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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HMGA2
Z-value: 0.35
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Transcription factors associated with HMGA2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMGA2 | hg19_v2_chr12_+_66218212_66218244 | 0.45 | 4.8e-12 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_111580508 Show fit | 11.73 |
ENST00000368847.4
|
KIAA1919 |
|
| chr1_+_196621002 Show fit | 8.13 |
ENST00000367429.4
ENST00000439155.2 |
complement factor H |
|
| chr10_-_5046042 Show fit | 7.84 |
ENST00000421196.3
ENST00000455190.1 |
aldo-keto reductase family 1, member C2 |
|
| chr12_-_122751002 Show fit | 7.57 |
ENST00000267199.4
|
vacuolar protein sorting 33 homolog A (S. cerevisiae) |
|
| chr6_-_52705641 Show fit | 5.95 |
ENST00000370989.2
|
glutathione S-transferase alpha 5 |
|
| chr1_+_196621156 Show fit | 5.92 |
ENST00000359637.2
|
complement factor H |
|
| chr2_-_216257849 Show fit | 5.84 |
ENST00000456923.1
|
fibronectin 1 |
|
| chr15_+_43985084 Show fit | 5.76 |
ENST00000434505.1
ENST00000411750.1 |
creatine kinase, mitochondrial 1A |
|
| chr15_+_43885252 Show fit | 5.60 |
ENST00000453782.1
ENST00000300283.6 ENST00000437924.1 ENST00000450086.2 |
creatine kinase, mitochondrial 1B |
|
| chr19_-_36297632 Show fit | 4.76 |
ENST00000588266.2
|
proline dehydrogenase (oxidase) 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMGA2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.7 | 7.9 | GO:2000576 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 1.1 | 7.8 | GO:0009753 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.7 | 7.6 | GO:0035751 | regulation of lysosomal lumen pH(GO:0035751) |
| 0.1 | 5.9 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 1.9 | 5.8 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.5 | 5.8 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.2 | 5.8 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.8 | 4.8 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.7 | 4.8 | GO:0008218 | bioluminescence(GO:0008218) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 10.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.3 | 7.9 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.8 | 7.6 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.4 | 5.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 5.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 4.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 4.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 4.5 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.7 | 2.8 | GO:0070876 | SOSS complex(GO:0070876) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.1 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.4 | 10.5 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.4 | 7.9 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 1.3 | 7.8 | GO:0018636 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115) |
| 0.1 | 5.9 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.7 | 5.8 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 5.8 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 1.2 | 4.8 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.0 | 4.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.5 | 4.6 | GO:0036080 | GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.8 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 4.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 2.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 2.3 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 1.9 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 1.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 14.1 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 11.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 7.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 5.9 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 5.8 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.2 | 4.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 4.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 3.8 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 3.0 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 2.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |