 of 235 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	48.0	GO:0005615	extracellular space(GO:0005615)
2.9	41.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	22.8	GO:0030018	Z disc(GO:0030018)
1.6	21.4	GO:0005577	fibrinogen complex(GO:0005577)
1.6	18.6	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	17.1	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	13.3	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	9.8	GO:0001669	acrosomal vesicle(GO:0001669)
0.6	8.4	GO:0030478	actin cap(GO:0030478)
0.0	7.8	GO:0016323	basolateral plasma membrane(GO:0016323)

Showing 1 to 10 of 83 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	46.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.3	29.7	GO:0008307	structural constituent of muscle(GO:0008307)
0.2	21.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.8	19.0	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.1	13.0	GO:0051087	chaperone binding(GO:0051087)
1.1	12.8	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.8	12.4	GO:0015643	toxic substance binding(GO:0015643)
0.0	10.7	GO:0005509	calcium ion binding(GO:0005509)
0.2	10.5	GO:0015485	cholesterol binding(GO:0015485)
1.9	9.6	GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)

Showing 1 to 10 of 167 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	44.8	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.7	41.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	20.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	15.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	11.6	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	9.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	5.8	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	5.7	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1	5.3	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	4.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta

Showing 1 to 10 of 35 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	39.0	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.8	21.9	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
1.3	21.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.3	17.0	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
1.0	16.7	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.2	15.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.6	9.6	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.5	8.6	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.2	8.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	8.0	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions

Showing 1 to 10 of 78 entries

Results for HMGA1

Z-value: 0.16

Motif logo

Transcription factors associated with HMGA1

Activity-expression correlation:

Activity profile of HMGA1 motif

Sorted Z-values of HMGA1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: