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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HMX2
Z-value: 1.01
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Transcription factors associated with HMX2
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_95241951 Show fit | 42.86 |
ENST00000358334.5
ENST00000359263.4 ENST00000371488.3 |
myoferlin |
|
| chr12_+_104680659 Show fit | 28.63 |
ENST00000526691.1
ENST00000531691.1 ENST00000388854.3 ENST00000354940.6 ENST00000526390.1 ENST00000531689.1 |
thioredoxin reductase 1 |
|
| chr2_-_151344172 Show fit | 26.17 |
ENST00000375734.2
ENST00000263895.4 ENST00000454202.1 |
Rho family GTPase 3 |
|
| chr7_-_87856280 Show fit | 25.91 |
ENST00000490437.1
ENST00000431660.1 |
sorcin |
|
| chr7_-_87856303 Show fit | 25.17 |
ENST00000394641.3
|
sorcin |
|
| chr10_-_95242044 Show fit | 22.76 |
ENST00000371501.4
ENST00000371502.4 ENST00000371489.1 |
myoferlin |
|
| chr5_+_167913450 Show fit | 22.70 |
ENST00000231572.3
ENST00000538719.1 |
arginyl-tRNA synthetase |
|
| chr5_+_154393260 Show fit | 20.72 |
ENST00000435029.4
|
kinesin family member 4B |
|
| chr1_+_99127225 Show fit | 20.08 |
ENST00000370189.5
ENST00000529992.1 |
sorting nexin 7 |
|
| chrX_+_119737806 Show fit | 19.15 |
ENST00000371317.5
|
malignant T cell amplified sequence 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.5 | 65.6 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 7.3 | 51.1 | GO:0097577 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 5.1 | 40.6 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 3.2 | 28.6 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 1.6 | 25.1 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.2 | 23.8 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 7.6 | 22.7 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 1.4 | 20.7 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 6.4 | 19.1 | GO:0002188 | translation reinitiation(GO:0002188) |
| 1.8 | 18.4 | GO:0007144 | female meiosis I(GO:0007144) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 80.8 | GO:0005901 | caveola(GO:0005901) |
| 7.3 | 51.1 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.1 | 38.3 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 1.8 | 37.8 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.5 | 27.2 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 26.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.5 | 25.1 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 22.6 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.3 | 19.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 18.2 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 67.6 | GO:0005543 | phospholipid binding(GO:0005543) |
| 1.3 | 51.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 41.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 6.8 | 40.6 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 9.5 | 28.6 | GO:0098626 | methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626) |
| 2.5 | 25.1 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 1.6 | 22.9 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 7.6 | 22.7 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.7 | 22.5 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.3 | 19.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 70.7 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.3 | 34.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.5 | 26.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 19.5 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 1.3 | 18.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.5 | 15.1 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.2 | 11.6 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 10.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.3 | 10.6 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 10.3 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 40.6 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 1.0 | 37.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.8 | 28.6 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.0 | 25.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 23.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.9 | 18.4 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.7 | 18.2 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 1.4 | 16.9 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 14.4 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 14.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |