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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for HOXA1
Z-value: 0.67
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Transcription factors associated with HOXA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA1 | hg19_v2_chr7_-_27135591_27135658 | -0.04 | 5.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_104152922 Show fit | 31.82 |
ENST00000309982.5
ENST00000438105.2 ENST00000297574.6 |
brain and acute leukemia, cytoplasmic |
|
| chr8_-_27468842 Show fit | 28.84 |
ENST00000523500.1
|
clusterin |
|
| chr5_-_42825983 Show fit | 28.79 |
ENST00000506577.1
|
selenoprotein P, plasma, 1 |
|
| chr8_-_27462822 Show fit | 23.03 |
ENST00000522098.1
|
clusterin |
|
| chr8_-_27468945 Show fit | 22.94 |
ENST00000405140.3
|
clusterin |
|
| chr8_-_27115931 Show fit | 19.27 |
ENST00000523048.1
|
stathmin-like 4 |
|
| chr20_-_23618582 Show fit | 18.46 |
ENST00000398411.1
ENST00000376925.3 |
cystatin C |
|
| chrX_-_13835147 Show fit | 18.39 |
ENST00000493677.1
ENST00000355135.2 |
glycoprotein M6B |
|
| chr8_-_27469196 Show fit | 18.10 |
ENST00000546343.1
ENST00000560566.1 |
clusterin |
|
| chr20_+_44036620 Show fit | 17.53 |
ENST00000372710.3
|
dysbindin (dystrobrevin binding protein 1) domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.5 | 92.9 | GO:0061518 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.1 | 42.1 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.7 | 32.3 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.1 | 28.4 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 2.4 | 23.6 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 6.6 | 19.8 | GO:2000439 | positive regulation of monocyte extravasation(GO:2000439) |
| 4.6 | 18.5 | GO:0051541 | elastin metabolic process(GO:0051541) negative regulation of blood vessel remodeling(GO:0060313) |
| 1.8 | 18.4 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 6.1 | 18.3 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 1.4 | 17.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 92.9 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.2 | 53.5 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.3 | 37.9 | GO:0005604 | basement membrane(GO:0005604) |
| 0.2 | 37.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.4 | 32.0 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.3 | 26.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.5 | 24.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.3 | 22.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 3.7 | 18.3 | GO:0071546 | perinucleolar chromocenter(GO:0010370) pi-body(GO:0071546) |
| 1.2 | 17.2 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 92.9 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 1.3 | 29.2 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 28.2 | GO:0015631 | tubulin binding(GO:0015631) |
| 4.7 | 23.6 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.9 | 19.8 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.6 | 18.6 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.2 | 18.5 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 6.1 | 18.3 | GO:0034584 | piRNA binding(GO:0034584) |
| 0.1 | 18.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.4 | 17.1 | GO:0003785 | actin monomer binding(GO:0003785) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 87.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 34.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 33.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.4 | 18.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.3 | 17.5 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.3 | 16.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.5 | 15.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 14.1 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.3 | 13.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.3 | 11.6 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 90.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.8 | 21.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 17.1 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.9 | 16.0 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.9 | 15.7 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.4 | 15.4 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.5 | 14.1 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.4 | 12.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.5 | 12.3 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 10.4 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |